Thesis Reference - Archive ouverte UNIGE
... The recruitment of dendritic cells to sites of infections and their migration to lymph nodes is fundamental for antigen processing and presentation to T cells. I showed that antibody blockade of junctional adhesion molecule C (JAM-C) on endothelial cells removed JAM-C away from junctions and increas ...
... The recruitment of dendritic cells to sites of infections and their migration to lymph nodes is fundamental for antigen processing and presentation to T cells. I showed that antibody blockade of junctional adhesion molecule C (JAM-C) on endothelial cells removed JAM-C away from junctions and increas ...
CLC Chloride Channels in Caenorhabditis elegans*
... there is just one additional CLC gene in its genome, bringing the total number to six. Sequence comparison and hydropathy analysis revealed that all predicted CLC proteins from C. elegans share domains D1 through D12 with their mammalian counterparts (2). These domains may span the lipid bilayer 10 ...
... there is just one additional CLC gene in its genome, bringing the total number to six. Sequence comparison and hydropathy analysis revealed that all predicted CLC proteins from C. elegans share domains D1 through D12 with their mammalian counterparts (2). These domains may span the lipid bilayer 10 ...
Peer-reviewed Article PDF - e
... Furthermore, TRPC proteins have been shown to associate with Orai1 and STIM1 in a dynamic ternary complex regulated by the occupation of membrane receptors in several cell models, which might play an important role in the function of SOC [15]. As SOC induction is directly dependent on ER/SR Ca2+ sto ...
... Furthermore, TRPC proteins have been shown to associate with Orai1 and STIM1 in a dynamic ternary complex regulated by the occupation of membrane receptors in several cell models, which might play an important role in the function of SOC [15]. As SOC induction is directly dependent on ER/SR Ca2+ sto ...
Mochii - Salamander Genome Project
... and differentiation of notochord during tail regeneration (Taniguchi et al. in preparation). This method should be useful for identifying and characterizing the soluble factors derived from the Xenopus spinal cord. Fibroblast growth factors (FGFs) were expressed in the urodele spinal cord and were s ...
... and differentiation of notochord during tail regeneration (Taniguchi et al. in preparation). This method should be useful for identifying and characterizing the soluble factors derived from the Xenopus spinal cord. Fibroblast growth factors (FGFs) were expressed in the urodele spinal cord and were s ...
Staphylococcus aureus , and Streptococcus pneumoniae , coli
... chamber. Interestingly, the effects of cycloheximide varied substantially according to the stimulus. Migration to intact S. pneumoniae did not require new protein synthesis with migration after cycloheximide at 98.9% of nontreated monolayers. Migration to E. coli was substantially inhibited (69.3% o ...
... chamber. Interestingly, the effects of cycloheximide varied substantially according to the stimulus. Migration to intact S. pneumoniae did not require new protein synthesis with migration after cycloheximide at 98.9% of nontreated monolayers. Migration to E. coli was substantially inhibited (69.3% o ...
Tese Hugo Fraga
... reinforcing the need for further studies aimed at their preservation and propagation. Plant tissue culture encompasses a range of biotechnology tools that enable the conservation and plant breeding. The somatic embryogenesis (SE) morphogenetic route can be employed for mass clonal propagation of eli ...
... reinforcing the need for further studies aimed at their preservation and propagation. Plant tissue culture encompasses a range of biotechnology tools that enable the conservation and plant breeding. The somatic embryogenesis (SE) morphogenetic route can be employed for mass clonal propagation of eli ...
Requirement of Heavy Neurofilament Subunit in the Development of
... 1993). Similar conclusions have also been reached by expressing rat NFs in an insect cell line that lacks endogenous IFs (Nakagawa et al., 1995) and in transgenic mice by forcing expression of mouse NFs in oligodendrocytes which normally lack IFs (Lee et al., 1993). These results argue that in vivo, ...
... 1993). Similar conclusions have also been reached by expressing rat NFs in an insect cell line that lacks endogenous IFs (Nakagawa et al., 1995) and in transgenic mice by forcing expression of mouse NFs in oligodendrocytes which normally lack IFs (Lee et al., 1993). These results argue that in vivo, ...
Branching of Sensory and Sympathetic Neurites in vitro Is Inhibited
... characteristic neuronal shapes. Observations and manipulations in vivo also indicate that intrinsic factors determine important aspects of neuronal form (Sotelo and Arsenio-Nunes, 1976; Van der Loos, 1965). It is clear, then, from a variety of studies that intrinsic regulatory factors contribute to ...
... characteristic neuronal shapes. Observations and manipulations in vivo also indicate that intrinsic factors determine important aspects of neuronal form (Sotelo and Arsenio-Nunes, 1976; Van der Loos, 1965). It is clear, then, from a variety of studies that intrinsic regulatory factors contribute to ...
Sepsis is a common condition, and more than 19 million cases of
... cell surface expression in LPS treated neutrophils whilst preserving efficient bacterial killing, support the notion that MPLA may hold promise as adjunctive therapy for Gram negative sepsis. Persistent activation of TLR pathways, as occurs in the early stages of sepsis, has been associated with exc ...
... cell surface expression in LPS treated neutrophils whilst preserving efficient bacterial killing, support the notion that MPLA may hold promise as adjunctive therapy for Gram negative sepsis. Persistent activation of TLR pathways, as occurs in the early stages of sepsis, has been associated with exc ...
protcell
... that if any party shall succeed in seizing or attaching by any means or otherwise levying execution against any cellular assets attributable to any cell of the company in respect of a liability not attributable to that cell, that party shall hold those assets or their proceeds on trust for the compa ...
... that if any party shall succeed in seizing or attaching by any means or otherwise levying execution against any cellular assets attributable to any cell of the company in respect of a liability not attributable to that cell, that party shall hold those assets or their proceeds on trust for the compa ...
HER2
... • Connects the αC helix with the A-loop, stabilizing the helix in the active site • Bond is conserved among ErbB family members: K851-E734 (EGFR), K856-E739 (ErbB4) ...
... • Connects the αC helix with the A-loop, stabilizing the helix in the active site • Bond is conserved among ErbB family members: K851-E734 (EGFR), K856-E739 (ErbB4) ...
NF-kB as a primary regulator of the stress response
... proteosome pathway mediates the regulated degradation of many proteins that play an essential role in cell cycle progression, immune response, transcriptional control, development and apoptosis. Activation of NF-kB is achieved through the signal-induced proteolytic degradation of IkB which is mediat ...
... proteosome pathway mediates the regulated degradation of many proteins that play an essential role in cell cycle progression, immune response, transcriptional control, development and apoptosis. Activation of NF-kB is achieved through the signal-induced proteolytic degradation of IkB which is mediat ...
Comprehensive Analysis of Human Cytomegalovirus MicroRNA
... also regulate host immune responses and mediate viral immune evasion. For example, HCMV miR-UL112-1, EBV miR-BART25p, and KSHV miR-K12-7 help to protect infected cells from natural killer (NK) cell recognition by suppressing expression of major histocompatibility complex class I-related chain B (MIC ...
... also regulate host immune responses and mediate viral immune evasion. For example, HCMV miR-UL112-1, EBV miR-BART25p, and KSHV miR-K12-7 help to protect infected cells from natural killer (NK) cell recognition by suppressing expression of major histocompatibility complex class I-related chain B (MIC ...
The Pathogenic Fungus Paracoccidioides brasiliensis Exports
... natants were concentrated 20-fold using an Amicon ultrafiltration system (100kDa cutoff). Concentrated supernatants containing high-molecular-weight components were centrifuged at 15,000 ⫻ g (30 min) to remove aggregates, and the resulting supernatant was then ultracentrifuged at 100,000 ⫻ g for 1 h ...
... natants were concentrated 20-fold using an Amicon ultrafiltration system (100kDa cutoff). Concentrated supernatants containing high-molecular-weight components were centrifuged at 15,000 ⫻ g (30 min) to remove aggregates, and the resulting supernatant was then ultracentrifuged at 100,000 ⫻ g for 1 h ...
Novel Inhibitory Action of Tunicamycin Homologues Suggests a
... direct experimental manipulation of this modification in intact cells. The nucleoside antibiotic tunicamycin (TM) * (see Fig. 1 A) has been used extensively to investigate the role of protein N-linked glycosylation in protein processing, receptor activation, viral multiplication and such cellular pr ...
... direct experimental manipulation of this modification in intact cells. The nucleoside antibiotic tunicamycin (TM) * (see Fig. 1 A) has been used extensively to investigate the role of protein N-linked glycosylation in protein processing, receptor activation, viral multiplication and such cellular pr ...
Activation of hilA expression at low pH requires the signal sensor
... reduced to less than 10 % of that in the parent strain at pH 6?0. This mutant strain also showed undetectable synthesis of an invasion gene product, SipC, at pH 6?0 and reduced cell invasion capacity – as low as 20 % of that of the parent. In this mutant, the reduction in hilA expression was much le ...
... reduced to less than 10 % of that in the parent strain at pH 6?0. This mutant strain also showed undetectable synthesis of an invasion gene product, SipC, at pH 6?0 and reduced cell invasion capacity – as low as 20 % of that of the parent. In this mutant, the reduction in hilA expression was much le ...
Regeneration in the aging peripheral nervous system The Harvard
... flies and mice (interestingly, complete absence of insulin signaling often results in reduced lifespan) (Kenyon, 2005). Furthering the significance of the insulin pathway in aging, other components of the insulin signaling pathway have been perturbed across a variety of species, all with the result ...
... flies and mice (interestingly, complete absence of insulin signaling often results in reduced lifespan) (Kenyon, 2005). Furthering the significance of the insulin pathway in aging, other components of the insulin signaling pathway have been perturbed across a variety of species, all with the result ...
The lysosome as a command-and-control center for cellular
... activators of mTORC1 (Hara et al., 1998; Wang et al., 1998) upstream of the Rag GTPases (Sancak et al., 2008). Of note, arginine, an amino acid crucial for mammalian embryogenesis and early development, is highly concentrated in rat liver lysosomes ...
... activators of mTORC1 (Hara et al., 1998; Wang et al., 1998) upstream of the Rag GTPases (Sancak et al., 2008). Of note, arginine, an amino acid crucial for mammalian embryogenesis and early development, is highly concentrated in rat liver lysosomes ...
The lysosome as a command-and-control center for cellular
... activators of mTORC1 (Hara et al., 1998; Wang et al., 1998) upstream of the Rag GTPases (Sancak et al., 2008). Of note, arginine, an amino acid crucial for mammalian embryogenesis and early development, is highly concentrated in rat liver lysosomes ...
... activators of mTORC1 (Hara et al., 1998; Wang et al., 1998) upstream of the Rag GTPases (Sancak et al., 2008). Of note, arginine, an amino acid crucial for mammalian embryogenesis and early development, is highly concentrated in rat liver lysosomes ...
The molecular basis of skeletal muscle atrophy
... unloading, with or without cortisol treatment, atrophy still occurred (51). Importantly, treatment of unloaded rats with an inhibitor of glucocorticoids, RU-38486, also did not inhibit disuse atrophy (95). Thus glucocorticoids do not appear to be required for disuse atrophy. In the case of cachexia, ...
... unloading, with or without cortisol treatment, atrophy still occurred (51). Importantly, treatment of unloaded rats with an inhibitor of glucocorticoids, RU-38486, also did not inhibit disuse atrophy (95). Thus glucocorticoids do not appear to be required for disuse atrophy. In the case of cachexia, ...