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The Rhopalosiphum padi virus 59 internal ribosome entry site is
The Rhopalosiphum padi virus 59 internal ribosome entry site is

... shown to function in a Drosophila cell-based in vitro translation system and also functions efficiently in RRL and wheat germ lysates (Woolaway et al., 2001). The ability of the RhPV 59 IRES to function in insect translation systems suggests potential utility of this IRES in insect cell expression s ...
Microtubules
Microtubules

... Otherwise rapid disassembly at the plus end ensues, and the tubulin dimers are available for growth of another microtubule. A website of the Borisy lab has movies depicting microtubule instability. See, e.g., movie #1 on centrosomal control of microtubule dynamics. ...
A C-terminus Mitochondrial-localization Region and BH3 Domain of
A C-terminus Mitochondrial-localization Region and BH3 Domain of

WOX11 and 12 Are Involved in the First-Step Cell
WOX11 and 12 Are Involved in the First-Step Cell

PDF
PDF

... data obtained from chick suggests that sequential BMP-FGF signaling is sufficient to establish thymus fate (Neves et al., 2012). By contrast, SHH signaling promotes parathyroid fate and is a negative regulator of thymus fate. In its absence, embryos lack Gcm2, downregulate Tbx1 and expand Bmp4 and F ...
Responses to Cell Loss Become Restricted as the Supporting Cells
Responses to Cell Loss Become Restricted as the Supporting Cells

... utricles from neonatal mice, time-lapse recordings in the vicinity of dying HCs showed that numerous SCs change shape and organize multicellular actin purse strings that reseal the epithelium. In contrast, adult SCs appeared resistant to deformation, with resealing responses limited to just a few ne ...
Auxin and self-organization at the shoot apical
Auxin and self-organization at the shoot apical

... animals lies in the regulation of their organogenetic capacity over time. Unlike most animals, in which organogenesis occurs during embryonic development, plants can form new organs throughout their life cycle. Post-embryonic development occurs thanks to specialized tissues containing stem-cell nich ...
Brief Report - The Journal of Cell Biology
Brief Report - The Journal of Cell Biology

... the liver of the mammalian host, thrombospondin-related anonymous protein (TRAP)1 (Robson et al., 1988) is a candidate ligand for interaction with host cell or substrate receptors. TRAP is a type 1 transmembrane protein that carries two adhesive domains in its extracellular portion, an A-type domain ...
FGF1 inhibits p53-dependent apoptosis and cell cycle arrest via an
FGF1 inhibits p53-dependent apoptosis and cell cycle arrest via an

... these cell lines for the expression of bcl-2, a classical repressed target gene of p53 (Figure 1c). We tried to confirm that FGF1 mRNA regulation was p53-dependent by inducing p53 activation in an independent manner, using etoposide in REtsAF cells. Etoposide, like temperature shift, induces the acti ...
PDF
PDF

here - The Nebenführ Lab
here - The Nebenführ Lab

Differential Subnuclear Localization of RNA Strands of Opposite
Differential Subnuclear Localization of RNA Strands of Opposite

... organelle, the spatially clustered biochemical reactions also require the trafficking and precise localization of all of the molecules involved. Thus, organized trafficking and localization of molecules are hallmarks of a living cell. Elucidating the underlying pathways and regulatory mechanisms of ...
Cyclophilin A enhances macrophage differentiation and lipid uptake
Cyclophilin A enhances macrophage differentiation and lipid uptake

... debris contribute to fatty lesions leading to atherosclerotic plaque formation. High blood glucose levels further facilitate monocyte adhesion to endothelial cells, differentiation of monocyte into macrophages ultimately promoting atherogenesis [1], thus increasing the risk of vascular disease in di ...
Identification and Characterization of the Acid Phosphatase HppA in
Identification and Characterization of the Acid Phosphatase HppA in

... world’s population and is believed to be the main etiological agent of gastric diseases and/or carcinomas [19, 20]. H. pylori apparently favors neutral pH for growth, but it resides in extremely low pH conditions, which results from the presence of gastric acid or the occasional acid shocks that occ ...
Life, Death, and Cell Proliferation
Life, Death, and Cell Proliferation

... Jurkat T cells were left untreated (A) or treated for 5 hr (B) or 12 hr (C) with anti-human Fas mAb (Clone DX2, Cat. No. 555670) and Protein G. Cells were incubated with Annexin V–PE in a buffer containing 7–AAD (Cat. No. 555816) and analyzed by flow cytometry. Untreated cells were primarily Annexin ...
Carbon partitioning in sugarcane (Saccharum species)
Carbon partitioning in sugarcane (Saccharum species)

... parenchyma cells (Rae et al., 2009). Sucrose unloaded from phloem into the apoplast can follow two paths to vacuoles of parenchyma cells (Figure 1). In one path, sucrose is transported directly into parenchyma cells by sucrose transporters of the plasma membrane, then into the vacuole, mostly under ...
Full Paper - Calcutta Research Group
Full Paper - Calcutta Research Group

... Collector for the first time. Dammalapati garu, who took me to the collector’s office is an important person in the Guntur political circles and a prominent man at the Sri Venkateswarswami temple1 in Guntur. He was visiting the Collector at his camp office with two of his friends to seek permission ...
Isolated cell behavior drives the evolution of
Isolated cell behavior drives the evolution of

... to cell death and the failure to form macroscopic colonies on agar. We next compared the antibiotic concentration required to prevent colony formation after overnight growth with the scMIC measured in liquid culture. These quantities should be equivalent: each colony observed on an agar plate develo ...
Antibiotic-loaded silica nanoparticle–collagen composite
Antibiotic-loaded silica nanoparticle–collagen composite

... . However, no ideal treatment is available at this time7. Nowadays, ...
Dev Biol 364(2), 138-48. PDF
Dev Biol 364(2), 138-48. PDF

... 2008; Zallen, 2007). The signaling pathway that controls PCP consists of Celsr/Flamingo, Frizzled (Fzd), Disheveled (Dvl/Dsh), Van Gogh/strabisumus (Vang/stbm), Diego, and Prickle (Pk). The PCP pathway is proposed to modulate the cytoskeleton and influence cell morphology rather than cell fates in ma ...
Characterization of the Cytosolic Proteins Involved in the Amoeboid
Characterization of the Cytosolic Proteins Involved in the Amoeboid

... p16 incorporates into MSP filaments and blocks further assembly by acting as a capping protein. My results imply that although the specific components differ, actin-based and MSP-based systems both rely on the interplay of positive and negative regulators of cytoskeletal assembly to maintain the pac ...
View Full Page PDF
View Full Page PDF

Cytokinesis defines a spatial landmark for hepatocyte polarization
Cytokinesis defines a spatial landmark for hepatocyte polarization

... Rodrı́guez-Fraticelli et al., 2011). Epithelial tissue consists of one or more layers of polarized cells that are connected through junctional complexes (tight junctions, adherens junctions, desmosomes and gap junctions), which enables them to act as a structural and functional unit. Epithelial cell ...
Chapter ONE - VU Research Portal
Chapter ONE - VU Research Portal

... G2 phase, they are kept inactive by phosphorylation of the Thr14 and Tyr15 residues located in the ATP binding site of Cdk1 (Gould and Nurse, 1989; Mueller et al., 1995; reviewed in Lindqvist, 2009; O’Farrell, 2001). The kinases responsible for these Cdk-inhibitory actions are Myt1 and Wee1, of whic ...
- ResearchOnline@JCU
- ResearchOnline@JCU

... the initial stages of thermal stress and subsequent bleaching (Edmunds and Gates, 2003; Lesser and Farrell, 2004; Dove et al., 2006). This is despite the proposal that a number of host mechanisms that may be involved in coral stress and bleaching (Gates et al., 1992). The increasing incidence of dis ...
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Extracellular matrix



In biology, the extracellular matrix (ECM) is a collection of extracellular molecules secreted by cells that provides structural and biochemical support to the surrounding cells. Because multicellularity evolved independently in different multicellular lineages, the composition of ECM varies between multicellular structures; however, cell adhesion, cell-to-cell communication and differentiation are common functions of the ECM.The animal extracellular matrix includes the interstitial matrix and the basement membrane. Interstitial matrix is present between various animal cells (i.e., in the intercellular spaces). Gels of polysaccharides and fibrous proteins fill the interstitial space and act as a compression buffer against the stress placed on the ECM. Basement membranes are sheet-like depositions of ECM on which various epithelial cells rest.The plant ECM includes cell wall components, like cellulose, in addition to more complex signaling molecules. Some single-celled organisms adopt multicelluar biofilms in which the cells are embedded in an ECM composed primarily of extracellular polymeric substances (EPS).
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