A GH3-like Domain in Reaper Is Required for Mitochondrial
... knockout mice do not exhibit any overt phenotypes (21). Although this could well indicate some functional redundancy among the IAPs, it may also reflect a requirement for additional events in the activation of caspases and cell death in vertebrate cells. In particular, many apoptotic stimuli in vert ...
... knockout mice do not exhibit any overt phenotypes (21). Although this could well indicate some functional redundancy among the IAPs, it may also reflect a requirement for additional events in the activation of caspases and cell death in vertebrate cells. In particular, many apoptotic stimuli in vert ...
Antibodies produced in vitro in the detection of periodontal bacteria
... Efforts to understand the pathophysiology of various immune-related diseases for developing efficient diagnostic methods have resulted in the production of monoclonal, polyclonal, and recombinant antibodies of different grades of specificity by stimulating the immune system in diverse animal models (B ...
... Efforts to understand the pathophysiology of various immune-related diseases for developing efficient diagnostic methods have resulted in the production of monoclonal, polyclonal, and recombinant antibodies of different grades of specificity by stimulating the immune system in diverse animal models (B ...
Amino acid regulation of mTORC1 Liron Bar-Peled
... characterized as a powerful fungicide inducing a striking G, arrest in Saccharomyces cerevisiae (4). Its antiproliferative properties also extend to ...
... characterized as a powerful fungicide inducing a striking G, arrest in Saccharomyces cerevisiae (4). Its antiproliferative properties also extend to ...
Disassembling bacterial extracellular matrix with
... [9], have been studied to treat bacterial infections due to their potential to encapsulate and deliver therapeutic compounds in a sustained fashion. Among these devices, p olymeric biodegradable nanoparticles (NPs) made up of the biocompatible poly(lactic-co-glycolic acid) (PLGA), have been investig ...
... [9], have been studied to treat bacterial infections due to their potential to encapsulate and deliver therapeutic compounds in a sustained fashion. Among these devices, p olymeric biodegradable nanoparticles (NPs) made up of the biocompatible poly(lactic-co-glycolic acid) (PLGA), have been investig ...
Chapter 4 MEMBRANE TRANSPORT OF OPIOIDS: RELATIVE
... Transport across the BBB can be divided into passive and active transport processes (de Lange & Danhof 2002). Passive transport of compounds across the BBB is dependent on physicochemical properties, such as lipophilicity, degree of ionisation and number of hydrogen bonds (van Bree et al. 1988). Act ...
... Transport across the BBB can be divided into passive and active transport processes (de Lange & Danhof 2002). Passive transport of compounds across the BBB is dependent on physicochemical properties, such as lipophilicity, degree of ionisation and number of hydrogen bonds (van Bree et al. 1988). Act ...
Disruption of morphogenesis and transformation of
... suspensor may consist of a single cell or more than 100 cells, and it may be small or large relative to the embryo proper. Suspensors typically are filamentous, columnar, spherical, or irregular in shape, and the boundary between the suspensor and embryo proper can be distinct or diffuse. Following ...
... suspensor may consist of a single cell or more than 100 cells, and it may be small or large relative to the embryo proper. Suspensors typically are filamentous, columnar, spherical, or irregular in shape, and the boundary between the suspensor and embryo proper can be distinct or diffuse. Following ...
Targets hidden by fibrin networks still need to find their place in the
... The treatment of rheumatoid arthritis has undergone a huge revolution in the past two decades with the incoming of biological therapies, which have been designed out of a better understanding of pathogenic mechanisms. However, while these compounds successfully prevent -or at least slow down- joint ...
... The treatment of rheumatoid arthritis has undergone a huge revolution in the past two decades with the incoming of biological therapies, which have been designed out of a better understanding of pathogenic mechanisms. However, while these compounds successfully prevent -or at least slow down- joint ...
Requirements for CPC localization during anaphase
... regulates proper chromosome segregation in this phase. B) At the start of anaphase, Esp1p regulates partial release of Cdc14p, leading to dephosphorylation of Sli15p. C) At late anaphase the CPC is located at the midbody. If no chromatin is present at the midbody, the CPC will localize Boi1p and Boi ...
... regulates proper chromosome segregation in this phase. B) At the start of anaphase, Esp1p regulates partial release of Cdc14p, leading to dephosphorylation of Sli15p. C) At late anaphase the CPC is located at the midbody. If no chromatin is present at the midbody, the CPC will localize Boi1p and Boi ...
The paroxysm of Plasmodium vivax malaria
... In vivo studies on the paroxysm of P. vivax malaria As was first demonstrated by Golgi in 1889 [1], a malarial paroxysm is preceded by the synchronous rupture of schizont-infected red blood cells. This observation led to the idea that malarial fever is the product of fever-inducing toxins (pyrogens) ...
... In vivo studies on the paroxysm of P. vivax malaria As was first demonstrated by Golgi in 1889 [1], a malarial paroxysm is preceded by the synchronous rupture of schizont-infected red blood cells. This observation led to the idea that malarial fever is the product of fever-inducing toxins (pyrogens) ...
LIINA JAKOBSON The roles of abscisic acid, CO , and the cuticle in
... exchange to the stomata. The cuticle is also essential in other agricultural aspects, such as resistance to pathogens or fruit cracking. Cuticular permeability can be adjusted in response to different environmental factors. The major constituent of the cuticle is the cutin, which accounts for 40%–80 ...
... exchange to the stomata. The cuticle is also essential in other agricultural aspects, such as resistance to pathogens or fruit cracking. Cuticular permeability can be adjusted in response to different environmental factors. The major constituent of the cuticle is the cutin, which accounts for 40%–80 ...
PDF + SI
... The gliotransmitter D-serine is released upon (S)-␣-amino-3-hydroxy5-methyl-4-isoxazolepropionic acid兾kainate and metabotropic glutamate receptor stimulation, but the mechanisms involved are unknown. Here, by using a highly sensitive bioassay to continuously monitor extracellular D-serine levels, we ...
... The gliotransmitter D-serine is released upon (S)-␣-amino-3-hydroxy5-methyl-4-isoxazolepropionic acid兾kainate and metabotropic glutamate receptor stimulation, but the mechanisms involved are unknown. Here, by using a highly sensitive bioassay to continuously monitor extracellular D-serine levels, we ...
Gut microbiota translocation to the pancreatic lymph nodes
... www.jem.org/cgi/doi/10.1084/jem.20150744 ...
... www.jem.org/cgi/doi/10.1084/jem.20150744 ...
R on Dendritic Cells - The Journal of Immunology
... C57BL/6 mice deficient in p53. Jaws II cells have surface markers characteristic of myeloid DC and can be activated to secrete cytokines and present Ag (42). Jaws II cells were purchased from the American Type Culture Collection and grown as recommended in Alpha Minimum Essential Medium (Invitrogen ...
... C57BL/6 mice deficient in p53. Jaws II cells have surface markers characteristic of myeloid DC and can be activated to secrete cytokines and present Ag (42). Jaws II cells were purchased from the American Type Culture Collection and grown as recommended in Alpha Minimum Essential Medium (Invitrogen ...
Keeping the immune system in check: a role for mitophagy
... mitochondria is therefore a critical challenge for the cell. Surveillance systems that monitor mitochondrial status enable the cell to identify and either repair or eliminate dysfunctional mitochondria. Mitophagy is a selective form of autophagy that eliminates dysfunctional mitochondria from the po ...
... mitochondria is therefore a critical challenge for the cell. Surveillance systems that monitor mitochondrial status enable the cell to identify and either repair or eliminate dysfunctional mitochondria. Mitophagy is a selective form of autophagy that eliminates dysfunctional mitochondria from the po ...
Bax cleavage is mediated by calpain during drug-induced
... et al., 1996; Squier and Cohen, 1997). Recent data have illustrated the central role of mitochondria in initiating cell death. Upon induction of apoptosis this organelle undergoes a series of changes that are crucial to the death program. One event, the mitochondrial permeability transition (PT), re ...
... et al., 1996; Squier and Cohen, 1997). Recent data have illustrated the central role of mitochondria in initiating cell death. Upon induction of apoptosis this organelle undergoes a series of changes that are crucial to the death program. One event, the mitochondrial permeability transition (PT), re ...
Endoplasmic reticulum–mitochondria contacts: function of the junction
... endoplasmic reticulum (ER) tubules circumscribe the mitochondrial membrane. b,c | Live confocal fluorescence time-lapse images of Cos‑7 cells (b) and yeast cells (c) showing mitochondrial constriction followed by division taking place at the site of an ER tubule crossing the mitochondria. Arrows ind ...
... endoplasmic reticulum (ER) tubules circumscribe the mitochondrial membrane. b,c | Live confocal fluorescence time-lapse images of Cos‑7 cells (b) and yeast cells (c) showing mitochondrial constriction followed by division taking place at the site of an ER tubule crossing the mitochondria. Arrows ind ...
Factors Associated with Successful Tissue Harvest for Descemet`s
... David C. Shield and Jimmy K. Lee. Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut. Several challenges prohibit Descemet’s Membrane Endothelial Keratoplasty (DMEK) from becoming widely adopted as the next generation of corneal transplant for ...
... David C. Shield and Jimmy K. Lee. Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut. Several challenges prohibit Descemet’s Membrane Endothelial Keratoplasty (DMEK) from becoming widely adopted as the next generation of corneal transplant for ...
Reichenbach_final.pd
... 5 hours.[56] In rodents, the degradation rates of the natural epothilones were found to be as follows: epothilone A, 0.50 n mol/min.mg serum protein; epothilone B, 1.02 nmol/min/mg protein; and epothilone D, 1.20 nmol/min.mg seruim protein (BMS, data on file). The differences in metabolism between s ...
... 5 hours.[56] In rodents, the degradation rates of the natural epothilones were found to be as follows: epothilone A, 0.50 n mol/min.mg serum protein; epothilone B, 1.02 nmol/min/mg protein; and epothilone D, 1.20 nmol/min.mg seruim protein (BMS, data on file). The differences in metabolism between s ...
High-Molecular-Weight Forms of Tyrosinase and the
... The Ronald O. Perelman Department of Dermatology and the Department of Ccll Biolo gy, N cw York University School of Medicine, New York, New York; and "Departmcnt of Dermatology, Yale University School of Medicine, New Haven, Connecticut, U.S.A. ...
... The Ronald O. Perelman Department of Dermatology and the Department of Ccll Biolo gy, N cw York University School of Medicine, New York, New York; and "Departmcnt of Dermatology, Yale University School of Medicine, New Haven, Connecticut, U.S.A. ...
PDF
... We next sought to identify potential molecular links between Baz and F-actin assembly that might explain their reciprocal relationship at epithelial edges. For these experiments, we used DC as our model system. A good candidate for such a link is Pten, as it binds directly to Baz and influences acti ...
... We next sought to identify potential molecular links between Baz and F-actin assembly that might explain their reciprocal relationship at epithelial edges. For these experiments, we used DC as our model system. A good candidate for such a link is Pten, as it binds directly to Baz and influences acti ...
PDF
... Moscona (1970) have recently shown that the existence of the proper organization at the cellular level is required for the hormonal induction of glutamine synthetase in the embryonic neural retina. They have also shown that inducibility is irreversibly lost after cell dissociation, as result of meta ...
... Moscona (1970) have recently shown that the existence of the proper organization at the cellular level is required for the hormonal induction of glutamine synthetase in the embryonic neural retina. They have also shown that inducibility is irreversibly lost after cell dissociation, as result of meta ...
Gain and Loss of Photosynthetic Membranes during
... null nor uniform with respect to thylakoid maturation. We also found that, depending on their position within the SAM, plastids undergo different developmental processes that can lead to either acquisition or loss of thylakoid membranes. These processes are not restricted to the SAM, but continue al ...
... null nor uniform with respect to thylakoid maturation. We also found that, depending on their position within the SAM, plastids undergo different developmental processes that can lead to either acquisition or loss of thylakoid membranes. These processes are not restricted to the SAM, but continue al ...
Microbiology Focus 6.1 - The Role of - Sigma
... intracellular persistence of MRSA also occurs in human infections. This is a subject of intense debate which is also difficult to assess experimentally. In addition to this problem, antibiotic therapy for MRSA infections is becoming more difficult in hospitals because of strong biofilm-forming prope ...
... intracellular persistence of MRSA also occurs in human infections. This is a subject of intense debate which is also difficult to assess experimentally. In addition to this problem, antibiotic therapy for MRSA infections is becoming more difficult in hospitals because of strong biofilm-forming prope ...
Cell encapsulation
Cell microencapsulation technology involves immobilization of the cells within a polymeric semi-permeable membrane that permits the bidirectional diffusion of molecules such as the influx of oxygen, nutrients, growth factors etc. essential for cell metabolism and the outward diffusion of waste products and therapeutic proteins. At the same time, the semi-permeable nature of the membrane prevents immune cells and antibodies from destroying the encapsulated cells regarding them as foreign invaders.The main motive of cell encapsulation technology is to overcome the existing problem of graft rejection in tissue engineering applications and thus reduce the need for long-term use of immunosuppressive drugs after an organ transplant to control side effects.