Why cancer cells have a more hyperpolarised mitochondrial
... The fact that there is a disparity in ΨIM between normal and cancer cells is well established and has already been leveraged in human drug trials [40-41]. Delocalized lipophilic cations (DLCs) can cross membranes and their positive charge means they are drawn to, and accumulate in, the mitochondrial ...
... The fact that there is a disparity in ΨIM between normal and cancer cells is well established and has already been leveraged in human drug trials [40-41]. Delocalized lipophilic cations (DLCs) can cross membranes and their positive charge means they are drawn to, and accumulate in, the mitochondrial ...
CRS Newsletter. Volume 25, Number 2. 2008
... taste is a greater determinant of whether the desired dose can be effectively delivered and also of medication compliance and, hence, therapeutic outcome for children (3). Indeed, recent ...
... taste is a greater determinant of whether the desired dose can be effectively delivered and also of medication compliance and, hence, therapeutic outcome for children (3). Indeed, recent ...
Reversible translocation of cytidylyltransferase between cytosol and
... 12-myristate 13-acetate, indicating that hydrolysis can be a rapid process [21]. Since the existence of a phosphatidylcholine cycle was recently proposed [22], it seemed conceivable that, for an efficient regulation of cell metabolism, resynthesis should be regulated in the same range of time as hyd ...
... 12-myristate 13-acetate, indicating that hydrolysis can be a rapid process [21]. Since the existence of a phosphatidylcholine cycle was recently proposed [22], it seemed conceivable that, for an efficient regulation of cell metabolism, resynthesis should be regulated in the same range of time as hyd ...
Detergent-Insoluble Membrane Compartment CD20 Required for Its
... loops. Complete digestion of extracellular regions would be expected to result in either 8- or 15-kDa N-terminal fragments depending on whether the polypeptide is exposed at the cell surface on the carboxyl side of TM1. For these studies we used both trypsin, which cuts specifically on the carboxyli ...
... loops. Complete digestion of extracellular regions would be expected to result in either 8- or 15-kDa N-terminal fragments depending on whether the polypeptide is exposed at the cell surface on the carboxyl side of TM1. For these studies we used both trypsin, which cuts specifically on the carboxyli ...
"Monoclonal Antibodies to Human Cell Surface Antigens". In
... During the last 25 years, large numbers of monoclonal antibodies (MAbs) have been produced that have facilitated the purification and functional characterization of a plethora of leukocyte surface molecules. The antibodies have been even more useful as markers for cell populations, allowing the coun ...
... During the last 25 years, large numbers of monoclonal antibodies (MAbs) have been produced that have facilitated the purification and functional characterization of a plethora of leukocyte surface molecules. The antibodies have been even more useful as markers for cell populations, allowing the coun ...
PDF
... The remainder of the duct and pore lumenal space, as well as the lumen of the canal cell, was filled with fibrous electron-dense material (Fig. 1I,J). This fibrous ECM material disappeared from the duct and pore by 6 hours later, at which time the cuticle lining of the duct and pore had been secrete ...
... The remainder of the duct and pore lumenal space, as well as the lumen of the canal cell, was filled with fibrous electron-dense material (Fig. 1I,J). This fibrous ECM material disappeared from the duct and pore by 6 hours later, at which time the cuticle lining of the duct and pore had been secrete ...
(ECM) Binding Sites on the Basal Surface of Embryonic Corneal
... L-[2,3aH]proline, 23.7 Ci/mmol, New England Nuclear, Boston, MA) or [3H]leucine (30 ~Ci/ml, L-[2,3,4,5-3H]leucine, 120 Ci/mmol, ICN Biomedicals Inc., Irvine, CA). After a 16-24-h incubation, the tissue and media were harvested in 0.01 M Tris (pH 7.4) with 2 mM EDTA and EGTA and protease inhibitors, ...
... L-[2,3aH]proline, 23.7 Ci/mmol, New England Nuclear, Boston, MA) or [3H]leucine (30 ~Ci/ml, L-[2,3,4,5-3H]leucine, 120 Ci/mmol, ICN Biomedicals Inc., Irvine, CA). After a 16-24-h incubation, the tissue and media were harvested in 0.01 M Tris (pH 7.4) with 2 mM EDTA and EGTA and protease inhibitors, ...
Place cell references - The University of Texas at Dallas
... plasticity from experimental measurements is crucial for understanding how neural systems adapt their representations of relevant biological information. Current analysis methods using histogram estimates of spike rate functions in nonoverlapping temporal windows do not track the evolution of recept ...
... plasticity from experimental measurements is crucial for understanding how neural systems adapt their representations of relevant biological information. Current analysis methods using histogram estimates of spike rate functions in nonoverlapping temporal windows do not track the evolution of recept ...
ORDINARy DIFFERENTIAL EqUATIONS AND CELLULAR
... The system evolves over time. The interactions of the agents take place in a certain order. This order should, in principle, not be sequential since agents behave individually in parallel with each other. In practice however, since computers are sequential in nature,the order needs to be serialized ...
... The system evolves over time. The interactions of the agents take place in a certain order. This order should, in principle, not be sequential since agents behave individually in parallel with each other. In practice however, since computers are sequential in nature,the order needs to be serialized ...
Regulative germ cell specification in axolotl embryos: a primitive trait
... urodele embryos PGCs do not develop from predetermined cells. Rather, urodele PGCs appear to develop from unspecialized mesodermal tissue that has responded to appropriate extracellular influences. Therefore the embryos of urodele and anuran amphibians have diverged in the way that they produce PGCs ...
... urodele embryos PGCs do not develop from predetermined cells. Rather, urodele PGCs appear to develop from unspecialized mesodermal tissue that has responded to appropriate extracellular influences. Therefore the embryos of urodele and anuran amphibians have diverged in the way that they produce PGCs ...
Imaging Cell Wall Architecture in Single Zinnia
... directly probe for polysaccharide and aromatic molecules in native as well as treated plant material (Carpita et al., 2001; McCann et al., 2001). FTIR spectromicroscopy is not only able to identify chemical components in a specific system but also can determine their distribution and relative abunda ...
... directly probe for polysaccharide and aromatic molecules in native as well as treated plant material (Carpita et al., 2001; McCann et al., 2001). FTIR spectromicroscopy is not only able to identify chemical components in a specific system but also can determine their distribution and relative abunda ...
Effects of the regulatory proteins MITF and TFEB on
... Autophagy is a fundamental process in cell biology and is an essential part of normal cell function. Autophagy is a degradation pathway in which the cell digests organelles and worn-out parts of itself and is able to recycle metabolites from the digested material. This system is vital for cell clean ...
... Autophagy is a fundamental process in cell biology and is an essential part of normal cell function. Autophagy is a degradation pathway in which the cell digests organelles and worn-out parts of itself and is able to recycle metabolites from the digested material. This system is vital for cell clean ...
LY-294002-inhibitable PI 3-kinase and regulation of baseline rates
... involved in apical membrane Na⫹ entry into the cells that fluctuate spontaneously between open and closed states of the channel. Channel densities are expressed in units of millions of channels per cm2 of planar area or per 100 m2, approximating the planar area occupied by a single cell. It may be ...
... involved in apical membrane Na⫹ entry into the cells that fluctuate spontaneously between open and closed states of the channel. Channel densities are expressed in units of millions of channels per cm2 of planar area or per 100 m2, approximating the planar area occupied by a single cell. It may be ...
Viral Ed - The University of North Carolina at Chapel Hill
... CD4+T-cell Count Associated with Risk of AIDS and Non-AIDS-related Malignancies • Risk factors for fatal AIDS-defining malignancies (ADM) and non-ADM in the D:A:D study – Of 1246 deaths, 112 ADM and 193 non-ADM related ...
... CD4+T-cell Count Associated with Risk of AIDS and Non-AIDS-related Malignancies • Risk factors for fatal AIDS-defining malignancies (ADM) and non-ADM in the D:A:D study – Of 1246 deaths, 112 ADM and 193 non-ADM related ...
Thesis-1972D-H792p
... It should be pointed out that compounds such as penicillin, vancomycin, or D-amino acids which inhibit division activity and cell wall synthesis do not impair DNA synthesis (Grula et al., 1968), Other investigators, (Weidel, Frank, and Martin, 1964) have equated inhibition of cell division, in the p ...
... It should be pointed out that compounds such as penicillin, vancomycin, or D-amino acids which inhibit division activity and cell wall synthesis do not impair DNA synthesis (Grula et al., 1968), Other investigators, (Weidel, Frank, and Martin, 1964) have equated inhibition of cell division, in the p ...
GFP is the way to glow: bioimaging of the plant endomembrane
... with a molecular mass of approximately 27 kDa. It emits green fluorescence upon excitation with UV or blue light. As specific secretory proteins or signals can be fused to GFP, usually without altering their targeting, it is a useful alternative to conventional dyes previously used to investigate en ...
... with a molecular mass of approximately 27 kDa. It emits green fluorescence upon excitation with UV or blue light. As specific secretory proteins or signals can be fused to GFP, usually without altering their targeting, it is a useful alternative to conventional dyes previously used to investigate en ...
University of Groningen Bacillus subtilis at near
... Retentostat cultivation of B. subtilis A bioreactor consists of many parts, and with a typical experimental duration of more than 40 days, there are many risks of failure that render a retentostat cultivation useless for further analysis. A number of adaptations to the retentostat setup, such as the ...
... Retentostat cultivation of B. subtilis A bioreactor consists of many parts, and with a typical experimental duration of more than 40 days, there are many risks of failure that render a retentostat cultivation useless for further analysis. A number of adaptations to the retentostat setup, such as the ...
Antimicrob Agents Chemother
... series of events resulting in the induction of specific genes. The fluoroquinolone antibiotic ciprofloxacin has recently been reported to upregulate interleukin-2 (IL-2) gene induction. In the present investigation, the effect of ciprofloxacin at supratherapeutic concentrations on immediate-early (< ...
... series of events resulting in the induction of specific genes. The fluoroquinolone antibiotic ciprofloxacin has recently been reported to upregulate interleukin-2 (IL-2) gene induction. In the present investigation, the effect of ciprofloxacin at supratherapeutic concentrations on immediate-early (< ...
The avian organizer
... induction in avian ectoderm, but elicits the formation of a primitive streak expressing also organizer markers. (Streit et al., 1998). This finding was at first sight unexpected after the identification of chordin as a bona fide neural inducer in Xenopus (Kessel and Pera, 1998). It appears that neur ...
... induction in avian ectoderm, but elicits the formation of a primitive streak expressing also organizer markers. (Streit et al., 1998). This finding was at first sight unexpected after the identification of chordin as a bona fide neural inducer in Xenopus (Kessel and Pera, 1998). It appears that neur ...
Salicylic Acid Regulates Plasmodesmata Closure
... permeability phenotype, which is manifested by transgenic plants overexpressing PDLP5 under the control of the 35S promoter (hereafter called PDLP5 plants). To this end, comparative PD permeability assays were performed on 3-week-old wild-type Col-0, PDLP5, NahG, and homozygous F3 progenies of the c ...
... permeability phenotype, which is manifested by transgenic plants overexpressing PDLP5 under the control of the 35S promoter (hereafter called PDLP5 plants). To this end, comparative PD permeability assays were performed on 3-week-old wild-type Col-0, PDLP5, NahG, and homozygous F3 progenies of the c ...
International Society for Biological Therapy of Cancer 23rd Annual
... of cells to the clinically relevant immunosuppressive drug mycophenolate mofetil (MMF, a prodrug of mycophenolic acid, MPA). Studies using Daudi and Sup-B15 human B-lineage tumor cells, OKT3stimulated peripheral blood mononuclear cell derived human T cells and established human T-cell lines demonstr ...
... of cells to the clinically relevant immunosuppressive drug mycophenolate mofetil (MMF, a prodrug of mycophenolic acid, MPA). Studies using Daudi and Sup-B15 human B-lineage tumor cells, OKT3stimulated peripheral blood mononuclear cell derived human T cells and established human T-cell lines demonstr ...
Cell encapsulation
Cell microencapsulation technology involves immobilization of the cells within a polymeric semi-permeable membrane that permits the bidirectional diffusion of molecules such as the influx of oxygen, nutrients, growth factors etc. essential for cell metabolism and the outward diffusion of waste products and therapeutic proteins. At the same time, the semi-permeable nature of the membrane prevents immune cells and antibodies from destroying the encapsulated cells regarding them as foreign invaders.The main motive of cell encapsulation technology is to overcome the existing problem of graft rejection in tissue engineering applications and thus reduce the need for long-term use of immunosuppressive drugs after an organ transplant to control side effects.