The Matrix Protein Hikaru genki Localizes to Cholinergic Synaptic
... Figure 1. Hig localizes in the synaptic clefts of cholinergic synapses in the brain. A, Distribution of Hig in the brain. Frontal sections of the anterior and posterior brain regions are shown. Hig was observed in the entire synaptic region labeled with Brp in the WT brain, whereas Hig signals disap ...
... Figure 1. Hig localizes in the synaptic clefts of cholinergic synapses in the brain. A, Distribution of Hig in the brain. Frontal sections of the anterior and posterior brain regions are shown. Hig was observed in the entire synaptic region labeled with Brp in the WT brain, whereas Hig signals disap ...
PDF - Bezanilla Lab
... to genetic and biochemical studies. Many species can be cultured on simple defined media, where growth is rapid, making them ideal material for metabolic studies. Developmental responses to hormones and to environmental inputs can be studied both at the level of individual cells and in multicellular ...
... to genetic and biochemical studies. Many species can be cultured on simple defined media, where growth is rapid, making them ideal material for metabolic studies. Developmental responses to hormones and to environmental inputs can be studied both at the level of individual cells and in multicellular ...
Early Progenitor Cell Marker Expression Distinguishes Type II From
... (mTORC1) as evidenced by aberrant phosphorylation of several downstream signaling proteins including S6 kinase 1 (S6K1), ribosomal protein S6 (S6), and 4-elongation factor binding protein-1 (4E-BP1) in tubers (6Y8) (Fig. 1). The polyhydramnios, megalencephaly, symptomatic epilepsy syndrome (PS) is a ...
... (mTORC1) as evidenced by aberrant phosphorylation of several downstream signaling proteins including S6 kinase 1 (S6K1), ribosomal protein S6 (S6), and 4-elongation factor binding protein-1 (4E-BP1) in tubers (6Y8) (Fig. 1). The polyhydramnios, megalencephaly, symptomatic epilepsy syndrome (PS) is a ...
CARBOHYDRATE METABOLISM
... • feedback inhibited by glucose-6-phosphate, the product of the reaction • relatively low Km for glucose (about 0.1 mM) • Glucose-6-phosphate, unlike glucose, is negatively charged, which prevents its exit from cells. • The liver is a glucose buffer for the blood. Its activity assures constant gluco ...
... • feedback inhibited by glucose-6-phosphate, the product of the reaction • relatively low Km for glucose (about 0.1 mM) • Glucose-6-phosphate, unlike glucose, is negatively charged, which prevents its exit from cells. • The liver is a glucose buffer for the blood. Its activity assures constant gluco ...
The Nervous System
... outside. The charge difference creates a form of stored energy called a membrane potential. Protein channels (shown in green) that can allow the movement of electrically charged ions across the membrane remain closed in a resting cell, thus maintaining the membrane potential. ...
... outside. The charge difference creates a form of stored energy called a membrane potential. Protein channels (shown in green) that can allow the movement of electrically charged ions across the membrane remain closed in a resting cell, thus maintaining the membrane potential. ...
File produced at level 10
... (Figure 2; Nunnari et al. 1997). The fluorescently labeled mitochondrial networks observed over time subsequently divided into pieces and then fused again in different arrangements. All membrane fusion events in the cell are tightly regulated by protein mediators. Otherwise, a hopeless jumble of str ...
... (Figure 2; Nunnari et al. 1997). The fluorescently labeled mitochondrial networks observed over time subsequently divided into pieces and then fused again in different arrangements. All membrane fusion events in the cell are tightly regulated by protein mediators. Otherwise, a hopeless jumble of str ...
BMP4 regulation of sensory organ development in the chick inner ear
... Chapter I - Introduction ...
... Chapter I - Introduction ...
Physiology of Gonadotropin-Releasing Hormone (GnRH): Beyond
... Submit Manuscript | http://medcraveonline.com ...
... Submit Manuscript | http://medcraveonline.com ...
REVIEWS - Haseloff Lab
... C-terminal Gly carboxyl group of ubiquitin is linked through an isopeptide bond to an accessible amino group (typically a Lys ε-amino) in the target. By attaching ubiquitin in various ways, distinct target fates can be achieved. For example, by reiterative rounds of ubiquitylation, polymeric ubiquit ...
... C-terminal Gly carboxyl group of ubiquitin is linked through an isopeptide bond to an accessible amino group (typically a Lys ε-amino) in the target. By attaching ubiquitin in various ways, distinct target fates can be achieved. For example, by reiterative rounds of ubiquitylation, polymeric ubiquit ...
Kinetic Analysis of the L-type Calcium Current in Enzymatically
... calcium influx in the h e a r t muscle a n d plays a key role in the regulation of contractility. Because of the crucial role played by Ica-h, considerable attention has been placed on the characteristics of the calcium influx through the dihydropyridinesensitive calcium channels (Campbell and Giles ...
... calcium influx in the h e a r t muscle a n d plays a key role in the regulation of contractility. Because of the crucial role played by Ica-h, considerable attention has been placed on the characteristics of the calcium influx through the dihydropyridinesensitive calcium channels (Campbell and Giles ...
Force development by the contractile vacuole
... and the mineral oil, the CV rounded against this force during its rounding phase. It can, therefore, be supposed that the tension at the surface of the CV increases during the rounding phase. We previously proposed a hypothesis (Tominaga et al., 1998a; Tominaga et al., 1999) that an increase in the ...
... and the mineral oil, the CV rounded against this force during its rounding phase. It can, therefore, be supposed that the tension at the surface of the CV increases during the rounding phase. We previously proposed a hypothesis (Tominaga et al., 1998a; Tominaga et al., 1999) that an increase in the ...
PDF Full-text
... two non-α-helical domains. Amino acids are organized in heptad repeat pattern in the central rod domain, whereas variability in the primary structure of IFs characterizes the amino-terminal head and the carboxy-terminal tail domains. The in silico structural prediction of IFs suggests that the centr ...
... two non-α-helical domains. Amino acids are organized in heptad repeat pattern in the central rod domain, whereas variability in the primary structure of IFs characterizes the amino-terminal head and the carboxy-terminal tail domains. The in silico structural prediction of IFs suggests that the centr ...
Ana Maria da Silva Esteves Dissertation presented to obtain
... better suited for osmoprotection. This is one more illustration of solute replacement, a strategy generally used by organisms that rely on solute accumulation for osmoregulation. The patterns of compatible solute accumulation by Pyrococcus furiosus in response to heat stress are known, but the effec ...
... better suited for osmoprotection. This is one more illustration of solute replacement, a strategy generally used by organisms that rely on solute accumulation for osmoregulation. The patterns of compatible solute accumulation by Pyrococcus furiosus in response to heat stress are known, but the effec ...
... sequence overlapping with a calmodulin binding region, followed by an association domain which is important in holoenzyme formation. Immunoelectron microscopy of CaM kinase purified from rat brain indicates that the kinase has an overall “flower”-like structure, with a central core composed of 8-10 ...
Nitrite transport to the chloroplast in Chlamydomonas reinhardtii
... the study of its putative specific transporters. In plant and animal cells, anionic channels have been shown to be permeable to both nitrate and nitrite (Barbier-Brygoo et al., 2000; Frachisse et al., 2000; May et al., 2000; Waldegger and Jentsch, 2000). In plants, anion channels contribute to the r ...
... the study of its putative specific transporters. In plant and animal cells, anionic channels have been shown to be permeable to both nitrate and nitrite (Barbier-Brygoo et al., 2000; Frachisse et al., 2000; May et al., 2000; Waldegger and Jentsch, 2000). In plants, anion channels contribute to the r ...
The neuropharmacology of impulsive behaviour
... has been inferred from the therapeutic efficacy of psychostimulant drugs, such as amphetamine and methylphenidate, in the treatment of ADHD (see Table 1). However, psychostimulant drugs do not reduce all forms of impulsivity. In fact, amphetamine has quite consistently been found to enhance impulsiv ...
... has been inferred from the therapeutic efficacy of psychostimulant drugs, such as amphetamine and methylphenidate, in the treatment of ADHD (see Table 1). However, psychostimulant drugs do not reduce all forms of impulsivity. In fact, amphetamine has quite consistently been found to enhance impulsiv ...
PDF
... parasites have solved the problem of adjusting proliferation to a wide variety of host cells. What is not understood are the mechanistic details that afford this tremendous cell division flexibility, while also preserving the fidelity of chromosome replication. Viewed from the restricted principles ...
... parasites have solved the problem of adjusting proliferation to a wide variety of host cells. What is not understood are the mechanistic details that afford this tremendous cell division flexibility, while also preserving the fidelity of chromosome replication. Viewed from the restricted principles ...
Distinct roles of doublecortin modulating the microtubule cytoskeleton.
... therefore impede kinesin movement along the microtubules. Moores and co-workers therefore examined kinesin motion along doublecortinstabilised tracks and found, surprisingly, that doublecortin binding did not prevent walking by kinesin motors. This means that cellular transport can occur along doubl ...
... therefore impede kinesin movement along the microtubules. Moores and co-workers therefore examined kinesin motion along doublecortinstabilised tracks and found, surprisingly, that doublecortin binding did not prevent walking by kinesin motors. This means that cellular transport can occur along doubl ...
Here - Muscle Health Research Centre
... accompanying software. Analysis of blots was performed using ImageJ freeware. It should be noted that significant changes in proteins normally used as loading controls (e.g., GAPDH) during skeletal muscle regeneration occur. Therefore, Ponceau-stained membranes were imaged, and an appropriate band w ...
... accompanying software. Analysis of blots was performed using ImageJ freeware. It should be noted that significant changes in proteins normally used as loading controls (e.g., GAPDH) during skeletal muscle regeneration occur. Therefore, Ponceau-stained membranes were imaged, and an appropriate band w ...
Auxin and other signals on the move in plants Auxins are a class of
... of the activity or expression of specific transporters. Most macronutrients are used to manufacture amino acids, proteins, nucleic acids, phospholipids, chlorophyll or the cell wall. Phosphorus and magnesium, mainly in the form of Mg-ATP, have an important function in bioenergetics. Potassium and ca ...
... of the activity or expression of specific transporters. Most macronutrients are used to manufacture amino acids, proteins, nucleic acids, phospholipids, chlorophyll or the cell wall. Phosphorus and magnesium, mainly in the form of Mg-ATP, have an important function in bioenergetics. Potassium and ca ...
Biological significance of structural differences between two highly
... a 3-10 helix and a supporting a-helix, but lacks the active site cysteine and the two carboxy terminal helices found in the core domain of Ubcs (Fig. 1B) [8,17]. Based on a primary structure alignment, the residues important for binding Ub (Mms2-Ser32 and -Ile62) [18] and Ubc13 (Mms2-Phe13) [7] are ...
... a 3-10 helix and a supporting a-helix, but lacks the active site cysteine and the two carboxy terminal helices found in the core domain of Ubcs (Fig. 1B) [8,17]. Based on a primary structure alignment, the residues important for binding Ub (Mms2-Ser32 and -Ile62) [18] and Ubc13 (Mms2-Phe13) [7] are ...
Endoplasmic reticulum–mitochondria contacts: function of the junction
... function that is also carried out at the ER–mitochondria junction14. Cells with defective members of the ERMES complex have a lower rate of PS conversion to PC than wild-type cells, indicating that ERMES may be important for coupling at sites of lipid exchange11. However, others have reported no sig ...
... function that is also carried out at the ER–mitochondria junction14. Cells with defective members of the ERMES complex have a lower rate of PS conversion to PC than wild-type cells, indicating that ERMES may be important for coupling at sites of lipid exchange11. However, others have reported no sig ...
Localization of Ptr ToxA Produced by Pyrenophora tritici
... interactions with integrin receptors with or without the internalization of the receptor and its ligand (Cherny et al., 1993; Memmo and McKeown-Longo, 1998; Hynes, 2002). Internalization of receptor has been coopted as a mechanism for pathogen uptake by animal cells (Marjomaki et al., 2002). Althoug ...
... interactions with integrin receptors with or without the internalization of the receptor and its ligand (Cherny et al., 1993; Memmo and McKeown-Longo, 1998; Hynes, 2002). Internalization of receptor has been coopted as a mechanism for pathogen uptake by animal cells (Marjomaki et al., 2002). Althoug ...
Biofilm exopolysaccharides
... limited extent (Geddie & Sutherland, 1994). The resultant polysaccharides yield highly viscous aqueous solutions with viscoelastic properties. The acetylated polysaccharides are also fairly resistant to most of the alginate lyases which can degrade the algal products (Sutherland, 1997). In both type ...
... limited extent (Geddie & Sutherland, 1994). The resultant polysaccharides yield highly viscous aqueous solutions with viscoelastic properties. The acetylated polysaccharides are also fairly resistant to most of the alginate lyases which can degrade the algal products (Sutherland, 1997). In both type ...
High Resolution Two-Dimensional Electrophoresis of Proteins*
... them W-labeled E. coli. The labeling period was followed by a chase period of 30 min during which time the nematodes were fed unlabeled E. coli. After this time no labeled E. coli proteins could be detected. Sample ...
... them W-labeled E. coli. The labeling period was followed by a chase period of 30 min during which time the nematodes were fed unlabeled E. coli. After this time no labeled E. coli proteins could be detected. Sample ...
Signal transduction
Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.