Defects in mesoderm, neural tube and vascular development in
... severe defects in mesodermally derived tissues. Notochord and somites are absent; the heart and ...
... severe defects in mesodermally derived tissues. Notochord and somites are absent; the heart and ...
05_chapter 1
... poly(glycolic acid), poly(ethylene glycol), etc. are very promising in the formulation of dosage forms [Kim, 2004]. Chitin, poly (β-(1→4)-N-acetyl-D-glucosamine), first identified in 1884, is a naturally occurring polysaccharide consisting of amino sugars. This biopolymer is synthesized by an extrem ...
... poly(glycolic acid), poly(ethylene glycol), etc. are very promising in the formulation of dosage forms [Kim, 2004]. Chitin, poly (β-(1→4)-N-acetyl-D-glucosamine), first identified in 1884, is a naturally occurring polysaccharide consisting of amino sugars. This biopolymer is synthesized by an extrem ...
Metaplastic carcinoma of the breast: A clinicopathological review
... carcinoma of breast(6). Tumour size is another prognostic factor. Patient with a tumour not larger than 5 cm had a better survival rate. The incidence of Axillary lymphnode metastasis is low in Metaplastic carcinoma (7,8,9,10). These findings suggest that, unlike Invasive carcinoma of breast,Axillar ...
... carcinoma of breast(6). Tumour size is another prognostic factor. Patient with a tumour not larger than 5 cm had a better survival rate. The incidence of Axillary lymphnode metastasis is low in Metaplastic carcinoma (7,8,9,10). These findings suggest that, unlike Invasive carcinoma of breast,Axillar ...
Cross-Presentation Proteases in MHC Class I Presentation and
... Ag presentation. In contrast, only a small minority (,5%) of the peptides generated were of the correct size to bind to any particular MHC class I molecule, whereas a substantially larger fraction (∼20%) of products were too long for stable binding (23). In the one case that has been analyzed, the p ...
... Ag presentation. In contrast, only a small minority (,5%) of the peptides generated were of the correct size to bind to any particular MHC class I molecule, whereas a substantially larger fraction (∼20%) of products were too long for stable binding (23). In the one case that has been analyzed, the p ...
Thesis Reference - Archive ouverte UNIGE
... that have to be eliminated. In this thesis, I will particularly focus on the case of the infection caused by the protozoan parasite Leishmania major, which will be the focus of the third chapter of this introduction. ...
... that have to be eliminated. In this thesis, I will particularly focus on the case of the infection caused by the protozoan parasite Leishmania major, which will be the focus of the third chapter of this introduction. ...
Ccbe1 regulates Vegfc-mediated induction of Vegfr3
... terminus of the protein. The protein localizes to secretory vesicles (Alders et al., 2009), and is secreted to the ECM, where it binds proteins such as collagens or vitronectin (Bos et al., 2011). Consistently, Ccbe1 functions non-cell-autonomously in zebrafish (Hogan et al., 2009a). There are no de ...
... terminus of the protein. The protein localizes to secretory vesicles (Alders et al., 2009), and is secreted to the ECM, where it binds proteins such as collagens or vitronectin (Bos et al., 2011). Consistently, Ccbe1 functions non-cell-autonomously in zebrafish (Hogan et al., 2009a). There are no de ...
high-throughput transient gene expression in plant
... transfection. The plant cell microarray has several potential applications. It is useful as a high-throughput protein production platform for testing and optimizing foreign gene expression, expression of cDNA libraries, gene silencing experiments, creating protein chips, testing metabolic engineerin ...
... transfection. The plant cell microarray has several potential applications. It is useful as a high-throughput protein production platform for testing and optimizing foreign gene expression, expression of cDNA libraries, gene silencing experiments, creating protein chips, testing metabolic engineerin ...
Sample pages 1 PDF
... tion of tissues. Hence, it is always recommended that a fresh formaldehyde solution is made from paraformaldehyde (PFA) powder and used immediately. Glutaraldehyde was introduced by Sabatini et al. in 1963 as an especially useful fixative for ultrastructural studies [22]. This compound has two aldeh ...
... tion of tissues. Hence, it is always recommended that a fresh formaldehyde solution is made from paraformaldehyde (PFA) powder and used immediately. Glutaraldehyde was introduced by Sabatini et al. in 1963 as an especially useful fixative for ultrastructural studies [22]. This compound has two aldeh ...
Mycobacterial hypersensitivity pneumonitis + requires TLR9–MyD88 in lung CD11b + cells
... these cytokine responses were compatible with those reported previously in clinical HP patients (M. avium HP versus non-HP strain; IL-12p40, p,0.01; TNF-a, p,0.05; IFN-c, p,0.01; IL-4, p.0.05; fig. 2c–e and data not shown) [5]. The lungs of mice exposed to M. avium HP strain, but not non-HP strain, ...
... these cytokine responses were compatible with those reported previously in clinical HP patients (M. avium HP versus non-HP strain; IL-12p40, p,0.01; TNF-a, p,0.05; IFN-c, p,0.01; IL-4, p.0.05; fig. 2c–e and data not shown) [5]. The lungs of mice exposed to M. avium HP strain, but not non-HP strain, ...
1 Electrophysiology and pacemaker function of the - AJP
... canine hearts the pacemaker cells are more concentrated in the proximity of the sinus node artery at the junction of the superior vena cava and the right atrium (12, 94, 99). Studies on the cytological organization of the SAN have revealed a structure composed of a dense array of connective tissue i ...
... canine hearts the pacemaker cells are more concentrated in the proximity of the sinus node artery at the junction of the superior vena cava and the right atrium (12, 94, 99). Studies on the cytological organization of the SAN have revealed a structure composed of a dense array of connective tissue i ...
Characterization of Chloroplast Division Using the Arabidopsis
... Leaf primordial cells from arc5 are shown in Figure 4b and cells from Landsberg erecta seedlings are shown in Figure 4d. The number of chloroplast profiles per cell is similar in wild-type and arc5 cells. There is also little difference in plastid morphology, internal thylakoid membrane structure, o ...
... Leaf primordial cells from arc5 are shown in Figure 4b and cells from Landsberg erecta seedlings are shown in Figure 4d. The number of chloroplast profiles per cell is similar in wild-type and arc5 cells. There is also little difference in plastid morphology, internal thylakoid membrane structure, o ...
Amassin, an olfactomedin protein, mediates the massive
... within 50 s and is complete by 150 s (Fig. 1). Clots settle onto the substratum; the cells spread out at the edges of the clots and appear viable for 1–3 d. To study the biochemistry of intercoelomocyte adhesion, we devised a reliable method to prevent clotting. This is accomplished by rapidly mixin ...
... within 50 s and is complete by 150 s (Fig. 1). Clots settle onto the substratum; the cells spread out at the edges of the clots and appear viable for 1–3 d. To study the biochemistry of intercoelomocyte adhesion, we devised a reliable method to prevent clotting. This is accomplished by rapidly mixin ...
Structural requirements of KTS-disintegrins for inhibition of α1β1
... N-terminal part of the α subunit that plays a central role in ligand binding [6], and play an important role in the physiology of many organs and in innate immunity, inflammation and autoimmunity [7]. The αI-domain-containing integrins that mediate direct adhesion to collagens seem to have a relativ ...
... N-terminal part of the α subunit that plays a central role in ligand binding [6], and play an important role in the physiology of many organs and in innate immunity, inflammation and autoimmunity [7]. The αI-domain-containing integrins that mediate direct adhesion to collagens seem to have a relativ ...
Origin of the zebrafish endocrine and exocrine
... embryos that allow cell fates and movements to be traced. In recent years, several studies have revealed that the zebrafish pancreas shares many properties with the mammalian pancreas. Thus, the zebrafish pancreas consists of both an endocrine and an exocrine component (Slack, 1995; Biemar et al., 200 ...
... embryos that allow cell fates and movements to be traced. In recent years, several studies have revealed that the zebrafish pancreas shares many properties with the mammalian pancreas. Thus, the zebrafish pancreas consists of both an endocrine and an exocrine component (Slack, 1995; Biemar et al., 200 ...
5
... Doxorubicin (Dox) is a widely used anticancer drug in the treatment of many types of cancers.1,2 However, systemic administration of Dox itself elicits severe cardiac toxicity due to the lack of ability to target cancer cells, and also shows the multidrug resistance effect.3,4 To improve therapeutic ...
... Doxorubicin (Dox) is a widely used anticancer drug in the treatment of many types of cancers.1,2 However, systemic administration of Dox itself elicits severe cardiac toxicity due to the lack of ability to target cancer cells, and also shows the multidrug resistance effect.3,4 To improve therapeutic ...
Human pluripotent stem cells
... cardiomyocytes, for example, drug discovery and cardiotoxicity screening as currently envisioned by the pharmaceutical industry and regulatory agencies [1–3]. Investigators are already using human PSC-derived cardiomyocytes as in vitro models of incompletely understood monogenic diseases, such as ch ...
... cardiomyocytes, for example, drug discovery and cardiotoxicity screening as currently envisioned by the pharmaceutical industry and regulatory agencies [1–3]. Investigators are already using human PSC-derived cardiomyocytes as in vitro models of incompletely understood monogenic diseases, such as ch ...
The role of AMPK and CREB-1 in the regulation of mitochondrial
... chain complexes. We chose the AMP activated kinase (AMPK) and cyclic AMP-response element binding protein 1 (CREB-1) as promising candidates, which could control the process of mitochondrial proliferation. To analyze whether AMPK regulates the cytochrome c promoter, a cell line stably expressing a c ...
... chain complexes. We chose the AMP activated kinase (AMPK) and cyclic AMP-response element binding protein 1 (CREB-1) as promising candidates, which could control the process of mitochondrial proliferation. To analyze whether AMPK regulates the cytochrome c promoter, a cell line stably expressing a c ...
Evidence for tankyrases as antineoplastic targets in lung cancer
... targeting it for ubiquitination and proteasomal destruction. Ligand binding engages a pathway involving Dishevelled (Dvl) that inhibits GSK3, allowing β-catenin to accumulate in a hypophosphorylated form. This stabilized form of β-catenin can translocate to the nucleus, where it activates target gen ...
... targeting it for ubiquitination and proteasomal destruction. Ligand binding engages a pathway involving Dishevelled (Dvl) that inhibits GSK3, allowing β-catenin to accumulate in a hypophosphorylated form. This stabilized form of β-catenin can translocate to the nucleus, where it activates target gen ...
Enzymatic reduction of disulfide bonds in lysosomes
... optimally active at low pH and capable of catalyzing disulfide bond reduction both in vivo and in vitro. The active site, determined by mutagenesis, consists of a pair of cysteine residues separated by two amino acids, similar to other enzymes of the thioredoxin family. The enzyme is a soluble glyco ...
... optimally active at low pH and capable of catalyzing disulfide bond reduction both in vivo and in vitro. The active site, determined by mutagenesis, consists of a pair of cysteine residues separated by two amino acids, similar to other enzymes of the thioredoxin family. The enzyme is a soluble glyco ...
HISTOLOGICAL AND SEM STUDIES ON ORGANOGENESIS IN
... revealed that smooth-surfaced nodular callus segments of A. deliciosa were covered by a membranous layer. The layer completely covered some parts of the callus but in other regions was torn or partly damaged and had the appearance of a network. These observations correspond with those in a SEM study ...
... revealed that smooth-surfaced nodular callus segments of A. deliciosa were covered by a membranous layer. The layer completely covered some parts of the callus but in other regions was torn or partly damaged and had the appearance of a network. These observations correspond with those in a SEM study ...
Osmotic Water Permeability of Isolated Protoplasts. Modifications
... cell dimensions, induced by an osmoticum change in the external medium. Measurements of Pos by standard light microscopy have been performed on epidermal cells (Url, 1971; Stadelmann and Lee-Stadelmann, 1989) and more recently on mouse oocytes (Gao et al., 1994, 1996). When individual cells cannot b ...
... cell dimensions, induced by an osmoticum change in the external medium. Measurements of Pos by standard light microscopy have been performed on epidermal cells (Url, 1971; Stadelmann and Lee-Stadelmann, 1989) and more recently on mouse oocytes (Gao et al., 1994, 1996). When individual cells cannot b ...
Stem Cell Therapy In Pediatric Neurological Disorders
... muscular dystrophy have been some of them. All the advances in imaging, pharmacology and surgical techniques failed to make a significant dent in the quality of lives of these children. However in the recent few years there has been a development in the field of regenerative medicine whereby stem ce ...
... muscular dystrophy have been some of them. All the advances in imaging, pharmacology and surgical techniques failed to make a significant dent in the quality of lives of these children. However in the recent few years there has been a development in the field of regenerative medicine whereby stem ce ...
A1982PM90100001
... in serum was not always an accurate measure of the degree of folate deficiency since very low results could be obtained in many patients without any haematological evidence of the deficiency. “A number of groups in Israel, Sweden, Canada, Holland, and Britain had already reported assays of whole blo ...
... in serum was not always an accurate measure of the degree of folate deficiency since very low results could be obtained in many patients without any haematological evidence of the deficiency. “A number of groups in Israel, Sweden, Canada, Holland, and Britain had already reported assays of whole blo ...
guideline on development, production, characterisation
... As for any medicinal product, the manufacturing process of a product that has been developed using a platform manufacturing approach should be appropriately validated at the time of marketing authorisation application. Validation studies should include data derived from the final manufacturing proce ...
... As for any medicinal product, the manufacturing process of a product that has been developed using a platform manufacturing approach should be appropriately validated at the time of marketing authorisation application. Validation studies should include data derived from the final manufacturing proce ...
Characterization of a Novel Chemokine
... Finn-Eirik Johansen, Oddmund Bakke and Guttorm Haraldsen ...
... Finn-Eirik Johansen, Oddmund Bakke and Guttorm Haraldsen ...
Cell encapsulation
Cell microencapsulation technology involves immobilization of the cells within a polymeric semi-permeable membrane that permits the bidirectional diffusion of molecules such as the influx of oxygen, nutrients, growth factors etc. essential for cell metabolism and the outward diffusion of waste products and therapeutic proteins. At the same time, the semi-permeable nature of the membrane prevents immune cells and antibodies from destroying the encapsulated cells regarding them as foreign invaders.The main motive of cell encapsulation technology is to overcome the existing problem of graft rejection in tissue engineering applications and thus reduce the need for long-term use of immunosuppressive drugs after an organ transplant to control side effects.