Genes and (Common) Pathways Underlying Drug Addiction
... here had not been directly linked to addiction. ‘‘GnRH signaling pathway’’ was reported to activate gene expression and secretion of gonadotropins and regulate stress pathways in the hypothalamo-pituitary gonadal axis and mammalian reproduction [25]. It is reasonable to hypothesize that the pathway ...
... here had not been directly linked to addiction. ‘‘GnRH signaling pathway’’ was reported to activate gene expression and secretion of gonadotropins and regulate stress pathways in the hypothalamo-pituitary gonadal axis and mammalian reproduction [25]. It is reasonable to hypothesize that the pathway ...
Protein Folding at the Exit Tunnel
... partially folded conformations often interconvert faster than the rate-determining steps, hence they do not give rise to distinct kinetic phases. In addition, computer simulations suggest that kinetic intermediates are usually present, yet they may be poorly populated, hence experimentally undetecta ...
... partially folded conformations often interconvert faster than the rate-determining steps, hence they do not give rise to distinct kinetic phases. In addition, computer simulations suggest that kinetic intermediates are usually present, yet they may be poorly populated, hence experimentally undetecta ...
Amyotrophic lateral sclerosis: Protein
... 2-DE and bioinformatics. When used within the framework of proper experimental designs, proteomic technologies can be very powerful at providing clues or answers to many crucial biological questions, including changes in protein expression, PTM, protein-protein interactions and protein activities. T ...
... 2-DE and bioinformatics. When used within the framework of proper experimental designs, proteomic technologies can be very powerful at providing clues or answers to many crucial biological questions, including changes in protein expression, PTM, protein-protein interactions and protein activities. T ...
The proteasomal deubiquitinating enzyme POH1 promotes the
... proteins to sites of DSBs is coordinated by post-translational modifications, in particular by ubiquitin conjugation. The p53 binding protein (53BP1) acts to promote NHEJ in several contexts, inhibits HR, and is part of a mechanism that shields lesions arising in replication stress through mitosis an ...
... proteins to sites of DSBs is coordinated by post-translational modifications, in particular by ubiquitin conjugation. The p53 binding protein (53BP1) acts to promote NHEJ in several contexts, inhibits HR, and is part of a mechanism that shields lesions arising in replication stress through mitosis an ...
Marginally hydrophobic transmembrane helices shaping membrane protein folding
... that the extracytoplasmic leaflet contains most of the phosphatidylcholine, sphingomyelin, and glycosphingolipids, while phosphatidylserine and phosphatidylethanolamine are enriched in the cytoplasmic leaflet (27) . How the asymmetry is established and maintained is not well understood. In addition ...
... that the extracytoplasmic leaflet contains most of the phosphatidylcholine, sphingomyelin, and glycosphingolipids, while phosphatidylserine and phosphatidylethanolamine are enriched in the cytoplasmic leaflet (27) . How the asymmetry is established and maintained is not well understood. In addition ...
Charge asymmetry in the proteins of the outer membrane
... soluble proteins (Rees et al., 1989; Rees and Eisenberg, 2000). The structures of OMBBs, on the other hand, are such that they are more like inside-out soluble proteins. The lipid-facing exterior is highly hydrophobic, but the interior is often accessible to water and is composed of small hydrophili ...
... soluble proteins (Rees et al., 1989; Rees and Eisenberg, 2000). The structures of OMBBs, on the other hand, are such that they are more like inside-out soluble proteins. The lipid-facing exterior is highly hydrophobic, but the interior is often accessible to water and is composed of small hydrophili ...
Regulation of cdk2 Activity in Endothelial Cells That Are Inhibited
... EC proliferation is regulated by soluble growth factors, such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF),1,29 as well insoluble components of the extracellular matrix.30 It has been shown that in vitro stimulation of EC proliferation by both VEGF and bFGF ...
... EC proliferation is regulated by soluble growth factors, such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF),1,29 as well insoluble components of the extracellular matrix.30 It has been shown that in vitro stimulation of EC proliferation by both VEGF and bFGF ...
Chapter 1
... RBC cytoskeleton through the tethering sites of integral proteins located in the lipid bilayer. ► The lipid bilayer plus the integral proteins chemically isolate and regulate the cell interior. ► Cytoskeleton provides rigid support and stability to lipid bilayer. Is also responsible for deformabilit ...
... RBC cytoskeleton through the tethering sites of integral proteins located in the lipid bilayer. ► The lipid bilayer plus the integral proteins chemically isolate and regulate the cell interior. ► Cytoskeleton provides rigid support and stability to lipid bilayer. Is also responsible for deformabilit ...
Template for Electronic Submission to ACS Journals - Lirias
... We determined the pcDronpa crystal structure in the fluorescent green-on, non-fluorescent green-off and red state (PDB ID = 4HQ8, 4HQ9 and 4HQC). The structures were determined to a resolution of 1.95, 2.07 and 2.05 Å, respectively (Supporting Table 1). The overall structure and quaternary organizat ...
... We determined the pcDronpa crystal structure in the fluorescent green-on, non-fluorescent green-off and red state (PDB ID = 4HQ8, 4HQ9 and 4HQC). The structures were determined to a resolution of 1.95, 2.07 and 2.05 Å, respectively (Supporting Table 1). The overall structure and quaternary organizat ...
Oxidized Amino Acids in Lens Protein with Age
... for quantitation of DT andde-DT, respectively. Essentially identical MCO of the model proteins RNase and lysozyme (9). Howresults were obtained using the m/z = 805 and 811 ions, for DT and ever, this assay proved to be of limited value for analysis of ds-DT, respectively, which were measured simulta ...
... for quantitation of DT andde-DT, respectively. Essentially identical MCO of the model proteins RNase and lysozyme (9). Howresults were obtained using the m/z = 805 and 811 ions, for DT and ever, this assay proved to be of limited value for analysis of ds-DT, respectively, which were measured simulta ...
MicroRNA Regulation of CNS Myelination
... MicroRNAs (miRNAs) are a class of small (~22 nt) noncoding RNAs that are capable of posttranscriptionally silencing mRNAs that contain sequences complementary to the miRNAs’ 7–8 bp “seed” sequence (Bartel, 2004; Wu and Belasco, 2008). Because single miRNAs are predicted to often target up to hundred ...
... MicroRNAs (miRNAs) are a class of small (~22 nt) noncoding RNAs that are capable of posttranscriptionally silencing mRNAs that contain sequences complementary to the miRNAs’ 7–8 bp “seed” sequence (Bartel, 2004; Wu and Belasco, 2008). Because single miRNAs are predicted to often target up to hundred ...
Two-step and one-step secretion mechanisms in Gram
... CU fimbriae are typically encoded in individual gene clusters, where all subunits in addition to the chaperone and usher are encoded. The number of subunits varies from system to system. For instance, the Type 1 pili cluster codes for four known subunits (Fim A, F, G and H), whereas the P pili clust ...
... CU fimbriae are typically encoded in individual gene clusters, where all subunits in addition to the chaperone and usher are encoded. The number of subunits varies from system to system. For instance, the Type 1 pili cluster codes for four known subunits (Fim A, F, G and H), whereas the P pili clust ...
Examination of the role of signal transduction and oxidative stress in
... pathogenicity. It is therefore important to study any possible molecular mechanisms that allow any risk prediction for established or novel fibrous materials. A number of researchers have looked at the mechanistic aspects of fibre toxicity, but as yet, no clear consensus has emerged. One of the key ...
... pathogenicity. It is therefore important to study any possible molecular mechanisms that allow any risk prediction for established or novel fibrous materials. A number of researchers have looked at the mechanistic aspects of fibre toxicity, but as yet, no clear consensus has emerged. One of the key ...
1. The BCL-2 Family Reunion.
... homologs do not appear to control cell death, and their functions remain obscure (reviewed in Mollereau, 2009). For these reasons, our discussion focuses on vertebrate BCL-2 family function. A Family Portrait BCL-2 and its relatives are functionally classified as either antiapoptotic or proapoptotic ...
... homologs do not appear to control cell death, and their functions remain obscure (reviewed in Mollereau, 2009). For these reasons, our discussion focuses on vertebrate BCL-2 family function. A Family Portrait BCL-2 and its relatives are functionally classified as either antiapoptotic or proapoptotic ...
ABSTRACT Title of dissertation: MOLECULAR MECHANISMS OF NEURONAL
... Neuronal development relies on the coordination of various biological mechanisms, including the trafficking and function of neurotransmitter receptors and synaptic cell adhesion molecules (CAMs). In this dissertation, I investigated various distinct, yet related, mechanisms of neuronal development: ...
... Neuronal development relies on the coordination of various biological mechanisms, including the trafficking and function of neurotransmitter receptors and synaptic cell adhesion molecules (CAMs). In this dissertation, I investigated various distinct, yet related, mechanisms of neuronal development: ...
Paper 2
... tem. In GTP␥S-treated tip cells, tubular vacuoles were sometimes the only form seen. When the drug was washed out and hyphae left in GTP␥S-free solution for 45 min before rescoring, tip cells recovered the typical range of control morphologies (Fig. 9). GTP␥S also promoted tubule frequency in the se ...
... tem. In GTP␥S-treated tip cells, tubular vacuoles were sometimes the only form seen. When the drug was washed out and hyphae left in GTP␥S-free solution for 45 min before rescoring, tip cells recovered the typical range of control morphologies (Fig. 9). GTP␥S also promoted tubule frequency in the se ...
Signal Peptidases
... co-workers discovered that the light chain of IgG from myeloma cells was synthesized in a higher molecular weight form and was converted to its mature form when endoplasmic reticulum vesicles (microsomes) were added to the translation system.2 Milstein proposed a model based on these results in whic ...
... co-workers discovered that the light chain of IgG from myeloma cells was synthesized in a higher molecular weight form and was converted to its mature form when endoplasmic reticulum vesicles (microsomes) were added to the translation system.2 Milstein proposed a model based on these results in whic ...
Reversal of Physiological Stress
... Downloaded from molpharm.aspetjournals.org at ASPET Journals on August 1, 2017 ...
... Downloaded from molpharm.aspetjournals.org at ASPET Journals on August 1, 2017 ...
Ways of Ion Channel Gating in Plant Cells
... coupled via membrane electrical activities (White et al., 1999). Not only do they in¯uence membrane voltage through the ionic currents they mediate, but their activities can also be regulated by membrane voltage. Ion channels can be divided into four `historically-based' groups according to gating m ...
... coupled via membrane electrical activities (White et al., 1999). Not only do they in¯uence membrane voltage through the ionic currents they mediate, but their activities can also be regulated by membrane voltage. Ion channels can be divided into four `historically-based' groups according to gating m ...
Articulins and epiplasmins - Journal of Cell Science
... organization of the membrane skeleton in protists. Articulins and epiplasmins represent two distinct classes of cytoskeletal proteins, since different polypeptides were labeled by articulin core domain-specific or epiplasmin epitope-specific antibodies in each organism studied. In one case, a polype ...
... organization of the membrane skeleton in protists. Articulins and epiplasmins represent two distinct classes of cytoskeletal proteins, since different polypeptides were labeled by articulin core domain-specific or epiplasmin epitope-specific antibodies in each organism studied. In one case, a polype ...
Words - ctahr
... Addition of Ca to deficient cells does not restore normal morphology, indicating its role is played during cell wall formation. The structural role of Ca could be in the binding of otherwise free-COOH groups of the peptidoglycan layer (8), or by lending stability to the lipoprotein (14). Bergersen ( ...
... Addition of Ca to deficient cells does not restore normal morphology, indicating its role is played during cell wall formation. The structural role of Ca could be in the binding of otherwise free-COOH groups of the peptidoglycan layer (8), or by lending stability to the lipoprotein (14). Bergersen ( ...
to the complete text
... demonstrated that localized yielding of the surface of animal cells results in a pressure decrease in the subtending cytoplasm and that non-equilibrium pressures can persist for 10 s or so over a distance of 10 mm. These observations are important because they question the long-held assumption that ...
... demonstrated that localized yielding of the surface of animal cells results in a pressure decrease in the subtending cytoplasm and that non-equilibrium pressures can persist for 10 s or so over a distance of 10 mm. These observations are important because they question the long-held assumption that ...
BAOJ Neurology
... receptor play a crucial role in the development of depression and anxiety-like behavior in adulthood. Our lab has been long involved in the study of Serotonin and its signaling through the 5-HT1A- receptor during early hippocampal development. We have been trying to nail down the signaling cascade, ...
... receptor play a crucial role in the development of depression and anxiety-like behavior in adulthood. Our lab has been long involved in the study of Serotonin and its signaling through the 5-HT1A- receptor during early hippocampal development. We have been trying to nail down the signaling cascade, ...
review i article
... However, new observations indicate that several bacterial plasmids carry genes capable of killing their host in a seemingly spiteful manner. In addition, recent experiments have identified plasmid genes that are conditionally lethal in a host-specific manner. What all these systems have in common is ...
... However, new observations indicate that several bacterial plasmids carry genes capable of killing their host in a seemingly spiteful manner. In addition, recent experiments have identified plasmid genes that are conditionally lethal in a host-specific manner. What all these systems have in common is ...
Somatic cancer mutations in the MLL1 histone methyltransferase
... the MLL1 SET domain with the WRA proteins reorients its SET-I region, leading to a closed conformation which is active. While this effect is mainly due to the interaction of the RA heterodimer with MLL1, it has been found that MLL1 requires all the three complex partners (WDR5, ASH2L, RBBP5) to exhi ...
... the MLL1 SET domain with the WRA proteins reorients its SET-I region, leading to a closed conformation which is active. While this effect is mainly due to the interaction of the RA heterodimer with MLL1, it has been found that MLL1 requires all the three complex partners (WDR5, ASH2L, RBBP5) to exhi ...
Signal transduction
Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.