Epoxyeicosatrienoic Acids Increase Intracellular
... attributed to activation of vascular smooth muscle cell (SMC) K1 channels. However, in some cells, EETs activate Ca21 channels, resulting in Ca21 influx and increased intracellular Ca21 concentration ([Ca21]i). We investigated whether EETs also can activate Ca21 channels in vascular SMC and whether ...
... attributed to activation of vascular smooth muscle cell (SMC) K1 channels. However, in some cells, EETs activate Ca21 channels, resulting in Ca21 influx and increased intracellular Ca21 concentration ([Ca21]i). We investigated whether EETs also can activate Ca21 channels in vascular SMC and whether ...
BDNF-induced local protein synthesis and synaptic
... hnRNPA2 (Muslimov et al., 2011). In a recent study, the guanine (G)-quadruplex structures present in the 30 UTRs of CaMKIIa and PSD95 mRNAs were shown to direct these transcripts into dendrites (Subramanian et al., 2011). Taken together, these results demonstrate that the RNA structure adopted by th ...
... hnRNPA2 (Muslimov et al., 2011). In a recent study, the guanine (G)-quadruplex structures present in the 30 UTRs of CaMKIIa and PSD95 mRNAs were shown to direct these transcripts into dendrites (Subramanian et al., 2011). Taken together, these results demonstrate that the RNA structure adopted by th ...
Homeostasis of glucose
... 5.Increase in Ca++ causes microtubules to contract which moves insulin vesicles to the cell surface for dumping Supporting this theory: 1. Hyperpolarization diminishes secretion of insulin 2. Certain hypoglycemic agents promote insulin secretion by decreasing K+ conductance ...
... 5.Increase in Ca++ causes microtubules to contract which moves insulin vesicles to the cell surface for dumping Supporting this theory: 1. Hyperpolarization diminishes secretion of insulin 2. Certain hypoglycemic agents promote insulin secretion by decreasing K+ conductance ...
THE DYNAMIN SUPERFAMILY: UNIVERSAL MEMBRANE
... nerve terminals114. This might be because uncoating of endocytic profiles occurs independently of scission. Indeed, the uptake of transferrin in COS cells is clathrindependent and mutants of dynamin that slow the scission reaction give rise to trapped vesicles that no longer have a clathrin coat87. ...
... nerve terminals114. This might be because uncoating of endocytic profiles occurs independently of scission. Indeed, the uptake of transferrin in COS cells is clathrindependent and mutants of dynamin that slow the scission reaction give rise to trapped vesicles that no longer have a clathrin coat87. ...
Modification-specific proteomics: Strategies for characterization of
... for identifying candidate substrate proteins for certain types of PTM, such as tyrosine phosphorylation. However, the small size of the structural motifs of other common PTMs (for example, protein methylation and acetylation) makes it difficult to generate pan-specific antibodies, which recognize PT ...
... for identifying candidate substrate proteins for certain types of PTM, such as tyrosine phosphorylation. However, the small size of the structural motifs of other common PTMs (for example, protein methylation and acetylation) makes it difficult to generate pan-specific antibodies, which recognize PT ...
AMPA Receptors Are Involved in Store-Operated Calcium
... The process of store-operated calcium entry (SOCE) leads to refilling the endoplasmic reticulum (ER) with calcium ions (Ca2+ ) after their release into the cytoplasm. Interactions between (ER)-located Ca2+ sensors (stromal interaction molecule 1 [STIM1] and STIM2) and plasma membrane-located Ca2+ ch ...
... The process of store-operated calcium entry (SOCE) leads to refilling the endoplasmic reticulum (ER) with calcium ions (Ca2+ ) after their release into the cytoplasm. Interactions between (ER)-located Ca2+ sensors (stromal interaction molecule 1 [STIM1] and STIM2) and plasma membrane-located Ca2+ ch ...
A new fusion hypothesis for the origin of Eukarya: better than
... (the Last Eukaryal Common Ancestor) (Fig. 1A). This lineage might be as ancient as those that led to Bacteria and Archaea. In this scenario, FECA (the First Eukaryal Common Ancestor) might have even predated the divergence of the various phyla of modern archaea and bacteria (Fig. 1A). In contrast, i ...
... (the Last Eukaryal Common Ancestor) (Fig. 1A). This lineage might be as ancient as those that led to Bacteria and Archaea. In this scenario, FECA (the First Eukaryal Common Ancestor) might have even predated the divergence of the various phyla of modern archaea and bacteria (Fig. 1A). In contrast, i ...
PAK1 Mediates Resistance to PI3 Kinase Inhibition in Lymphomas
... patients in the United States alone (1). These tumors are molecularly and clinically heterogeneous, with dramatically different responses and outcomes with standard therapies. While some patients can be cured of their disease with standard regimens, the majority of these patients relapse and eventua ...
... patients in the United States alone (1). These tumors are molecularly and clinically heterogeneous, with dramatically different responses and outcomes with standard therapies. While some patients can be cured of their disease with standard regimens, the majority of these patients relapse and eventua ...
Fibrous proteins and collagen
... Each fibrous protein exhibits special mechanical properties, resulting from its unique structure, which are obtained by combining specific amino acids into regular, secondary structural elements. This is in contrast to globular proteins, whose shapes are the result of complex interactions between se ...
... Each fibrous protein exhibits special mechanical properties, resulting from its unique structure, which are obtained by combining specific amino acids into regular, secondary structural elements. This is in contrast to globular proteins, whose shapes are the result of complex interactions between se ...
This is the accepted version of the following article:
... hyperphosphorylated, insoluble and filamentous tau protein is a common feature of many human neurodegenerative diseases, collectively referred to as tauopathies [3], of which the most common is Alzheimer’s disease (AD) [4]. Additionally, increased phosphorylated tau and total tau levels, combined wi ...
... hyperphosphorylated, insoluble and filamentous tau protein is a common feature of many human neurodegenerative diseases, collectively referred to as tauopathies [3], of which the most common is Alzheimer’s disease (AD) [4]. Additionally, increased phosphorylated tau and total tau levels, combined wi ...
Regulation of the subcellular distribution of key cellular RNA
... Their activity is regulated by phosphorylation of serine residues in the arginine/serine-rich domain by protein ...
... Their activity is regulated by phosphorylation of serine residues in the arginine/serine-rich domain by protein ...
Cellular Respiration Webquest
... Go to: Biology in Motion. Read & complete the activity. (http://www.biologyinmotion.com/atp/index.html) 1. What is ATP? ...
... Go to: Biology in Motion. Read & complete the activity. (http://www.biologyinmotion.com/atp/index.html) 1. What is ATP? ...
of Pseudomonas aeruginosa - BMC Microbiology
... may occur through reversible induction of ampC expression during exposure to certain β-lactams (cephamycins and carbapenems) and β-lactamase inhibitors (clavulanic acid). An important treatment fail occurs when ampC regulation is lost due to de-repression, this condition generally involves genetic m ...
... may occur through reversible induction of ampC expression during exposure to certain β-lactams (cephamycins and carbapenems) and β-lactamase inhibitors (clavulanic acid). An important treatment fail occurs when ampC regulation is lost due to de-repression, this condition generally involves genetic m ...
Charakterisierung peroxisomaler und Lipid
... accumulation of nonpolar lipids and phospholipids upon growth on medium containing oleic acid as a sole carbon source. Ldh1p is thought to play a role in maintaining the lipid homeostasis in yeast by regulating both phospholipid and nonpolar lipid levels. It is known that the peroxisomal matrix prot ...
... accumulation of nonpolar lipids and phospholipids upon growth on medium containing oleic acid as a sole carbon source. Ldh1p is thought to play a role in maintaining the lipid homeostasis in yeast by regulating both phospholipid and nonpolar lipid levels. It is known that the peroxisomal matrix prot ...
The potato tuber mitochondrial proteome
... potato plastidial isoform of adenylate kinase,with which it showed 76% identity, it will ...
... potato plastidial isoform of adenylate kinase,with which it showed 76% identity, it will ...
ER storage diseases: a role for ERGIC
... Why is ERAD unable to cope with certain mutant proteins? A simple explanation would be that their rate of synthesis exceeds the capacity of degradation. However, not all transport-incompetent Ig mutants cause RB biogenesis when degradation is inhibited. Therefore, additional features must be present ...
... Why is ERAD unable to cope with certain mutant proteins? A simple explanation would be that their rate of synthesis exceeds the capacity of degradation. However, not all transport-incompetent Ig mutants cause RB biogenesis when degradation is inhibited. Therefore, additional features must be present ...
Microtubules
... E.g., during prophase of mitosis, microtubules grow out from the centrosome. If the plus end of a microtubule makes contact with a chromosome, the end becomes stabilized. Otherwise rapid disassembly at the plus end ensues, and the tubulin dimers are available for growth of another microtubule. A web ...
... E.g., during prophase of mitosis, microtubules grow out from the centrosome. If the plus end of a microtubule makes contact with a chromosome, the end becomes stabilized. Otherwise rapid disassembly at the plus end ensues, and the tubulin dimers are available for growth of another microtubule. A web ...
Signaling by truncated Dab1 protein - Development
... reelin signaling (Howell et al., 1999a; Rice et al., 1998). This decrease is partly independent of Dab1 tyrosine phosphorylation (Howell et al., 2000), suggesting that some other change induced by activated VLDLR and apoER2, for example, possible serine phosphorylation or relocalization of Dab1, tri ...
... reelin signaling (Howell et al., 1999a; Rice et al., 1998). This decrease is partly independent of Dab1 tyrosine phosphorylation (Howell et al., 2000), suggesting that some other change induced by activated VLDLR and apoER2, for example, possible serine phosphorylation or relocalization of Dab1, tri ...
Capabilities and limitations of gel electrophoresis for elemental
... Native gel electrophoresis is a widely used technique, in which the tertiary structure of the proteins is preserved. Hence, it is often applied if an enzyme has to retain its activity after separation. This is why it is a possible separation technique for metal–protein complexes, which would be dist ...
... Native gel electrophoresis is a widely used technique, in which the tertiary structure of the proteins is preserved. Hence, it is often applied if an enzyme has to retain its activity after separation. This is why it is a possible separation technique for metal–protein complexes, which would be dist ...
thyroid synthesis, mode of action, metabolic functions and disorders
... • Each thyroglobulin molecule contains up to 30 thyroxine molecules and a few triiodothyronine molecules. • Stored Thyroid Hormones maintain the body’s requirement of T3 and T4 for up to 2-3 months Release of Thyroid Hormones • Thyroglobulin itself is not secreted into the circulation • Thyroglobuli ...
... • Each thyroglobulin molecule contains up to 30 thyroxine molecules and a few triiodothyronine molecules. • Stored Thyroid Hormones maintain the body’s requirement of T3 and T4 for up to 2-3 months Release of Thyroid Hormones • Thyroglobulin itself is not secreted into the circulation • Thyroglobuli ...
MEF2 responds to multiple calciumregulated signals in the control of
... neuron over ®ber type-speci®c gene expression is demonstrated most clearly by experiments in which crossinnervation or electrical pacing can convert one myo®ber subtype to another (Romanul and Van der Meulen, 1966; Williams et al., 1986; Pette and Vrbova, 1992). Although our understanding of muscle ...
... neuron over ®ber type-speci®c gene expression is demonstrated most clearly by experiments in which crossinnervation or electrical pacing can convert one myo®ber subtype to another (Romanul and Van der Meulen, 1966; Williams et al., 1986; Pette and Vrbova, 1992). Although our understanding of muscle ...
immunodetection of arabinogalactan proteins in different types of
... epitopes recognized by JIM 13 Mab were not detected. In contrast, immunolabelling of G. candicans ovules with JIM 8 Mab was not so clearly detectable as the epitope recognized by JIM 13 Mab. In mature ovules taken from open flowers, unpollinated or 24 h after pollination, JIM 8 Mab labelling produce ...
... epitopes recognized by JIM 13 Mab were not detected. In contrast, immunolabelling of G. candicans ovules with JIM 8 Mab was not so clearly detectable as the epitope recognized by JIM 13 Mab. In mature ovules taken from open flowers, unpollinated or 24 h after pollination, JIM 8 Mab labelling produce ...
Involvement of CD14 and Complement Receptors CR3 and CR4 in
... 100-fold higher LPS concentration, whereas under serum-free conditions, 3C10 completely inhibited LPS-induced TNF release at LPS concentrations of #100 ng/ml (Fig. 1A). 3C10 also decreased GBS-induced TNF production, shifting the GBS dose-response curve about 2- to 5-fold to the right (Fig. 1B). Nei ...
... 100-fold higher LPS concentration, whereas under serum-free conditions, 3C10 completely inhibited LPS-induced TNF release at LPS concentrations of #100 ng/ml (Fig. 1A). 3C10 also decreased GBS-induced TNF production, shifting the GBS dose-response curve about 2- to 5-fold to the right (Fig. 1B). Nei ...
Signal transduction
Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.