PDF - Bezanilla Lab
... Studies using reverse genetic approaches are now increasing. This review does not attempt to catalogue such studies but illustrates their potential by focusing on two examples. The first example is the study of sulfur assimilation. Plants, like fungi and bacteria, acquire sulfur by the reduction of s ...
... Studies using reverse genetic approaches are now increasing. This review does not attempt to catalogue such studies but illustrates their potential by focusing on two examples. The first example is the study of sulfur assimilation. Plants, like fungi and bacteria, acquire sulfur by the reduction of s ...
Cardiac Stem Cells and Mechanisms of Myocardial Regeneration
... A severe reduction in cell number, however, occurs acutely after ischemic injury that inevitably results in scar formation not only in the heart but also in other organs, whether their parenchymal cells are highly proliferating, slowly cycling, or terminally differentiated (263, 280, 410, 512). The ...
... A severe reduction in cell number, however, occurs acutely after ischemic injury that inevitably results in scar formation not only in the heart but also in other organs, whether their parenchymal cells are highly proliferating, slowly cycling, or terminally differentiated (263, 280, 410, 512). The ...
Intravenously-Delivered Mesenchymal Stem Cells: Systemic Anti
... This “inflammatory” concept of disease progression has led us to explore the potential of a particular strategy that has the capacity not only to modulate inflammatory responses, but also to favorably alter other mechanisms believed to contribute to progressive LV dysfunction. That strategy is the s ...
... This “inflammatory” concept of disease progression has led us to explore the potential of a particular strategy that has the capacity not only to modulate inflammatory responses, but also to favorably alter other mechanisms believed to contribute to progressive LV dysfunction. That strategy is the s ...
The Development of the Integument: Spatial, Temporal, and
... teeth have developed (Fig. 17) in such experimental combinations. As a minimal conservative explanation, it seems that the presence or absence of teeth in the tooth row is a function of the presence or absence of inductively active mesodermal papilla cells. Perhaps we should begin to analyse the too ...
... teeth have developed (Fig. 17) in such experimental combinations. As a minimal conservative explanation, it seems that the presence or absence of teeth in the tooth row is a function of the presence or absence of inductively active mesodermal papilla cells. Perhaps we should begin to analyse the too ...
FasL gene knock-down therapy enhances the
... brain cancer in the central nervous system. Currently, the mean survival of patients affected by glioblastoma multiforme (GBM; the most aggressive form of malignant glioma) after conventional therapy consisting of surgical resection followed by radiotherapy and chemotherapy, remains just over 14 mon ...
... brain cancer in the central nervous system. Currently, the mean survival of patients affected by glioblastoma multiforme (GBM; the most aggressive form of malignant glioma) after conventional therapy consisting of surgical resection followed by radiotherapy and chemotherapy, remains just over 14 mon ...
Marrow-Derived Facilitating Cells Transplantation: Role of Bone
... cell populations. Facilitating cells (FC), isolated as CD8 positive (CD8␣⫹) and ␣␥␦ TCR negative (␣␥␦TCR⫺) are bone marrow (BM)-derived cells that reliably promote purified allogeneic stem cell (SC) reconstitution with resulting transplantation tolerance across complete MHC barriers without clinic ...
... cell populations. Facilitating cells (FC), isolated as CD8 positive (CD8␣⫹) and ␣␥␦ TCR negative (␣␥␦TCR⫺) are bone marrow (BM)-derived cells that reliably promote purified allogeneic stem cell (SC) reconstitution with resulting transplantation tolerance across complete MHC barriers without clinic ...
Full-Text PDF
... Autophagy is an intracellular process that involves degradation of damaged organelles, protein aggregates and intracellular pathogens with a key role not only in maintaining cellular homeostasis and guaranteeing adequate energy levels, but also as a defense mechanism against microorganisms, a proces ...
... Autophagy is an intracellular process that involves degradation of damaged organelles, protein aggregates and intracellular pathogens with a key role not only in maintaining cellular homeostasis and guaranteeing adequate energy levels, but also as a defense mechanism against microorganisms, a proces ...
The Neurosecretory Neuron in Neuroendocrine
... distribution parallels the sites of formation and/or storage of catecholamine as determined by the fluorescence-technique (Fuxe, et ah, 1966a). • If it can be established that physiologically active catecholamines released from neurons reach target cells by a vascular route, such as the hypophysial ...
... distribution parallels the sites of formation and/or storage of catecholamine as determined by the fluorescence-technique (Fuxe, et ah, 1966a). • If it can be established that physiologically active catecholamines released from neurons reach target cells by a vascular route, such as the hypophysial ...
2 - Liu Lab
... clinically aggressive disease for which there is no targeted therapy1–3. BET bromodomain inhibitors, which have shown efficacy in several models of cancer4–6, have not been evaluated in TNBC. These inhibitors displace BET bromodomain proteins such as BRD4 from chromatin by competing with their acety ...
... clinically aggressive disease for which there is no targeted therapy1–3. BET bromodomain inhibitors, which have shown efficacy in several models of cancer4–6, have not been evaluated in TNBC. These inhibitors displace BET bromodomain proteins such as BRD4 from chromatin by competing with their acety ...
Computational models of plant development and form
... from observations and experiments. Modeling offers a powerful method for studying causality, because in models cause-effect relations can be defined explicitly, opening the door to rigorous study of their implications. Analysis of self-organization. The form of plants is not coded directly in their ...
... from observations and experiments. Modeling offers a powerful method for studying causality, because in models cause-effect relations can be defined explicitly, opening the door to rigorous study of their implications. Analysis of self-organization. The form of plants is not coded directly in their ...
Boundless Study Slides
... • G protein any of a class of proteins, found in cell membranes, that pass signals between hormone receptors and effector enzymes • gene expression the transcription and translation of a gene into messenger RNA and, thus, into a protein • glycoprotein a protein with covalently-bonded carbohydrates ...
... • G protein any of a class of proteins, found in cell membranes, that pass signals between hormone receptors and effector enzymes • gene expression the transcription and translation of a gene into messenger RNA and, thus, into a protein • glycoprotein a protein with covalently-bonded carbohydrates ...
Nodal mutant eXtraembryonic ENdoderm (XEN
... lines were derived according to a previously published protocol (Artus et al., 2010) (Fig. 1A). The genotype of individual XEN cell lines was confirmed by PCR after isolation and expansion, using primers specific for either Nodal or LacZ, which was knocked into the Nodal locus as part of the deletio ...
... lines were derived according to a previously published protocol (Artus et al., 2010) (Fig. 1A). The genotype of individual XEN cell lines was confirmed by PCR after isolation and expansion, using primers specific for either Nodal or LacZ, which was knocked into the Nodal locus as part of the deletio ...
the far c-terminus of tpx2 contributes to spindle morphogenesis
... between phases of polymerization, depolymerization and pausing (Mitchison & Kirschner, 1984; Walker et al., 1988; Shelden & Wadsworth, 1993). Initially, GTP hydrolysis was shown to govern this process in vitro; however, cellular dynamics are more complex due to regulation from microtubule polymeras ...
... between phases of polymerization, depolymerization and pausing (Mitchison & Kirschner, 1984; Walker et al., 1988; Shelden & Wadsworth, 1993). Initially, GTP hydrolysis was shown to govern this process in vitro; however, cellular dynamics are more complex due to regulation from microtubule polymeras ...
The Roles of Germin Gene Products in Plants Under
... metabolic rates seen. Moreover, there are probably a number of genes that code for proteins involved in the more complex developmental aspects of germination and seedling establishment. Seedling establishment needs the mobilization of stored reserves, involving such supporting tissues as the cotyled ...
... metabolic rates seen. Moreover, there are probably a number of genes that code for proteins involved in the more complex developmental aspects of germination and seedling establishment. Seedling establishment needs the mobilization of stored reserves, involving such supporting tissues as the cotyled ...
Mast cells and basophils in acquired immunity
... Mast cells, like basophils, are derived from CD34+ hematopoietic progenitor cells but, unlike basophils, mature mast cells ordinarily do not circulate in the blood. Mast cells typically complete their differentiation in vascularized tissues (and, especially in rodents, in serosallined cavities). How ...
... Mast cells, like basophils, are derived from CD34+ hematopoietic progenitor cells but, unlike basophils, mature mast cells ordinarily do not circulate in the blood. Mast cells typically complete their differentiation in vascularized tissues (and, especially in rodents, in serosallined cavities). How ...
151 Compact cell image projector
... used to investigate the influence of stimulatory rhythm on contraction amplitude of isolated rat ventricular myocytes. Peak cell shortening amplitude was recorded during electric stimulation at the average rate of 0.5 Hz with different stimulatory patterns: regular and pseudo-random rhythms, as well ...
... used to investigate the influence of stimulatory rhythm on contraction amplitude of isolated rat ventricular myocytes. Peak cell shortening amplitude was recorded during electric stimulation at the average rate of 0.5 Hz with different stimulatory patterns: regular and pseudo-random rhythms, as well ...
Imaging neural crest cell dynamics during formation
... guiding trunk neural crest cells. When presumptive somites are rotated by 180°, neural crest cells and motor axons migrate through the (now) caudal somite (Bronner-Fraser and Stern, 1991). This segregation of neural crest cells to follow a specific migratory route or corridor suggests that the funct ...
... guiding trunk neural crest cells. When presumptive somites are rotated by 180°, neural crest cells and motor axons migrate through the (now) caudal somite (Bronner-Fraser and Stern, 1991). This segregation of neural crest cells to follow a specific migratory route or corridor suggests that the funct ...
Imaging neural crest cell dynamics during formation
... guiding trunk neural crest cells. When presumptive somites are rotated by 180°, neural crest cells and motor axons migrate through the (now) caudal somite (Bronner-Fraser and Stern, 1991). This segregation of neural crest cells to follow a specific migratory route or corridor suggests that the funct ...
... guiding trunk neural crest cells. When presumptive somites are rotated by 180°, neural crest cells and motor axons migrate through the (now) caudal somite (Bronner-Fraser and Stern, 1991). This segregation of neural crest cells to follow a specific migratory route or corridor suggests that the funct ...
Patterning the Xenopus blastula - Development
... mRNAs are present in the oocyte and early embryo and have dorsalizing activity when injected into embryos (Xwnt 11: Ku and Melton, 1993; Xwnt-8b: Cui et al., 1995). But the roles of the endogenous molecules have yet to be defined. Recent studies have indicated that homologs of the Drosophila frizzle ...
... mRNAs are present in the oocyte and early embryo and have dorsalizing activity when injected into embryos (Xwnt 11: Ku and Melton, 1993; Xwnt-8b: Cui et al., 1995). But the roles of the endogenous molecules have yet to be defined. Recent studies have indicated that homologs of the Drosophila frizzle ...
Extracellular matrix
In biology, the extracellular matrix (ECM) is a collection of extracellular molecules secreted by cells that provides structural and biochemical support to the surrounding cells. Because multicellularity evolved independently in different multicellular lineages, the composition of ECM varies between multicellular structures; however, cell adhesion, cell-to-cell communication and differentiation are common functions of the ECM.The animal extracellular matrix includes the interstitial matrix and the basement membrane. Interstitial matrix is present between various animal cells (i.e., in the intercellular spaces). Gels of polysaccharides and fibrous proteins fill the interstitial space and act as a compression buffer against the stress placed on the ECM. Basement membranes are sheet-like depositions of ECM on which various epithelial cells rest.The plant ECM includes cell wall components, like cellulose, in addition to more complex signaling molecules. Some single-celled organisms adopt multicelluar biofilms in which the cells are embedded in an ECM composed primarily of extracellular polymeric substances (EPS).