Mast Cell-Derived Exosomes Induce Phenotypic and Functional
... these molecules. Tolerosomes assembled in and released from the small intestinal epithelial cells are another example of exosomelike structures (9). Tolerosomes isolated from serum shortly after Ag feeding or from in vitro-pulsed intestinal epithelial cells are fully capable of inducing Ag-specific ...
... these molecules. Tolerosomes assembled in and released from the small intestinal epithelial cells are another example of exosomelike structures (9). Tolerosomes isolated from serum shortly after Ag feeding or from in vitro-pulsed intestinal epithelial cells are fully capable of inducing Ag-specific ...
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
... not via targeting but through macrophage loading (Seltzer, 1989; Tilcock, 1995; Kostarelos and Emfietzoglou, 1999). By this approach, it is the surrounding parenchyma, and not the pathology, that will change in intensity. The rapid sequestration of intravenously injected colloidal particles from the ...
... not via targeting but through macrophage loading (Seltzer, 1989; Tilcock, 1995; Kostarelos and Emfietzoglou, 1999). By this approach, it is the surrounding parenchyma, and not the pathology, that will change in intensity. The rapid sequestration of intravenously injected colloidal particles from the ...
ABSTRACT
... First of all, I have to thank my parents and my brothers Brenton and Gareth for giving me all the love and support that I have needed through this arduous process. I would like to thank my brother, Gareth, for being there for me and talking me out to get my mind off of things when I had one of those ...
... First of all, I have to thank my parents and my brothers Brenton and Gareth for giving me all the love and support that I have needed through this arduous process. I would like to thank my brother, Gareth, for being there for me and talking me out to get my mind off of things when I had one of those ...
Title Soybean extracts increase cell surface ZIP4 abundance and
... increase ZIP4 could potentially enhance zinc absorption by the intestine. In this study, we used mouse Hepa cells, which regulate mouse Zip4 (mZip4) in a manner indistinguishable from that in intestinal enterocytes, to screen for suitable food components able to increase the abundance of ZIP4. Using ...
... increase ZIP4 could potentially enhance zinc absorption by the intestine. In this study, we used mouse Hepa cells, which regulate mouse Zip4 (mZip4) in a manner indistinguishable from that in intestinal enterocytes, to screen for suitable food components able to increase the abundance of ZIP4. Using ...
How do dendrites take their shape?
... course of much of the twentieth century, the prevailing belief that axons take the more active role in wiring the brain and in establishing synaptic specificity led researchers to focus on the development of axons more than that of the dendrites. In addition, the complexity and diversity of dendriti ...
... course of much of the twentieth century, the prevailing belief that axons take the more active role in wiring the brain and in establishing synaptic specificity led researchers to focus on the development of axons more than that of the dendrites. In addition, the complexity and diversity of dendriti ...
hematopoietic stem cells: to be or notch to be
... nucleus, where it binds RBP-J and indirectly to the DNA. Despite the apparent simplicity of this pathway with no intermediate effectors, Notch signaling involves an extremely accurate regulation, which is multifactorially achieved. For example, multiple enzymes can modify the Notch protein post-tran ...
... nucleus, where it binds RBP-J and indirectly to the DNA. Despite the apparent simplicity of this pathway with no intermediate effectors, Notch signaling involves an extremely accurate regulation, which is multifactorially achieved. For example, multiple enzymes can modify the Notch protein post-tran ...
Whey Products - New Zealand Institute of Chemistry
... Most WPCs contain 5-7% milkfat in the dry powdered product. This fat originated in the milk and is not removed by the cream separators through which the whey passes before ultrafiltration. The most modern WPCs use either microfiltration (like ultrafiltration but using membranes with pores sized at a ...
... Most WPCs contain 5-7% milkfat in the dry powdered product. This fat originated in the milk and is not removed by the cream separators through which the whey passes before ultrafiltration. The most modern WPCs use either microfiltration (like ultrafiltration but using membranes with pores sized at a ...
video slide
... • Transcription factors bind directly to specific regions of DNA – And control the transcription of specific genes ...
... • Transcription factors bind directly to specific regions of DNA – And control the transcription of specific genes ...
Subcellular Localization of Catalase Encoded by the ctt1+ Gene in
... When the cell extracts from the mutant were fractionated, catalase activity was not detected in either the cytosolic fraction or the organellar fraction, indicating that both cytosolic and peroxisomal catalases are ctt1+ products. When the presence of the Ctt1 polypeptide was verified by Western blo ...
... When the cell extracts from the mutant were fractionated, catalase activity was not detected in either the cytosolic fraction or the organellar fraction, indicating that both cytosolic and peroxisomal catalases are ctt1+ products. When the presence of the Ctt1 polypeptide was verified by Western blo ...
Chapter 10 - MBFys Home Page
... 21). The inner wall of the optic cup gives rise to the retina, while the outer wall gives rise to the retinal pigment epithelium. This epithelium is a thin melanin-containing structure that reduces backscattering of light that enters the eye; it also plays a critical role in the maintenance of photo ...
... 21). The inner wall of the optic cup gives rise to the retina, while the outer wall gives rise to the retinal pigment epithelium. This epithelium is a thin melanin-containing structure that reduces backscattering of light that enters the eye; it also plays a critical role in the maintenance of photo ...
From Sequence to Structure
... peptide backbone, to polar organic molecules, and to water. This tendency dominates the interactions in which they participate. Some of them can change their charge state depending on their pH or the microenvironment. Aspartic acid and glutamic acid have pKa values near 5 in aqueous solution, so the ...
... peptide backbone, to polar organic molecules, and to water. This tendency dominates the interactions in which they participate. Some of them can change their charge state depending on their pH or the microenvironment. Aspartic acid and glutamic acid have pKa values near 5 in aqueous solution, so the ...
Autophagy at the crossroads of catabolism and anabolism
... specific cargoes such as mitochondria, peroxisomes and ribosomes, and protein aggregates. Selective autophagy is mediated by autophagy cargo receptors that bind cargo earmarked with degradation signals, most commonly ubiquitin in mammals, through their ubiquitin-binding domain (UBD). These receptors ...
... specific cargoes such as mitochondria, peroxisomes and ribosomes, and protein aggregates. Selective autophagy is mediated by autophagy cargo receptors that bind cargo earmarked with degradation signals, most commonly ubiquitin in mammals, through their ubiquitin-binding domain (UBD). These receptors ...
Evolution of acidocalcisomes and their role in polyphosphate
... (Lu et al. 1998). Physiological experiments in L. donovani also suggested the presence of the V-Hþ-ATPase and the V-Hþ-PPase in different compartments (Rodrigues et al. 1999b). The V-Hþ-PPase also exists elsewhere in some species. It was initially described in chromatophore membranes of Rhodospirill ...
... (Lu et al. 1998). Physiological experiments in L. donovani also suggested the presence of the V-Hþ-ATPase and the V-Hþ-PPase in different compartments (Rodrigues et al. 1999b). The V-Hþ-PPase also exists elsewhere in some species. It was initially described in chromatophore membranes of Rhodospirill ...
Repositório da Universidade de Lisboa
... The ability to associate and process a vast amount and various types of data is an advantage that information and communication technologies bring to biology. However, most bioinformatics either focus solely on evolution, and we call it phylogenetics, or ignores the evolutionary history of its objec ...
... The ability to associate and process a vast amount and various types of data is an advantage that information and communication technologies bring to biology. However, most bioinformatics either focus solely on evolution, and we call it phylogenetics, or ignores the evolutionary history of its objec ...
Evolution of acidocalcisomes and their role in polyphosphate
... (Lu et al. 1998). Physiological experiments in L. donovani also suggested the presence of the V-Hþ-ATPase and the V-Hþ-PPase in different compartments (Rodrigues et al. 1999b). The V-Hþ-PPase also exists elsewhere in some species. It was initially described in chromatophore membranes of Rhodospirill ...
... (Lu et al. 1998). Physiological experiments in L. donovani also suggested the presence of the V-Hþ-ATPase and the V-Hþ-PPase in different compartments (Rodrigues et al. 1999b). The V-Hþ-PPase also exists elsewhere in some species. It was initially described in chromatophore membranes of Rhodospirill ...
BIOCHEMISTRY
... Historically, Biochemistry is intimately related to Organic Chemistry, which deals with the chemical properties of compounds that make part of living matter, and to Physiology, which deals with the functions of living organisms. The terms “physiological chemistry” and “biochemistry” as equivalent co ...
... Historically, Biochemistry is intimately related to Organic Chemistry, which deals with the chemical properties of compounds that make part of living matter, and to Physiology, which deals with the functions of living organisms. The terms “physiological chemistry” and “biochemistry” as equivalent co ...
A pervasive role of histone acetyltransferases and deacetylases in
... necessary for NF-kB-dependent transcriptional activity is present only in p65, c-Rel and RelB. However, RelB–p65 heterodimeric complexes are inhibitory because they cannot bind to DNA. Because they lack a TAD, DNA-bound p50 or p52 homodimers function as transcriptional repressors, but they can stimu ...
... necessary for NF-kB-dependent transcriptional activity is present only in p65, c-Rel and RelB. However, RelB–p65 heterodimeric complexes are inhibitory because they cannot bind to DNA. Because they lack a TAD, DNA-bound p50 or p52 homodimers function as transcriptional repressors, but they can stimu ...
Spatiotemporal Patterning of Reactive Oxygen Production and Ca2+
... cytosolic Ca2 increase. Thus, the spatiotemporal pattern of the Ca 2 wave is determined by peripheral ROS production. The second, later ROS component localizes to the mitochondria and is a direct consequence of the Ca 2 wave. The first component, but not the second, is required for short-term ada ...
... cytosolic Ca2 increase. Thus, the spatiotemporal pattern of the Ca 2 wave is determined by peripheral ROS production. The second, later ROS component localizes to the mitochondria and is a direct consequence of the Ca 2 wave. The first component, but not the second, is required for short-term ada ...
Dense Core Vesicle Release: Controlling the Where as
... the reason the DCVs were missing from the motor neurons in the CaMKII mutant was because they had fused with the plasma membrane and released their cargoes at a much higher rate than in wild-type animals. Interestingly, even transmembrane DCV markers were decreased. This suggests a very rapid endocy ...
... the reason the DCVs were missing from the motor neurons in the CaMKII mutant was because they had fused with the plasma membrane and released their cargoes at a much higher rate than in wild-type animals. Interestingly, even transmembrane DCV markers were decreased. This suggests a very rapid endocy ...
Aritro Sen
... Regulation of estradiol (E) production, central to ovarian follicular development and reproductive function, is mediated by a complex interaction of pituitary gonadotropins such as FSH with locally produced regulatory molecules. While the regulation of E production by pituitary gonadotropins, steroi ...
... Regulation of estradiol (E) production, central to ovarian follicular development and reproductive function, is mediated by a complex interaction of pituitary gonadotropins such as FSH with locally produced regulatory molecules. While the regulation of E production by pituitary gonadotropins, steroi ...
The Ovine Lens Cytoskeleton - Lincoln University Research Archive
... Intermediate filament proteins are referred to as such on the basis of their average diameter (10 nm) is intermediate to that of microfilaments (characteristically 5-8 nm in diameter) and the microtubules (typically 20-25 nm in diameter; Strelkov et al., 2003; Pitz & Moll, 2002). Intermediate filame ...
... Intermediate filament proteins are referred to as such on the basis of their average diameter (10 nm) is intermediate to that of microfilaments (characteristically 5-8 nm in diameter) and the microtubules (typically 20-25 nm in diameter; Strelkov et al., 2003; Pitz & Moll, 2002). Intermediate filame ...
A Model of Primitive Streak Initiation in the Chick Embryo
... can be produced when the blastoderm is cut into quarters, one in each segment. The streak normally forms adjacent to the posterior marginal zone and there is evidence (see Bachvarova et al., 1998) that this structure causes streak induction. All (or at least most) of the marginal zone has the abilit ...
... can be produced when the blastoderm is cut into quarters, one in each segment. The streak normally forms adjacent to the posterior marginal zone and there is evidence (see Bachvarova et al., 1998) that this structure causes streak induction. All (or at least most) of the marginal zone has the abilit ...
Dopaminergic Transmission and Wake
... metabotropic, meaning that they are coupled to guanosine-triphosphate (GTP)hydrolysing proteins (G-proteins) and affect ion channels indirectly. D1/D5 dopamine receptors are coupled to the Gs, and the related Golf, G-proteins, the alpha subunit of which stimulates the activity of adenylyl cyclase, a ...
... metabotropic, meaning that they are coupled to guanosine-triphosphate (GTP)hydrolysing proteins (G-proteins) and affect ion channels indirectly. D1/D5 dopamine receptors are coupled to the Gs, and the related Golf, G-proteins, the alpha subunit of which stimulates the activity of adenylyl cyclase, a ...
The glycocalyx of the sperm surface
... The glycocalyx of the sperm surface Sabine Schröter, Caroline Osterhoff, Wendy McArdle and Richard Ivell1 IHF Institute for Hormone and Fertility Research, University of Hamburg, Grandweg 64, 22529 Hamburg, Germany The surface of mammalian spermatozoa is covered by a dense coating of carbohydrate-ri ...
... The glycocalyx of the sperm surface Sabine Schröter, Caroline Osterhoff, Wendy McArdle and Richard Ivell1 IHF Institute for Hormone and Fertility Research, University of Hamburg, Grandweg 64, 22529 Hamburg, Germany The surface of mammalian spermatozoa is covered by a dense coating of carbohydrate-ri ...
Signal transduction
Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.