between TLRs and FcRs Polyfunctional Th Cells by Cross
... Therefore, we investigated the initiation of immune responses after simultaneous recognition of Ab-opsonized pathogens by PRRs and FcRs on monocyte-derived immature DCs (iDCs), because DCs are the most efficient APCs and secrete a plethora of cytokines and lipid mediators that direct polarization of ...
... Therefore, we investigated the initiation of immune responses after simultaneous recognition of Ab-opsonized pathogens by PRRs and FcRs on monocyte-derived immature DCs (iDCs), because DCs are the most efficient APCs and secrete a plethora of cytokines and lipid mediators that direct polarization of ...
A Possible Role for the Cnidarian Homologue of Serum Response
... MADS-box of both genes is identical in sequence and more similar to SRFs of other organisms than to non-SRF MADS-box-containing proteins from other organisms. Within the N terminus of the predicted protein, a motif of 14 amino acids is nearly identical between Hydra and Hydractinia. This motif is ab ...
... MADS-box of both genes is identical in sequence and more similar to SRFs of other organisms than to non-SRF MADS-box-containing proteins from other organisms. Within the N terminus of the predicted protein, a motif of 14 amino acids is nearly identical between Hydra and Hydractinia. This motif is ab ...
Development of differentiation assay in neuroblastoma to elucidate
... overall survival of only 50%. Amplification of MYCN and overexpression of its coded protein is associated with rapid tumour progression and poor outcome. Induction of terminal differentiation is a very promising approach to neuroblastoma treatment. However, there’s no golden standard to asses neurob ...
... overall survival of only 50%. Amplification of MYCN and overexpression of its coded protein is associated with rapid tumour progression and poor outcome. Induction of terminal differentiation is a very promising approach to neuroblastoma treatment. However, there’s no golden standard to asses neurob ...
PDF
... of cellular potential, and is marked by an increase in epigenetic restriction (Gifford et al., 2013; Skora and Spradling, 2010). As development commences, the zygote loses its totipotent capacity and undergoes successive cleavages to give rise to the blastocyst, which comprises three distinct lineag ...
... of cellular potential, and is marked by an increase in epigenetic restriction (Gifford et al., 2013; Skora and Spradling, 2010). As development commences, the zygote loses its totipotent capacity and undergoes successive cleavages to give rise to the blastocyst, which comprises three distinct lineag ...
cell cycle
... They may make their own growth factor They may convey a growth factor’s signal without the presence of the growth factor ...
... They may make their own growth factor They may convey a growth factor’s signal without the presence of the growth factor ...
molecular mechanisms of mechanoperception in plants
... patterns have been shown to inform the organization of cortical microtubule arrays in the epidermis of hypocotyls and at the shoot apical meristem (Hamant et al., 2008; Hejnowicz et al., 2000; Uyttewaal et al., 2012) and even in protoplasts exposed to centrifugal forces (Wymer et al., 1996). Root ap ...
... patterns have been shown to inform the organization of cortical microtubule arrays in the epidermis of hypocotyls and at the shoot apical meristem (Hamant et al., 2008; Hejnowicz et al., 2000; Uyttewaal et al., 2012) and even in protoplasts exposed to centrifugal forces (Wymer et al., 1996). Root ap ...
Recruiting Coreceptors to the T Cell Receptor Complex
... is simple (monophasic) and it was possible to estimate 2D binding constants, revealing that CD8-MHC class I interaction has much (100-fold) lower affinity than the TCR-pMHC interaction, consistent with measurements of the solution or 3D affinity (van der Merwe and Davis, 2003). This indicates that C ...
... is simple (monophasic) and it was possible to estimate 2D binding constants, revealing that CD8-MHC class I interaction has much (100-fold) lower affinity than the TCR-pMHC interaction, consistent with measurements of the solution or 3D affinity (van der Merwe and Davis, 2003). This indicates that C ...
Developmental control of blood cell migration by the Drosophila VEGF pathway. Cell 108, 865-876. pdf
... to test the effect of complete loss of RAS-MAPK pathway activity in embryonic hemocytes, because pathway components are both maternally and zygotically required and expressed. Zygotic loss of function mutations in any of the three genes encoding adaptor proteins (drk, dshc) or a RAS exchange factor ...
... to test the effect of complete loss of RAS-MAPK pathway activity in embryonic hemocytes, because pathway components are both maternally and zygotically required and expressed. Zygotic loss of function mutations in any of the three genes encoding adaptor proteins (drk, dshc) or a RAS exchange factor ...
Identification of the first invertebrate interleukin
... kinases of the JAK family. After receptor dimerization, JAK phosphorylates a tyrosine residue on the receptor, and cytoplasmic STAT is recruited to the complex. JAK then phosphorylates STAT, which dimerizes, translocates to the nucleus, and induces gene transcription. In Drosophila melanogaster one ...
... kinases of the JAK family. After receptor dimerization, JAK phosphorylates a tyrosine residue on the receptor, and cytoplasmic STAT is recruited to the complex. JAK then phosphorylates STAT, which dimerizes, translocates to the nucleus, and induces gene transcription. In Drosophila melanogaster one ...
vilnius university
... Their long-term proliferative capacity in culture makes this system convenient for ex vivo gene transfer. Genetically engineered myogenic cells with improved survival properties would be a mean to improve transplanted cells survival rates in the damaged heart tissues. There were performed primary tr ...
... Their long-term proliferative capacity in culture makes this system convenient for ex vivo gene transfer. Genetically engineered myogenic cells with improved survival properties would be a mean to improve transplanted cells survival rates in the damaged heart tissues. There were performed primary tr ...
Reciprocal signaling between Drosophila epidermal muscle
... cells. stripe mRNA is apparent at late stage 11, before and during germ band retraction (Volk and VijayRaghavan, 1994). In stripe loss-of-function mutant embryos, EMA-specific genes including groovin, delila and β1 tubulin are not expressed, indicating that stripe is required for their expression (F ...
... cells. stripe mRNA is apparent at late stage 11, before and during germ band retraction (Volk and VijayRaghavan, 1994). In stripe loss-of-function mutant embryos, EMA-specific genes including groovin, delila and β1 tubulin are not expressed, indicating that stripe is required for their expression (F ...
Single Cell Electrical Characterization Techniques
... Study of the cell has emerged as a distinct new field, and acknowledged to be one of the fundamental building blocks of life. Moreover, the cells have unique biophysical and biochemical properties to maintain and sense the physiological surrounding environment to fulfill its specific functions [1,2] ...
... Study of the cell has emerged as a distinct new field, and acknowledged to be one of the fundamental building blocks of life. Moreover, the cells have unique biophysical and biochemical properties to maintain and sense the physiological surrounding environment to fulfill its specific functions [1,2] ...
Emerging roles for lipids in non-apoptotic cell death
... Necroptosis. Necroptosis is a non-apoptotic form of RCD that is implicated in homeostatic and pathological cell death in the immune system, brain, and other tissues.38 Necroptosis can be induced by cytokines such as tumor necrosis factor-alpha (TNF-α). In the presence of caspase inhibitors, TNF-α in ...
... Necroptosis. Necroptosis is a non-apoptotic form of RCD that is implicated in homeostatic and pathological cell death in the immune system, brain, and other tissues.38 Necroptosis can be induced by cytokines such as tumor necrosis factor-alpha (TNF-α). In the presence of caspase inhibitors, TNF-α in ...
cell-substratum adhesion of neurite growth cones, and its role in
... contacts can be determined, and the cells are not altered by the process, allowing subsequent procedures [9, 131. This technique has been profitably used to investigate the progression of adhesive contacts during cell migration, adhesive interactions during cell-cell contact and the relationship of ...
... contacts can be determined, and the cells are not altered by the process, allowing subsequent procedures [9, 131. This technique has been profitably used to investigate the progression of adhesive contacts during cell migration, adhesive interactions during cell-cell contact and the relationship of ...
Diefenbach, A., and D.H. Raulet. 2002. The innate immune response to tumors and its role in the induction of T cell immunity. Immunological Reviews 188:9-21.
... tumors in aged mutant mice specifically lacking T and B cells as a result of a targeted mutation of the Rag-2 gene (23). Significantly, the same analysis indicated an independent role for the innate immune response in tumor immunity. When compared to Rag-2-mutant mice, mice deficient in both Rag-2 a ...
... tumors in aged mutant mice specifically lacking T and B cells as a result of a targeted mutation of the Rag-2 gene (23). Significantly, the same analysis indicated an independent role for the innate immune response in tumor immunity. When compared to Rag-2-mutant mice, mice deficient in both Rag-2 a ...
Author comments - Springer Static Content Server
... page 3, lines 102-107: “An important miRNA in CRC seems to be miR-143, which, has been described to be down regulated in CRC [18] and to inhibit the translation of KRAS mRNA, thereby altering RAS signaling and inhibiting tumor cell growth [19]. Pichler et al found that low miR-143 expression was an ...
... page 3, lines 102-107: “An important miRNA in CRC seems to be miR-143, which, has been described to be down regulated in CRC [18] and to inhibit the translation of KRAS mRNA, thereby altering RAS signaling and inhibiting tumor cell growth [19]. Pichler et al found that low miR-143 expression was an ...
The Plant Cell Wall Integrity Maintenance
... in plants since a large number of RLK-encoding genes have been identified in plant genomes, with several of them implicated in CWI maintenance (Engelsdorf and Hamann 2014). In yeast, three different stimulus perception and signal generation mechanisms are contributing to CWI maintenance and interact ...
... in plants since a large number of RLK-encoding genes have been identified in plant genomes, with several of them implicated in CWI maintenance (Engelsdorf and Hamann 2014). In yeast, three different stimulus perception and signal generation mechanisms are contributing to CWI maintenance and interact ...
Folliculin directs the formation of a Rab34–RILP
... FNIP2 transfected cells revealed three distinct classes of FLCN-GFP/ Lysotracker-Red dynamics (Fig 2A). Peri-nuclear, FLCN-positive lysosomes tended to be slightly larger and engaged in short saltatory movements (Fig 2Ai and Movie EV1 zoom panels), whereas peripheral FLCN-positive lysosomes moved ra ...
... FNIP2 transfected cells revealed three distinct classes of FLCN-GFP/ Lysotracker-Red dynamics (Fig 2A). Peri-nuclear, FLCN-positive lysosomes tended to be slightly larger and engaged in short saltatory movements (Fig 2Ai and Movie EV1 zoom panels), whereas peripheral FLCN-positive lysosomes moved ra ...
Title Scaffold proteins in mammalian MAP kinase
... phosphatase (39), and OSM (osmosensing scaffold for MEKK3), a MEKK3-binding protein (40). Dynamic Regulation of MAPK Signaling Modules Mediated by Scaffold Proteins—MAPK scaffold proteins may function merely to increase the local concentration of their associated signaling components, as suggested b ...
... phosphatase (39), and OSM (osmosensing scaffold for MEKK3), a MEKK3-binding protein (40). Dynamic Regulation of MAPK Signaling Modules Mediated by Scaffold Proteins—MAPK scaffold proteins may function merely to increase the local concentration of their associated signaling components, as suggested b ...
Requirement for ß-Catenin in Anterior
... The anterior-posterior axis of the mouse embryo becomes explicit morphologically at embryonic day (E)1 6.5, when the first mesoderm forms in the primitive streak region at the posterior side of the embryo. However, recent experiments show that anterior-posterior polarity is established at least 1 d ...
... The anterior-posterior axis of the mouse embryo becomes explicit morphologically at embryonic day (E)1 6.5, when the first mesoderm forms in the primitive streak region at the posterior side of the embryo. However, recent experiments show that anterior-posterior polarity is established at least 1 d ...
