Linking abnormal mitosis to the acquisition of DNA damage
... during prolonged mitosis, and suggest that some cells may be more prone to such damage than others. As an example, several studies have demonstrated that efficient loading of components of the condensin II complex to chromosomes requires functional pRb, and that pRb loss, or mutations in pRb that ab ...
... during prolonged mitosis, and suggest that some cells may be more prone to such damage than others. As an example, several studies have demonstrated that efficient loading of components of the condensin II complex to chromosomes requires functional pRb, and that pRb loss, or mutations in pRb that ab ...
Therapeutic approaches to Lysosomal Storage Disorders
... Lysosomal Storage Disorders (LSDs) are a group of about 50 diseases characterized by an accumulation of undegraded molecules inside the lysosome, resulting in the formation of large intracellular vacuoles. They are usually caused by lack of a lysosomal hydrolases, or by lack of its activator or tran ...
... Lysosomal Storage Disorders (LSDs) are a group of about 50 diseases characterized by an accumulation of undegraded molecules inside the lysosome, resulting in the formation of large intracellular vacuoles. They are usually caused by lack of a lysosomal hydrolases, or by lack of its activator or tran ...
Copyright Information of the Article Published Online TITLE Dynamic
... cells or myofibroblasts (MFs). MFs are spindle-shaped cells with stress fibres and welldeveloped fibronexus, and they display α-smooth muscle actin immunohistochemically and smooth-muscle myofilaments ultrastructurally. MFs play a crucial role in physiological and pathological processes. Derived fro ...
... cells or myofibroblasts (MFs). MFs are spindle-shaped cells with stress fibres and welldeveloped fibronexus, and they display α-smooth muscle actin immunohistochemically and smooth-muscle myofilaments ultrastructurally. MFs play a crucial role in physiological and pathological processes. Derived fro ...
Membrane receptors in the gastrointestinal tract
... Guanylate cyclase is stimulated by sodium nitroprussiate, sodium azide, hydroxylamine, sodium nitrite and insulin in various cell systems (9). The second pathway uses phospholipase C which transforms phosphatidylinositol-4,5-bisphosphate (PIP2) into two messengers: inositol 1,4,5trisphosphate (IP3) ...
... Guanylate cyclase is stimulated by sodium nitroprussiate, sodium azide, hydroxylamine, sodium nitrite and insulin in various cell systems (9). The second pathway uses phospholipase C which transforms phosphatidylinositol-4,5-bisphosphate (PIP2) into two messengers: inositol 1,4,5trisphosphate (IP3) ...
Guidance cues involved in the development of the peripheral
... 2.2. Neurotrophic factors Some molecules that are classified as neurotrophic factors because of their effects on neuronal survival can also regulate neural migration and the direction of axon outgrowth (Markus et al., 2002). For example, it was shown many years ago that the neurites of chick dorsal ...
... 2.2. Neurotrophic factors Some molecules that are classified as neurotrophic factors because of their effects on neuronal survival can also regulate neural migration and the direction of axon outgrowth (Markus et al., 2002). For example, it was shown many years ago that the neurites of chick dorsal ...
Oct-4 controls cell-cycle progression of embryonic stem cells
... octamer sequence motif (5 -ATGCAAAT-3 ) is active irrespective of its distance from the site of transcriptional initiation [2,14]. However, in differentiated cells, Oct-4 can transactivate its targets only when the octamer motif is in a proximal position [3,15,16]. If the octamer motif is at a dis ...
... octamer sequence motif (5 -ATGCAAAT-3 ) is active irrespective of its distance from the site of transcriptional initiation [2,14]. However, in differentiated cells, Oct-4 can transactivate its targets only when the octamer motif is in a proximal position [3,15,16]. If the octamer motif is at a dis ...
Oxidative Stress Contributes to Autophagy
... and Sorbonne Universités, Université Pierre et Marie Curie, University of Paris 06 (M.E.P.-P.; S.D.L.), Unité Mixte de Recherche 8226, Laboratoire de Biologie Moléculaire et Cellulaire des Eucaryotes, Institut de Biologie Physico-Chimique, 75005 Paris, France ...
... and Sorbonne Universités, Université Pierre et Marie Curie, University of Paris 06 (M.E.P.-P.; S.D.L.), Unité Mixte de Recherche 8226, Laboratoire de Biologie Moléculaire et Cellulaire des Eucaryotes, Institut de Biologie Physico-Chimique, 75005 Paris, France ...
T-Cell Abnormalities in Common Variable Immunodeficiency
... lymphocytic infiltration, bronchiectasis, enteropathy, and opportunistic infections were more frequent [27, 29-31]. T-cell receptor excision circles (TRECs) and kappadeleting recombination excision circles (KRECs), such as circular DNA segments that persist in T cells and B cells, were recently cons ...
... lymphocytic infiltration, bronchiectasis, enteropathy, and opportunistic infections were more frequent [27, 29-31]. T-cell receptor excision circles (TRECs) and kappadeleting recombination excision circles (KRECs), such as circular DNA segments that persist in T cells and B cells, were recently cons ...
Control de la estabilidad de ciclinas de G1 por nutrientes Sara
... hen environmental conditions change, Saccharomyces cerevisiae, like other organisms, takes several coordinated decisions about growth, cell division, and maintaining homeostasis. Nutrient status is among the most important environmental conditions that must be accurately sensed and responded to in o ...
... hen environmental conditions change, Saccharomyces cerevisiae, like other organisms, takes several coordinated decisions about growth, cell division, and maintaining homeostasis. Nutrient status is among the most important environmental conditions that must be accurately sensed and responded to in o ...
Ethanol Induced Hepatotoxicity in Albino Rats
... preparations from group B, the proximal convoluted tubules in cortex were dilated and their epithelial cells showed hydropic changes with cytoplasmic vacuolations in some areas. Loss of brush border, patchy necrosis, presence of cellular debris and accumulation of inflammatory exudates within lumina ...
... preparations from group B, the proximal convoluted tubules in cortex were dilated and their epithelial cells showed hydropic changes with cytoplasmic vacuolations in some areas. Loss of brush border, patchy necrosis, presence of cellular debris and accumulation of inflammatory exudates within lumina ...
Morphine Modulates Mouse Hippocampal Progenitor Cell Lineages
... most well known role, Notch1 maintains NPCs in the undifferentiated state by inhibiting neuronal differentiation. It was reported that Notch1 inhibits neurogenesis by turning CSL-SKIP into an activator and stimulating the transcription of Hes1 and Hes5 [17]. Moreover, transient activation of Notch1 ...
... most well known role, Notch1 maintains NPCs in the undifferentiated state by inhibiting neuronal differentiation. It was reported that Notch1 inhibits neurogenesis by turning CSL-SKIP into an activator and stimulating the transcription of Hes1 and Hes5 [17]. Moreover, transient activation of Notch1 ...
Fluorescence resonance energy transfer (FRET) microscopy
... (range 700–1000 nm), allowing excitation of a wide variety of fluorophores with higher axial resolution, greater sample penetration, reduced photobleaching of marker dyes, and increased cell viability. These advantages allow investigations on thick living tissue specimens that would not otherwise be ...
... (range 700–1000 nm), allowing excitation of a wide variety of fluorophores with higher axial resolution, greater sample penetration, reduced photobleaching of marker dyes, and increased cell viability. These advantages allow investigations on thick living tissue specimens that would not otherwise be ...
p53 Pathway in Renal Cell Carcinoma Is Repressed by a Dominant
... derivative pLXSP, obtained by substitution of neo selectable marker to purocells can also be associated with the suppression of apoptotic mechmycin resistance. pBabe-siHdm2 plasmid was generated by insertion of H1 anisms of cellular response to stresses, such as the p53 tumor sup- promoter into the ...
... derivative pLXSP, obtained by substitution of neo selectable marker to purocells can also be associated with the suppression of apoptotic mechmycin resistance. pBabe-siHdm2 plasmid was generated by insertion of H1 anisms of cellular response to stresses, such as the p53 tumor sup- promoter into the ...
Tonoplast Intrinsic Protein Isoforms as Markers for Vacuolar Functions
... anti-TIP peptide antibodies gave results similar to those obtained with pea root tip extracts (data not shown). These results together demonstrate a high degree of specificity of each anti-TIP peptide antibody preparation to its corresponding protein. The additional bands of z40 kD (Figure 1B) repre ...
... anti-TIP peptide antibodies gave results similar to those obtained with pea root tip extracts (data not shown). These results together demonstrate a high degree of specificity of each anti-TIP peptide antibody preparation to its corresponding protein. The additional bands of z40 kD (Figure 1B) repre ...
Phospholipase C-γ1 is a guanine nucleotide exchange factor for
... Dynamin is a member of the GTPase superfamily that essentially participates in clathrin-mediated endocytosis in cells. Three mammalian isoforms of dynamin have been detected (Liu and Robinson, 1995; Urrutia et al., 1997). Dynamin-1 is exclusively expressed in neuronal cells (Nakata et al., 1991). Bu ...
... Dynamin is a member of the GTPase superfamily that essentially participates in clathrin-mediated endocytosis in cells. Three mammalian isoforms of dynamin have been detected (Liu and Robinson, 1995; Urrutia et al., 1997). Dynamin-1 is exclusively expressed in neuronal cells (Nakata et al., 1991). Bu ...
as a PDF
... anti-TIP peptide antibodies gave results similar to those obtained with pea root tip extracts (data not shown). These results together demonstrate a high degree of specificity of each anti-TIP peptide antibody preparation to its corresponding protein. The additional bands of z40 kD (Figure 1B) repre ...
... anti-TIP peptide antibodies gave results similar to those obtained with pea root tip extracts (data not shown). These results together demonstrate a high degree of specificity of each anti-TIP peptide antibody preparation to its corresponding protein. The additional bands of z40 kD (Figure 1B) repre ...
Where in the Cell Are You? Probing HIV
... cells (APCs) and T cells through the binding of the T cell receptors (TCRs) with cognate major histocompatibility complex (MHC) molecules on APCs, in which case the term immunological synapse is used [19,20]. Although immunological synapses generally utilize many of the same adhesion molecules as vi ...
... cells (APCs) and T cells through the binding of the T cell receptors (TCRs) with cognate major histocompatibility complex (MHC) molecules on APCs, in which case the term immunological synapse is used [19,20]. Although immunological synapses generally utilize many of the same adhesion molecules as vi ...
fluphenazine and perphenazine impact on melanogenesis and
... Abstract: Fluphenazine and perphenazine as a phenothiazine-class antipsychotic drugs are widely used to treat psychoses and schizophrenia, however their use is associated with significant side effects such as extrapyramidal symptoms as well as ocular and skin disorders. The aim of this study was to ...
... Abstract: Fluphenazine and perphenazine as a phenothiazine-class antipsychotic drugs are widely used to treat psychoses and schizophrenia, however their use is associated with significant side effects such as extrapyramidal symptoms as well as ocular and skin disorders. The aim of this study was to ...
View Full Page PDF - Physiological Reviews
... act over a greater distance to direct immune cell movement and activation in tissue (85). These three systems, 1) selectin binding to carbohydrate mucinlike molecules, 2) cell adhesion molecules from the Ig and the extracellular matrix protein families binding to integrins, and 3) chemoattractants a ...
... act over a greater distance to direct immune cell movement and activation in tissue (85). These three systems, 1) selectin binding to carbohydrate mucinlike molecules, 2) cell adhesion molecules from the Ig and the extracellular matrix protein families binding to integrins, and 3) chemoattractants a ...
Full-Text PDF
... to the thymus and as they mature T cells express a clonally restricted T cell receptor (TCR) and develop into two major lineages referred to as TCRαβ+ and TCRγδ+ . The TCRαβ+ lineage represents the major population of T cells in the peripheral immune system comprising >90% of the total T cells. Thes ...
... to the thymus and as they mature T cells express a clonally restricted T cell receptor (TCR) and develop into two major lineages referred to as TCRαβ+ and TCRγδ+ . The TCRαβ+ lineage represents the major population of T cells in the peripheral immune system comprising >90% of the total T cells. Thes ...
The structure and function of the Golgi apparatus
... can be detected by dbEST searching (Andreeva et al., unpublished observations), however their functions and intracellular localization are not known. Spectrin has been detected in Chlamydomonas (Lorenz et al., 1995) and pea (Bisikirska and Sikorski, 1997). Mobility of the Golgi apparatus While in ma ...
... can be detected by dbEST searching (Andreeva et al., unpublished observations), however their functions and intracellular localization are not known. Spectrin has been detected in Chlamydomonas (Lorenz et al., 1995) and pea (Bisikirska and Sikorski, 1997). Mobility of the Golgi apparatus While in ma ...
Cell encapsulation
Cell microencapsulation technology involves immobilization of the cells within a polymeric semi-permeable membrane that permits the bidirectional diffusion of molecules such as the influx of oxygen, nutrients, growth factors etc. essential for cell metabolism and the outward diffusion of waste products and therapeutic proteins. At the same time, the semi-permeable nature of the membrane prevents immune cells and antibodies from destroying the encapsulated cells regarding them as foreign invaders.The main motive of cell encapsulation technology is to overcome the existing problem of graft rejection in tissue engineering applications and thus reduce the need for long-term use of immunosuppressive drugs after an organ transplant to control side effects.