ICAM-1 - The Journal of Cell Biology
... cytoplasmic amino acids in reverse order (ICAM-1,505-47s) and control peptide 4 were synthesized with the solid phase method (34). Peptides ICAM-1,47s_5os and ICAM-1,5os~tTS were synthesized with an Applied Bitsystems synthesizer (model 430; Applied Biosystems Inc., Foster City, CA) using small scal ...
... cytoplasmic amino acids in reverse order (ICAM-1,505-47s) and control peptide 4 were synthesized with the solid phase method (34). Peptides ICAM-1,47s_5os and ICAM-1,5os~tTS were synthesized with an Applied Bitsystems synthesizer (model 430; Applied Biosystems Inc., Foster City, CA) using small scal ...
Cell Functions Phospholipid-Binding Motif that Regulates T Subunit
... of the plasma membrane, thereby shielding them from phosphorylation (12). This notion is consistent with in vitro studies demonstrating that phospholipid binding by the CD3 chains can limit the magnitude of their ITAM phosphorylation (12, 13). Based on these findings, a new mechanism for regulating ...
... of the plasma membrane, thereby shielding them from phosphorylation (12). This notion is consistent with in vitro studies demonstrating that phospholipid binding by the CD3 chains can limit the magnitude of their ITAM phosphorylation (12, 13). Based on these findings, a new mechanism for regulating ...
Antisense phenotypes reveal a role for SHY, a pollen
... predicted. Most of the T1 transformants showed a 2:1 KanR:KanS ratio, suggesting that transmission of the transgene might be impaired. Crosses of KanR T1 or subsequent generation plants (see Table S1) as female with V26 pollen resulted in full seed capsules, demonstrating that female fertility was n ...
... predicted. Most of the T1 transformants showed a 2:1 KanR:KanS ratio, suggesting that transmission of the transgene might be impaired. Crosses of KanR T1 or subsequent generation plants (see Table S1) as female with V26 pollen resulted in full seed capsules, demonstrating that female fertility was n ...
Anterior PAR proteins function during cytokinesis and
... from each particular assay was quantified (Total n). These embryos were first divided into groups based on gross embryonic phenotypes observed: wild type (hatched) and unhatched embryos. Unhatched embryos are embryos that did not arrest at the one-cell stage but arrested later in development. Of the ...
... from each particular assay was quantified (Total n). These embryos were first divided into groups based on gross embryonic phenotypes observed: wild type (hatched) and unhatched embryos. Unhatched embryos are embryos that did not arrest at the one-cell stage but arrested later in development. Of the ...
The ethmoid bone: clinical imaging anatomy from an embryological
... pathways from the frontal and maxillary sinuses (ostiomeatal complex). It contains the ethmoid air cells, which play an important role in olfactory sensation, humidification, ventilation, and phonation. The ethmoid bone consists of 4 parts: the perpendicular plate, cribriform plate, and 2 ethmoidal ...
... pathways from the frontal and maxillary sinuses (ostiomeatal complex). It contains the ethmoid air cells, which play an important role in olfactory sensation, humidification, ventilation, and phonation. The ethmoid bone consists of 4 parts: the perpendicular plate, cribriform plate, and 2 ethmoidal ...
pdf, 1.1 MB - The Nebenführ Lab
... disappears. This event not only marks the separation of the two daughter cells, but also initiates a range of biochemical modifications that transform the calloserich, flexible cell plate into a cellulose-rich, stiff primary cell wall. In highly vacuolated cells these common mechanisms of cytokinesi ...
... disappears. This event not only marks the separation of the two daughter cells, but also initiates a range of biochemical modifications that transform the calloserich, flexible cell plate into a cellulose-rich, stiff primary cell wall. In highly vacuolated cells these common mechanisms of cytokinesi ...
Chediak-Higashi–Like Granules in Acute
... Fig 1. (A1) Two neutrophils from a case of APL with CH-like granules. The promyelocytes looks normal in all parameters except in the primary granules. They are more abundant than normally seen; they are immature, different sized, and there is no dark purple of blue mature azure granules. The PMN loo ...
... Fig 1. (A1) Two neutrophils from a case of APL with CH-like granules. The promyelocytes looks normal in all parameters except in the primary granules. They are more abundant than normally seen; they are immature, different sized, and there is no dark purple of blue mature azure granules. The PMN loo ...
Isoform 5 of PIPKIc regulates the endosomal trafficking and
... (PH) domain, phox-homology (PX) domain, band 4.1 ezrin radixin moesin homology (FERM) domain or the Bin/ Amphiphysin/Rvs (BAR) domain to modulate their activities (Betson et al., 2002; Harlan et al., 1994; Lemmon et al., 2002; Toker, 2002; Yoon et al., 2012). In particular, PI(4,5)P2 regulates vario ...
... (PH) domain, phox-homology (PX) domain, band 4.1 ezrin radixin moesin homology (FERM) domain or the Bin/ Amphiphysin/Rvs (BAR) domain to modulate their activities (Betson et al., 2002; Harlan et al., 1994; Lemmon et al., 2002; Toker, 2002; Yoon et al., 2012). In particular, PI(4,5)P2 regulates vario ...
Autoregulation of Actin Synthesis by Physiological
... Modulation of osmotic effects by C2 toxin and phalloidin After primary culture for 18h, hepatocytes were incubated with normotonic or hypotonic medium with or without phalloidin or C2 toxin, respectively. Under normotonic conditions, phalloidin dramatically decreased cellular G-actin by 70% after in ...
... Modulation of osmotic effects by C2 toxin and phalloidin After primary culture for 18h, hepatocytes were incubated with normotonic or hypotonic medium with or without phalloidin or C2 toxin, respectively. Under normotonic conditions, phalloidin dramatically decreased cellular G-actin by 70% after in ...
Nociceptor and Hair Cell Transducer Properties of TRPA1, a
... us to hear and keep balance. The apical surface of hair cells is characterized by a protruding bundle of actin-rich stereocilia that form the mechanosensory organelle. Models of mechanotransduction, supported by ample physiological and anatomical evidence, imply the presence of one or two mechanosen ...
... us to hear and keep balance. The apical surface of hair cells is characterized by a protruding bundle of actin-rich stereocilia that form the mechanosensory organelle. Models of mechanotransduction, supported by ample physiological and anatomical evidence, imply the presence of one or two mechanosen ...
BAFF, APRIL and their receptors: Structure, function - Serval
... (nanomolar range), but not at all to BAFF-R. When receptors are dimerized as Ig fusion proteins, all receptors efficiently bind ligands in the low to subnanomolar range, with the exception of BAFF-R that does not bind to APRIL (Table 1, and reviewed in [30]). In comparison, APRIL binding to heparan ...
... (nanomolar range), but not at all to BAFF-R. When receptors are dimerized as Ig fusion proteins, all receptors efficiently bind ligands in the low to subnanomolar range, with the exception of BAFF-R that does not bind to APRIL (Table 1, and reviewed in [30]). In comparison, APRIL binding to heparan ...
Cell-Mediated Crystallization of Calcium Oxalate in
... synthesis and accumulation of these chambers signify the differentiation of a crystal-forming cell early in its development (Arnott and Pautard, 1970; Frank and Jensen, 1970; Horner and Whitmoyer, 1972; Franceschi, 1984; Kausch and Horner, 1984). Because they function to compartmentalize developing ...
... synthesis and accumulation of these chambers signify the differentiation of a crystal-forming cell early in its development (Arnott and Pautard, 1970; Frank and Jensen, 1970; Horner and Whitmoyer, 1972; Franceschi, 1984; Kausch and Horner, 1984). Because they function to compartmentalize developing ...
Origin of the zebrafish endocrine and exocrine
... present. By 52 hpf, the two buds have merged (Field et al., 2003; schematized in Fig. 1) to form a single pancreatic islet of endocrine cells, surrounded by exocrine tissue, with the entire structure localized to the right side of the ventral midline. Molecular markers reveal that pancreatic develop ...
... present. By 52 hpf, the two buds have merged (Field et al., 2003; schematized in Fig. 1) to form a single pancreatic islet of endocrine cells, surrounded by exocrine tissue, with the entire structure localized to the right side of the ventral midline. Molecular markers reveal that pancreatic develop ...
Essentials of Anatomy and Physiology, 9e (Marieb)
... A) adenine bonds to thymine and guanine bonds to cytosine B) adenine bonds to adenine and guanine bonds to guanine C) adenine bonds to guanine and thymine bones to cytosine D) adenine bonds to cytosine and thymine bonds to guanine E) adenine bonds to uracil and guanine bonds to cytosine Answer: A Di ...
... A) adenine bonds to thymine and guanine bonds to cytosine B) adenine bonds to adenine and guanine bonds to guanine C) adenine bonds to guanine and thymine bones to cytosine D) adenine bonds to cytosine and thymine bonds to guanine E) adenine bonds to uracil and guanine bonds to cytosine Answer: A Di ...
Cell-cycle-regulated expression of STIL controls centriole number in
... RNA interference, we show that STIL is required for centriole duplication in human cells. Conversely, overexpression of STIL triggers the near-simultaneous formation of multiple daughter centrioles surrounding each mother, which is highly reminiscent of the phenotype produced by overexpression of th ...
... RNA interference, we show that STIL is required for centriole duplication in human cells. Conversely, overexpression of STIL triggers the near-simultaneous formation of multiple daughter centrioles surrounding each mother, which is highly reminiscent of the phenotype produced by overexpression of th ...
FOG1 recruits the NuRD repressor complex to mediate
... which is supported by the observation that restoring GATA-1 activity in G1E cells induces all of the known GATA-1 target genes (Welch et al, 2004). Activation of many but not all of these genes requires FOG-1 binding by GATA-1. For example, GATA-1 bearing a valine to glycine substitution mutation at ...
... which is supported by the observation that restoring GATA-1 activity in G1E cells induces all of the known GATA-1 target genes (Welch et al, 2004). Activation of many but not all of these genes requires FOG-1 binding by GATA-1. For example, GATA-1 bearing a valine to glycine substitution mutation at ...
Activation of Hedgehog signaling by loss of GNAS causes
... studies in our mouse model, we propose that Hedgehog inhibitors currently used in the clinic for other conditions, such as cancer, may possibly be repurposed for treating heterotopic ossification and other diseases caused by GNAS inactivation. The human skeleton is a complex organ that forms during ...
... studies in our mouse model, we propose that Hedgehog inhibitors currently used in the clinic for other conditions, such as cancer, may possibly be repurposed for treating heterotopic ossification and other diseases caused by GNAS inactivation. The human skeleton is a complex organ that forms during ...
Vesicle trafficking dynamics and visualization of zones of exocytosis
... Imaging). The regions measured are defined as follows. The apical dome region extended from the tip to the location where the semihemispherical dome joined the cylindrical body of the tube, which averaged 3 lm distal to the apex. The adjacent region spanned the area from 3 lm to 10 lm distal to the ...
... Imaging). The regions measured are defined as follows. The apical dome region extended from the tip to the location where the semihemispherical dome joined the cylindrical body of the tube, which averaged 3 lm distal to the apex. The adjacent region spanned the area from 3 lm to 10 lm distal to the ...
Neuroblast migration along the anteroposterior axis of C. elegans is
... mom-2 transcripts were occasionally detected in posterior seam cells in early L1 larvae. Consistent with the early embryonic function of mom-2 (Thorpe et al., 1997), we found that mom-2 transcripts were already present in the zygote (Fig. 2B). At the four-cell stage, mom-2 transcripts were enriched ...
... mom-2 transcripts were occasionally detected in posterior seam cells in early L1 larvae. Consistent with the early embryonic function of mom-2 (Thorpe et al., 1997), we found that mom-2 transcripts were already present in the zygote (Fig. 2B). At the four-cell stage, mom-2 transcripts were enriched ...
Muscle Contraction and Cell Motility
... progress in research on muscle contraction and cell motility, not only for investigators in these research fields but also for general readers who are interested in these topics. One of the most attractive features of living organisms is their ability to move. In vertebrate animals, including humans ...
... progress in research on muscle contraction and cell motility, not only for investigators in these research fields but also for general readers who are interested in these topics. One of the most attractive features of living organisms is their ability to move. In vertebrate animals, including humans ...
Cell regulation by the Apc protein Apc as master regulator of epithelia
... The first recognised function of Apc was its role in Wnt signalling [4,5]. This function is one of the driving forces for how mutations in Apc ensure that cells remain proliferative. Many of the molecular details of this pathway have been described extensively in many reviews [6]. Apc negatively ...
... The first recognised function of Apc was its role in Wnt signalling [4,5]. This function is one of the driving forces for how mutations in Apc ensure that cells remain proliferative. Many of the molecular details of this pathway have been described extensively in many reviews [6]. Apc negatively ...
Extracellular matrix
In biology, the extracellular matrix (ECM) is a collection of extracellular molecules secreted by cells that provides structural and biochemical support to the surrounding cells. Because multicellularity evolved independently in different multicellular lineages, the composition of ECM varies between multicellular structures; however, cell adhesion, cell-to-cell communication and differentiation are common functions of the ECM.The animal extracellular matrix includes the interstitial matrix and the basement membrane. Interstitial matrix is present between various animal cells (i.e., in the intercellular spaces). Gels of polysaccharides and fibrous proteins fill the interstitial space and act as a compression buffer against the stress placed on the ECM. Basement membranes are sheet-like depositions of ECM on which various epithelial cells rest.The plant ECM includes cell wall components, like cellulose, in addition to more complex signaling molecules. Some single-celled organisms adopt multicelluar biofilms in which the cells are embedded in an ECM composed primarily of extracellular polymeric substances (EPS).