SLP-76-Cbl-Grb2-Shc Interactions in Fc RI Signaling
... factor (PDGF), these receptors have no intrinsic kinase activity. Signaling through these receptors is mediated through a conserved stretch of amino acids consisting of paired tyrosines and leucines in the consensus sequence (D/E)XXYXXL(Y)6-8 YXXL, termed the immunoreceptor tyrosine-based activation ...
... factor (PDGF), these receptors have no intrinsic kinase activity. Signaling through these receptors is mediated through a conserved stretch of amino acids consisting of paired tyrosines and leucines in the consensus sequence (D/E)XXYXXL(Y)6-8 YXXL, termed the immunoreceptor tyrosine-based activation ...
1 - UvA-DARE - University of Amsterdam
... Condorelli paper. Since then a consensus has been reached and the protein is now called GFAPδ (Condorelli et al., 1999; Middeldorp and Hol, 2011; Nielsen et al., 2002; Thomsen et al., 2013). Blechingberg and colleagues studied alternative splicing with a GFAP minigene construct and showed that the e ...
... Condorelli paper. Since then a consensus has been reached and the protein is now called GFAPδ (Condorelli et al., 1999; Middeldorp and Hol, 2011; Nielsen et al., 2002; Thomsen et al., 2013). Blechingberg and colleagues studied alternative splicing with a GFAP minigene construct and showed that the e ...
Non-specific chemical inhibition of the Fanconi anemia pathway
... Assembly of DNA damage-induced FANCD2 foci is a widely used indicator of upstream FA pathway integrity [8]. To identify novel small molecules that inhibit the FA pathway, PD20-EGFP-FANCD2 cells [13] were treated with chemical libraries and exposed to IR (15 Gy) to induce FANCD2 foci formation. A sig ...
... Assembly of DNA damage-induced FANCD2 foci is a widely used indicator of upstream FA pathway integrity [8]. To identify novel small molecules that inhibit the FA pathway, PD20-EGFP-FANCD2 cells [13] were treated with chemical libraries and exposed to IR (15 Gy) to induce FANCD2 foci formation. A sig ...
review cell division from a genetic perspective
... early landmarks normally and then fails at its diagnostic landmark. Of interest is the fate of landmarks that would have occurred in a normal cell cycle subsequent to the diagnostic landmark. Some of these may occur in a particular mutant, and others may not. The pattern observed for all of the muta ...
... early landmarks normally and then fails at its diagnostic landmark. Of interest is the fate of landmarks that would have occurred in a normal cell cycle subsequent to the diagnostic landmark. Some of these may occur in a particular mutant, and others may not. The pattern observed for all of the muta ...
REVIEW CELL DIVISION FROM A GENETIC PERSPECTIVE
... early landmarks normally and then fails at its diagnostic landmark. Of interest is the fate of landmarks that would have occurred in a normal cell cycle subsequent to the diagnostic landmark. Some of these may occur in a particular mutant, and others may not. The pattern observed for all of the muta ...
... early landmarks normally and then fails at its diagnostic landmark. Of interest is the fate of landmarks that would have occurred in a normal cell cycle subsequent to the diagnostic landmark. Some of these may occur in a particular mutant, and others may not. The pattern observed for all of the muta ...
review cell division from a genetic perspective
... early landmarks normally and then fails at its diagnostic landmark. Of interest is the fate of landmarks that would have occurred in a normal cell cycle subsequent to the diagnostic landmark. Some of these may occur in a particular mutant, and others may not. The pattern observed for all of the muta ...
... early landmarks normally and then fails at its diagnostic landmark. Of interest is the fate of landmarks that would have occurred in a normal cell cycle subsequent to the diagnostic landmark. Some of these may occur in a particular mutant, and others may not. The pattern observed for all of the muta ...
Amyotrophic Lateral Sclerosis SOD1
... Human cDNA coding for Rac1 (GenBank accession number NM_006908) was cloned by RT-PCR from human SH-SY5Y neuroblastoma cells using ...
... Human cDNA coding for Rac1 (GenBank accession number NM_006908) was cloned by RT-PCR from human SH-SY5Y neuroblastoma cells using ...
Structure and function of basement membranes
... Chauhan et al., 1993). However, we and others have not been able to demonstrate a direct growth promoting effect of HBAM on cells. Instead, HBGAM may regulate the activity of growth factors in a manner similar to that recently described for platelet factor 4 (Watson et al., 1994). Ironically, HBGAM ...
... Chauhan et al., 1993). However, we and others have not been able to demonstrate a direct growth promoting effect of HBAM on cells. Instead, HBGAM may regulate the activity of growth factors in a manner similar to that recently described for platelet factor 4 (Watson et al., 1994). Ironically, HBGAM ...
Q5D - ICH
... derived should be stated, and relevant references from the scientific literature should be cited. Information obtained directly from the source laboratory is preferred. When this is not available, literature references may be utilised. For human cell lines, it is relevant to describe the following c ...
... derived should be stated, and relevant references from the scientific literature should be cited. Information obtained directly from the source laboratory is preferred. When this is not available, literature references may be utilised. For human cell lines, it is relevant to describe the following c ...
chlamydomonas gymnogama and
... nants. It is possible that partial lysis of cell walls tein similar chemically to that of cell walls reinoccurs before and during the wall-shedding proc- forces the idea that what are at present undetectaess, as partial lysis of cell walls has been observed ble or relatively subtle differences in c ...
... nants. It is possible that partial lysis of cell walls tein similar chemically to that of cell walls reinoccurs before and during the wall-shedding proc- forces the idea that what are at present undetectaess, as partial lysis of cell walls has been observed ble or relatively subtle differences in c ...
Physcomitrella Cyclin-Dependent Kinase A Links
... 2000). In response to chemicals, including Suc and phytohormones, D-type cyclin (CYCD) is induced and binds to the A-type cyclin-dependent kinase (CDKA) to form a CDKA/CYCD complex. An active form of this complex regulates three proteins, which are themselves in a complex, namely, E2 promoter bindin ...
... 2000). In response to chemicals, including Suc and phytohormones, D-type cyclin (CYCD) is induced and binds to the A-type cyclin-dependent kinase (CDKA) to form a CDKA/CYCD complex. An active form of this complex regulates three proteins, which are themselves in a complex, namely, E2 promoter bindin ...
PDF
... confocal sections. (A-B⬘) Spalx1 and SphesC expression in S. purpuratus, shown at 8 hpf (56-cell stage; A,A⬘) and 10-12 hpf (mid-blastula stage; B,B⬘). (C-D⬘) Lvalx1 and LvhesC expression in L. variegatus, shown at 5 hpf (128 cell stage; C,C⬘) and 8 hpf (mid-blastula stage; D,D⬘). (E,E⬘) Lvdelta and ...
... confocal sections. (A-B⬘) Spalx1 and SphesC expression in S. purpuratus, shown at 8 hpf (56-cell stage; A,A⬘) and 10-12 hpf (mid-blastula stage; B,B⬘). (C-D⬘) Lvalx1 and LvhesC expression in L. variegatus, shown at 5 hpf (128 cell stage; C,C⬘) and 8 hpf (mid-blastula stage; D,D⬘). (E,E⬘) Lvdelta and ...
Plant Phosphoglycerolipids: The Gatekeepers of Vascular Cell
... The importance of phospholipids in the progression of xylem development was highlighted by the discovery of xylogen, an extracellular proteoglycan containing a glycosylphosphatidylinositol (GPI)-anchoring domains (Motose et al., 2004; Kobayashi et al., 2011). The GPI anchor is made of one molecule o ...
... The importance of phospholipids in the progression of xylem development was highlighted by the discovery of xylogen, an extracellular proteoglycan containing a glycosylphosphatidylinositol (GPI)-anchoring domains (Motose et al., 2004; Kobayashi et al., 2011). The GPI anchor is made of one molecule o ...
Sugar signals and the control of plant growth and
... Trehalose-6-phosphate synthase1 (TPS1) converts G6P and UDP-glucose (UDPG) to the growth signalling molecule T6P. Metabolism of T6P by trehalose-6-phosphate phosphatase (TPP) yields trehalose, which is hydrolysed to glucose by Trehalase1. T6P levels in Arabidopsis are correlated to those of sucrose, ...
... Trehalose-6-phosphate synthase1 (TPS1) converts G6P and UDP-glucose (UDPG) to the growth signalling molecule T6P. Metabolism of T6P by trehalose-6-phosphate phosphatase (TPP) yields trehalose, which is hydrolysed to glucose by Trehalase1. T6P levels in Arabidopsis are correlated to those of sucrose, ...
Heterodimerization and Endocytosis of Arabidopsis
... been successfully used to study gene regulation, signal transduction (reviewed in Sheen, 2001), protein targeting, and trafficking in plant cells (Jin et al., 2001, 2003; Kim et al., 2001; Ueda et al., 2001; Sohn et al., 2003; Park et al., 2004). In spite of many advantages, protoplasts also have li ...
... been successfully used to study gene regulation, signal transduction (reviewed in Sheen, 2001), protein targeting, and trafficking in plant cells (Jin et al., 2001, 2003; Kim et al., 2001; Ueda et al., 2001; Sohn et al., 2003; Park et al., 2004). In spite of many advantages, protoplasts also have li ...
Using a tyrosine-kinase inhibitor to possibly
... in the brain. Regulation of the JNK signaling pathway is complex and is influenced by multiple MKKKs. The most important function of the JNK pathway is how its reaction to extracellular stimuli affects certain cell functions like apoptosis and proliferation. How does the JNK pathways and Parkinson’s ...
... in the brain. Regulation of the JNK signaling pathway is complex and is influenced by multiple MKKKs. The most important function of the JNK pathway is how its reaction to extracellular stimuli affects certain cell functions like apoptosis and proliferation. How does the JNK pathways and Parkinson’s ...
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... Another toxin that carries its own translocation apparatus, anthrax toxin, has a completely different structure and mechanism of action. This toxin is synthesized by Bacillus anthracis and consists of three protein entities (107). The protein called the protective antigen (because antibodies against ...
... Another toxin that carries its own translocation apparatus, anthrax toxin, has a completely different structure and mechanism of action. This toxin is synthesized by Bacillus anthracis and consists of three protein entities (107). The protein called the protective antigen (because antibodies against ...
Human Signaling Protein 14-3-3 Interacts With
... domains of platelet GPIba and GPIbb were each polymerase chain reaction (PCR)-amplified from platelet cDNA generated by platelet RNA reverse transcription. Platelet RNA was isolated from the therapeutic pheresis material of a patient with essential thrombocythemia. The sense primers each contained E ...
... domains of platelet GPIba and GPIbb were each polymerase chain reaction (PCR)-amplified from platelet cDNA generated by platelet RNA reverse transcription. Platelet RNA was isolated from the therapeutic pheresis material of a patient with essential thrombocythemia. The sense primers each contained E ...
Expression of the chicken GATA factor family during
... murine and avian erythroid cells. Total RNA isolated from the avian, murine and human cells indicated was analysed by RT-PCR for GATA-1, GATA-2 and GATA-3 expression. As an internal control, reactions contained primers that specifically amplify ribosomal protein gene products (chicken S17, murine S1 ...
... murine and avian erythroid cells. Total RNA isolated from the avian, murine and human cells indicated was analysed by RT-PCR for GATA-1, GATA-2 and GATA-3 expression. As an internal control, reactions contained primers that specifically amplify ribosomal protein gene products (chicken S17, murine S1 ...
In-vivo detection of binary PKA network interactions upon activation
... the nucleus13–15. Deregulation of cAMP/PKA functions contribute to the manifestation of diseases such as cancer. Distinct R or PKAc kinase gene mutations/fusions provoke permanent PKAc activation which participate in disease etiology and progression. As examples, mutations in RIa and PKAc account fo ...
... the nucleus13–15. Deregulation of cAMP/PKA functions contribute to the manifestation of diseases such as cancer. Distinct R or PKAc kinase gene mutations/fusions provoke permanent PKAc activation which participate in disease etiology and progression. As examples, mutations in RIa and PKAc account fo ...
how death shapes life during development
... these cells? The destruction of cells was first observed by developmental biologists during the 1800s, but cell death was not clearly recognized as having a normal, formative role in developing animals until this was articulated by Glücksmann1 in 1951 (BOX 1). Several terms have been used to describ ...
... these cells? The destruction of cells was first observed by developmental biologists during the 1800s, but cell death was not clearly recognized as having a normal, formative role in developing animals until this was articulated by Glücksmann1 in 1951 (BOX 1). Several terms have been used to describ ...
Some Recent Work on the Structure of the Plant Cell Wall
... contribution that microchemistry is making toward solving the problems of cell wall structure. Microchemical studies of the plant cell wall have revealed it as a complex structure composed of distinct lamellae, the lamellae in turn being composed of one or more different chemical substances. The uni ...
... contribution that microchemistry is making toward solving the problems of cell wall structure. Microchemical studies of the plant cell wall have revealed it as a complex structure composed of distinct lamellae, the lamellae in turn being composed of one or more different chemical substances. The uni ...