Dynamics of the Cell Cycle: Checkpoints, Sizers, and Timers
... Modeling SKP2 or APC regulation No detailed information exists on how SKP2 is regulated during the cell cycle. It has been shown SKP2 is expressed and phosphorylated at G1/S transition and throughout the S phase, and its phosphorylation is related to CDK2 not CDK1 (Bilodeau et al., 1999). We assume ...
... Modeling SKP2 or APC regulation No detailed information exists on how SKP2 is regulated during the cell cycle. It has been shown SKP2 is expressed and phosphorylated at G1/S transition and throughout the S phase, and its phosphorylation is related to CDK2 not CDK1 (Bilodeau et al., 1999). We assume ...
Mycobacterial hypersensitivity pneumonitis + requires TLR9–MyD88 in lung CD11b + cells
... to contain heavy growth of M. avium, which was identical to that in sputum as determined by VNTR analysis (fig. 1d). Based on this constellation of findings, we made a diagnosis of HP due to inhalation of M. avium in the patient’s bathroom at home (i.e. hot tub lung), which he was advised to renovat ...
... to contain heavy growth of M. avium, which was identical to that in sputum as determined by VNTR analysis (fig. 1d). Based on this constellation of findings, we made a diagnosis of HP due to inhalation of M. avium in the patient’s bathroom at home (i.e. hot tub lung), which he was advised to renovat ...
Organ-Level Quorum Sensing Directs Regeneration in Hair Stem
... injury, while meeting stronger injury with full-scale cooperative activation of stem cells. INTRODUCTION The effective coordination of organ behavior, either under physiological conditions or as a response to injury, is essential for survival. Integration at the level of large-scale organ systems ha ...
... injury, while meeting stronger injury with full-scale cooperative activation of stem cells. INTRODUCTION The effective coordination of organ behavior, either under physiological conditions or as a response to injury, is essential for survival. Integration at the level of large-scale organ systems ha ...
Dynamics of the slowing segmentation clock reveal
... et al., 2008) and allow for more time to image embryos. Each peak of expression was correlated to the approximate anterior-posterior global position of the cell in the PSM and its position relative to the most recently formed somite. We used conventions in the field (Pourquié and Tam, 2001), with th ...
... et al., 2008) and allow for more time to image embryos. Each peak of expression was correlated to the approximate anterior-posterior global position of the cell in the PSM and its position relative to the most recently formed somite. We used conventions in the field (Pourquié and Tam, 2001), with th ...
Evidence for Multiple Calcium Response
... citralva, citronellal, eugenol, geraniol, hedione, menthone and phenethylalcohol, while Mix B [IP3-producing odors in rat biochemical assays (Breer and Boekhoff, 1991)] contained ethyl vanillin, isovaleric acid, lilial, lyral, phenylethylamine and triethylamine. In some experiments, subsets of these ...
... citralva, citronellal, eugenol, geraniol, hedione, menthone and phenethylalcohol, while Mix B [IP3-producing odors in rat biochemical assays (Breer and Boekhoff, 1991)] contained ethyl vanillin, isovaleric acid, lilial, lyral, phenylethylamine and triethylamine. In some experiments, subsets of these ...
Molecular Cloning of CD68, a Human Macrophage
... EBM 1 I and Y2/ I3 I , and two different sized proteins were observed depending on the cDNA clone used (Fig I); pCD68.1 encodes a protein of approximately 1 I O Kd, while CD68.2 encodes a protein of approximately 80 Kd. KPI failed to immunoprecipitate any protein from the transfectants, consistent w ...
... EBM 1 I and Y2/ I3 I , and two different sized proteins were observed depending on the cDNA clone used (Fig I); pCD68.1 encodes a protein of approximately 1 I O Kd, while CD68.2 encodes a protein of approximately 80 Kd. KPI failed to immunoprecipitate any protein from the transfectants, consistent w ...
Full Text - Molecular Cancer Research
... of Cdc25A (19). We sequenced the cdc25a gene from wild-type and standstill mutant embryos and found that the mutants contain a C to T mutation at codon 206 of the coding sequence, which is predicted to result in a premature stop codon and a truncated protein lacking the catalytic domain (Fig. 2B and ...
... of Cdc25A (19). We sequenced the cdc25a gene from wild-type and standstill mutant embryos and found that the mutants contain a C to T mutation at codon 206 of the coding sequence, which is predicted to result in a premature stop codon and a truncated protein lacking the catalytic domain (Fig. 2B and ...
VegT initiates endoderm formation
... that VegT plays a role in endoderm formation (Zhang et al., 1998). However, the effect of depleting VegT mRNA on early endoderm formation was not examined. Several other approaches to determine the role of VegT in germ layer formation have been used. Studies employing a VegT repressor construct (Hor ...
... that VegT plays a role in endoderm formation (Zhang et al., 1998). However, the effect of depleting VegT mRNA on early endoderm formation was not examined. Several other approaches to determine the role of VegT in germ layer formation have been used. Studies employing a VegT repressor construct (Hor ...
Vesicle trafficking dynamics and visualization of zones of exocytosis
... growth rate oscillations but the cycles are phase-shifted by 180 (Zonia et al., 2006). Hyperosmosis induces decreases in apical volume and growth rate, while hypo-osmosis induces increases in apical volume and growth rate (Zonia et al., 2006). These results indicate that cell elongation and polariz ...
... growth rate oscillations but the cycles are phase-shifted by 180 (Zonia et al., 2006). Hyperosmosis induces decreases in apical volume and growth rate, while hypo-osmosis induces increases in apical volume and growth rate (Zonia et al., 2006). These results indicate that cell elongation and polariz ...
Head muscle development - The Company of Biologists
... suggests that the mechanisms that underlie somitic and nonsomitic muscle development may be fundamentally different. Unfortunately, the regulation of muscle development from pre-otic mesoderm is largely enigmatic. Cranial neural crest cells, which provide all the connective tissue and tendons in the ...
... suggests that the mechanisms that underlie somitic and nonsomitic muscle development may be fundamentally different. Unfortunately, the regulation of muscle development from pre-otic mesoderm is largely enigmatic. Cranial neural crest cells, which provide all the connective tissue and tendons in the ...
The role of mTOR signaling in the regulation of protein synthesis
... (Goodman et al., 2011c). For instance, a net decrease in protein synthesis and/or a net increase in protein degradation can lead to disuse atrophy. Indeed, both decreased rates of protein synthesis and increased rates of protein degradation have been observed in several animal models of disuse atrop ...
... (Goodman et al., 2011c). For instance, a net decrease in protein synthesis and/or a net increase in protein degradation can lead to disuse atrophy. Indeed, both decreased rates of protein synthesis and increased rates of protein degradation have been observed in several animal models of disuse atrop ...
+Tec - Blood Journal
... not shown). Therefore, we conclude that Tec type IV is a peptide of 70 kD in vivo. A peptide of approximately 80 kD observed in Fig 3, lane 32D, is of the nonspecific binding of protein NG-horseradish peroxidase, because this band could not be observed when a different detection system with alkaline ...
... not shown). Therefore, we conclude that Tec type IV is a peptide of 70 kD in vivo. A peptide of approximately 80 kD observed in Fig 3, lane 32D, is of the nonspecific binding of protein NG-horseradish peroxidase, because this band could not be observed when a different detection system with alkaline ...
Some unanswered questions in radiation biology
... term survival of humans/cells in space will depend on improved knowledge of low and high LET radiation effects and their reduction. ...
... term survival of humans/cells in space will depend on improved knowledge of low and high LET radiation effects and their reduction. ...
Insulin-Like Growth Factor and Potassium Depolarization Maintain
... neurotrophic factor (BDNF), neurotrophin-3, neurotrophin4/5, insulin-like growth factor-1 (IGF-1), and the fibroblast growth factors (FGFs). Although neurotrophic factors are most often associated with their ability to support survival, they are also involved in a variety of other neuronal processes ...
... neurotrophic factor (BDNF), neurotrophin-3, neurotrophin4/5, insulin-like growth factor-1 (IGF-1), and the fibroblast growth factors (FGFs). Although neurotrophic factors are most often associated with their ability to support survival, they are also involved in a variety of other neuronal processes ...
(ECM) Binding Sites on the Basal Surface of Embryonic Corneal
... above preparations, so that the apical as well as the basal surfaces of the epithelia had equal exposure to the fluorescent probes. Incubation was carried out at 4"C or 37"C. Some of the epithelia were treated with additional trypsin (50 #g/ml) for 10 min at 37"C before or after exposure to the tagg ...
... above preparations, so that the apical as well as the basal surfaces of the epithelia had equal exposure to the fluorescent probes. Incubation was carried out at 4"C or 37"C. Some of the epithelia were treated with additional trypsin (50 #g/ml) for 10 min at 37"C before or after exposure to the tagg ...
PDF Full-text
... The application of reverse genetics to the protoplast-based cell wall regeneration system also provides an attractive approach for characterizing cell wall proteins. It is not easy, however, to establish a suspension culture cell line with specific genes knocked out. We therefore recently developed ...
... The application of reverse genetics to the protoplast-based cell wall regeneration system also provides an attractive approach for characterizing cell wall proteins. It is not easy, however, to establish a suspension culture cell line with specific genes knocked out. We therefore recently developed ...
- Bronco Scholar
... aberrantly spliced TTN mRNA in the TA of R6/2 mice relative to WT (p < 0.001) (n=12/group). We also found a significant difference in aberrantly spliced CLCN1 (p < 0.05) and INSR (p < 0.05) mRNAs in the IO of R6/2 mice relative to WT (n=6/group). However, we did not find significant differences in a ...
... aberrantly spliced TTN mRNA in the TA of R6/2 mice relative to WT (p < 0.001) (n=12/group). We also found a significant difference in aberrantly spliced CLCN1 (p < 0.05) and INSR (p < 0.05) mRNAs in the IO of R6/2 mice relative to WT (n=6/group). However, we did not find significant differences in a ...
Transient Exposure to Ethylene Stimulates Cell Division and Alters
... Most of ethylene’s known effects on plant development have been observed during continuous ethylene treatments. We wanted to examine the consequence of transient exposure to ethylene, and therefore documented the structural changes that took place following exposure to exogenous ethylene. We chose t ...
... Most of ethylene’s known effects on plant development have been observed during continuous ethylene treatments. We wanted to examine the consequence of transient exposure to ethylene, and therefore documented the structural changes that took place following exposure to exogenous ethylene. We chose t ...
Lats kinase is involved in the intestinal apical
... follicle cell (PFC). Mutations in the core Hpo pathway genes in the PFC lead to a misoriented mitotic spindle, a multilayered epithelium and abnormal cell polarity, consistent with the Hpo pathway being involved in the regulation of cellular polarity. However, it is not yet known whether the Hpo pat ...
... follicle cell (PFC). Mutations in the core Hpo pathway genes in the PFC lead to a misoriented mitotic spindle, a multilayered epithelium and abnormal cell polarity, consistent with the Hpo pathway being involved in the regulation of cellular polarity. However, it is not yet known whether the Hpo pat ...
Lecture 06, case study - Taxol - Cal State LA
... Cancer is caused by normal cells that acquire mutations causing them to proliferate and eventually metastasize, spreading throughout the body and causing inevitable death Small molecules that are selectively toxic to dividing cells have potential as anti-cancer drugs, by killing tumor cells but not ...
... Cancer is caused by normal cells that acquire mutations causing them to proliferate and eventually metastasize, spreading throughout the body and causing inevitable death Small molecules that are selectively toxic to dividing cells have potential as anti-cancer drugs, by killing tumor cells but not ...