Lessons on longevity from budding yeast
... immense contributions to this progress. Yeast longevity factors have now been shown to modulate ageing in invertebrate and mammalian models, and studies of yeast have resulted in some of the best candidates for anti-ageing drugs currently in development. The first interventions to slow human ageing ...
... immense contributions to this progress. Yeast longevity factors have now been shown to modulate ageing in invertebrate and mammalian models, and studies of yeast have resulted in some of the best candidates for anti-ageing drugs currently in development. The first interventions to slow human ageing ...
Peroxisome degradation requires catalytically active sterol
... many GRAM-domain proteins harbour additional lipidbinding motifs, e.g. FYVE or pleckstrin homology (PH) domains, they are thought to be associated with intracellular membranes. The physiological and biochemical functions of GRAM domains, however, have not been determined at either the cellular or mo ...
... many GRAM-domain proteins harbour additional lipidbinding motifs, e.g. FYVE or pleckstrin homology (PH) domains, they are thought to be associated with intracellular membranes. The physiological and biochemical functions of GRAM domains, however, have not been determined at either the cellular or mo ...
Two highly related regulatory subunits of PP2A exert opposite
... in situ hybridisation probes corresponding to nucleotides 1988-2176 and 9194 of the full-length mRNA, respectively, were generated by PCR from Xenopus cDNA libraries and cloned into pCR2.1 (Invitrogen). Xbra and gsc probes (Howell et al., 2002), pCS2-GFP, pFTX4K-EGFPSmad2 and the plasmid expressing ...
... in situ hybridisation probes corresponding to nucleotides 1988-2176 and 9194 of the full-length mRNA, respectively, were generated by PCR from Xenopus cDNA libraries and cloned into pCR2.1 (Invitrogen). Xbra and gsc probes (Howell et al., 2002), pCS2-GFP, pFTX4K-EGFPSmad2 and the plasmid expressing ...
PDF
... known as IrreC) and Sticks and stones (Sns) (Bour et al., 2000; RuizGomez et al., 2000; Strunkelnberg et al., 2001) – mediate the initial contact between fusing cells (Ruiz-Gomez et al., 2000; Galletta et al., 2004), triggering intracellular pathways that orchestrate the cytoskeletal rearrangements ...
... known as IrreC) and Sticks and stones (Sns) (Bour et al., 2000; RuizGomez et al., 2000; Strunkelnberg et al., 2001) – mediate the initial contact between fusing cells (Ruiz-Gomez et al., 2000; Galletta et al., 2004), triggering intracellular pathways that orchestrate the cytoskeletal rearrangements ...
Interferon Gamma-Treated Keratinocytes Activate T Cells in the
... [1]. Classical antigen presentation of proteins by these cell types involves endocytosis followed by partial digestion and binding' of the peptide fragments to MH C class II molecules [2,3]. MHC class II molecules with bound pep tides are then expressed on the surface of the antigen-presenting cell ...
... [1]. Classical antigen presentation of proteins by these cell types involves endocytosis followed by partial digestion and binding' of the peptide fragments to MH C class II molecules [2,3]. MHC class II molecules with bound pep tides are then expressed on the surface of the antigen-presenting cell ...
Deletion of Lipoteichoic Acid Synthase Impacts
... Lactobacillus acidophilus NCFM is a well-characterized probiotic microorganism, supported by a decade of genomic and functional phenotypic investigations. L. acidophilus deficient in lipoteichoic acid (LTA), a major immunostimulant in Grampositive bacteria, has been shown to shift immune system resp ...
... Lactobacillus acidophilus NCFM is a well-characterized probiotic microorganism, supported by a decade of genomic and functional phenotypic investigations. L. acidophilus deficient in lipoteichoic acid (LTA), a major immunostimulant in Grampositive bacteria, has been shown to shift immune system resp ...
A 3 -Truncated Transferrin Messenger RNA Is Expressed in Rat
... share sequence homology, including highly conserved cysteine residues. The approximate N-terminal half is homologous to the C-terminal half of each protein. X-ray analysis of the structure of rabbit serotransferrin revealed that each half forms a lobe of approximately 330 amino acids composing two d ...
... share sequence homology, including highly conserved cysteine residues. The approximate N-terminal half is homologous to the C-terminal half of each protein. X-ray analysis of the structure of rabbit serotransferrin revealed that each half forms a lobe of approximately 330 amino acids composing two d ...
Redox States of Plastids and Mitochondria
... Both ise1 mutant and ISE1-silenced tissues exhibit increased production of ROS. The transmembrane proton gradient is defective in ise1 mitochondria and likely leads to the observed increase in ROS production (Stonebloom et al., 2009). Thus, genetic studies have identified plastid and mitochondrial m ...
... Both ise1 mutant and ISE1-silenced tissues exhibit increased production of ROS. The transmembrane proton gradient is defective in ise1 mitochondria and likely leads to the observed increase in ROS production (Stonebloom et al., 2009). Thus, genetic studies have identified plastid and mitochondrial m ...
MESOPHYLL STRUCTURE AND CHLOROPLAST DENSITY IN
... and water use efficiency, and vice versa; plants that have maximal integral indexes grow in habitats at the ecological optimum for the given species (Pyankov et al., 1998; Ivanova and Pyankov, 2002). ...
... and water use efficiency, and vice versa; plants that have maximal integral indexes grow in habitats at the ecological optimum for the given species (Pyankov et al., 1998; Ivanova and Pyankov, 2002). ...
Now! - Soojeede.com
... A- Physiological local death (Necrobiosis) e.g. RBCs and squamous cell after end of their life span. B- Necrosis. ...
... A- Physiological local death (Necrobiosis) e.g. RBCs and squamous cell after end of their life span. B- Necrosis. ...
Cell behaviour and cleft palate in the mutant mouse
... be seen at their posterior end where the knife has cut a glancing transverse section through the tissue. By the 14th day of development (14-5 days) the ridges have grown well out and away from the palatal roof (Figs. lc,3a, c) and rotation can be seen to have begun in the anterior half (Fig. 3 a) of ...
... be seen at their posterior end where the knife has cut a glancing transverse section through the tissue. By the 14th day of development (14-5 days) the ridges have grown well out and away from the palatal roof (Figs. lc,3a, c) and rotation can be seen to have begun in the anterior half (Fig. 3 a) of ...
The preplacodal region - Kings College
... members of the Dlx family also counteract neural plate formation, but in addition both seem to play antagonistic roles during the specification of neural crest and placode precursors. Misexpression of Dlx5, Dlx3 or constitutively active Dlx3 represses neural and neural crest cells, while promoting t ...
... members of the Dlx family also counteract neural plate formation, but in addition both seem to play antagonistic roles during the specification of neural crest and placode precursors. Misexpression of Dlx5, Dlx3 or constitutively active Dlx3 represses neural and neural crest cells, while promoting t ...
Expression α Importance for the Up-Regulation of TNF- MOPC
... cultured tumor cells was determined by Western blot analysis. As reference point, we subjected concurrently 5, 10, and 30 ng of rIFN- to Western blot analysis. As seen in Fig. 3, although no IFN- protein was detected in supernatant of cultured tumor cells from untreated mice, IFN- protein was cle ...
... cultured tumor cells was determined by Western blot analysis. As reference point, we subjected concurrently 5, 10, and 30 ng of rIFN- to Western blot analysis. As seen in Fig. 3, although no IFN- protein was detected in supernatant of cultured tumor cells from untreated mice, IFN- protein was cle ...
Regulation of Metabolic Events during Embryo Development
... biochemical events that are involved in regulation of embryo development in Norway spruce. Embryogenesis involves coordination of multicellular patterning events which are critical for establishment of the apical-basal plan of the plant. Due to similarities with zygotic embryogenesis, the process of ...
... biochemical events that are involved in regulation of embryo development in Norway spruce. Embryogenesis involves coordination of multicellular patterning events which are critical for establishment of the apical-basal plan of the plant. Due to similarities with zygotic embryogenesis, the process of ...
Full Text
... members of the Dlx family also counteract neural plate formation, but in addition both seem to play antagonistic roles during the specification of neural crest and placode precursors. Misexpression of Dlx5, Dlx3 or constitutively active Dlx3 represses neural and neural crest cells, while promoting t ...
... members of the Dlx family also counteract neural plate formation, but in addition both seem to play antagonistic roles during the specification of neural crest and placode precursors. Misexpression of Dlx5, Dlx3 or constitutively active Dlx3 represses neural and neural crest cells, while promoting t ...
Protein kinase signaling networks in plant innate immunity
... peptides. These responses mainly mediated through CDPKs are co-regulated by MAPK cascades that can be further modulated by CAM. Ca2+ rise also regulates late responses within hours and days, including the production of SA, phytoalexin, camalexin and other defense compounds through gene regulation. T ...
... peptides. These responses mainly mediated through CDPKs are co-regulated by MAPK cascades that can be further modulated by CAM. Ca2+ rise also regulates late responses within hours and days, including the production of SA, phytoalexin, camalexin and other defense compounds through gene regulation. T ...
Fibroblast activation protein is induced by
... agents. Although MMPs and cysteine proteases have been well characterized as protease targets, the role of serine proteases in this context has not been investigated. Fibroblast activation protein (FAP) is a membrane-bound, constitutively active serine protease expressed by activated fibroblasts in ...
... agents. Although MMPs and cysteine proteases have been well characterized as protease targets, the role of serine proteases in this context has not been investigated. Fibroblast activation protein (FAP) is a membrane-bound, constitutively active serine protease expressed by activated fibroblasts in ...
UvA-DARE (Digital Academic Repository) Mitochondria in neutrophil
... XIAP is a closely related protein. Most of the non-apoptotic caspases play a role in processing regulatory cytokines of the immune system or are involved in immune signaling 16. It is, therefore, not surprising that immune signaling and apoptosis are such closely related processes. The TNF-α recepto ...
... XIAP is a closely related protein. Most of the non-apoptotic caspases play a role in processing regulatory cytokines of the immune system or are involved in immune signaling 16. It is, therefore, not surprising that immune signaling and apoptosis are such closely related processes. The TNF-α recepto ...
- Wiley Online Library
... a simple stimulatory role of [Ca2þ]i in endocytosis. Moreover, it is not known whether or how different types of endocytosis are differentially modulated by the same increase in [Ca2þ]i. Therefore, we believe that a clean molecular dissection of distinct vesicle recycling pathways is required to add ...
... a simple stimulatory role of [Ca2þ]i in endocytosis. Moreover, it is not known whether or how different types of endocytosis are differentially modulated by the same increase in [Ca2þ]i. Therefore, we believe that a clean molecular dissection of distinct vesicle recycling pathways is required to add ...
Phenolic compounds isolated from Pilea microphylla prevent
... DNA strand breaks, base modifications and genetic alterations3. These changes activate poly (ADP-ribose) polymerase, involved in a reaction that leads to apoptosis4. Therefore, protection against Fenton reagent-induced calf thymus DNA damage serves as a useful tool in testing bio-molecules that mitig ...
... DNA strand breaks, base modifications and genetic alterations3. These changes activate poly (ADP-ribose) polymerase, involved in a reaction that leads to apoptosis4. Therefore, protection against Fenton reagent-induced calf thymus DNA damage serves as a useful tool in testing bio-molecules that mitig ...
Rac1 accumulates in the nucleus during the G2 phase of the cell
... cell lines including MDCK, COS-1, and porcine aortic endothelial (PAE) cells (Fig. 1, B and C) and ECV304 human bladder carcinoma, HeLa, and NIH 3T3 (not depicted). GFP-Rac1 ranged from 5 ± 2% nuclear in MDCK cells to 30 ± 5% nuclear in COS-1 cells (Fig. 1 C). Constitutively GTP-bound GFP-Rac1L61 wa ...
... cell lines including MDCK, COS-1, and porcine aortic endothelial (PAE) cells (Fig. 1, B and C) and ECV304 human bladder carcinoma, HeLa, and NIH 3T3 (not depicted). GFP-Rac1 ranged from 5 ± 2% nuclear in MDCK cells to 30 ± 5% nuclear in COS-1 cells (Fig. 1 C). Constitutively GTP-bound GFP-Rac1L61 wa ...
PDF - ScienceAsia
... ABSTRACT: In order to improve polyhydroxyalkanoate (PHA) production, it is necessary to investigate and understand the kinetic growth profile of fermentable bacteria under various fermentation conditions. Modern determination methods can only give the amount and type of PHA monomers without other po ...
... ABSTRACT: In order to improve polyhydroxyalkanoate (PHA) production, it is necessary to investigate and understand the kinetic growth profile of fermentable bacteria under various fermentation conditions. Modern determination methods can only give the amount and type of PHA monomers without other po ...
STUDENTS` MISCONCEPTIONS ABOUT CELL BIOLOGY AND
... corrected or students are made to bring conceptual change. However, before misconception can be corrected, they need to be identified. It is a well known fact that students enter in biology classroom with a lot of misconceptions which are based on their beliefs and observations. In Ethiopia only few ...
... corrected or students are made to bring conceptual change. However, before misconception can be corrected, they need to be identified. It is a well known fact that students enter in biology classroom with a lot of misconceptions which are based on their beliefs and observations. In Ethiopia only few ...
pdf, 1.5 MB - The Nebenführ Lab
... Cloning of Soybean a-1,2 Mannosidase I The enzyme a-1,2 mannosidase I belongs to the class I a-mannosidases, a family of enzymes which remove a-1,2mannosyl residues from the high Man N-linked oligosaccharides that are synthesized in the ER (Moremen et al., 1994). These are the first modification rea ...
... Cloning of Soybean a-1,2 Mannosidase I The enzyme a-1,2 mannosidase I belongs to the class I a-mannosidases, a family of enzymes which remove a-1,2mannosyl residues from the high Man N-linked oligosaccharides that are synthesized in the ER (Moremen et al., 1994). These are the first modification rea ...
Cellular differentiation
In developmental biology, cellular differentiation isa cell changes from one cell type to another. Most commonly this is a less specialized type becoming a more specialized type, such as during cell growth. Differentiation occurs numerous times during the development of a multicellular organism as it changes from a simple zygote to a complex system of tissues and cell types. Differentiation continues in adulthood as adult stem cells divide and create fully differentiated daughter cells during tissue repair and during normal cell turnover. Some differentiation occurs in response to antigen exposure. Differentiation dramatically changes a cell's size, shape, membrane potential, metabolic activity, and responsiveness to signals. These changes are largely due to highly controlled modifications in gene expression and are the study of epigenetics. With a few exceptions, cellular differentiation almost never involves a change in the DNA sequence itself. Thus, different cells can have very different physical characteristics despite having the same genome.A cell that can differentiate into all cell types of the adult organism is known as pluripotent. Such cells are called embryonic stem cells in animals and meristematic cells in higher plants. A cell that can differentiate into all cell types, including the placental tissue, is known as totipotent. In mammals, only the zygote and subsequent blastomeres are totipotent, while in plants many differentiated cells can become totipotent with simple laboratory techniques. In cytopathology, the level of cellular differentiation is used as a measure of cancer progression. ""Grade"" is a marker of how differentiated a cell in a tumor is.