Renin Precursor Synthesis and Renin
... If pure submaxillary renin is mixed with mouse plasma it does not bind to other proteins. This facilitates its enzymatic activity in mouse plasma, but does not offer an explanation for the highmolecular-weight forms. In order to mimic complex-formation of renin with plasma proteins 1251-labelled pur ...
... If pure submaxillary renin is mixed with mouse plasma it does not bind to other proteins. This facilitates its enzymatic activity in mouse plasma, but does not offer an explanation for the highmolecular-weight forms. In order to mimic complex-formation of renin with plasma proteins 1251-labelled pur ...
INTERNATIONAL WORKSHOP
... secreted growth and differentiation factors that is expressed predominantly in skeletal muscle. Deletion of myostatin causes a dramatic and widespread increase in skeletal muscle mass due to an increase in both number and size of muscle fibers, particularly the fast glycolytic (type IIB) fibers. Con ...
... secreted growth and differentiation factors that is expressed predominantly in skeletal muscle. Deletion of myostatin causes a dramatic and widespread increase in skeletal muscle mass due to an increase in both number and size of muscle fibers, particularly the fast glycolytic (type IIB) fibers. Con ...
Chapter 16—Probes for Endocytosis, Receptors and Ion Channels
... 16.1 Probes for Following Receptor Binding and Phagocytosis The plasma membrane defines the inside and outside of the cell. It not only encloses the cytosol to maintain the intracellular environment but also serves as a formidable barrier to the extracellular environment. Because cells require input ...
... 16.1 Probes for Following Receptor Binding and Phagocytosis The plasma membrane defines the inside and outside of the cell. It not only encloses the cytosol to maintain the intracellular environment but also serves as a formidable barrier to the extracellular environment. Because cells require input ...
The Role of the Plant Nucleolus in Pre-mRNA Processing
... are organised in gene clusters and expressed as polycistronic precursor snoRNAs (Brown et al. 2003). The detection of these polycistronic precursors in CBs and the nucleolus by in situ hybridisation suggests that processing occurs in both locations and/or that pre-snoRNAs traffic to the nucleolus vi ...
... are organised in gene clusters and expressed as polycistronic precursor snoRNAs (Brown et al. 2003). The detection of these polycistronic precursors in CBs and the nucleolus by in situ hybridisation suggests that processing occurs in both locations and/or that pre-snoRNAs traffic to the nucleolus vi ...
File
... First, sodium, potassium, and chloride ions are the most important ions involved in the development of membrane potentials in nerve and muscle fibers, as well as in the neuronal cells in the nervous system. The concentration gradient of each of these ions across the membrane helps determine the volt ...
... First, sodium, potassium, and chloride ions are the most important ions involved in the development of membrane potentials in nerve and muscle fibers, as well as in the neuronal cells in the nervous system. The concentration gradient of each of these ions across the membrane helps determine the volt ...
Inhibition of c-myc Expression in Cells by Targeting an RNA
... can lead to sequence-independent effects that in part may be attributable to affinity for extracellular proteins such as heparin and fibronectin (Chavany et al., 1995; Stein, 1995; Khaled et al., 1996). Nonspecific activity is enhanced by the presence of two short sequence motifs, the G quartet and ...
... can lead to sequence-independent effects that in part may be attributable to affinity for extracellular proteins such as heparin and fibronectin (Chavany et al., 1995; Stein, 1995; Khaled et al., 1996). Nonspecific activity is enhanced by the presence of two short sequence motifs, the G quartet and ...
Transcriptional Regulation of Metabolism
... Our knowledge of metabolism mainly results from the long-standing and very extensive work of a myriad of biochemists. They first achieved the identification of enzymatic steps, their functional characterization, and the discovery of regulatory loops with which they are associated. For decades, allos ...
... Our knowledge of metabolism mainly results from the long-standing and very extensive work of a myriad of biochemists. They first achieved the identification of enzymatic steps, their functional characterization, and the discovery of regulatory loops with which they are associated. For decades, allos ...
Hypothalamus - aHuman Project
... ¾How does it all come together? • Increased blood osmolarity causes osmosensitive OVLT neurons to shrink • TRPV1 channels open, leading to depolarisation and eventually firing of OVLT neurons (graded response) ...
... ¾How does it all come together? • Increased blood osmolarity causes osmosensitive OVLT neurons to shrink • TRPV1 channels open, leading to depolarisation and eventually firing of OVLT neurons (graded response) ...
Glycolysis and Anaerobic Respiration Lecture Notes
... through additional biochemical pathways that occur in the cytosol. • The combination of glycolysis pulse these additional pathways is called fermentation. • Fermentation does not produce any additional ATP but it does regenerate NAD+ which is used to keep glycolysis ...
... through additional biochemical pathways that occur in the cytosol. • The combination of glycolysis pulse these additional pathways is called fermentation. • Fermentation does not produce any additional ATP but it does regenerate NAD+ which is used to keep glycolysis ...
Sperm entry is sufficient to trigger division of the
... embryo surrounded by an endosperm-like tissue. The endospermlike tissue does not express paternally provided reporters, which led to the proposal that the single cdka;1 sperm cell causes preferential fertilization of the egg cell, producing an embryo that triggers autonomous division in the central ...
... embryo surrounded by an endosperm-like tissue. The endospermlike tissue does not express paternally provided reporters, which led to the proposal that the single cdka;1 sperm cell causes preferential fertilization of the egg cell, producing an embryo that triggers autonomous division in the central ...
Structural Basis for Bivalent Smac-Mimetics Recognition in the IAP
... compound 3, proving that the enhanced affinity of compound 3 for lkBIR2BIR3 is due to simultaneous binding of the divalent molecule to two distinct protein domains. Cell based inhibition assays Compounds 2 and 3 were tested for 72 h on HL60 leukemia cells. The results given in Table 1 indicate that ...
... compound 3, proving that the enhanced affinity of compound 3 for lkBIR2BIR3 is due to simultaneous binding of the divalent molecule to two distinct protein domains. Cell based inhibition assays Compounds 2 and 3 were tested for 72 h on HL60 leukemia cells. The results given in Table 1 indicate that ...
Root Hairs. Plant Cell Monographs.
... was purified and found to be glycosylated. It was estimated to be about 32 kDa when glycosylated and has an isoelectric point of about 6.4. However, only the N-terminal region was sequenced, and no homology was observed to any other proteins other than a germin (Matthysse and Kijne 1998). Germins ar ...
... was purified and found to be glycosylated. It was estimated to be about 32 kDa when glycosylated and has an isoelectric point of about 6.4. However, only the N-terminal region was sequenced, and no homology was observed to any other proteins other than a germin (Matthysse and Kijne 1998). Germins ar ...
Organic Chemistry Notes Student
... A. Carbohydrates - ______________________________________ Monosaccharides are the simplest ______________________. • The carbohydrate monomers are ___________________ • A monosaccharide has a formula that is a multiple of CH2O ______________________ ...
... A. Carbohydrates - ______________________________________ Monosaccharides are the simplest ______________________. • The carbohydrate monomers are ___________________ • A monosaccharide has a formula that is a multiple of CH2O ______________________ ...
Brock Biology of Microorganisms, 14e (Madigan et al.) Chapter 2
... 5) Both hydrophilic and charged molecules readily diffuse through the cytoplasmic membrane. Answer: FALSE Bloom's Taxonomy: Comprehension Chapter Section: 2.9 6) ATP-binding cassette transport systems have high substrate affinity and thus help microorganisms survive in low nutrient environments. Ans ...
... 5) Both hydrophilic and charged molecules readily diffuse through the cytoplasmic membrane. Answer: FALSE Bloom's Taxonomy: Comprehension Chapter Section: 2.9 6) ATP-binding cassette transport systems have high substrate affinity and thus help microorganisms survive in low nutrient environments. Ans ...
Lipid Microdomains in Synapse Formation
... been shown to exist in cell plasma membranes.1,2 They are responsible for a number of cellular processes including regulation of signaling molecules, neuronal outgrowth, axonal guidance, and synaptic transmission.3−7 Such microdomains consist of both protein and lipid components with an enrichment o ...
... been shown to exist in cell plasma membranes.1,2 They are responsible for a number of cellular processes including regulation of signaling molecules, neuronal outgrowth, axonal guidance, and synaptic transmission.3−7 Such microdomains consist of both protein and lipid components with an enrichment o ...
Biochemistry 7/e
... Degradation of stored glycogen (glycogenolysis) occurs through the action of glycogen phosphorylase. The action of phosphorylase is to phosphorolytically remove single glucose residues from a-(1,4)-linkages within the glycogen molecules. The product of this reaction is glucose-1-phosphate. The ...
... Degradation of stored glycogen (glycogenolysis) occurs through the action of glycogen phosphorylase. The action of phosphorylase is to phosphorolytically remove single glucose residues from a-(1,4)-linkages within the glycogen molecules. The product of this reaction is glucose-1-phosphate. The ...
Immunohistochemical description of the endogenous cannabinoid
... Analysis of the CB1 receptor expression in the rat brain by in situ hybridization histochemistry and immunocytochemistry has provided important insights into the functional neuroanatomy of the endocannabinoid system (Matsuda et al., 1993; Pettit et al., 1998; Egertová and Elphick, 2000; Van Sickle ...
... Analysis of the CB1 receptor expression in the rat brain by in situ hybridization histochemistry and immunocytochemistry has provided important insights into the functional neuroanatomy of the endocannabinoid system (Matsuda et al., 1993; Pettit et al., 1998; Egertová and Elphick, 2000; Van Sickle ...
mTORC1 Activates SREBP-1c and Uncouples Lipogenesis From Gluconeogenesis Please share
... PNAS, Li et al. (3) identify a bifurcation point in the insulin-signaling pathway that could help resolve this important paradox. The liver plays a central role in controlling metabolic homeostasis by serving as a key site for glucose and lipid metabolism. In insulin-sensitive hepatocytes, insulin b ...
... PNAS, Li et al. (3) identify a bifurcation point in the insulin-signaling pathway that could help resolve this important paradox. The liver plays a central role in controlling metabolic homeostasis by serving as a key site for glucose and lipid metabolism. In insulin-sensitive hepatocytes, insulin b ...
NIH Public Access - The Scripps Research Institute
... 4°C over 60 min, methionine biosynthetic inhibitory amino acids (25 mg/L each L-valine, Lisoleucine, L-leucine, L-lysine, L-threonine, L-pheynlalanine) and 90 mg/L of Lselenomethionine (Medicillin, catalog number MD045004D) were added. Gene expression was then induced by addition of isopropyl-β-D-th ...
... 4°C over 60 min, methionine biosynthetic inhibitory amino acids (25 mg/L each L-valine, Lisoleucine, L-leucine, L-lysine, L-threonine, L-pheynlalanine) and 90 mg/L of Lselenomethionine (Medicillin, catalog number MD045004D) were added. Gene expression was then induced by addition of isopropyl-β-D-th ...
Full Text - Labs / Projects - Fred Hutchinson Cancer Research Center
... DNA sequences, LUN (23) (Fig. 1D). Like human Topors, CG15104 interacted with Drosophila topoisomerase I and p53 (Dmp53) in vitro (Fig. 1A; see Fig. 3A). On the basis of this similarity and the conserved binding activities, we have named this Drosophila protein dTopors. The human and Drosophila Topo ...
... DNA sequences, LUN (23) (Fig. 1D). Like human Topors, CG15104 interacted with Drosophila topoisomerase I and p53 (Dmp53) in vitro (Fig. 1A; see Fig. 3A). On the basis of this similarity and the conserved binding activities, we have named this Drosophila protein dTopors. The human and Drosophila Topo ...
Serotonin 1B Receptor Modulates Frequency Response Curves and
... Neuromodulatory signals such as serotonin are broadly released in the brain in response to changes in internal state (Trulson and Jacobs 1979, 1981) but transform the response properties of sensory neurons in highly specific ways (Hurley et al. 2004; Mooney et al. 1996; Xiang and Prince 2003). This ...
... Neuromodulatory signals such as serotonin are broadly released in the brain in response to changes in internal state (Trulson and Jacobs 1979, 1981) but transform the response properties of sensory neurons in highly specific ways (Hurley et al. 2004; Mooney et al. 1996; Xiang and Prince 2003). This ...
Structural Mechanisms for Regulation of Membrane
... structural basis for regulation of membrane traffic by Rab GTPases has expanded considerably. This review highlights structural insights regarding the mechanisms for membrane targeting, regulation of the GTPase cycle, interaction with effectors and specificity determination. ...
... structural basis for regulation of membrane traffic by Rab GTPases has expanded considerably. This review highlights structural insights regarding the mechanisms for membrane targeting, regulation of the GTPase cycle, interaction with effectors and specificity determination. ...
A painful TR(i)P to lysosomes
... of TRPA1-mediated Ca2+ responses: Complete removal of external Ca2+ failed to abolish AITC-induced [Ca2+]i increase and neuropeptide release in DRG neurons. Blocking TRPA1 channels with ruthenium red, a membrane-impermeable blocker, was also ineffective. However, the AITC-induced responses were enti ...
... of TRPA1-mediated Ca2+ responses: Complete removal of external Ca2+ failed to abolish AITC-induced [Ca2+]i increase and neuropeptide release in DRG neurons. Blocking TRPA1 channels with ruthenium red, a membrane-impermeable blocker, was also ineffective. However, the AITC-induced responses were enti ...
Evolutionarily conserved recognition and innate immunity to fungal
... with C. neoformans for 2 h in the presence of blocking antiSCARF1 antibodies showed an ⵑ55–60% reduction in binding (Fig. 3 d and not depicted), confirming that SCARF1 can mediate binding of mammalian cells to this pathogen. Staining of peritoneal macrophages with anti-SCARF1 antibodies confirmed co ...
... with C. neoformans for 2 h in the presence of blocking antiSCARF1 antibodies showed an ⵑ55–60% reduction in binding (Fig. 3 d and not depicted), confirming that SCARF1 can mediate binding of mammalian cells to this pathogen. Staining of peritoneal macrophages with anti-SCARF1 antibodies confirmed co ...
Signal transduction
Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.