Mitochondrial dysfunction in Parkinson`s disease
... a parkin upstream factor that accumulates on mitochondria upon depolarization of mitochondria and recruits parkin onto mitochondria [73]. As a mitochondrial protein, PINK1 has multiple roles in mitochondria, including mitophagy [73], mitochondrial traffic [74], mitochondrial dynamics [75] and comple ...
... a parkin upstream factor that accumulates on mitochondria upon depolarization of mitochondria and recruits parkin onto mitochondria [73]. As a mitochondrial protein, PINK1 has multiple roles in mitochondria, including mitophagy [73], mitochondrial traffic [74], mitochondrial dynamics [75] and comple ...
REVIEWS - Unisciel
... different super-repeats23. There are two types of superrepeat that are composed of seven and eleven domains, respectively. These are about 25–30 nm and 43 nm long, the latter being the repeat distance of the helix that describes the arrangement of myosin heads on the thick filament. Six copies of th ...
... different super-repeats23. There are two types of superrepeat that are composed of seven and eleven domains, respectively. These are about 25–30 nm and 43 nm long, the latter being the repeat distance of the helix that describes the arrangement of myosin heads on the thick filament. Six copies of th ...
1 Chapter 1 Introduction 1.1 – Introduction Proteins are
... provide insight into the fundamental processes in vivo and offer the potential of designing protein/peptide based materials and therapeutic agents. ...
... provide insight into the fundamental processes in vivo and offer the potential of designing protein/peptide based materials and therapeutic agents. ...
Reviews
... the fate of cells from epidermal to neural. Substantial progress has been made only recently by the finding in amphibians that BMP4 is a neural inhibitor and epidermal inducer, and that endogenous antagonists of BMPs are secreted by the organizer. However, recent results in the chick point to the ex ...
... the fate of cells from epidermal to neural. Substantial progress has been made only recently by the finding in amphibians that BMP4 is a neural inhibitor and epidermal inducer, and that endogenous antagonists of BMPs are secreted by the organizer. However, recent results in the chick point to the ex ...
Mechanisms of plasmid stable maintenance with special
... the probability of receiving a plasmid by a dividing cell there are very special strategies adopted by plasmids preventing plasmid-free segregants from surviving. The idea of an “addiction” mechanism leading to very efficient plasmid maintenance comes from Koyama (Koyama et al., 1975). In his consid ...
... the probability of receiving a plasmid by a dividing cell there are very special strategies adopted by plasmids preventing plasmid-free segregants from surviving. The idea of an “addiction” mechanism leading to very efficient plasmid maintenance comes from Koyama (Koyama et al., 1975). In his consid ...
Nuclear-fallout, a Drosophila protein that cycles from the cytoplasm
... actin reorganizes to form an oblong ring outlining the nucleus and its polar centrosomes. During prophase, actin and the tightly associated plasma membrane invaginate to form furrows between the nuclei. At metaphase, these furrows encompass each newly formed spindle in a half-shell. These structures ...
... actin reorganizes to form an oblong ring outlining the nucleus and its polar centrosomes. During prophase, actin and the tightly associated plasma membrane invaginate to form furrows between the nuclei. At metaphase, these furrows encompass each newly formed spindle in a half-shell. These structures ...
PDF
... The patterns of polypeptide synthesis of oocytes labelled from either 0 to 3 h or from 18 to 21 h (i.e. after culture) are shown in Figs 3 and 4 respectively. These profiles confirm that maturation is accompanied by major changes in the patterns of protein synthesis which involve a substantial incre ...
... The patterns of polypeptide synthesis of oocytes labelled from either 0 to 3 h or from 18 to 21 h (i.e. after culture) are shown in Figs 3 and 4 respectively. These profiles confirm that maturation is accompanied by major changes in the patterns of protein synthesis which involve a substantial incre ...
... side of the plasma membrane to generate phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3 or PIP3), which is a potent second messenger. PKB regulation by its activator PDK1 precisely relies on a PtdIns(3,4,5)P3 binding domain, named Pleckstrin Homology domain (PH-domain). Both PDK1 and PKB a ...
Cytochrome c Release and Apoptosis Induced by Mitochondrial
... TR3, an immediate-early response gene and an orphan member of the steroidthyroid hormone-retinoid receptor superfamily of transcription factors, regulates apoptosis through an unknown mechanism. In response to apoptotic stimuli, TR3 translocates from the nucleus to mitochondria to induce cytochrome ...
... TR3, an immediate-early response gene and an orphan member of the steroidthyroid hormone-retinoid receptor superfamily of transcription factors, regulates apoptosis through an unknown mechanism. In response to apoptotic stimuli, TR3 translocates from the nucleus to mitochondria to induce cytochrome ...
The Nrf2/ARE Pathway as a Potential Therapeutic Target in
... phase II detoxification and cytoprotective genes. It was first identified by Rushmore et al. (54, 55) and has subsequently been found to be important in controlling myriad genes in most tissues (29). The putative transcription factor acting on the ARE is Nrf2 (20), a basic leucine zipper transcripti ...
... phase II detoxification and cytoprotective genes. It was first identified by Rushmore et al. (54, 55) and has subsequently been found to be important in controlling myriad genes in most tissues (29). The putative transcription factor acting on the ARE is Nrf2 (20), a basic leucine zipper transcripti ...
Chapter 2 Reivew of Lierature
... 1995) which are involved in the rewarding effects of nicotine. These behavioral abnormalities develop gradually and progressively during a course of repeated exposure to a drug of abuse, and can persist for months or years after discontinuation of drug use. As a result, drug addiction can be conside ...
... 1995) which are involved in the rewarding effects of nicotine. These behavioral abnormalities develop gradually and progressively during a course of repeated exposure to a drug of abuse, and can persist for months or years after discontinuation of drug use. As a result, drug addiction can be conside ...
Biochemical and genetic analysis of leucine-, isoleucine
... Most of the nutritional mutants isolated from Neurospora were found to have requirements for single growth factors and clearly supported the concept that each gene controls the production of only one enzyme. ...
... Most of the nutritional mutants isolated from Neurospora were found to have requirements for single growth factors and clearly supported the concept that each gene controls the production of only one enzyme. ...
10 Translocation in the Phloem Chapter
... and the xylem—extend throughout the plant body. The phloem is generally found on the outer side of both primary and secondary vascular tissues (Figures 10.1 and 10.2). In plants with secondary growth the phloem constitutes the inner bark. The cells of the phloem that conduct sugars and other organic ...
... and the xylem—extend throughout the plant body. The phloem is generally found on the outer side of both primary and secondary vascular tissues (Figures 10.1 and 10.2). In plants with secondary growth the phloem constitutes the inner bark. The cells of the phloem that conduct sugars and other organic ...
Spatial localization of the first and last enzymes effectively connects
... Figure 3 Localized enzymes form a tree-like loop-dense network A matrix representing the connectivity of the 1214 different biochemical reactions of E.coli was constructed (see Additional file 1: Figure S1B). A. Left Diagram illustrating the clustering (cls) and within-group connectivity (wgc) of lo ...
... Figure 3 Localized enzymes form a tree-like loop-dense network A matrix representing the connectivity of the 1214 different biochemical reactions of E.coli was constructed (see Additional file 1: Figure S1B). A. Left Diagram illustrating the clustering (cls) and within-group connectivity (wgc) of lo ...
Temporal coding in the gustatory system
... R.M. Hallock, P.M. Di Lorenzo / Neuroscience and Biobehavioral Reviews 30 (2006) 1145–1160 ...
... R.M. Hallock, P.M. Di Lorenzo / Neuroscience and Biobehavioral Reviews 30 (2006) 1145–1160 ...
Genomic structure, chromosomal localization, and conserved alternative splice forms of thrombopoietin
... amino terminal half of TPO (epo homologous domain). This domain is 8 1 % to 85% identical between any two species, whereas the carboxyl half is only 57% to 67% identical. A conserved dibasic amino acid motif that could represent a protease cleavage site is present at the carboxyl end of the epo homo ...
... amino terminal half of TPO (epo homologous domain). This domain is 8 1 % to 85% identical between any two species, whereas the carboxyl half is only 57% to 67% identical. A conserved dibasic amino acid motif that could represent a protease cleavage site is present at the carboxyl end of the epo homo ...
curriculum vitae- michael hippler
... Future experiments will be directed to elucidate protein-protein-interactions of PGRL1 and metalbinding dynamics of the protein. (ii) Light is a necessary substrate for photosynthesis, but its absorption by pigment molecules such as chlorophyll can cause severe oxidative damage and result in cell de ...
... Future experiments will be directed to elucidate protein-protein-interactions of PGRL1 and metalbinding dynamics of the protein. (ii) Light is a necessary substrate for photosynthesis, but its absorption by pigment molecules such as chlorophyll can cause severe oxidative damage and result in cell de ...
Differential Auxin-Transporting Activities of PIN
... mediated by PINOID (PID; a Ser/Thr protein kinase)/PP2A phosphatase (Michniewicz et al., 2007). The central hydrophilic domain of PINs might provide the molecule-specific cue for PIN polarity, together with as yet unknown cell-specific factors. Different recycling behaviors of PINs, which show varia ...
... mediated by PINOID (PID; a Ser/Thr protein kinase)/PP2A phosphatase (Michniewicz et al., 2007). The central hydrophilic domain of PINs might provide the molecule-specific cue for PIN polarity, together with as yet unknown cell-specific factors. Different recycling behaviors of PINs, which show varia ...
... cells, the spatio-temporal activation of the intrinsic and extrinsic apoptosis pathways were analyzed. In damaged neuronal cells of the ipsilateral cortex and hippocampus an important contribution of the intrinsic mitochondrial pathway through caspase-9 activation was shown to account for most of ne ...
The transmembrane proteins UNC-40/DCC, PTP-3/LAR
... Methods). From these reads (Supplemental Figure 1) and from cDNAs reported on Wormbase, a mig-21 gene structure was determined as depicted in Supplemental Figures 1 and 2. The 3’ end (exons 2-5) was identical to that reported by (MIDDELKOOP et al. 2012). The first exon defined by RNA seq in our pred ...
... Methods). From these reads (Supplemental Figure 1) and from cDNAs reported on Wormbase, a mig-21 gene structure was determined as depicted in Supplemental Figures 1 and 2. The 3’ end (exons 2-5) was identical to that reported by (MIDDELKOOP et al. 2012). The first exon defined by RNA seq in our pred ...
glycogen metabolism
... for Glycogen Breakdown • Muscular activity or its anticipation leads to the release of epinephrine (adrenaline),from the adrenal medulla. • Epinephrine markedly stimulates glycogen breakdown in muscle and, to a lesser extent, in the liver. • The liver is more responsive to glucagon, a polypeptide ho ...
... for Glycogen Breakdown • Muscular activity or its anticipation leads to the release of epinephrine (adrenaline),from the adrenal medulla. • Epinephrine markedly stimulates glycogen breakdown in muscle and, to a lesser extent, in the liver. • The liver is more responsive to glucagon, a polypeptide ho ...
Capping protein: new insights into mechanism
... high concentrations of protein under conditions in which S100B binds tightly to the 12- and 28-residue a-subunit peptides and to denatured CP [26,28]. Relatively high concentrations of the non-ionic detergent Triton-X100 did allow S100B to bind weakly to CP without denaturing either protein, however ...
... high concentrations of protein under conditions in which S100B binds tightly to the 12- and 28-residue a-subunit peptides and to denatured CP [26,28]. Relatively high concentrations of the non-ionic detergent Triton-X100 did allow S100B to bind weakly to CP without denaturing either protein, however ...
A structural comparison of molybdenum cofactor
... each family, sequence similarities are obvious, while no signi¢cant homologies can be detected between members of di¡erent families. This classi¢cation represents a unifying approach in terms of the overall enzyme structure, but, at the same time, it does not require the Mo/W center to be coordinate ...
... each family, sequence similarities are obvious, while no signi¢cant homologies can be detected between members of di¡erent families. This classi¢cation represents a unifying approach in terms of the overall enzyme structure, but, at the same time, it does not require the Mo/W center to be coordinate ...
Signal transduction
Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.