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Phosphate Groups Modifying Myelin Basic Proteins Are
Phosphate Groups Modifying Myelin Basic Proteins Are

... development of this specialized membrane system (3, 9, 34). In mammals, one-third of the total myelin protein of the ...
Candidate Vaccine Neisseria meningitidis a to Genome
Candidate Vaccine Neisseria meningitidis a to Genome

... therefore, is limited by extensive antigenic diversity of the surfaceaccessible loops of PorA (17, 18). Reverse vaccinology (19) has been used to identify new vaccine candidates for prevention of group B meningococcal disease. This approach begins with the genomic sequence instead of Ags identified ...
Identification and cDNA cloning of a Xenopus nucleolar
Identification and cDNA cloning of a Xenopus nucleolar

... mitosis by cdc2 kinase (Peter et al., 1990). Serine residues in acidic domains at the amino terminus are likely targets for CK II phosphorylation and TPXKK motifs in basic domains at the amino terminus are probable targets for cdc2 kinase phosphorylation. Phosphorylation of nucleolin by cdc2 kinase ...
Helen D. Kollias and John C. McDermott
Helen D. Kollias and John C. McDermott

... multifunctional growth factors that regulate key events of metazoan development, disease, and repair (44, 45). In 1981, TGF-␤ effects were first reported by Roberts and colleagues (65), who found that TGF-␤ induced rat kidney fibroblasts to proliferate. Since then, TGF-␤ has been found to have a ple ...
Auxinas
Auxinas

... Marchant, A., Bhalerao, R., Casimiro, I., Eklof, J., Casero, P.J., Bennett, M., and Sandberg, G. (2002). AUX1 promotes lateral root formation by facilitating indole-3-acetic acid distribution between sink and source tissues in the Arabidopsis seedling. Plant Cell 14: 589-597 Reprinted from Muday, G. ...
PDF
PDF

... Moscona (1970) have recently shown that the existence of the proper organization at the cellular level is required for the hormonal induction of glutamine synthetase in the embryonic neural retina. They have also shown that inducibility is irreversibly lost after cell dissociation, as result of meta ...
Daughter-Specific Transcription Factors Regulate Cell Size Control
Daughter-Specific Transcription Factors Regulate Cell Size Control

... obvious in mother cells. In part this is because mother cells are almost always born larger than daughters [3], but it has also been shown that daughters are slower to pass Start than mothers even when both are made equally large (greater than normal mother or daughter size) [19]. This finding sugge ...
NOVEL SPERM-SPECIFIC GLYCOLYTIC ISOZYMES GENERATED
NOVEL SPERM-SPECIFIC GLYCOLYTIC ISOZYMES GENERATED

... Targeted gene disruption of glycolytic enzymes expressed only during spermatogenesis indicates that glycolysis is essential for sperm motility and male fertility. This pathway is compartmentalized in the principal piece of the sperm flagellum, where several spermatogenic cell-specific isozymes are b ...

 Program
and
Abstracts
from
the
Fifth
Annual
Canadian
Neuroscience
Meeting
 May
29
–
June
1
2011
 Quebec
City
Convention
Center


 Program
and
Abstracts
from
the
Fifth
Annual
Canadian
Neuroscience
Meeting
 May
29
–
June
1
2011
 Quebec
City
Convention
Center


... Abstract:
"Glycine
and
GABA
are
depolarizing
during
early
development
but
the
purpose
is
 unclear.
Altering
depolarizing
glycine
signaling
from
the
beginning
of
development
in
zebrafish
 embryos
by
over‐expressing
the
potassium‐chloride
co‐transporter
type‐2
(KCC2)
to
reverse
the
 chloride
gradient
 ...
Evolution of Brachyury proteins: identification of a novel regulatory
Evolution of Brachyury proteins: identification of a novel regulatory

... metazoans, and the availability of full-length cDNAs for orthologues from all major phyla, prompted us to test whether these proteins have intrinsically different activities, or whether their different functions reflect changes in their cellular contexts during evolution. We therefore compared the e ...
Transforming growth factor-β and myostatin signaling in skeletal
Transforming growth factor-β and myostatin signaling in skeletal

... multifunctional growth factors that regulate key events of metazoan development, disease, and repair (44, 45). In 1981, TGF-␤ effects were first reported by Roberts and colleagues (65), who found that TGF-␤ induced rat kidney fibroblasts to proliferate. Since then, TGF-␤ has been found to have a ple ...
Molecular cloning and characterization of chitinase
Molecular cloning and characterization of chitinase

... DNA from S. lividans TK64 was partially digested with Suu3AI and was then subjected to ultracentrifugation on a sucrose gradient (Maniatis et al., 1982). DNA fragments of 5-20 kb in size were collected, mixed with pIJ702 that had been treated with BglII and dephosphorylated, and then the fragments w ...
Separate Functions of Gelsolin Mediate Sequential Steps of
Separate Functions of Gelsolin Mediate Sequential Steps of

... altered residues was directed by the following considerations: the aminoterminal half of gelsolin is largely responsible for severing and capping activities and is regulated by phosphoinositides (Janmey and Stossel, 1987; Yin, 1987; Weeds and Maciver, 1993); in vitro severing assays have demonstrate ...
Chromosome Segregation in Budding Yeast: Sister Chromatid
Chromosome Segregation in Budding Yeast: Sister Chromatid

... segregation machinery that is conserved in all eukaryotes. Early on, it was recognized that the two sister chromatids must be held tightly together at metaphase to resist spindle forces, thereby allowing their attachment to microtubules from opposite poles. However, the nature of this cohesion was n ...
Shigella boydii Involved in O-antigen Synthesis By
Shigella boydii Involved in O-antigen Synthesis By

... 3.3.1 Donor substrate specificity .........................................................................- 58 3.3.2 Role of pyrophosphate in acceptor substrate specificity ..............................- 60 3.3.3 Screening of compounds as potential inhibitors ..................................... ...
Pancreas or liver choice within endoderm
Pancreas or liver choice within endoderm

... Temporal and spatial relation between pancreas and liver specification We first sought to define the exact time and place where the earliest markers of the pancreas and liver are activated. RT-PCR was used to investigate Pdx1 gene expression in endoderm fragments dissected from the ventral foregut o ...
Failsafe Mechanisms Coordinate Cell Division and the Initiation of
Failsafe Mechanisms Coordinate Cell Division and the Initiation of

... Chapter 1: Introduction ...
Dynamics of Tubulovesicular Recycling Endosomes in Hippocampal
Dynamics of Tubulovesicular Recycling Endosomes in Hippocampal

... system (Stanford University, C ell Sciences Imaging Facility). To measure the overlap between two fluorophores in double-stained samples, we analyzed confocal images with the Molecular Dynamics MultiProbe 2010 image analysis software. The data shown are the means 6 SE of at least ...
Anion-Channel Blockers Inhibit S-Type Anion
Anion-Channel Blockers Inhibit S-Type Anion

... chemicals on physiologically regulated stomatal apertures can be used to determine the functions of guard cell anion channels. An initial anion-channel-blocker study has provided support for the hypothesis that anion channels represent an essential mechanism for regulation of stomatal closing (Schro ...
Role of the posterior vacuole in Spraguea lophii (Microsporidia
Role of the posterior vacuole in Spraguea lophii (Microsporidia

... oxygen generated was proportional to the level of spore firing and the amount of H2O2 substrate added to the medium containing primed spore material. In the absence of hydrogen peroxide, activated spores yielded no detectable oxygen and spore hatching was greatly reduced. The enzyme ACOX is always f ...
the vagus nerve - European Medical Journal
the vagus nerve - European Medical Journal

... stomach and duodenum followed by a progressive reduction in the small intestine and colon.17 The fact that gastric myenteric neurons are activated by vagal input was also demonstrated immunohistochemically with the detection of c-Fos and phosphorylated c-AMP response element binding protein (p-CREB) ...
The PDZ-GEF Dizzy regulates cell shape of migrating macrophages
The PDZ-GEF Dizzy regulates cell shape of migrating macrophages

... the transcription start site. The difference between dizzyEP and dizzyP phenotypes is probably due to the distinct properties of the Pelements. In contrast to dizzyP, dizzyEP has an hsp70 promoter at its 3⬘ end that could allow a sufficient level of dizzy transcription controlled by endogenous enhan ...
TAL1occupancy_WuRevised_v16 - bx.psu.edu
TAL1occupancy_WuRevised_v16 - bx.psu.edu

... functions in primitive erythropoiesis. Furthermore, a motif search on TAL1 binding sites in human proerythroblasts revealed that E-boxes are absent from over one-fifth of the sites. Indeed, GATA motifs ranked as the most overrepresented motifs, and they were closer to TAL1 peak summits than E-boxes ...
Role of the cytoskeleton in communication between L
Role of the cytoskeleton in communication between L

... in steady-state concentration of ROS regulate signal transduction pathways, gene expression, proliferation, and cell death by apoptosis.49,53,60 Uninhibited increases in ROS production, in which antioxidant defenses become inadequate, lead to oxidative stress.49,55 Increases in ROS beyond 10 µmol/l ...
Investigating the role of papain-like cysteine protease RD21 in plant
Investigating the role of papain-like cysteine protease RD21 in plant

... 1.1. Classification and structure of papain-like cysteine proteases Proteases are grouped into families and clans in the MEROPS database based on structural and evolutionary criteria (http://merops.sanger.ac.uk/, Rawlings et al., 2008). To date, 70 families belonging to 12 different clans are cystei ...
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Signal transduction



Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.
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