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... identify two early gene clusters whose promoters show significant enrichment for NRF2/ETS transcription factor binding sites. We further demonstrate that Ets transcription factors, but not Nrf2, are regulated during early adipogenesis and that Ets2 is essential for the normal progression of the adip ...
... identify two early gene clusters whose promoters show significant enrichment for NRF2/ETS transcription factor binding sites. We further demonstrate that Ets transcription factors, but not Nrf2, are regulated during early adipogenesis and that Ets2 is essential for the normal progression of the adip ...
Arabidopsis mutants in sphingolipid synthesis as tools to
... interactions and tracking of fluorescent particles may give more information of the PD microdomains (Jacobson et al., 2007; Pike, 2009; Lingwood and Simons, 2010). Given the high elusiveness of the structure and organization of PD, microdomain studies require other approaches as the use of Arabidops ...
... interactions and tracking of fluorescent particles may give more information of the PD microdomains (Jacobson et al., 2007; Pike, 2009; Lingwood and Simons, 2010). Given the high elusiveness of the structure and organization of PD, microdomain studies require other approaches as the use of Arabidops ...
Specific localization of nesprin-1-α2, the short isoform of nesprin
... Background: Nesprin-1-giant (1008kD) is a protein of the outer nuclear membrane that links nuclei to the actin cytoskeleton via amino-terminal calponin homology domains. The short nesprin-1 isoform, nesprin-1-α2, is present only in skeletal and cardiac muscle and several pathogenic mutations occur w ...
... Background: Nesprin-1-giant (1008kD) is a protein of the outer nuclear membrane that links nuclei to the actin cytoskeleton via amino-terminal calponin homology domains. The short nesprin-1 isoform, nesprin-1-α2, is present only in skeletal and cardiac muscle and several pathogenic mutations occur w ...
University of Birmingham Leptomycin B induces apoptosis in cells
... double-stranded DNA viruses contain a circular 8 kb genome encoding only eight genes, which are subdivided into early (E1, E2, E4, E5, E6 and E7) and late (L1 and L2) genes (reviewed in ref. 1). The varying ability of the different HPV types to induce either benign lesions or anogenital neoplasia ha ...
... double-stranded DNA viruses contain a circular 8 kb genome encoding only eight genes, which are subdivided into early (E1, E2, E4, E5, E6 and E7) and late (L1 and L2) genes (reviewed in ref. 1). The varying ability of the different HPV types to induce either benign lesions or anogenital neoplasia ha ...
View PDF - Elly Nedivi
... learning and memory, act through a mechanism analogous to that of growth factors, namely, through second messenger pathways leading to transcriptional activation (reviewed in Refs. 21, 93). It had been known for two decades that protein synthesis inhibitors could affect memory retention in mammals, ...
... learning and memory, act through a mechanism analogous to that of growth factors, namely, through second messenger pathways leading to transcriptional activation (reviewed in Refs. 21, 93). It had been known for two decades that protein synthesis inhibitors could affect memory retention in mammals, ...
The integrin–actin connection, an eternal love affair
... platforms, which brings kinases and substrates together. Integrin-bound signalling molecules, on the other hand, bind to actin binding proteins, enforcing the integrin± cytoskeleton connection. As it turns out for integrin-linked kinase (ILK), such adapter function might be even more important in vi ...
... platforms, which brings kinases and substrates together. Integrin-bound signalling molecules, on the other hand, bind to actin binding proteins, enforcing the integrin± cytoskeleton connection. As it turns out for integrin-linked kinase (ILK), such adapter function might be even more important in vi ...
Expression of the RET Receptor Tyrosine Kinase and GDNFR
... studies have shown that GDNF binds to a novel glycosylphosphatidylinositol (GPI)-linked protein (termed GDNFRa) by promoting the formation at the cell surface of a physical complex involving GDNF, GDNFR-a, and RET.19,20 As ...
... studies have shown that GDNF binds to a novel glycosylphosphatidylinositol (GPI)-linked protein (termed GDNFRa) by promoting the formation at the cell surface of a physical complex involving GDNF, GDNFR-a, and RET.19,20 As ...
Cancer Genome Landscapes - Department of Statistics, Purdue
... matter” below). Another explanation is that metastatic lesions have not yet been studied in sufficient detail to identify these genetic alterations, particularly if the mutations are heterogeneous in nature. But another possible explanation is that there are no metastasis genes. A malignant primary ...
... matter” below). Another explanation is that metastatic lesions have not yet been studied in sufficient detail to identify these genetic alterations, particularly if the mutations are heterogeneous in nature. But another possible explanation is that there are no metastasis genes. A malignant primary ...
The Role of the Cell Cycle Machinery in
... and protein localization. Further mechanisms of modulation are achieved through the interaction with inhibitory and scaffolding proteins. CDK inhibitor proteins, known as Kip-related proteins (KRPs) or CDK inhibitors, play a major role in controlling cell cycle progression. All KRPs bind the A-type ...
... and protein localization. Further mechanisms of modulation are achieved through the interaction with inhibitory and scaffolding proteins. CDK inhibitor proteins, known as Kip-related proteins (KRPs) or CDK inhibitors, play a major role in controlling cell cycle progression. All KRPs bind the A-type ...
Membrane Trafficking During Plant Cytokinesis
... the cell plate. With regard to the latter, it will be interesting to determine if in addition to PIN1 other asymmetrically distributed plasma membrane proteins such as AUX1 (30) are also targeted to the cell plate. Sorting signals Polarized trafficking of KORRIGAN, an endo-1,4-beta-glucanase required ...
... the cell plate. With regard to the latter, it will be interesting to determine if in addition to PIN1 other asymmetrically distributed plasma membrane proteins such as AUX1 (30) are also targeted to the cell plate. Sorting signals Polarized trafficking of KORRIGAN, an endo-1,4-beta-glucanase required ...
Genome-wide gene expression in uro mutant
... (At3g15540), FMO (YUCCA1) (At4g32540), AMP1 (At3g54720), CYC2b (At4g35620), CYC1 (At4g37490), CYC2a (At2g17620), EXPL3 (At3g45960), XTR9 (At4g25820), XTR6 (At4g25810), and genes encoding glycosyl hydrolase family protein 85 (At3g61000) and glycosyl transferase family protein 48 (At1g06490), respecti ...
... (At3g15540), FMO (YUCCA1) (At4g32540), AMP1 (At3g54720), CYC2b (At4g35620), CYC1 (At4g37490), CYC2a (At2g17620), EXPL3 (At3g45960), XTR9 (At4g25820), XTR6 (At4g25810), and genes encoding glycosyl hydrolase family protein 85 (At3g61000) and glycosyl transferase family protein 48 (At1g06490), respecti ...
mrsa
... wall synthesis. Without a cell wall, the bacterial cells cannot maintain their shape in changing osmotic conditions. This puts significant selective pressure on the microbes to evolve, as they cannot survive the osmotic stress. Any microbe that can resist these drugs will survive and reproduce more, ...
... wall synthesis. Without a cell wall, the bacterial cells cannot maintain their shape in changing osmotic conditions. This puts significant selective pressure on the microbes to evolve, as they cannot survive the osmotic stress. Any microbe that can resist these drugs will survive and reproduce more, ...
SCD1 is required for cell cytokinesis and polarized
... HINKEL (Strompen et al., 2002), which encodes a kinesinrelated protein, defines a third class of genes required for phragmoplast-mediated expansion and cell plate guidance. Recent reverse genetic studies have linked the function of HINKEL and division plane-localized components of a mitogen-activate ...
... HINKEL (Strompen et al., 2002), which encodes a kinesinrelated protein, defines a third class of genes required for phragmoplast-mediated expansion and cell plate guidance. Recent reverse genetic studies have linked the function of HINKEL and division plane-localized components of a mitogen-activate ...
Transcriptional Activity of Male Gamete
... al. 1998, Meshi et al. 2000). The OCT motif in the histone promoter has been identified as a cis-acting element involved in proliferation-coupled and S phase-specific expression. Almost all plant histone gene promoters in the genome databases contain at least one OCT motif in their proximal regions ...
... al. 1998, Meshi et al. 2000). The OCT motif in the histone promoter has been identified as a cis-acting element involved in proliferation-coupled and S phase-specific expression. Almost all plant histone gene promoters in the genome databases contain at least one OCT motif in their proximal regions ...
Dimensional analysis of Expansive Growth of Cells with Walls
... sporangiophores of P. blakesleeanus. There is evidence supporting this prediction. In a variety of higher plant cells within tissue, a pH-dependent protein (expansin) is found to loosen the wall by disrupting the hydrogen bonds between microfibrils [5,8]. In large internode algal cells of C. coralli ...
... sporangiophores of P. blakesleeanus. There is evidence supporting this prediction. In a variety of higher plant cells within tissue, a pH-dependent protein (expansin) is found to loosen the wall by disrupting the hydrogen bonds between microfibrils [5,8]. In large internode algal cells of C. coralli ...
Identification of the Tuberous Sclerosis Complex
... specifically binds to these lipids (Stokoe et al., 1997). PDK1 then phosphorylates and activates Akt (Alessi et al., 1997). The regulation of S6K1 is much more complex, with both PI3K-dependent and -independent signaling pathways involved in its activation (Chung et al., 1994; Weng et al., 1995). Se ...
... specifically binds to these lipids (Stokoe et al., 1997). PDK1 then phosphorylates and activates Akt (Alessi et al., 1997). The regulation of S6K1 is much more complex, with both PI3K-dependent and -independent signaling pathways involved in its activation (Chung et al., 1994; Weng et al., 1995). Se ...
Primordial germ cell migration - The International Journal of
... have allowed for the elegant analysis of the signaling machinery required for cell-shape changes and motility. It is likely that the general paradigm for cell migration established from in vitro studies will also apply to migratory populations that arise during embryogenesis or disease in vivo. Howe ...
... have allowed for the elegant analysis of the signaling machinery required for cell-shape changes and motility. It is likely that the general paradigm for cell migration established from in vitro studies will also apply to migratory populations that arise during embryogenesis or disease in vivo. Howe ...
Review Cell Death Signalling Pathways in the
... progression of many diseases. Apoptosis is essential for the development and survival of multi-cellular organisms. Malignant diseases, including haematologic malignancies, are associated with defects in the cell death mechanism. These defects are not only important for the growth advantage of malign ...
... progression of many diseases. Apoptosis is essential for the development and survival of multi-cellular organisms. Malignant diseases, including haematologic malignancies, are associated with defects in the cell death mechanism. These defects are not only important for the growth advantage of malign ...
Drosophila Importin-a2 Is Involved in Synapse, Axon and Muscle
... cargoes rather than general nuclear import. Indeed, in neuronal systems, Importin-a isoforms can mediate very specific processes such as axonal tiling and communication of an injury signal. To study nuclear import during development, we examined the expression and function of Importin-a2 in Drosophi ...
... cargoes rather than general nuclear import. Indeed, in neuronal systems, Importin-a isoforms can mediate very specific processes such as axonal tiling and communication of an injury signal. To study nuclear import during development, we examined the expression and function of Importin-a2 in Drosophi ...
... There are different ways to produce anthocyanins naturally, but cell cultures seem to be the most promising option [3]–[5]. They offer a wide range of possibilities for large-scale production of high quality products. Dougall and Weyrauch [4] studied the growth of carrot cells with limitations on th ...
Impact of the cell lifecycle on bacteriophage T4 infection
... larger quantities and specifically for phage reproduction in order for the productivity to increase. In fact, intracellular RNA concentration was observed to correlate strongly and significantly with an increase in burst size, decrease in lysis time, and increase in phage productivity during infecti ...
... larger quantities and specifically for phage reproduction in order for the productivity to increase. In fact, intracellular RNA concentration was observed to correlate strongly and significantly with an increase in burst size, decrease in lysis time, and increase in phage productivity during infecti ...
Susana Lopes, PhD Institution: CEDOC
... This project sets out to investigate the role of time in the left-right organizer (LRO). This transient embryonic organ is crucial for determining the left-right identity of the vertebrate body-plan. Inside this organ there are exciting biophysical mechanisms of development to be investigated. Namel ...
... This project sets out to investigate the role of time in the left-right organizer (LRO). This transient embryonic organ is crucial for determining the left-right identity of the vertebrate body-plan. Inside this organ there are exciting biophysical mechanisms of development to be investigated. Namel ...
CRISPR/Cas9 Screens Reveal Requirements for Host Cell Sulfation
... translocated into the host cytoplasm. T3SSs from different pathogens transfer distinct sets of effectors that can enable pathogen adhesion, internalization, or modulation of diverse host processes, often redundantly (Shames and Finlay, 2012). The Gram-negative marine bacterium Vibrio parahaemolyticu ...
... translocated into the host cytoplasm. T3SSs from different pathogens transfer distinct sets of effectors that can enable pathogen adhesion, internalization, or modulation of diverse host processes, often redundantly (Shames and Finlay, 2012). The Gram-negative marine bacterium Vibrio parahaemolyticu ...