Cytotoxic effect of lomefloxacin in culture of human epidermal
... normal human fibroblasts, keratinocytes and Caucasian melanocytes, confirmed the ability of lomefloxacin to induce DNA damage such as strand breaks and pyrimidine dimers. The activation of the p53 pathway was also demonstrated. Another study has shown that fluoroquinolones, including lomefloxacin, a ...
... normal human fibroblasts, keratinocytes and Caucasian melanocytes, confirmed the ability of lomefloxacin to induce DNA damage such as strand breaks and pyrimidine dimers. The activation of the p53 pathway was also demonstrated. Another study has shown that fluoroquinolones, including lomefloxacin, a ...
ERK Nuclear Translocation Is Dimerization
... The precise mechanism of ERK transport across the nuclear pore is not fully understood. ERK lacks a nuclear localization sequence, leading to the suggestion that ERK may enter by a piggyback mechanism via binding to nuclear localization sequence-containing proteins (5). Nuclear localization sequence ...
... The precise mechanism of ERK transport across the nuclear pore is not fully understood. ERK lacks a nuclear localization sequence, leading to the suggestion that ERK may enter by a piggyback mechanism via binding to nuclear localization sequence-containing proteins (5). Nuclear localization sequence ...
Mechanisms of liver allograft rejection in man
... causing liver damage during episodes of rejection. Not all infiltrating lymphocytes respond to HLA antigens [48, 491 and the function of these remaining T-cells and of the other cell types is uncertain, as are the mechanisms causing their recruitment to the graft. Cellular recruitment to the graft. ...
... causing liver damage during episodes of rejection. Not all infiltrating lymphocytes respond to HLA antigens [48, 491 and the function of these remaining T-cells and of the other cell types is uncertain, as are the mechanisms causing their recruitment to the graft. Cellular recruitment to the graft. ...
Coupling of thraustochytrids and POM, and of bacterio
... Although the riverine influence is rather small and locally limited compared with other major estuaries receiving greater river discharges (e.g., Biggs & Howell 1984), the high abundance of thraustochytrids was connected to river discharge (Naganuma et al. 1998, Kimura & Naganuma 2001). In this stud ...
... Although the riverine influence is rather small and locally limited compared with other major estuaries receiving greater river discharges (e.g., Biggs & Howell 1984), the high abundance of thraustochytrids was connected to river discharge (Naganuma et al. 1998, Kimura & Naganuma 2001). In this stud ...
Monolignol glucosides as intermediate compounds in
... synthesis of coniferin and a slow turnover of this compound (Marcinowski and Grisebach 1977). The concentration of coniferin in differentiating xylem of Japanese black pine (Pinus thunbergii Parl.) is highest at the beginning of May, before the most active lignifying season, June and July, and there ...
... synthesis of coniferin and a slow turnover of this compound (Marcinowski and Grisebach 1977). The concentration of coniferin in differentiating xylem of Japanese black pine (Pinus thunbergii Parl.) is highest at the beginning of May, before the most active lignifying season, June and July, and there ...
Encapsulation Services
... Liposomal formulations Since the first liposomal pharmaceutical product, Doxil, was approved in 1995 there are now several successful liposomal formulations. Most of them have to be administrated intravenously due to the degradation of lipids in the gastrointestinal tract. However, some recent f ...
... Liposomal formulations Since the first liposomal pharmaceutical product, Doxil, was approved in 1995 there are now several successful liposomal formulations. Most of them have to be administrated intravenously due to the degradation of lipids in the gastrointestinal tract. However, some recent f ...
Dubrulle and Pourquie, 2004 - Development
... Each cell contributing to the paraxial mesoderm undergoes a series of stereotypical events, from its specification in the caudal part of the embryo to its incorporation into a somite (Fig. 1A). The first step in paraxial mesoderm formation is a change in the cellular adhesion properties. Cells conta ...
... Each cell contributing to the paraxial mesoderm undergoes a series of stereotypical events, from its specification in the caudal part of the embryo to its incorporation into a somite (Fig. 1A). The first step in paraxial mesoderm formation is a change in the cellular adhesion properties. Cells conta ...
New insights into root gravitropic signalling
... (Boonsirichai et al., 2003). Much research and speculations have focused on how a physical signal (statolith sedimentation) can be translated into a moving physiological signal. It has been proposed that an interaction between the sedimenting amyloplasts and proteins belonging to the endoplasmic ret ...
... (Boonsirichai et al., 2003). Much research and speculations have focused on how a physical signal (statolith sedimentation) can be translated into a moving physiological signal. It has been proposed that an interaction between the sedimenting amyloplasts and proteins belonging to the endoplasmic ret ...
Germ Cell Speci fi cation - Molecular Biology and Genetics
... cytoplasm inherited from the oocyte (Seydoux and Braun 2006). In this section, we describe evidence for each of these mechanisms acting in C. elegans. ...
... cytoplasm inherited from the oocyte (Seydoux and Braun 2006). In this section, we describe evidence for each of these mechanisms acting in C. elegans. ...
Gram-positive bacteria enhance HIV-1 susceptibility
... PRRs in STD and BV immune responses, and among the specific PRRs, TLR2 signaling is considered as a critical stimulus for enhanced HIV acquisition during STD and BV infections, because it has been shown to promote HIV replication in various immune cells.27-31 Thus, we hypothesized that when STDs or ...
... PRRs in STD and BV immune responses, and among the specific PRRs, TLR2 signaling is considered as a critical stimulus for enhanced HIV acquisition during STD and BV infections, because it has been shown to promote HIV replication in various immune cells.27-31 Thus, we hypothesized that when STDs or ...
Barbiturates Directly Inhibit the Calmodulin/Calcineurin Complex: a
... Barbiturates Inhibit Nuclear Factor of Activated T Cells in Human T Lymphocytes. Inactivation of the transcription factor NFAT is associated with severe immunodeficiency syndromes and results in increased susceptibility to infections (Feske et al., 2000). To study the effect of barbiturates on the a ...
... Barbiturates Inhibit Nuclear Factor of Activated T Cells in Human T Lymphocytes. Inactivation of the transcription factor NFAT is associated with severe immunodeficiency syndromes and results in increased susceptibility to infections (Feske et al., 2000). To study the effect of barbiturates on the a ...
The Rhopalosiphum padi virus 59 internal ribosome entry site is
... picornavirus proteins. It has been shown that the 59 UTRs and the intergenic regions (IGRs) of these virus genomes contain IRES elements (Sasaki & Nakashima, 1999; Domier et al., 2000; Wilson et al., 2000a; Woolaway et al., 2001). The IGR IRES elements are unusual in that they direct translation ini ...
... picornavirus proteins. It has been shown that the 59 UTRs and the intergenic regions (IGRs) of these virus genomes contain IRES elements (Sasaki & Nakashima, 1999; Domier et al., 2000; Wilson et al., 2000a; Woolaway et al., 2001). The IGR IRES elements are unusual in that they direct translation ini ...
Nociceptor and Hair Cell Transducer Properties of TRPA1, a
... nociceptive sensory processes that innervate the bladder epithelium (l ). m, The same antibodies detect an expected band of ⬃128 kDa in Western blots from peripheral nerve lysate. ...
... nociceptive sensory processes that innervate the bladder epithelium (l ). m, The same antibodies detect an expected band of ⬃128 kDa in Western blots from peripheral nerve lysate. ...
GPCR endocytosis confers uniformity in responses to chemically
... collected by centrifugation at 4°C. Each drug condition had a total of two biological replicates. One biological replicate was carried out per medium type as follows: 1. drug-treated cells were grown in “Heavy” medium and untreated cells were grown in “Light” medium, and 2. drugtreated cells were gr ...
... collected by centrifugation at 4°C. Each drug condition had a total of two biological replicates. One biological replicate was carried out per medium type as follows: 1. drug-treated cells were grown in “Heavy” medium and untreated cells were grown in “Light” medium, and 2. drugtreated cells were gr ...
The transplantation of nuclei from single cultured cells into
... chromosome losses take place during the early mitotic divisions of transplanted cultured-cell nuclei, the first-transfer blastulae which provide nuclei for serial transfers could contain, or sometimes consist of, cells with incomplete chromosome sets. In this case, the developmental variation within ...
... chromosome losses take place during the early mitotic divisions of transplanted cultured-cell nuclei, the first-transfer blastulae which provide nuclei for serial transfers could contain, or sometimes consist of, cells with incomplete chromosome sets. In this case, the developmental variation within ...
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... chromosome losses take place during the early mitotic divisions of transplanted cultured-cell nuclei, the first-transfer blastulae which provide nuclei for serial transfers could contain, or sometimes consist of, cells with incomplete chromosome sets. In this case, the developmental variation within ...
... chromosome losses take place during the early mitotic divisions of transplanted cultured-cell nuclei, the first-transfer blastulae which provide nuclei for serial transfers could contain, or sometimes consist of, cells with incomplete chromosome sets. In this case, the developmental variation within ...
fist: an Arabidopsis mutant with altered cell division planes and
... Introduction Control of cell division orientation is thought to be a critical aspect of morphogenesis in plants. Plant cells are glued together by the middle lamella and, thus, are not able to move relative to one another during development. As a consequence, organ and body shape are generated by ot ...
... Introduction Control of cell division orientation is thought to be a critical aspect of morphogenesis in plants. Plant cells are glued together by the middle lamella and, thus, are not able to move relative to one another during development. As a consequence, organ and body shape are generated by ot ...
Numerical simulation of morphogenetic movements in
... generated within the cells that properly react and respond so that the global architecture changes, but the embryo can progressively perform more specialised functions. The strong connection between mechanics and genetics has been studied for a long time, showing how genes control and influence the ...
... generated within the cells that properly react and respond so that the global architecture changes, but the embryo can progressively perform more specialised functions. The strong connection between mechanics and genetics has been studied for a long time, showing how genes control and influence the ...
MICROSCOPIC AND FUNCTIONAL STUDIES ON
... microscopy (TEM) was used to image extracellular vesicles from different sources. Because of their small size, 30-500 nm, examination of extracellular vesicles requires high resolution from research equipment. The results obtained in this study show that transmission electron microscopy and confocal ...
... microscopy (TEM) was used to image extracellular vesicles from different sources. Because of their small size, 30-500 nm, examination of extracellular vesicles requires high resolution from research equipment. The results obtained in this study show that transmission electron microscopy and confocal ...
physiology of ion transport across the tonoplast of higher plants
... The enzyme resembles the F0F1-ATPases (F-ATPases) of mitochondria, chloroplasts, and eubacteria in their multimeric structure, lack of a phosphorylated intermediate, and insensitivity to vanadate (84). An evolutionary relationship between F-type and V-type ATPases is indicated by sequence homologies ...
... The enzyme resembles the F0F1-ATPases (F-ATPases) of mitochondria, chloroplasts, and eubacteria in their multimeric structure, lack of a phosphorylated intermediate, and insensitivity to vanadate (84). An evolutionary relationship between F-type and V-type ATPases is indicated by sequence homologies ...
chinese hamster cells can be reversibly blocked before mitosis with
... sample times 50 jA of balanced saline solution containing 40/iCi/ml [3H]leucine (New England Nuclear, sp. act. 5-0 Ci/mmol) was added to the respective vials, resulting in a final concentration of 1 lid/ ml. After 15 min, the medium was poured from each vial and 5 ml of cold 5 % trichloroacetic acid ...
... sample times 50 jA of balanced saline solution containing 40/iCi/ml [3H]leucine (New England Nuclear, sp. act. 5-0 Ci/mmol) was added to the respective vials, resulting in a final concentration of 1 lid/ ml. After 15 min, the medium was poured from each vial and 5 ml of cold 5 % trichloroacetic acid ...
Levels of Ycg1 Limit Condensin Function during the Cell Cycle
... Emerging evidence suggests that proteasomal degradation of an individual subunit may be one mechanism that limits condensin activity. In Drosophila melanogaster, the Cap-H2 subunit of condensin II is targeted for ubiquitin-mediated degradation, and blocking this degradation results in partial chromo ...
... Emerging evidence suggests that proteasomal degradation of an individual subunit may be one mechanism that limits condensin activity. In Drosophila melanogaster, the Cap-H2 subunit of condensin II is targeted for ubiquitin-mediated degradation, and blocking this degradation results in partial chromo ...
Regulation of KNOLLE syntaxin - Journal of Cell Science
... Likewise, the Caenorhabditis syn-4 gene is involved in embryo cleavage divisions but also plays a role in nuclear membrane reformation (Jantsch-Plunger and Glotzer, 1999). In contrast to the other two syntaxins, KNOLLE is required only for de novo formation of the partitioning plasma membrane during ...
... Likewise, the Caenorhabditis syn-4 gene is involved in embryo cleavage divisions but also plays a role in nuclear membrane reformation (Jantsch-Plunger and Glotzer, 1999). In contrast to the other two syntaxins, KNOLLE is required only for de novo formation of the partitioning plasma membrane during ...
Membrane Potential and Electrostatics of Phospholipid Bilayers with
... Simulations of asymmetric lipid membranes were set up and performed in three steps: (i) First, single-component symmetric bilayers composed of 128 POPC, POPE, and POPS lipids and around 5000 water molecules were simulated for a period of 100 ns. On the basis of these simulations, the information reg ...
... Simulations of asymmetric lipid membranes were set up and performed in three steps: (i) First, single-component symmetric bilayers composed of 128 POPC, POPE, and POPS lipids and around 5000 water molecules were simulated for a period of 100 ns. On the basis of these simulations, the information reg ...
Cell encapsulation
Cell microencapsulation technology involves immobilization of the cells within a polymeric semi-permeable membrane that permits the bidirectional diffusion of molecules such as the influx of oxygen, nutrients, growth factors etc. essential for cell metabolism and the outward diffusion of waste products and therapeutic proteins. At the same time, the semi-permeable nature of the membrane prevents immune cells and antibodies from destroying the encapsulated cells regarding them as foreign invaders.The main motive of cell encapsulation technology is to overcome the existing problem of graft rejection in tissue engineering applications and thus reduce the need for long-term use of immunosuppressive drugs after an organ transplant to control side effects.