Direct detection of ligand–protein interaction using AFM
... The monograph presents the use of atomic force microscopy (AFM) as a tool for the identification of cancerous cells by studies of the expression of different types of molecules directly on the surface of living cells. The full quantitative description (that is not accessible by other techniques) per ...
... The monograph presents the use of atomic force microscopy (AFM) as a tool for the identification of cancerous cells by studies of the expression of different types of molecules directly on the surface of living cells. The full quantitative description (that is not accessible by other techniques) per ...
Retinoic Acid and the Development of the Endoderm
... boundaries of early endoderm, as shown by changes to pancreatic differentiation [9,10,77], it is not clear as to what the RA is affecting at these early stages. Studies of RA signaling in endoderm development has largely concentrated on its role in the differentiation and growth of particular endode ...
... boundaries of early endoderm, as shown by changes to pancreatic differentiation [9,10,77], it is not clear as to what the RA is affecting at these early stages. Studies of RA signaling in endoderm development has largely concentrated on its role in the differentiation and growth of particular endode ...
Anti-bacteria and In Vivo Tumor Treatment by Reactive Oxygen
... were cultured in DMEM supplemented with 10% FBS at 37 °C in a humified atmosphere containing 5% CO2. And then the cells were seeded in 96-well plates at a density of 1×105 cells per well at different pH values (pH = 5.5, 6.8 and 7.4). After 15 h adhesion, the 6-nm MNPs was added into the medium and ...
... were cultured in DMEM supplemented with 10% FBS at 37 °C in a humified atmosphere containing 5% CO2. And then the cells were seeded in 96-well plates at a density of 1×105 cells per well at different pH values (pH = 5.5, 6.8 and 7.4). After 15 h adhesion, the 6-nm MNPs was added into the medium and ...
Human Fatty Acid Transport Protein 2a/Very Long Chain Acyl
... tissues is non-random and is distinct and characteristic of a specific cell type or an intracellular compartment. How these distinct patterns are generated and maintained is poorly understood, but it is reasonable to expect that the source of the fatty acid, either from endogenous or exogenous sourc ...
... tissues is non-random and is distinct and characteristic of a specific cell type or an intracellular compartment. How these distinct patterns are generated and maintained is poorly understood, but it is reasonable to expect that the source of the fatty acid, either from endogenous or exogenous sourc ...
Suppressor analysis of the protein kinase Elm1p, an enzyme
... bud-site selection appear to be independent of one another, since specific mutations exist that interfere with one but not the other pathway. It is postulated that in axial budding, a labile marker is present at the previous site of budding, and thus nutrioit conditions that delay bud formation allo ...
... bud-site selection appear to be independent of one another, since specific mutations exist that interfere with one but not the other pathway. It is postulated that in axial budding, a labile marker is present at the previous site of budding, and thus nutrioit conditions that delay bud formation allo ...
Condensin II Promotes the Formation of Chromosome Territories by
... In Drosophila, multiple chromosome organization schemes have been well characterized. The Rabl configuration is observed in many diploid nuclei such as those of the early embryo and the larval central nervous system [19,20]. Polyploid-polytene chromosomes, such as those of the larval salivary gland, ...
... In Drosophila, multiple chromosome organization schemes have been well characterized. The Rabl configuration is observed in many diploid nuclei such as those of the early embryo and the larval central nervous system [19,20]. Polyploid-polytene chromosomes, such as those of the larval salivary gland, ...
Effects of Mandrax and Cannabis on the cellular Abstract
... Methaqualone and 25 mg of antihistamine–diphenhydramine hydrochloride) (Ray, 1978 and van Zyl, 2001) was introduced pharmaceutically as a non-barbiturate, non-addictive sleeping pill (van Zyl, 2001), as a result of it having sedative and hypnotic properties as well as some anticonvulsant and antitus ...
... Methaqualone and 25 mg of antihistamine–diphenhydramine hydrochloride) (Ray, 1978 and van Zyl, 2001) was introduced pharmaceutically as a non-barbiturate, non-addictive sleeping pill (van Zyl, 2001), as a result of it having sedative and hypnotic properties as well as some anticonvulsant and antitus ...
BAFF, APRIL and their receptors: Structure, function - Serval
... subject to rarer intergenic splicing events removing the transmembrane and intracellular domains to yield soluble forms of TACI. However, TACI being a Type III protein, these proteins are not predicted to be secreted (Fig. 2A). In mouse TACI, the initiating methionine and CRD1 are in the same exon. ...
... subject to rarer intergenic splicing events removing the transmembrane and intracellular domains to yield soluble forms of TACI. However, TACI being a Type III protein, these proteins are not predicted to be secreted (Fig. 2A). In mouse TACI, the initiating methionine and CRD1 are in the same exon. ...
manipulation of respiratory burst of neutrophils using c1
... inflammation. (Taken from Janeway et.al., 2005).............................................................. 8 Figure 2-2 NADPH oxidase complex and where it can be found. Taken from Fig. 1 in Dahlgren et al, 1999. ..................................................................................... ...
... inflammation. (Taken from Janeway et.al., 2005).............................................................. 8 Figure 2-2 NADPH oxidase complex and where it can be found. Taken from Fig. 1 in Dahlgren et al, 1999. ..................................................................................... ...
Exploiting the chick embryonic environment to reprogram
... to neural crest migratory cues and integrate into neural crest-derived tissues: some neural, notably the sympathetic ganglia and enteric nervous system, although never the adrenal gland; and others non-neural, such as the meninges and tail. Cells injected at E6 do not show such targeting, integratin ...
... to neural crest migratory cues and integrate into neural crest-derived tissues: some neural, notably the sympathetic ganglia and enteric nervous system, although never the adrenal gland; and others non-neural, such as the meninges and tail. Cells injected at E6 do not show such targeting, integratin ...
Plant immune and growth receptors share common signalling
... hetero-oligomers (Kusumi et al., 2011), e.g. FLS2- or BRI1-SERK3/BAK1 complexes. In plants, the cell wall has additional influence on the PM organisation and dynamics (Martinière et al., 2012). As a consequence, lateral mobility and distribution of lipids and proteins within the PM is highly hetero ...
... hetero-oligomers (Kusumi et al., 2011), e.g. FLS2- or BRI1-SERK3/BAK1 complexes. In plants, the cell wall has additional influence on the PM organisation and dynamics (Martinière et al., 2012). As a consequence, lateral mobility and distribution of lipids and proteins within the PM is highly hetero ...
BRAIN CCR2 Ly-6C monocytes are crucial for the
... (Boring et al., 1997; Kuziel et al., 1997), there have been numerous publications examining the effects of CCR2 deficiency in a variety of murine models of infectious and autoimmune diseases. In fact, a number of studies indicated that CCR2 and its ligand CCL2 may play a role in the pathogenesis of ...
... (Boring et al., 1997; Kuziel et al., 1997), there have been numerous publications examining the effects of CCR2 deficiency in a variety of murine models of infectious and autoimmune diseases. In fact, a number of studies indicated that CCR2 and its ligand CCL2 may play a role in the pathogenesis of ...
Role of the OPG/RANK/RANKL triad in calcifications of - HAL
... and protein kinase C and phosphatidylinositol 3-kinase/Akt activation via syndecan-1. OPGinduced activation of monocyte chemotaxis toward different chemokines is due to the interactions of OPG with heparin and chondroitin sulphates [20]. Similarly, RANKL enhances monocyte migration through its bindi ...
... and protein kinase C and phosphatidylinositol 3-kinase/Akt activation via syndecan-1. OPGinduced activation of monocyte chemotaxis toward different chemokines is due to the interactions of OPG with heparin and chondroitin sulphates [20]. Similarly, RANKL enhances monocyte migration through its bindi ...
6.3. La supervivencia de las motoneuronas espinales de pollo mantenidas
... still unknown. In the present work, we describe the ability of the GDNF family members to promote chicken motoneuron survival in culture. We show the presence of Ret and GFR␣-1, GFR␣-2, and GFR␣-4 in chicken motoneurons using in situ Glial cell line-derived neurotrophic factor (GDN F), neurturin (NT ...
... still unknown. In the present work, we describe the ability of the GDNF family members to promote chicken motoneuron survival in culture. We show the presence of Ret and GFR␣-1, GFR␣-2, and GFR␣-4 in chicken motoneurons using in situ Glial cell line-derived neurotrophic factor (GDN F), neurturin (NT ...
Role of GATA factors in development, differentiation, and
... possessing three germ layers are linked to the evolution of axis formation and bilateral symmetry. In contrast to diploblastic animals, triploblastic bilaterians (with the exception of a few highly reduced forms) have complete digestive tracts with separate mouth and anus. The through-gut system ena ...
... possessing three germ layers are linked to the evolution of axis formation and bilateral symmetry. In contrast to diploblastic animals, triploblastic bilaterians (with the exception of a few highly reduced forms) have complete digestive tracts with separate mouth and anus. The through-gut system ena ...
Emtriva - Gilead Sciences, Inc.
... Significantly increased drug exposures were seen when EMTRIVA was administered to subjects with renal impairment [See Clinical Pharmacology (12.3)]. Therefore, the dosing interval or dose of EMTRIVA should be adjusted in patients with baseline creatinine clearance less than 50 mL per min using the f ...
... Significantly increased drug exposures were seen when EMTRIVA was administered to subjects with renal impairment [See Clinical Pharmacology (12.3)]. Therefore, the dosing interval or dose of EMTRIVA should be adjusted in patients with baseline creatinine clearance less than 50 mL per min using the f ...
Relationship of Net Chloride Flow across the Human Erythrocyte
... modification of Dalmark's method (1975b). The first portion (A) was washed in 75 mM KCI, 120 mM sucrose, and 5 mM HEPES, and then resuspended in the same solution (ice cold) at 10% hematocrit with 75 jig/ml nystatin (E. R. Squibb & Sons, Inc., Princeton, NJ) (added as a 5-mg/ml solution in methanol) ...
... modification of Dalmark's method (1975b). The first portion (A) was washed in 75 mM KCI, 120 mM sucrose, and 5 mM HEPES, and then resuspended in the same solution (ice cold) at 10% hematocrit with 75 jig/ml nystatin (E. R. Squibb & Sons, Inc., Princeton, NJ) (added as a 5-mg/ml solution in methanol) ...
PDF
... major Ig isotype found in the skin mucosa although IgM is also present but in low quantities. In general, fish antibodies are protective against invading pathogens on mucosal surfaces as shown by Wang et al. (85, 86) and Dickerson and Clark (87) that naive fish exposed to sub-lethal infection of I. ...
... major Ig isotype found in the skin mucosa although IgM is also present but in low quantities. In general, fish antibodies are protective against invading pathogens on mucosal surfaces as shown by Wang et al. (85, 86) and Dickerson and Clark (87) that naive fish exposed to sub-lethal infection of I. ...
LRRK2 and neuroinflammation: partners in crime
... SNpc of experimental animal models and of post-mortem brains from patients with PD [48-50]. Moreover, the presence of extensive proliferation of reactive and phagocytic macrophages positive for human leukocyte antigen (HLA) has been shown around dopaminergic neurons in the SNpc of patients with PD [ ...
... SNpc of experimental animal models and of post-mortem brains from patients with PD [48-50]. Moreover, the presence of extensive proliferation of reactive and phagocytic macrophages positive for human leukocyte antigen (HLA) has been shown around dopaminergic neurons in the SNpc of patients with PD [ ...
Extracellular ATP Functions as an
... ATP is a vital molecule used by living organisms as a universal source of energy required to drive the cogwheels of intracellular biochemical reactions necessary for growth and development. Animal cells release ATP to the extracellular milieu, where it functions as the primary signaling cue at the e ...
... ATP is a vital molecule used by living organisms as a universal source of energy required to drive the cogwheels of intracellular biochemical reactions necessary for growth and development. Animal cells release ATP to the extracellular milieu, where it functions as the primary signaling cue at the e ...
The maize mutant narrow sheath fails to establish
... of the division indices, given as the fraction of cells that have undergone recent cell division, for [P2] and [P3] leaf primordial cells were performed as described by Sylvester et al. (1990). Preparation of KNOX antibody Polyclonal antisera that recognize KNOX (Kerstetter et al., 1994) proteins we ...
... of the division indices, given as the fraction of cells that have undergone recent cell division, for [P2] and [P3] leaf primordial cells were performed as described by Sylvester et al. (1990). Preparation of KNOX antibody Polyclonal antisera that recognize KNOX (Kerstetter et al., 1994) proteins we ...
Plasma membrane HATPase regulation is required for auxin
... need to be transported in or out of a cell with a larger volume than a cell with a smaller volume. In addition, for the nearly cylindrical cells found in etiolated hypocotyls, the ratio of cell surface to cell volume decreases with increasing diameter. Considering that the cell surface is the interf ...
... need to be transported in or out of a cell with a larger volume than a cell with a smaller volume. In addition, for the nearly cylindrical cells found in etiolated hypocotyls, the ratio of cell surface to cell volume decreases with increasing diameter. Considering that the cell surface is the interf ...
Serine/Threonine Kinase 3-Phosphoinositide
... To execute persistent migration, cells establish leading and trailing edges in which different signaling pathways stimulate membrane protrusion and retraction, respectively. In most cases, cell orientation is determined by external gradients of soluble and/or adhesive factors. Even in the absence of ...
... To execute persistent migration, cells establish leading and trailing edges in which different signaling pathways stimulate membrane protrusion and retraction, respectively. In most cases, cell orientation is determined by external gradients of soluble and/or adhesive factors. Even in the absence of ...
Microfluidic devices for drug discovery and analysis
... controlled by external physical forces such as magnetic and electric fields. These microdevices may either be integrated into existing macrodevices, or constitute comprehensive analytical systems by themselves. The miniaturization provided by these high-throughput devices allows for a large number o ...
... controlled by external physical forces such as magnetic and electric fields. These microdevices may either be integrated into existing macrodevices, or constitute comprehensive analytical systems by themselves. The miniaturization provided by these high-throughput devices allows for a large number o ...
Cell encapsulation
Cell microencapsulation technology involves immobilization of the cells within a polymeric semi-permeable membrane that permits the bidirectional diffusion of molecules such as the influx of oxygen, nutrients, growth factors etc. essential for cell metabolism and the outward diffusion of waste products and therapeutic proteins. At the same time, the semi-permeable nature of the membrane prevents immune cells and antibodies from destroying the encapsulated cells regarding them as foreign invaders.The main motive of cell encapsulation technology is to overcome the existing problem of graft rejection in tissue engineering applications and thus reduce the need for long-term use of immunosuppressive drugs after an organ transplant to control side effects.