An RNA-Sequencing Transcriptome and Splicing Database of Glia
... York, New York 10032, 5Department of Anatomy, University of California, San Francisco, San Francisco, California 94143-0452, 6Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Victoria, Australia 3010, and 7Department of Systems Biology, 8Center for Motor Neuron Biolog ...
... York, New York 10032, 5Department of Anatomy, University of California, San Francisco, San Francisco, California 94143-0452, 6Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Victoria, Australia 3010, and 7Department of Systems Biology, 8Center for Motor Neuron Biolog ...
Document
... •eukaryotes have 3 nuclear RNA polymerases, which transcribe unique sets of genes •RNA pol II transcribes protein coding genes and must respond to and integrate a diverse set of signals in order to regulate expression of >25k genes •in vitro transcription systems for pol II show accurate initiation ...
... •eukaryotes have 3 nuclear RNA polymerases, which transcribe unique sets of genes •RNA pol II transcribes protein coding genes and must respond to and integrate a diverse set of signals in order to regulate expression of >25k genes •in vitro transcription systems for pol II show accurate initiation ...
A Gibberellin-Regulated Calcineurin B in Rice Localizes to
... Many developmental and environmental signals are transduced through changes in intracellular calcium concentrations, yet only a few calcium-binding proteins have been identified in plants. Calcineurin B-like (CBL) proteins are calcium-binding proteins that are thought to function as plant signal tra ...
... Many developmental and environmental signals are transduced through changes in intracellular calcium concentrations, yet only a few calcium-binding proteins have been identified in plants. Calcineurin B-like (CBL) proteins are calcium-binding proteins that are thought to function as plant signal tra ...
Three multidomain esterases from the cellulolytic
... characterized XynB enzyme (781 amino acids) includes an internal acetylesterase domain in addition to its N-terminal xylanase catalytic domain. A third gene, xynE, is predicted to encode a multidomain enzyme of 792 amino acids including a family 11 xylanase domain and a C-terminal esterase domain. T ...
... characterized XynB enzyme (781 amino acids) includes an internal acetylesterase domain in addition to its N-terminal xylanase catalytic domain. A third gene, xynE, is predicted to encode a multidomain enzyme of 792 amino acids including a family 11 xylanase domain and a C-terminal esterase domain. T ...
Action Potential
... • The opening of ion channels in the plasma membrane converts chemical potential to electrical potential • A neuron at resting potential contains many open K+ channels and fewer open Na+ channels; K+ diffuses out of the cell • Anions trapped inside the cell contribute to the negative charge within ...
... • The opening of ion channels in the plasma membrane converts chemical potential to electrical potential • A neuron at resting potential contains many open K+ channels and fewer open Na+ channels; K+ diffuses out of the cell • Anions trapped inside the cell contribute to the negative charge within ...
The Neuronal Membrane at Rest
... by the tack must be translated into neural signals that travel rapidly and reliably up the long sensory nerves of your leg. In the spinal cord, these signals are transferred to interneurons. Some of these neurons connect with the parts of your brain that interpret the signals as being painful. Other ...
... by the tack must be translated into neural signals that travel rapidly and reliably up the long sensory nerves of your leg. In the spinal cord, these signals are transferred to interneurons. Some of these neurons connect with the parts of your brain that interpret the signals as being painful. Other ...
Dictionary of Interfaces in Proteins (DIP). Data Bank of
... folding (e.g. see Peng et al., 1995) indicate that molten globules do have major secondary structures resembling native topology. These results suggest the existence of a intermediate state containing pre-formed secondary structural units that have to be closely packed during further folding. The co ...
... folding (e.g. see Peng et al., 1995) indicate that molten globules do have major secondary structures resembling native topology. These results suggest the existence of a intermediate state containing pre-formed secondary structural units that have to be closely packed during further folding. The co ...
This Week in Microbiology
... Vincent: So how hardy are they? You can dry them out and they’re fine, right? Jonathan: They’re fine. We routinely take spores in the lab and to prove that they’re spores, we treat th ...
... Vincent: So how hardy are they? You can dry them out and they’re fine, right? Jonathan: They’re fine. We routinely take spores in the lab and to prove that they’re spores, we treat th ...
Ribosomes: Cashing in on crystals
... density map and a complete atomic model may be available in the near future. A similar level of atomic detail is seen in the 5.5 Å resolution map of the 30S ribosomal subunit from the bacterium Thermus thermophilus. Clemons et al. [3] produced a map of the small subunit with the characteristic shape ...
... density map and a complete atomic model may be available in the near future. A similar level of atomic detail is seen in the 5.5 Å resolution map of the 30S ribosomal subunit from the bacterium Thermus thermophilus. Clemons et al. [3] produced a map of the small subunit with the characteristic shape ...
pET System Manual
... Almost all of the pET vectors can express proteins that do not contain vector-encoded sequences. An Nde I or Nco I site is available in many vectors for cloning into the AUG start codon at the 5' end of the insert coding sequence. Similarly, proteins without vector-encoded C-terminal fusions are obt ...
... Almost all of the pET vectors can express proteins that do not contain vector-encoded sequences. An Nde I or Nco I site is available in many vectors for cloning into the AUG start codon at the 5' end of the insert coding sequence. Similarly, proteins without vector-encoded C-terminal fusions are obt ...
Model Description Sheet
... Format: Alpha carbon backbone RP: Zcorp with plaster Description: According to the CDC, 34.9% of United States adults are obese, which is linked to premature death, heart disease, cancer, respiratory disorders, fertility problems, Type 2 diabetes, and stroke. Over- and under-eating are related to br ...
... Format: Alpha carbon backbone RP: Zcorp with plaster Description: According to the CDC, 34.9% of United States adults are obese, which is linked to premature death, heart disease, cancer, respiratory disorders, fertility problems, Type 2 diabetes, and stroke. Over- and under-eating are related to br ...
1 CHAPTER I INTRODUCTION The nucleus of the cell contains our
... molecule was bending or folding in an additional coiled-coil motif, or superhelix conformation (42). The data also demonstrated that the lysine-rich histone fraction is unnecessary for forming the same diffraction pattern as seen with whole nucleohistone fibers (43). Using improved techniques to vis ...
... molecule was bending or folding in an additional coiled-coil motif, or superhelix conformation (42). The data also demonstrated that the lysine-rich histone fraction is unnecessary for forming the same diffraction pattern as seen with whole nucleohistone fibers (43). Using improved techniques to vis ...
Central Role of Voltage Gated Calcium Channels and
... One of the ways in which calcium channels influence neuronal and many other activities is via signaling pathways that control gene expression. This involves regulation of various transcription factors, including CREB. Calcium entry specifically through LTCC is particularly important for transcriptio ...
... One of the ways in which calcium channels influence neuronal and many other activities is via signaling pathways that control gene expression. This involves regulation of various transcription factors, including CREB. Calcium entry specifically through LTCC is particularly important for transcriptio ...
Topology Prediction of Membrane Proteins
... erse the membrane and are tightly packed into bundles (Fig. 2a). They are composed of mainly hydrophobic residues where the side chains can form van der Waals interactions with the fatty acid chains in the membrane core. All polar amide and carbonyl groups in the backbone are hydrogen bonded intern ...
... erse the membrane and are tightly packed into bundles (Fig. 2a). They are composed of mainly hydrophobic residues where the side chains can form van der Waals interactions with the fatty acid chains in the membrane core. All polar amide and carbonyl groups in the backbone are hydrogen bonded intern ...
Title Non-coding functions of alternative pre-mRNA - DR-NTU
... interact with promoter regions of the stem cell-specific genes OCT4 and NANOG. However, the downstream effect of this interaction is isoform-specific: MBD2a promotes human pluripotent stem cell differentiation, whereas MBD2c activates OCT4 and thus reinforces the stem cell status. Interestingly, OCT ...
... interact with promoter regions of the stem cell-specific genes OCT4 and NANOG. However, the downstream effect of this interaction is isoform-specific: MBD2a promotes human pluripotent stem cell differentiation, whereas MBD2c activates OCT4 and thus reinforces the stem cell status. Interestingly, OCT ...
Asymmetries in Cell Division, Cell Size, and Furrowing in the
... reasons. Indeed, misregulation of asymmetric cell divisions is believed to have dramatic consequences potentially leading to pathogenesis such as cancers. In diverse model organisms, asymmetric cell divisions result in two daughter cells, which differ not only by their fate but also in size. This is ...
... reasons. Indeed, misregulation of asymmetric cell divisions is believed to have dramatic consequences potentially leading to pathogenesis such as cancers. In diverse model organisms, asymmetric cell divisions result in two daughter cells, which differ not only by their fate but also in size. This is ...
The expanding universe of alkaloid biosynthesis Vincenzo De Luca
... that is similar to that of chalcone synthase (CHS; EC 2.3.1.74). Unlike CHS, however, ACS will not accept 4-coumaroyl-CoA as a substrate. The initial isolation of an ACSI clone (reviewed in [2•]), and the subsequent characterization of the tandemly arranged and 94% homologous ACSII gene [3], reveale ...
... that is similar to that of chalcone synthase (CHS; EC 2.3.1.74). Unlike CHS, however, ACS will not accept 4-coumaroyl-CoA as a substrate. The initial isolation of an ACSI clone (reviewed in [2•]), and the subsequent characterization of the tandemly arranged and 94% homologous ACSII gene [3], reveale ...
AtSpc98p and plant microtubule nucleation
... cells. Microtubule nucleation involving Spc98p-containing γ-tubulin complexes could then be conserved among all eukaryotes, despite differences in structure and spatial distribution of microtubule organizing centers. ...
... cells. Microtubule nucleation involving Spc98p-containing γ-tubulin complexes could then be conserved among all eukaryotes, despite differences in structure and spatial distribution of microtubule organizing centers. ...
Yeast Genes Required for Transport from the Endoplasmic
... suppress other mutants blocked in transport (see below), a 5.8-kb insert (Fig. 2A) was used which extended beyond this fully suppressing region by 2.2 kb to the left and 1.4 kb to the right. It therefore seemed unlikely that this 5.8-kb fragment contained a truncation of the BOSI gene. Recently, DNA ...
... suppress other mutants blocked in transport (see below), a 5.8-kb insert (Fig. 2A) was used which extended beyond this fully suppressing region by 2.2 kb to the left and 1.4 kb to the right. It therefore seemed unlikely that this 5.8-kb fragment contained a truncation of the BOSI gene. Recently, DNA ...
PDF
... sodium currents either by an inhibitor of voltage-gated sodium channels or by antisense-mediated knockdown of an subunit of voltage-gated sodium channels (Nav1.6a) also decreases the RB cell death (Svoboda et al., 2001; Pineda et al., 2006), thereby suggesting that neurotrophic inputs, kinase regu ...
... sodium currents either by an inhibitor of voltage-gated sodium channels or by antisense-mediated knockdown of an subunit of voltage-gated sodium channels (Nav1.6a) also decreases the RB cell death (Svoboda et al., 2001; Pineda et al., 2006), thereby suggesting that neurotrophic inputs, kinase regu ...
Archives of Microbiology
... f r o m p r o l o n g e d nutrient deprivation. S o m e o f the bacterial r e s p o n s e s to e n v i r o n m e n t a l stimuli i n c l u d e the p r o d u c tion of: (1) c a r b o n - s t a r v a t i o n proteins (Cst), w h i c h are m a i n l y i n v o l v e d in the u p t a k e and utilization o ...
... f r o m p r o l o n g e d nutrient deprivation. S o m e o f the bacterial r e s p o n s e s to e n v i r o n m e n t a l stimuli i n c l u d e the p r o d u c tion of: (1) c a r b o n - s t a r v a t i o n proteins (Cst), w h i c h are m a i n l y i n v o l v e d in the u p t a k e and utilization o ...
Asymmetric Cell Divisions: Zygotes of Fucoid Algae as a
... embryos represent examples of asymmetric divisions in which intrinsic factors control daughter cell fates (Betschinger and Knoblich 2004; Cowan and Hyman 2004). 2. In some cases, the cytokinetic plane is positioned such that the daughter cells are placed in different locations within the developing ...
... embryos represent examples of asymmetric divisions in which intrinsic factors control daughter cell fates (Betschinger and Knoblich 2004; Cowan and Hyman 2004). 2. In some cases, the cytokinetic plane is positioned such that the daughter cells are placed in different locations within the developing ...
... biomass (dry weight), limiting substrate and the production of secondary metabolite (anthocyanin); but its main limitation is to assume that the degradation of anthocyanins is an independent cell growth process. Zhang et al. [3] propose a structured model for strawberry cell cultures (Fragaria anana ...
Androgens Down-Regulate bcl-2 Protooncogene Expression in ZR
... HE ANDROGEN receptor is expressed in 50 –90% of breast tumors (1–3). Androgens or androgenic compounds, such as testosterone propionate (4 – 6), fluoxymesterone (7–9), and calusterone (10), have been shown to inhibit breast cancer growth in a proportion of women comparable to that achieved with othe ...
... HE ANDROGEN receptor is expressed in 50 –90% of breast tumors (1–3). Androgens or androgenic compounds, such as testosterone propionate (4 – 6), fluoxymesterone (7–9), and calusterone (10), have been shown to inhibit breast cancer growth in a proportion of women comparable to that achieved with othe ...
Transcription Factor Veracity: 1s GBF3 Responsible for ABA
... Florida, Gainesville, Florida 32611 ...
... Florida, Gainesville, Florida 32611 ...
Signal transduction
Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.