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... indirect association between SmoCT and PP4. We reasoned that if PP4 inhibits Smo phosphorylation through amino acids 626-678, deletion of this Smo-PP4 interacting domain should abolish Smo-PP4 interaction thus may lead to high basal phosphorylation of Smo. Indeed, we found that deletion of amino aci ...
... indirect association between SmoCT and PP4. We reasoned that if PP4 inhibits Smo phosphorylation through amino acids 626-678, deletion of this Smo-PP4 interacting domain should abolish Smo-PP4 interaction thus may lead to high basal phosphorylation of Smo. Indeed, we found that deletion of amino aci ...
Control of Gonadotropin Secretion by Follicle
... between the biotin moiety and one amino acid of the peptide. Three biotinylated derivatives of lGnRH-III were tested for bioactivity. The peptide derivative biotinylated on Lys8 with two spacer arms of aminocaproic acid (Bxx-Lys8lGnRH-III) had selective FSH-releasing activity at a dose of 108 M on ...
... between the biotin moiety and one amino acid of the peptide. Three biotinylated derivatives of lGnRH-III were tested for bioactivity. The peptide derivative biotinylated on Lys8 with two spacer arms of aminocaproic acid (Bxx-Lys8lGnRH-III) had selective FSH-releasing activity at a dose of 108 M on ...
PDF - Multinational Arabidopsis Steering Committee
... should stand next to your poster, find your abstract in this book and note the new abstract number. The new number is your poster number, NOT the number it was assigned when you originally submitted. Posters are sequenced by topic and presenter. See the poster list below to determine which group con ...
... should stand next to your poster, find your abstract in this book and note the new abstract number. The new number is your poster number, NOT the number it was assigned when you originally submitted. Posters are sequenced by topic and presenter. See the poster list below to determine which group con ...
The mitochondrial carnitine/acylcarnitine carrier: Function
... Most of the functional and structural properties of the mitochondrial CAC transporter have been elucidated after the characterization of the carnitine acyl transferases, as usually occurs for membrane proteins with respect to soluble enzymes. This review focuses on the molecular aspects of CAC which ...
... Most of the functional and structural properties of the mitochondrial CAC transporter have been elucidated after the characterization of the carnitine acyl transferases, as usually occurs for membrane proteins with respect to soluble enzymes. This review focuses on the molecular aspects of CAC which ...
LVA and HVA Ca Currents in Ventricular Muscle Cells of the
... currents. We propose that these currents may have a role in pacemaking as well as providing part of the calcium influx necessary for excitation-contraction coupling. Voltage-gated calcium channels are a common feature of all invertebrate and vertebrate muscles (McDonald et al. 1994). A variety of di ...
... currents. We propose that these currents may have a role in pacemaking as well as providing part of the calcium influx necessary for excitation-contraction coupling. Voltage-gated calcium channels are a common feature of all invertebrate and vertebrate muscles (McDonald et al. 1994). A variety of di ...
The Plant Membrane-Associated REMORIN1.3 Accumulates in
... that REM1.3 displays nonuniform perihaustorial accumulation, delimiting discrete membrane domains at the EHM (Fig. 1). Similar to REM1.3, the P. infestans RXLR effector AVRblb2 localizes to the PM and dramatically relocalizes to the EHM during host infection (Bozkurt et al., 2011, 2012). We observed ...
... that REM1.3 displays nonuniform perihaustorial accumulation, delimiting discrete membrane domains at the EHM (Fig. 1). Similar to REM1.3, the P. infestans RXLR effector AVRblb2 localizes to the PM and dramatically relocalizes to the EHM during host infection (Bozkurt et al., 2011, 2012). We observed ...
The metabolic basis of Candida albicans
... starvation activates both the MAP Kinase and cAMP-PKA pathways via ammonium permease (Mep2p). Adenylyl cyclase (Cdc35p) not only responds to Ras1p, it is also activated in response to G-proteins (Gpr1p and Gpa2p), which are activated by glucose deficiency and the presence of methionine. Cdc35p also a ...
... starvation activates both the MAP Kinase and cAMP-PKA pathways via ammonium permease (Mep2p). Adenylyl cyclase (Cdc35p) not only responds to Ras1p, it is also activated in response to G-proteins (Gpr1p and Gpa2p), which are activated by glucose deficiency and the presence of methionine. Cdc35p also a ...
Combinatorial Gli gene function in floor plate and
... results show that Gli proteins have non-redundant functions as only Gli1 can induce floor plate differentiation. Gli proteins appear to recognize the same target genes in vivo Because both human Gli1 and Gli3 bind to the same DNA sequences in vitro (Kinzler and Vogelstein, 1990; Vortkamp et al., 199 ...
... results show that Gli proteins have non-redundant functions as only Gli1 can induce floor plate differentiation. Gli proteins appear to recognize the same target genes in vivo Because both human Gli1 and Gli3 bind to the same DNA sequences in vitro (Kinzler and Vogelstein, 1990; Vortkamp et al., 199 ...
Enzyme Catalysis - faculty at Chemeketa
... affinity for the substrate. 1. It does not compete with the substrate for the active site. 2. It does not need to resemble the structure of the substrate. 3. Its’ effect cannot be reversed by increasing the substrate concentration. ...
... affinity for the substrate. 1. It does not compete with the substrate for the active site. 2. It does not need to resemble the structure of the substrate. 3. Its’ effect cannot be reversed by increasing the substrate concentration. ...
Ca signaling and early embryonic patterning during zebrafish
... and (d) the definition of the morphological boundaries of specific tissue domains and embryonic structures, including future organ anlagen. 4. The potential down-stream targets of these Ca2+ transients are also discussed as well as how they might integrate with other pattern-forming signaling pathwa ...
... and (d) the definition of the morphological boundaries of specific tissue domains and embryonic structures, including future organ anlagen. 4. The potential down-stream targets of these Ca2+ transients are also discussed as well as how they might integrate with other pattern-forming signaling pathwa ...
- the University of Huddersfield Repository
... The functional role of H2O2 is due to some of its fundamental properties; it is easily synthesized, easily degraded, it is present within all types of cells, it has a longer half-life than radical ROS and, most importantly, its small uncharged molecule allows it to diffuse freely through membranes a ...
... The functional role of H2O2 is due to some of its fundamental properties; it is easily synthesized, easily degraded, it is present within all types of cells, it has a longer half-life than radical ROS and, most importantly, its small uncharged molecule allows it to diffuse freely through membranes a ...
The dehydratase ADT3 affects ROS homeostasis
... epicuticular waxes (Steyn et al., 2002; Pollard et al., 2008); in addition, phenylpropanoids ...
... epicuticular waxes (Steyn et al., 2002; Pollard et al., 2008); in addition, phenylpropanoids ...
Myr 8, A Novel Unconventional Myosin Expressed during Brain
... unconventional myosin from rat), that comprise the founding members of a new class of myosins, which we have designated class XVI. The head domain of myr 8 myosins contains an N-terminal extension composed of multiple ankyrin repeats, which biochemical evidence implicates in binding the protein phos ...
... unconventional myosin from rat), that comprise the founding members of a new class of myosins, which we have designated class XVI. The head domain of myr 8 myosins contains an N-terminal extension composed of multiple ankyrin repeats, which biochemical evidence implicates in binding the protein phos ...
Chapter 8: Energy generation:glycolysis
... The glycolysis pathway can be divided into two phases, the first phase comprising steps 1–5 and culminating in synthesis of glyceraldehyde 3-phosphate, and the second phase made up of steps 6–10, when glyceraldehyde 3-phosphate is metabolized into pyruvate. The first phase does not generate ATP. In ...
... The glycolysis pathway can be divided into two phases, the first phase comprising steps 1–5 and culminating in synthesis of glyceraldehyde 3-phosphate, and the second phase made up of steps 6–10, when glyceraldehyde 3-phosphate is metabolized into pyruvate. The first phase does not generate ATP. In ...
Biological ontologies for human functional annotation and
... Mapping BioTop to the UMLS Semantic Network Use of BioTop in text mining: Experimental validation of added value compared to GENIA / thesaurus approach Empirical Studies to create evidence of whether • Formal Ontologies better serve the needs of knowledge annotation / processing in biomedicine • Inf ...
... Mapping BioTop to the UMLS Semantic Network Use of BioTop in text mining: Experimental validation of added value compared to GENIA / thesaurus approach Empirical Studies to create evidence of whether • Formal Ontologies better serve the needs of knowledge annotation / processing in biomedicine • Inf ...
Unveiling the physiological and molecular basis of Mycobacterium
... presence of dormant populations of non-growing cells that reactivate during host immunosuppression. Bacterial biofilms, described as single or multispecies communities triggered by cell-density dependent Quorum-Sensing (QS) events, exhibit heterogeneous and stress-tolerant populations that thrive un ...
... presence of dormant populations of non-growing cells that reactivate during host immunosuppression. Bacterial biofilms, described as single or multispecies communities triggered by cell-density dependent Quorum-Sensing (QS) events, exhibit heterogeneous and stress-tolerant populations that thrive un ...
Maternal macho-1 is an intrinsic factor that makes cell
... this hypothesis, we investigated the formation of mesenchyme, notochord, muscle and nerve cord in macho-1-deficient and macho-1-overexpressing embryos. Our results showed that macho-1 not only is a muscle determinant but also plays a pivotal role as an intrinsic factor that controls the responsivene ...
... this hypothesis, we investigated the formation of mesenchyme, notochord, muscle and nerve cord in macho-1-deficient and macho-1-overexpressing embryos. Our results showed that macho-1 not only is a muscle determinant but also plays a pivotal role as an intrinsic factor that controls the responsivene ...
Cholesterol Synthesis
... acids, eicosanoids, retinoids, & various non-polar xenobiotics (drugs & other foreign compounds). Some P450 enzymes have broad substrate specificity. Mechanisms for detoxification of non-polar compounds include reactions such as hydroxylations that increase polarity, so that the products of these ...
... acids, eicosanoids, retinoids, & various non-polar xenobiotics (drugs & other foreign compounds). Some P450 enzymes have broad substrate specificity. Mechanisms for detoxification of non-polar compounds include reactions such as hydroxylations that increase polarity, so that the products of these ...
biolsci.org - International Journal of Biological Sciences
... The distribution of thiamin biosynthetic pathway in pathogenic bacteria Landscapes of thiamin biosynthetic genes or operons of some pathogens outlined via comparative genomics analysis demonstrated some specific thiamin biosynthetic pathways[42]. The salvage and transport pathways are ubiquitous in ...
... The distribution of thiamin biosynthetic pathway in pathogenic bacteria Landscapes of thiamin biosynthetic genes or operons of some pathogens outlined via comparative genomics analysis demonstrated some specific thiamin biosynthetic pathways[42]. The salvage and transport pathways are ubiquitous in ...
Biofilms are described as surface ... et al.,
... resulting in efficient heat transfer, energy loss, increased fluid frictional resistance and accelerated corrosion and also deteriorates the quality of various chemicals and process additives (Xiong and Liu, 2010). For example, in the paper industry, biofilms cause deterioration of chemicals like st ...
... resulting in efficient heat transfer, energy loss, increased fluid frictional resistance and accelerated corrosion and also deteriorates the quality of various chemicals and process additives (Xiong and Liu, 2010). For example, in the paper industry, biofilms cause deterioration of chemicals like st ...
Distribution of Agrin mRNAs in the Chick Embryo Nervous System
... than agrin from brain or spinal cord (Godfrey, 199 1). This difference in activity of agrin-like molecules from various tissues may be due to alternative splicing of agrin mRNA. Complete cDNA sequences coding for rat and chicken agrin have recently been obtained (Rupp et al., 199 1; Tsim et al., 199 ...
... than agrin from brain or spinal cord (Godfrey, 199 1). This difference in activity of agrin-like molecules from various tissues may be due to alternative splicing of agrin mRNA. Complete cDNA sequences coding for rat and chicken agrin have recently been obtained (Rupp et al., 199 1; Tsim et al., 199 ...
Self-amplifying autocrine actions of BDNF in axon development Pei-Lin Cheng , Ai-Hong Song
... highly branched dendrites. This polarized structure is essential for two primary neuronal functions: the reception and integration of synaptic inputs at the dendrite, and the conduction and delivery of output signals to other cells via the axon. For the formation of this polarity, the postmitotic ne ...
... highly branched dendrites. This polarized structure is essential for two primary neuronal functions: the reception and integration of synaptic inputs at the dendrite, and the conduction and delivery of output signals to other cells via the axon. For the formation of this polarity, the postmitotic ne ...
Time-Dependent Activation of Feed-Forward Inhibition in
... Experiments were done on adult locusts (mostly female) taken from the laboratory colony 3– 4 wk after their final molt. Animals were mounted dorsal side up on a custom-designed polycarbonate holder that allowed us to reproducibly align the stimulated eye with the stimulation apparatus. For extracell ...
... Experiments were done on adult locusts (mostly female) taken from the laboratory colony 3– 4 wk after their final molt. Animals were mounted dorsal side up on a custom-designed polycarbonate holder that allowed us to reproducibly align the stimulated eye with the stimulation apparatus. For extracell ...
Emerging therapeutic roles for NAD+ metabolism in mitochondrial
... Nicotinamide adenine dinucleotide (NAD+) is a central metabolic cofactor in eukaryotic cells that plays a critical role in regulating cellular metabolism and energy homeostasis. NAD+ in its reduced form (i.e. NADH) serves as the primary electron donor in mitochondrial respiratory chain, which involv ...
... Nicotinamide adenine dinucleotide (NAD+) is a central metabolic cofactor in eukaryotic cells that plays a critical role in regulating cellular metabolism and energy homeostasis. NAD+ in its reduced form (i.e. NADH) serves as the primary electron donor in mitochondrial respiratory chain, which involv ...
Signal transduction
Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.