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plantcell.org
plantcell.org

... and assignment of proper cell identities throughout the regenerated portion of the root. To address how radial patterning occurs during root tip regeneration, we examined ZmSCR expression and other markers after removing a portion of either the apical–basal axis or the radial axis. In both cases, ou ...
Molecular Plant-Microbe Interactions
Molecular Plant-Microbe Interactions

... level as PgyBR1 in soybean (data not shown) and was used as the wild-type strain for all our experiments. In order to characterize the functions of HopZ1 alleles in soybean, we constructed a T3SS knock-out mutant PgyBR1Rif:: hrcJΩnptII, which completely lost its ability to multiply in soybean, confi ...
Myosin-Powered Membrane Compartment Drives Cytoplasmic
Myosin-Powered Membrane Compartment Drives Cytoplasmic

... There are several well-studied eukaryotic models of active transport, including bud-directed traffic of membrane-bound organelles and vesicles in dividing yeast cells [8–11], long- and short-distance traffic in neurons, and melanosome transport to the cell periphery in melanocytes [3,4,12,13]. By an ...
Link
Link

... (Briscoe et al., 1999). These findings support the idea that transcription factors present in adjacent progenitor domains suppress the differentiation programs that operate in the progenitor domains they abut. They do so by cross-repressive interactions that position the boundaries between adjacent ...
Cell fate specification and maintenance in the female gametophyte
Cell fate specification and maintenance in the female gametophyte

... gametophytic phase. Successful reproduction depends on fate specification of the gametic cells within the embryo sac and on double fertilization. This double fertilization event is initiated by fusion of the central cell with one of the two sperm cells as well as fusion of the egg cell with the othe ...
Rb is required for progression through myogenic differentiation but
Rb is required for progression through myogenic differentiation but

... presence of severe differentiation deficits (Fig. 1, A–F). Hind limb muscles exhibited a dramatic reduction in mass with a complete absence of mature fibers compared with littermate controls (n  3 independent animals; Fig. 1, compare A with B). In addition, the morphology of the residual muscle fib ...
Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts,...
Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts,...

... Notch 2, as a binding partner of APP (Fassa et al. 2005; Fischer et al. 2005; Oh et al. 2005; Chen et al. 2006). Notch receptors are type I transmembrane proteins playing a critical role in both vertebrates and invertebrates during embryonic development and throughout the adult life. Notch proteins ...
Fcg Receptor Deficiency Attenuates Diabetic Nephropathy
Fcg Receptor Deficiency Attenuates Diabetic Nephropathy

Hairy Root Transformation Using Agrobacterium
Hairy Root Transformation Using Agrobacterium

... (Glycine max). This reporter greatly increased the percentage detection of transformants and was used as a tool to determine the function of the soybean Nod factor receptor, GmNFR1a (Lin et al., 2011). The tomato genome sequence has facilitated the discovery of many genes that regulate tomato growth ...
Lycopene - Pennington Biomedical Research Center
Lycopene - Pennington Biomedical Research Center

... • Absorption pathway is similar to that of dietary fat • Carotenoids are believed to passively diffuse from the micelles across the intestinal cell membrane into the mucosal cell • Once inside the intestinal cell, carotenoids may be converted to vitamin A, those that are provitamin A carotenoids, or ...
Cytochrome c Oxidase dysfunction in cancer
Cytochrome c Oxidase dysfunction in cancer

... There is a general organization of the mitochondrial respiratory chain in most eukaryotes. The mammalian respiratory chain consists of four enzyme complexes; NADH dehydrogenase, succinate dehydrogenase, the bc1 complex and CytcO (figure 1). All four enzymes contain redox-active cofactors involved in ...
Mechanical stimuli of skeletal muscle: implications on mTOR/p70s6k
Mechanical stimuli of skeletal muscle: implications on mTOR/p70s6k

Fcg Receptor Deficiency Attenuates Diabetic Nephropathy
Fcg Receptor Deficiency Attenuates Diabetic Nephropathy

... contribution of IgG Fcg receptors to diabetic renal injury in hyperglycemic, hypercholesterolemic mice. We used streptozotocin to induce diabetes in apolipoprotein E–deficient mice and in mice deficient in both apolipoprotein E and g-chain, the common subunit of activating Fcg receptors. After 15 week ...
The Role of Two-Component Signal Transduction Systems in
The Role of Two-Component Signal Transduction Systems in

Ca Signaling11
Ca Signaling11

... - critical for LT plasticity. - Knock-out mice for CaMKIV  cognition/memory deficits related to noxious shock stimulus and related to spatial learning (hippocampus). - both inhibition of either CREB or CaMKIV function  blocked cerebellar LTD (late phase) . ...
Farnesoid X Receptor Ligands Inhibit Vascular Smooth Muscle Cell
Farnesoid X Receptor Ligands Inhibit Vascular Smooth Muscle Cell

Nestin Is Required for the Proper SelfRenewal of Neural Stem Cells
Nestin Is Required for the Proper SelfRenewal of Neural Stem Cells

... significance of these regulations is not clear. The in vivo physiological function of nestin is essentially unknown. Evidence from in vitro experiments suggests that nestin plays a role in promoting cell survival and proliferation. Knockdown of nestin reduced cell growth in cultured neuroblastoma and ...
Functional Analysis of the Cellulose Synthase
Functional Analysis of the Cellulose Synthase

... functional redundancy within CSL families. However, it may also be the case that the activities of some CSLs may be spatially or temporally restricted, so that phenotypes that arise from disrupting their function are only apparent in particular cells or during a limited phase of development. Data fr ...
Berlin-Buch - Max Delbrück Center for Molecular Medicine
Berlin-Buch - Max Delbrück Center for Molecular Medicine

... treatment of the most prevalent diseases in the population, namely cardiovascular diseases, cancer, and neurological diseases. Two research clinics of the Charité University Medical School in Berlin-Buch, the Franz Volhard Clinic for Cardiovascular Diseases as well as the Robert Rössle Cancer Clinic ...
Cytokinin Lecture
Cytokinin Lecture

... Figure 21.7 Phenotypes of Arabidopsis plants harboring mutations in the cytokinin receptors ...
Dynamin as a mover and pincher during cell migration and invasion
Dynamin as a mover and pincher during cell migration and invasion

... these comets. Interestingly, Dyn2 is concentrated at the actin–vesicle-membrane interface but also extends along the length of the comet tails. This suggests a direct structurefunction relationship with the actin filament network, implicating dynamin in the regulation of actin polymerization. At the ...
Development
Development

... W TH12 fluorescence tubes). Subsequently, the roots were cleared in 3% sodium hypochlorite (Truchet et al., 1989) and examined under the transmission light microscope using Nomarski interference contrast. To enhance contrast, methylene blue was used in some experiments. For the experiments performed ...
HER-2/neu Gene Amplification Compared With HER
HER-2/neu Gene Amplification Compared With HER

... similar to but distinct from the epidermal growth factor receptor.7 Amplification of the HER-2/neu proto-oncogene leads to marked overexpression of the membrane-bound growth factor receptor protein at the cell surface.8 Given the location of the receptor at the cell’s external surface, there has bee ...
Title Soybean extracts increase cell surface ZIP4 abundance and
Title Soybean extracts increase cell surface ZIP4 abundance and

... Corporation, East Hills, NY). The blot was blocked with blocking solution (1% skim milk and 0.1% Tween 20 in phosphate-buffered saline (PBS) or SuperBlock blocking buffer (Thermo Fisher Scientific, Rockford, IL) supplemented with 0.1% Tween 20 and then incubated with anti-mZip4 monoclonal antibody ( ...
- Nottingham ePrints
- Nottingham ePrints

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SULF1

Sulfatase 1, also known as SULF1, is an enzyme which in humans is encoded by the SULF1 gene.Heparan sulfate proteoglycans (HSPGs) act as co-receptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endo-sulfatases, such as SULF1, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules.
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