Monitoring metabolic responses to chemotherapy initiator mass spectrometry (NIMS) imaging
... Genetic and environmental cues, including stresses from anti-cancer treatments, can induce significant changes in cell and tissue metabolism. Understanding the relationships between drug exposure and tissue metabolism can improve diagnosis and treatment outcomes, and speed the identification of new ...
... Genetic and environmental cues, including stresses from anti-cancer treatments, can induce significant changes in cell and tissue metabolism. Understanding the relationships between drug exposure and tissue metabolism can improve diagnosis and treatment outcomes, and speed the identification of new ...
View Full Page PDF - Physiological Reviews
... that patterned expression of more common adhesion molecules might also facilitate traffic of specific T cell subsets to the airway mucosa. To define the relationship between T cell phenotype and adhesiveness, we examined T cell adhesion to endothelial cell, fibroblast, and epithelial cell monolayers ...
... that patterned expression of more common adhesion molecules might also facilitate traffic of specific T cell subsets to the airway mucosa. To define the relationship between T cell phenotype and adhesiveness, we examined T cell adhesion to endothelial cell, fibroblast, and epithelial cell monolayers ...
Factor-1-Deficient Mice IL-15-Deficient and IFN Regulatory 3 Cells
... and IL-7R play a critical role in lymphopoiesis by inducing survival and proliferation of progenitor T lymphocytes (10). Studies in IL-15⫺/⫺ mice and IL-15R␣⫺/⫺ mice have confirmed a critical role for IL-15 in regulating the development and/or expansion of NK cells, NK-T cells, and distinct intestin ...
... and IL-7R play a critical role in lymphopoiesis by inducing survival and proliferation of progenitor T lymphocytes (10). Studies in IL-15⫺/⫺ mice and IL-15R␣⫺/⫺ mice have confirmed a critical role for IL-15 in regulating the development and/or expansion of NK cells, NK-T cells, and distinct intestin ...
Site directed mutagenesis of Drosophila flightin disrupts
... 1998). Thus, a small segment of the myosin coiled coil appears to have been evolutionarily conserved as a site of myosin binding protein interaction. Flightin fulfills an essential role in IFM development and function. Flies with a null mutation in the flightin gene (fln0) develop IFM with sarcomere ...
... 1998). Thus, a small segment of the myosin coiled coil appears to have been evolutionarily conserved as a site of myosin binding protein interaction. Flightin fulfills an essential role in IFM development and function. Flies with a null mutation in the flightin gene (fln0) develop IFM with sarcomere ...
Advanced continuous cultivation methods for systems microbiology
... methods termed changestats, such as the accelerostat (A-stat; Paalme et al., 1995) and dilution rate stat (D-stat; Kasemets et al., 2003). We will not focus on the specific details of control algorithms, which were presented earlier in ...
... methods termed changestats, such as the accelerostat (A-stat; Paalme et al., 1995) and dilution rate stat (D-stat; Kasemets et al., 2003). We will not focus on the specific details of control algorithms, which were presented earlier in ...
Double-Stranded RNA Induces Sickle Erythrocyte
... endothelium is posited as a major determinant of intracapillary transit time and a modulator of vaso-occlusive complications!-6 In recent years, specific adhesion pathways between both microvascular and large vein endothelium and sickle erythrocytes have been elucidated in a number of independent st ...
... endothelium is posited as a major determinant of intracapillary transit time and a modulator of vaso-occlusive complications!-6 In recent years, specific adhesion pathways between both microvascular and large vein endothelium and sickle erythrocytes have been elucidated in a number of independent st ...
Asymmetric Cell Division as a Route to Reduction in Cell Length
... African trypanosomes go through at least five developmental stages during their life cycle. The different cellular forms are classified using morphology, including the order of the nucleus, flagellum and kinetoplast along the anterior—posterior axis of the cell, the predominant cell surface molecule ...
... African trypanosomes go through at least five developmental stages during their life cycle. The different cellular forms are classified using morphology, including the order of the nucleus, flagellum and kinetoplast along the anterior—posterior axis of the cell, the predominant cell surface molecule ...
Cell Cycle in the Fucus Zygote Parallels a Somatic Cell
... these checkpoints, and their regulation after checkpoint activation is usually correlated with changes in their phosphorylation status as well as with associations with regulatory molecules such as CDK inhibitors (Lew and Kornbluth, 1996; Rudner and Murray, 1996; Hardwick, 1998). These checkpoints a ...
... these checkpoints, and their regulation after checkpoint activation is usually correlated with changes in their phosphorylation status as well as with associations with regulatory molecules such as CDK inhibitors (Lew and Kornbluth, 1996; Rudner and Murray, 1996; Hardwick, 1998). These checkpoints a ...
Two highly related regulatory subunits of PP2A exert opposite
... Julie Batut1,*,†, Bernhard Schmierer1,*, Jing Cao2, Laurel A. Raftery2, Caroline S. Hill1,§ and Michael Howell1,‡,§ We identify Bα (PPP2R2A) and Bδ (PPP2R2D), two highly related members of the B family of regulatory subunits of the protein phosphatase PP2A, as important modulators of TGF-β/Activin/N ...
... Julie Batut1,*,†, Bernhard Schmierer1,*, Jing Cao2, Laurel A. Raftery2, Caroline S. Hill1,§ and Michael Howell1,‡,§ We identify Bα (PPP2R2A) and Bδ (PPP2R2D), two highly related members of the B family of regulatory subunits of the protein phosphatase PP2A, as important modulators of TGF-β/Activin/N ...
Skeletal Muscle Stem Cells in the Spotlight: The Satellite Cell
... basis of being negative for CD45, CD31, and Sca1, and positive for CD34 and a7 integrin [57, 58]. Additional cell surface antigens, including CXCR4, b1 integrin, and syndecan-4 have also been utilized for isolation of myogenic progenitors from adult muscle [56, 68]. A range of fluorescence-based rep ...
... basis of being negative for CD45, CD31, and Sca1, and positive for CD34 and a7 integrin [57, 58]. Additional cell surface antigens, including CXCR4, b1 integrin, and syndecan-4 have also been utilized for isolation of myogenic progenitors from adult muscle [56, 68]. A range of fluorescence-based rep ...
TIBS Review - Structural Genomics Consortium
... cell cycle exit in neuroepithelial cells [35]. For example, in mitogen-stimulated primary B cells BRD2 controls cyclin A expression by directly binding to the cyclin A promoter, affecting S-phase progression [36]. In HeLa cells BRD2 has yet another function; it was found to affect alternative splic ...
... cell cycle exit in neuroepithelial cells [35]. For example, in mitogen-stimulated primary B cells BRD2 controls cyclin A expression by directly binding to the cyclin A promoter, affecting S-phase progression [36]. In HeLa cells BRD2 has yet another function; it was found to affect alternative splic ...
Arginase I Production in the Tumor
... synthase to produce citrulline and nitric oxide, important in vascular homeostasis and cytotoxic mechanisms of macrophages (12). High arginase activity has been described in patients with various malignancies including gastric, colon, breast, and lung cancers (13, 14). Most reports have associated t ...
... synthase to produce citrulline and nitric oxide, important in vascular homeostasis and cytotoxic mechanisms of macrophages (12). High arginase activity has been described in patients with various malignancies including gastric, colon, breast, and lung cancers (13, 14). Most reports have associated t ...
LPS- or Pseudomonas aeruginosa- mediated activation of
... one hand unsaturated fatty acids are discussed to diminish the gene expression of the TLR4 receptor (Lu et al., 2007; Liu et al., 2012). On the other hand PUFA are reported to disrupt membrane microdomain composition (Parker et al., 2008; Wong et al., 2009; Shaikh, Jolly & Chapkin, 2012), which migh ...
... one hand unsaturated fatty acids are discussed to diminish the gene expression of the TLR4 receptor (Lu et al., 2007; Liu et al., 2012). On the other hand PUFA are reported to disrupt membrane microdomain composition (Parker et al., 2008; Wong et al., 2009; Shaikh, Jolly & Chapkin, 2012), which migh ...
Signal Perception and Transduction: The Origin of
... Signal transduction systems often are inappropriately portrayed as simple linear chains of cause and effect, in part because effective conceptualization of what goes on when a cell perceives a signal is impoverished by our inability to put together the experimental information in any meaningful way. ...
... Signal transduction systems often are inappropriately portrayed as simple linear chains of cause and effect, in part because effective conceptualization of what goes on when a cell perceives a signal is impoverished by our inability to put together the experimental information in any meaningful way. ...
Phospholipase C-γ1 is a guanine nucleotide exchange factor for
... 1995). In addition to the GTPase domain, dynamin also contains a pleckstrin homology domain (PH) implicated in membrane binding, a GTPase effector domain (GED) shown to be essential for self-assembly and stimulated GTPase activity. It has been reported that purified dynamin-1 self-assembles and form ...
... 1995). In addition to the GTPase domain, dynamin also contains a pleckstrin homology domain (PH) implicated in membrane binding, a GTPase effector domain (GED) shown to be essential for self-assembly and stimulated GTPase activity. It has been reported that purified dynamin-1 self-assembles and form ...
Cell Division Activity during Apical Hook
... (Fig. 3B). The apical part contained 1.7 times more cells compared with the basal part. In addition, Cyc1B-GUS was predominantly expressed at the apical part of the hook, as determined by the number of cells expressing GUS (Fig. 2D). These results indicate that the differential growth along the apic ...
... (Fig. 3B). The apical part contained 1.7 times more cells compared with the basal part. In addition, Cyc1B-GUS was predominantly expressed at the apical part of the hook, as determined by the number of cells expressing GUS (Fig. 2D). These results indicate that the differential growth along the apic ...
Mode Suppressed TEM Cell Design For High Frequency IC
... is evaluated by using the full wave simulation tool CST Microwave Studio. Figure 7 shows the S parameter results for the modified TEM cell model with only the parallel traces on the walls. For the cell with only the parallel traces, the TE modes still disturb the TEM field in the cell at resonant fr ...
... is evaluated by using the full wave simulation tool CST Microwave Studio. Figure 7 shows the S parameter results for the modified TEM cell model with only the parallel traces on the walls. For the cell with only the parallel traces, the TE modes still disturb the TEM field in the cell at resonant fr ...
Sperm entry is sufficient to trigger division of the
... estimated that 70% of sperm cells of cdka;1 pollen express HTR10 at levels lower than those of wild type (Table 1; Fig. 1F). We thus investigated whether the level of expression of another component of sperm cell chromatin was affected by cdka;1. We studied the expression of CENTROMERIC HISTONE 3 (C ...
... estimated that 70% of sperm cells of cdka;1 pollen express HTR10 at levels lower than those of wild type (Table 1; Fig. 1F). We thus investigated whether the level of expression of another component of sperm cell chromatin was affected by cdka;1. We studied the expression of CENTROMERIC HISTONE 3 (C ...
EGF receptor signaling pathway Drosophila activation
... signaling pathways. One such pathway, the epidermal growth factor receptor (EGFR) pathway, is critical for cell differentiation, survival, and cell cycle regulation in many systems, including the Drosophila eye. We have identified a mutation in a novel gene, aveugle, based on its requirement for nor ...
... signaling pathways. One such pathway, the epidermal growth factor receptor (EGFR) pathway, is critical for cell differentiation, survival, and cell cycle regulation in many systems, including the Drosophila eye. We have identified a mutation in a novel gene, aveugle, based on its requirement for nor ...
Sugars as signaling molecules - Department of Molecular Biology
... inhibitors, and stress signals can all activate putative MAPKs that use myelin basic protein as substrate [17]. However, the differential effect of the PK inhibitor staurosporine on these signals suggests the involvement of different PKs in different transduction pathways [17]. The same PP inhibitor ...
... inhibitors, and stress signals can all activate putative MAPKs that use myelin basic protein as substrate [17]. However, the differential effect of the PK inhibitor staurosporine on these signals suggests the involvement of different PKs in different transduction pathways [17]. The same PP inhibitor ...
Macrophages but Not MyD88, in Bacteria
... only TLR4 signaling contributes to induce macrophage apoptosis (12). Also, agonist-specific activation of TLR4, but not TLR2, efficiently elicits cell death under NF-B inhibitory conditions. These results identify TLR4 as a major inducer of apoptosis in bacteria-infected macrophages (12). This obse ...
... only TLR4 signaling contributes to induce macrophage apoptosis (12). Also, agonist-specific activation of TLR4, but not TLR2, efficiently elicits cell death under NF-B inhibitory conditions. These results identify TLR4 as a major inducer of apoptosis in bacteria-infected macrophages (12). This obse ...
pig-1_final 121812
... PAR-4 and STRD-1 function in the same pathway as PIG-1 and promote other PIG-1dependent asymmetries: The observation that the strd-1(rr91); par-4(it57ts) double mutant died during embryogenesis, even at the permissive temperature for par-4(it57ts) (KIM et al. 2010; NARBONNE et al. 2010), precluded u ...
... PAR-4 and STRD-1 function in the same pathway as PIG-1 and promote other PIG-1dependent asymmetries: The observation that the strd-1(rr91); par-4(it57ts) double mutant died during embryogenesis, even at the permissive temperature for par-4(it57ts) (KIM et al. 2010; NARBONNE et al. 2010), precluded u ...