Light behind the curtain: photoregulation of nuclear architecture and
... plasticity. Plants sense light through the action of specialized photoreceptor protein families that absorb different wavelengths and intensities of light. Recent discoveries in the area of photobiology have uncovered photoreversible changes in nuclear organization correlated with transcriptional re ...
... plasticity. Plants sense light through the action of specialized photoreceptor protein families that absorb different wavelengths and intensities of light. Recent discoveries in the area of photobiology have uncovered photoreversible changes in nuclear organization correlated with transcriptional re ...
Retinoic Acid and the Development of the Endoderm
... the importance in regulating the activity of the receptor [71,72]. Specifically, deleting an RARγ2 in mouse ES cells and replacing it with the same receptor, but with mutated phospho-acceptor sites, demonstrated that phosphorylation was necessary for differentiation of these cells into neurons. In a ...
... the importance in regulating the activity of the receptor [71,72]. Specifically, deleting an RARγ2 in mouse ES cells and replacing it with the same receptor, but with mutated phospho-acceptor sites, demonstrated that phosphorylation was necessary for differentiation of these cells into neurons. In a ...
Paracetamol (Acetaminophen): mechanisms of action
... tone’ of different cells, explains paracetamol’s lack of platelet and anti-inflammatory effects. An active metabolite has been identified in mice. This metabolite (p-aminophenol) is then conjugated with arachidonic acid by fatty acid amide hydrolase to form AM404. AM404 exerts effect through CB rece ...
... tone’ of different cells, explains paracetamol’s lack of platelet and anti-inflammatory effects. An active metabolite has been identified in mice. This metabolite (p-aminophenol) is then conjugated with arachidonic acid by fatty acid amide hydrolase to form AM404. AM404 exerts effect through CB rece ...
Plant pathogen defense: Signalling, resistance and cell
... Utilization of plants have played a major role throughout the evolution of humans, and shaped the development of human society in profound ways. Plants provide essential nutritional value, act as medicinal resources as well as being used for recreational purposes and as building material. Since the ...
... Utilization of plants have played a major role throughout the evolution of humans, and shaped the development of human society in profound ways. Plants provide essential nutritional value, act as medicinal resources as well as being used for recreational purposes and as building material. Since the ...
Cellular and molecular mechanisms of sex differences in renal
... group has shown that TNF is involved in apoptosis after renal I/R and that p38 mitogen activated protein kinase (MAPK) and nuclear factor kappa B are crucial for TNF ...
... group has shown that TNF is involved in apoptosis after renal I/R and that p38 mitogen activated protein kinase (MAPK) and nuclear factor kappa B are crucial for TNF ...
Essays41 Chap03 - Essays in Biochemistry
... evolved from the same predecessor. The most primitive archaeal proteasomes contain just one - and one -subunit and their subunit stoichiometry is therefore 7,7,7,7. During evolution, each of these two subunits diverged into seven different - and -subunits, resulting in a stoichiometry of 1– ...
... evolved from the same predecessor. The most primitive archaeal proteasomes contain just one - and one -subunit and their subunit stoichiometry is therefore 7,7,7,7. During evolution, each of these two subunits diverged into seven different - and -subunits, resulting in a stoichiometry of 1– ...
Tese Hugo Fraga
... and culture médium supplementation with plant growth regulators are known to affect DNA methylation and protein expression profiles, modulating the phenotype and/or the embryogenic potential. In this context, the aim of this study was to deepen the knowledge about SE and EC cryopreservation of A. an ...
... and culture médium supplementation with plant growth regulators are known to affect DNA methylation and protein expression profiles, modulating the phenotype and/or the embryogenic potential. In this context, the aim of this study was to deepen the knowledge about SE and EC cryopreservation of A. an ...
The mechanism of redox sensing in Mycobacterium tuberculosis
... The role of ROS in TB pathogenesis is highlighted by the observation that alveolar macrophages and blood monocytes obtained from active TB patients produce significantly reduced levels of ROS upon Mtb infection compared with cells from healthy individuals [10,11]. This decrease in ROS is related to t ...
... The role of ROS in TB pathogenesis is highlighted by the observation that alveolar macrophages and blood monocytes obtained from active TB patients produce significantly reduced levels of ROS upon Mtb infection compared with cells from healthy individuals [10,11]. This decrease in ROS is related to t ...
A Cellular Adventure
... Lysosome: Yeah, I do get very full. Sometimes I feel like I’m going to burst. All of the organelles mumble “Oh, no… don’t burst!” Ryan: Well, what’s wrong with that? Lysosome: Remember when I said that I was full of digestive enzymes? Ryan: Yeah, but what does that have to do with anything? Lysosom ...
... Lysosome: Yeah, I do get very full. Sometimes I feel like I’m going to burst. All of the organelles mumble “Oh, no… don’t burst!” Ryan: Well, what’s wrong with that? Lysosome: Remember when I said that I was full of digestive enzymes? Ryan: Yeah, but what does that have to do with anything? Lysosom ...
The Other Lives of Ribosomal Proteins - PDXScholar
... Cellular mRNAs are produced in the nucleus and exported to the cytoplasm through nuclear pore complexes (NPC) that are found in the nuclear membrane. The correctly processed mRNAs are exported in the form of messenger ribonucleoproteins (mRNPs). Since the NPC allows the passage of only one mRNA mole ...
... Cellular mRNAs are produced in the nucleus and exported to the cytoplasm through nuclear pore complexes (NPC) that are found in the nuclear membrane. The correctly processed mRNAs are exported in the form of messenger ribonucleoproteins (mRNPs). Since the NPC allows the passage of only one mRNA mole ...
Kidins220/ARMS downregulation by excitotoxic activation of
... Fig. 2. Excitotoxic stimulation of NMDARs containing NR2B subunits induces a rapid and irreversible downregulation of Kidins220/ARMS levels in neurons. (A) Cortical neurons were stimulated with high concentrations of NMDA (100 μM) and the co-agonist glycine (10 μM) for various periods of time. The p ...
... Fig. 2. Excitotoxic stimulation of NMDARs containing NR2B subunits induces a rapid and irreversible downregulation of Kidins220/ARMS levels in neurons. (A) Cortical neurons were stimulated with high concentrations of NMDA (100 μM) and the co-agonist glycine (10 μM) for various periods of time. The p ...
Choreography of Transcriptomes and Lipidomes of
... However, none of these clusters was specialized or enriched with a specific functional group; on the contrary, many genes with the same functions were found in the different clusters. Regulation of the lipid metabolism genes and pathways will be discussed in detail in the corresponding sections below ...
... However, none of these clusters was specialized or enriched with a specific functional group; on the contrary, many genes with the same functions were found in the different clusters. Regulation of the lipid metabolism genes and pathways will be discussed in detail in the corresponding sections below ...
Interim Report and Unaudited Accounts 2008
... proprietary siRNA chemistry. RTP801i-14, which is being developed by Pfizer and Quark Pharmaceuticals for the treatment of Age-related Macular Degeneration (AMD), moved into human clinical phase II trials whereas AKIi-5 developed by Quark Pharmaceuticals for the treatment of Acute Kidney Injury is c ...
... proprietary siRNA chemistry. RTP801i-14, which is being developed by Pfizer and Quark Pharmaceuticals for the treatment of Age-related Macular Degeneration (AMD), moved into human clinical phase II trials whereas AKIi-5 developed by Quark Pharmaceuticals for the treatment of Acute Kidney Injury is c ...
Transport of dicarboxylates in Saccharomyces cerevisiae
... the L-malate concentration in the culture medium was increased by 21.6 ± 7.6 µM after 12 h of the cell growth. After 1.4 h the cell isolation, succinate activated the respiration only by 13%. However, with the increase in the L-malate level in the cells and decrease in the oxaloacetate concentration ...
... the L-malate concentration in the culture medium was increased by 21.6 ± 7.6 µM after 12 h of the cell growth. After 1.4 h the cell isolation, succinate activated the respiration only by 13%. However, with the increase in the L-malate level in the cells and decrease in the oxaloacetate concentration ...
Determination of De Novo Synthesized Amino Acids in Cellular
... proline was largely decreased. Apparently, hypoosmotic conditions stimulate the synthesis of proteins or peptides with a high proline content. The results show that already after 2 h of incubation with [U-13C]glucose there is a pronounced flux of 13C label into the cellular proteins, which is usuall ...
... proline was largely decreased. Apparently, hypoosmotic conditions stimulate the synthesis of proteins or peptides with a high proline content. The results show that already after 2 h of incubation with [U-13C]glucose there is a pronounced flux of 13C label into the cellular proteins, which is usuall ...
The Calcium Nutrition of Cotton
... cycle. In experiments in which 45 day old cotton plants were transferred from complete to calcium deficient solutions, the plants were permanently wilted within eight days after the transfer. In contrast, similar plants continued growth for considerable periods and even produced bolls when transferr ...
... cycle. In experiments in which 45 day old cotton plants were transferred from complete to calcium deficient solutions, the plants were permanently wilted within eight days after the transfer. In contrast, similar plants continued growth for considerable periods and even produced bolls when transferr ...
MAPK Phosphatase AP2C3 Induces Ectopic Proliferation of
... regulates environmental responses and developmental processes in all eukaryotes. Signal-induced phosphorylation of MAPKs increases their activity [1], while dephosphorylation by protein phosphatases reverts the MAPK modules to an inactive state, signifying MAPK phosphatases as part of the mechanisms ...
... regulates environmental responses and developmental processes in all eukaryotes. Signal-induced phosphorylation of MAPKs increases their activity [1], while dephosphorylation by protein phosphatases reverts the MAPK modules to an inactive state, signifying MAPK phosphatases as part of the mechanisms ...
Computational Models Reveal a Passive Mechanism for Cell
... cells should prevent extensive movement between lateral neighbours, and therefore mitotic pressure is unlikely to induce columnar movement [37]. Secondly, while circadian rhythms in migration velocity both within crypts and on small intestinal villi have been measured, there is no direct correlation ...
... cells should prevent extensive movement between lateral neighbours, and therefore mitotic pressure is unlikely to induce columnar movement [37]. Secondly, while circadian rhythms in migration velocity both within crypts and on small intestinal villi have been measured, there is no direct correlation ...
ABSTRACT Title of Thesis: EXPLORING THE ROLE OF NFκB
... The members (past and present) of the Wu lab have helped me in many ways. In particular, Subhamoy Pal and Katherine Randle have trained me in countless laboratory techniques, and were always quick to help when I had any sort of problems. I have also received a great deal of assistance from Dr. Eric ...
... The members (past and present) of the Wu lab have helped me in many ways. In particular, Subhamoy Pal and Katherine Randle have trained me in countless laboratory techniques, and were always quick to help when I had any sort of problems. I have also received a great deal of assistance from Dr. Eric ...
Role of the ABC Transporter Ste6 in Cell Fusion during Yeast
... The Ste6 protein is a member of the ABC-cassette transporter family related to the mammalian multidrug resistance (mdr) protein and the cystic fibrosis CFTR protein (16, 23, 31). The farnesylated and methylated peptide pheromone a-factor is exported directly from the cell by the Ste6 transporter and ...
... The Ste6 protein is a member of the ABC-cassette transporter family related to the mammalian multidrug resistance (mdr) protein and the cystic fibrosis CFTR protein (16, 23, 31). The farnesylated and methylated peptide pheromone a-factor is exported directly from the cell by the Ste6 transporter and ...
Musings on the Wanderer: What`s New in Our Understanding of
... (46) examined the terminal fields formed by regenerating axons and endings. These investigators reported marked differences in the regenerative capacities of the afferent and efferent arms of the vagus under the same surgical and maintenance conditions. It was demonstrated that, in the rat, vagal af ...
... (46) examined the terminal fields formed by regenerating axons and endings. These investigators reported marked differences in the regenerative capacities of the afferent and efferent arms of the vagus under the same surgical and maintenance conditions. It was demonstrated that, in the rat, vagal af ...
Changes in the Nuclear Envelope Environment Affect
... nuclear pore complexes, the inner and outer nuclear membranes must fuse to allow insertion into the nuclear envelope. Yeast and vertebrate nuclear pore complexes each have four pore membrane (POM) nucleoporins containing transmembrane domains. Other nucleoporins have motifs with potential for bendin ...
... nuclear pore complexes, the inner and outer nuclear membranes must fuse to allow insertion into the nuclear envelope. Yeast and vertebrate nuclear pore complexes each have four pore membrane (POM) nucleoporins containing transmembrane domains. Other nucleoporins have motifs with potential for bendin ...
FKBP12-rapamycin-associated protein associates
... A rapamycin-resistant allele of p70S6K generated by truncating its N and C termini (NTCT-p70S6K) has proved to be a valuable reagent in segregating the p70S6K regulatory signals (5). NTCT-p70S6K is sensitive to kinase-directed signals initiated by mitogens and growth factors, but it is insensitive t ...
... A rapamycin-resistant allele of p70S6K generated by truncating its N and C termini (NTCT-p70S6K) has proved to be a valuable reagent in segregating the p70S6K regulatory signals (5). NTCT-p70S6K is sensitive to kinase-directed signals initiated by mitogens and growth factors, but it is insensitive t ...
- Wiley Online Library
... responses mediated by the fungal protein ethylene-inducing xylanase (EIX). The movement of FYVE-positive endosomes before and after EIX application was examined using spinning disc confocal microscopy. We found that while FYVE-positive endosomes generally observe a random movement pattern, following ...
... responses mediated by the fungal protein ethylene-inducing xylanase (EIX). The movement of FYVE-positive endosomes before and after EIX application was examined using spinning disc confocal microscopy. We found that while FYVE-positive endosomes generally observe a random movement pattern, following ...
A Critical Role for Egr-1 Characterization of CD44 Induction by IL-1:
... reporter gene, CAT. Confluent ECV304 cell monolayers were resuspended after trypsinization in PBS in 0.4-cm electroporation cuvettes (Invitrogen, Groningen, The Netherlands). A total of 10 mg plasmid DNA was added to cells. After mixing, cells were left on ice for 10 min before transfection by elect ...
... reporter gene, CAT. Confluent ECV304 cell monolayers were resuspended after trypsinization in PBS in 0.4-cm electroporation cuvettes (Invitrogen, Groningen, The Netherlands). A total of 10 mg plasmid DNA was added to cells. After mixing, cells were left on ice for 10 min before transfection by elect ...
Signal transduction
Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.