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Chapter 4 - Neurasync
Chapter 4 - Neurasync

... The process of Chaperone Mediated Autophagy (CMA) is one of the 3 major autophagic pathways used in mammalian cells and organisms. All autophagic pathways involve the degradation of autophagocytosed components within lysosomes, and the reutilization of the produced building blocks; however, CMA is t ...
BMP4 regulation of sensory organ development in the chick inner ear
BMP4 regulation of sensory organ development in the chick inner ear

... surface of the epithelium. Hair cells do not contact the basal lamina, and they are isolated from one another by the supporting cells. At the apical surface of the epithelium, the supporting cell processes form tight and adherens junctions with each other and with the hair cells.(Nayak, et al. 2007) ...
Visualization of APP dimerization and APP-Notch2 fluorescence complementation
Visualization of APP dimerization and APP-Notch2 fluorescence complementation

... interactions using co-expression of APP and N1 or N2 in mammalian cells, and co-immunoprecipitation of APP with Notch antibodies (Oh et al. 2005). To demonstrate that these interactions also occur under physiologic conditions and are not the result of over-expression artifacts, here we confirm the en ...
CHAPTER 2 Literature Review I   Bone Homeostasis
CHAPTER 2 Literature Review I Bone Homeostasis

... University of Pretoria etd – Coetzee, M (2005) receptor and then signals downstream through several signaling cascades, most notably those involving NFκβ, mitogen-activated protein (MAP) kinases, extracellular signal-regulated kinase (Erk), Janus N-terminal kinase (JNK), and p38.62-64 Three distinc ...
GnRH-Gemcitabine  Conjugates  for  the  Treatment ... Independent  Prostate  Cancer:  Pharmacokinetic  Enhancements
GnRH-Gemcitabine Conjugates for the Treatment ... Independent Prostate Cancer: Pharmacokinetic Enhancements

... treating breast cancer bone metastases in mouse models due to the affinity of alendronate to bone tissue.25 Gemcitabine (2', 2’- difluorodeoxycytidine, dFdC), is an established and highly potent cytotoxic drug with a broad spectrum of cancer targets including colon, lung, pancreatic, breast, bladder ...
Proliferation and morphogenesis of the ER driven by the membrane
Proliferation and morphogenesis of the ER driven by the membrane

... motifs that function as a signal to trigger ER proliferation and morphogenesis. ...
Long-Distance Axonal Regeneration in the Transected Adult Rat
Long-Distance Axonal Regeneration in the Transected Adult Rat

... 1991; Bovolenta et al., 1992; Giulian, 1993; Schwab et al., 1993). Although not all adult neurons exhibit the same regenerative potential, most of them regenerate their lesioned axons if the appropriate conditions are provided. Injured axons are able to grow for long distances through pieces of peri ...
PDF version
PDF version

... Fertilization initiates a cascade of events that leads to breaking the symmetry of the oocyte, as evidenced by a local cessation of actomyosin contractility. What is the nature of the symmetry-breaking cue? It is not the sperm entry site nor paternal genetic material (Sadler and Shakes, 2000 Goldste ...
by Booij (Leyden). Introductory § i. systems § 2
by Booij (Leyden). Introductory § i. systems § 2

... A second fact is that the existence of this ...
What`s the Difference? Efficient Set Reconciliation without
What`s the Difference? Efficient Set Reconciliation without

... describe sketch-based methods for finding large differences in traffic flows. (See also [19].) An alternative approach to estimating set-difference size is provided by [11], whose algorithm can more generally estimate the difference between two functions with communication complexity very similar to ...
Document
Document

... Abstract ...
Liposome Delivery of Chlamydia muridarum Major Outer Membrane
Liposome Delivery of Chlamydia muridarum Major Outer Membrane

... (Th1) with an additional effect of secreted antibodies. A need for Th1-polarizing adjuvants in experimental chlamydia vaccines has been demonstrated, and antigen conformation has also been reported as being important for raising protective immunity. Methods. C57BL/6 mice vaccinated with native refol ...
Stem Cell Teachers` Kit
Stem Cell Teachers` Kit

... and repeated in the information boxes at the beginning of each activity. Teachers can mix and match activities to consolidate a particular area of stem cell science or biology they wish to address. Teachers can also combine a number of activities to make a lesson plan and even a number of activities ...
Auxin and other signals on the move in plants Auxins are a class of
Auxin and other signals on the move in plants Auxins are a class of

... Organization of the plant: As auxins contribute to organ shaping, they are also fundamentally required for proper development of the plant itself. Without hormonal regulation and organization, plants would be merely proliferating heaps of similar cells. Auxin employment begins in the embryo of the ...
Strategies for in vitro Transporter Testing and
Strategies for in vitro Transporter Testing and

1 - Utrecht University Repository
1 - Utrecht University Repository

... after which the platelets adhere to the damaged vascular endothelium and stop the hemorrhage. However, inappropriate integrin activation on platelets and subsequent uncontrolled platelet adhesion results in a pathological situation called thrombosis. Integrins on leukocytes and platelets adhere, in ...
Strategies for ocular siRNA delivery: Potential and limitations of non-viral nanocarriers
Strategies for ocular siRNA delivery: Potential and limitations of non-viral nanocarriers

Membrane immersion allows rhomboid proteases to achieve
Membrane immersion allows rhomboid proteases to achieve

... eLife digest Proteases are enzymes that break the peptide bonds that hold proteins together, and have a central role in many physiological processes, including digestion, blood clotting and programmed cell death. An important characteristic of proteases is that they are highly selective, only cuttin ...
Journal of Bacteriology
Journal of Bacteriology

... Interactions of pseudobactin 358 with deleterious and pathogenic rhizosphere microorganisms. In an antibiosis assay (Fig. 3), the cyanide-producing Pseudomonas strains All, A14, and A63, the pathogenic bacteria E. carotovora subsp. carotovora and E. carotovora subsp. atroseptica, and the pathogenic ...
Toll-like receptors: resent advances, open questions and
Toll-like receptors: resent advances, open questions and

Chapter 16—Probes for Endocytosis, Receptors and Ion Channels
Chapter 16—Probes for Endocytosis, Receptors and Ion Channels

... 16.1 Probes for Following Receptor Binding and Phagocytosis The plasma membrane defines the inside and outside of the cell. It not only encloses the cytosol to maintain the intracellular environment but also serves as a formidable barrier to the extracellular environment. Because cells require input ...
Biofilms  are  described  as  surface ... et al.,
Biofilms are described as surface ... et al.,

... Biofilms cause fouling of industrial equipment such as heat exchangers, cooling towers resulting in efficient heat transfer, energy loss, increased fluid frictional resistance and accelerated corrosion and also deteriorates the quality of various chemicals and process additives (Xiong and Liu, 2010 ...
An investigation into salbutamol sulphate ion pair interactions and
An investigation into salbutamol sulphate ion pair interactions and

... the formulation. The aim of this work was to form a salbutamol sulphate ion-pair and to characterise its transport properties. ...
Reperfusion of ischemic myocardium: Ultrastructural and
Reperfusion of ischemic myocardium: Ultrastructural and

... pool (30-32,45,46) has also been strongly associated with delayed recovery. Reimer et al. (46) showed that the adenine nucleotide pool was markedly dcreased after 15 minutes of reversible ischemia and that it was still slightly suppressed after 4 days of reflow. Microvascular defects causing persist ...
Fig. 2a
Fig. 2a

... Polymorphisms in the gene encoding the transcription factor IRF5 that lead to higher mRNA expression are associated with many autoimmune diseases. Here we show that IRF5 expression in macrophages was reversibly induced by inflammatory stimuli and contributed to the plasticity of macrophage polarizat ...
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Cell encapsulation



Cell microencapsulation technology involves immobilization of the cells within a polymeric semi-permeable membrane that permits the bidirectional diffusion of molecules such as the influx of oxygen, nutrients, growth factors etc. essential for cell metabolism and the outward diffusion of waste products and therapeutic proteins. At the same time, the semi-permeable nature of the membrane prevents immune cells and antibodies from destroying the encapsulated cells regarding them as foreign invaders.The main motive of cell encapsulation technology is to overcome the existing problem of graft rejection in tissue engineering applications and thus reduce the need for long-term use of immunosuppressive drugs after an organ transplant to control side effects.
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