Progression Liver Modulates Severe Malaria Disease in the
... Quantification of parasite liver loads by quantitative real-time PCR (qRTPCR) was conducted as previously described (23). In brief, mice were killed 42 h after sporozoite infection and livers were removed, homogenized, and subjected to RNA isolation via the RNeasy kit (Qiagen) with cDNA synthesized ...
... Quantification of parasite liver loads by quantitative real-time PCR (qRTPCR) was conducted as previously described (23). In brief, mice were killed 42 h after sporozoite infection and livers were removed, homogenized, and subjected to RNA isolation via the RNeasy kit (Qiagen) with cDNA synthesized ...
Full Text
... nucleosomes are the major targets for SWI/SNF action. Several other strategic changes to chromatin occur in multicellular organisms, including the appearance of histone H1, which may also create chromatin structures that require BAF complexes for conversion to more accessible DNA. With the evolution ...
... nucleosomes are the major targets for SWI/SNF action. Several other strategic changes to chromatin occur in multicellular organisms, including the appearance of histone H1, which may also create chromatin structures that require BAF complexes for conversion to more accessible DNA. With the evolution ...
The beneficial role of proteolysis in skeletal muscle growth and
... important to note that the exercise regimens between these studies were not identical and varied in aspects such as speed, treadmill inclination, and time. These are likely significant factors given the recent research by Schwalm et al. [99] that indicates that exercise intensity may be the crucial ...
... important to note that the exercise regimens between these studies were not identical and varied in aspects such as speed, treadmill inclination, and time. These are likely significant factors given the recent research by Schwalm et al. [99] that indicates that exercise intensity may be the crucial ...
RUNX/AML and C/EBP factors regulate CD11a
... The CCAAT/enhancer binding protein (C/EBP) family comprises 6 transcription factors (␣, , ␥, ␦, ⑀, and CHOP), which bind DNA as homodimers and heterodimers and whose expression within the hematopoietic system is largely restricted to the myeloid lineage.39,40 C/EBP␣ plays a critical role in neutrop ...
... The CCAAT/enhancer binding protein (C/EBP) family comprises 6 transcription factors (␣, , ␥, ␦, ⑀, and CHOP), which bind DNA as homodimers and heterodimers and whose expression within the hematopoietic system is largely restricted to the myeloid lineage.39,40 C/EBP␣ plays a critical role in neutrop ...
COMMUNICATION Two categories of mammalian galactose
... is the formation of branched structures. In addition, the Kupffer cell receptor has enhanced affinity for the O-linked glycans on the array. Like RHL-1, the Kupffer cell receptor binds to several GalNAc oligosaccharides modified at the 6-position with sulfate, sialic acid, or GlcNAc. However, the Ku ...
... is the formation of branched structures. In addition, the Kupffer cell receptor has enhanced affinity for the O-linked glycans on the array. Like RHL-1, the Kupffer cell receptor binds to several GalNAc oligosaccharides modified at the 6-position with sulfate, sialic acid, or GlcNAc. However, the Ku ...
MAPK Review
... Upstream regulation of ERK1/2 The collaborative findings from a number of laboratories led to the connection of ERK1/2 to their upstream regulators MAPK/ERK kinase 1 and 2 (MEK1/2); the identification of Raf isoforms as upstream activators of these MAP2Ks; and the observation that Raf is an effector ...
... Upstream regulation of ERK1/2 The collaborative findings from a number of laboratories led to the connection of ERK1/2 to their upstream regulators MAPK/ERK kinase 1 and 2 (MEK1/2); the identification of Raf isoforms as upstream activators of these MAP2Ks; and the observation that Raf is an effector ...
Challenges in Endometrial biopsy
... arrangement or affiliation with one or more organizations that could be perceived as a direct or indirect conflict of interest in the content of this presentation. ...
... arrangement or affiliation with one or more organizations that could be perceived as a direct or indirect conflict of interest in the content of this presentation. ...
Helical growth in plant organs: mechanisms and
... Fig. 1. Examples of helical growth forms in plants. (A) Path of circumnutation of the growing apex of the dodder Cuscuta gronovii (Convolvulaceae), mapped at 5 min intervals. The apex is moving toward the light (arrows) in wide right-handed circular movements. ω marks a fixed reference point. Adapte ...
... Fig. 1. Examples of helical growth forms in plants. (A) Path of circumnutation of the growing apex of the dodder Cuscuta gronovii (Convolvulaceae), mapped at 5 min intervals. The apex is moving toward the light (arrows) in wide right-handed circular movements. ω marks a fixed reference point. Adapte ...
Zasp is required for the assembly of functional integrin adhesion sites
... These observations point to a major role for integrins in S2R+ cell spreading and indicate that S2 cells spread on concanavalin A by an integrin-independent mechanism. We next tested if this difference in spreading can be exploited to screen for novel regulators of integrin-mediated cell spreading. ...
... These observations point to a major role for integrins in S2R+ cell spreading and indicate that S2 cells spread on concanavalin A by an integrin-independent mechanism. We next tested if this difference in spreading can be exploited to screen for novel regulators of integrin-mediated cell spreading. ...
The expression of a zebrafish gene homologous to Drosophila snail
... mutant for the genes twist (Thisse et al., 1988) or snail (Boulay et al., 1987) fail to form a ventral furrow and completely lack mesoderm, suggesting that the genes regulate downstream target genes that are involved in the determination of mesodermal fates as well as in the morphogenetic movements ...
... mutant for the genes twist (Thisse et al., 1988) or snail (Boulay et al., 1987) fail to form a ventral furrow and completely lack mesoderm, suggesting that the genes regulate downstream target genes that are involved in the determination of mesodermal fates as well as in the morphogenetic movements ...
Submembraneous microtubule cytoskeleton: biochemical and
... Therefore, these small changes in Ca2+ might trigger an enzymatic cascade leading to depolymerization. This view is also supported by previous studies demonstrating that a small amount of calmodulin can cause massive microtubule depolymerization in the presence of catalytic amounts of Ca2+, but not ...
... Therefore, these small changes in Ca2+ might trigger an enzymatic cascade leading to depolymerization. This view is also supported by previous studies demonstrating that a small amount of calmodulin can cause massive microtubule depolymerization in the presence of catalytic amounts of Ca2+, but not ...
Making parallel lines meet
... simultaneously characterize the first protein known to link cortical microtubules and cellulose microfibrils.14-16 Previously, the protein, named cellulose synthaseinteracting protein (CSI1), had been fished out of a yeast two-hybrid screen for proteins that interact with CESA; the protein is presen ...
... simultaneously characterize the first protein known to link cortical microtubules and cellulose microfibrils.14-16 Previously, the protein, named cellulose synthaseinteracting protein (CSI1), had been fished out of a yeast two-hybrid screen for proteins that interact with CESA; the protein is presen ...
PDF - Eleanor Maine Research Lab
... Germline stem cells proliferate by progressing through the mitotic cell cycle whereas daughters that initiate meiosis must leave the mitotic cell cycle. In budding yeast, nutrient deprivation causes G1 cell cycle arrest and meiotic initiation (Honigberg and Purnapatre, 2003; Wittenberg and La Valle, ...
... Germline stem cells proliferate by progressing through the mitotic cell cycle whereas daughters that initiate meiosis must leave the mitotic cell cycle. In budding yeast, nutrient deprivation causes G1 cell cycle arrest and meiotic initiation (Honigberg and Purnapatre, 2003; Wittenberg and La Valle, ...
Drosophila follicle cells are patterned by multiple
... were processed under identical conditions (Fig. 4E,F). Following expression of dskul in polar cells, Notch reporter levels were significantly elevated, both in the germarium and in stage 1-3 egg chambers. These observations indicate that Kul acts as an attenuator of Dl signaling in early-stage folli ...
... were processed under identical conditions (Fig. 4E,F). Following expression of dskul in polar cells, Notch reporter levels were significantly elevated, both in the germarium and in stage 1-3 egg chambers. These observations indicate that Kul acts as an attenuator of Dl signaling in early-stage folli ...
Corresponding author: Dr. A. Lacey Samuels
... breakdown products were consistently shown to be radioactive, indicating incorporation of 3H-phenylalanine into the lignin polymer (Supplemental Figure 1). To investigate the nature of the soluble metabolites that were labeled during the four hour incubation with 3H-phenylalanine, methanol soluble p ...
... breakdown products were consistently shown to be radioactive, indicating incorporation of 3H-phenylalanine into the lignin polymer (Supplemental Figure 1). To investigate the nature of the soluble metabolites that were labeled during the four hour incubation with 3H-phenylalanine, methanol soluble p ...
Xenopus laevis Stromal Cell-Derived Factor 1
... growth-related oncogene; cSDF-1, cat SDF-1; mSDF-1, mouse SDF-1. ...
... growth-related oncogene; cSDF-1, cat SDF-1; mSDF-1, mouse SDF-1. ...
trisphosphate specifically interacts with the phox homology domain
... PtdIns(3,4,5)P3 in cells (Auger et al., 1989; Vanhaesebroeck et al., 2001). With the obtained knowledge that PLD1PX has a high affinity for PtdIns(3,4,5)P3 in vitro, we wanted to examine whether this interaction occurs also in vivo. Therefore, we generated EGFP-PLD1 PX constructs. pEGFP-PLD1 PX wild ...
... PtdIns(3,4,5)P3 in cells (Auger et al., 1989; Vanhaesebroeck et al., 2001). With the obtained knowledge that PLD1PX has a high affinity for PtdIns(3,4,5)P3 in vitro, we wanted to examine whether this interaction occurs also in vivo. Therefore, we generated EGFP-PLD1 PX constructs. pEGFP-PLD1 PX wild ...
Disruption of gradient expression of Zic3 resulted in abnormal intra
... optic vesicle and optic cup at later stages (Fig. 2B,C). On flatmount retinas (Fig. 2D-G), we observed that Zic3 is expressed in a graded fashion with lower expression at the center and higher expression at the periphery. The graded expression recedes toward the retinal periphery over the course of ...
... optic vesicle and optic cup at later stages (Fig. 2B,C). On flatmount retinas (Fig. 2D-G), we observed that Zic3 is expressed in a graded fashion with lower expression at the center and higher expression at the periphery. The graded expression recedes toward the retinal periphery over the course of ...
Molecular regulation of the diatom cell cycle
... dynamics. Nutrient limitation at the end of a diatom bloom period is often accompanied by switches in the diatom life cycle phase from vegetative division to spore formation or sexual reproduction (Smetacek, 2012). The major limiting nutrients of primary production in the oceans are nitrogen, phosph ...
... dynamics. Nutrient limitation at the end of a diatom bloom period is often accompanied by switches in the diatom life cycle phase from vegetative division to spore formation or sexual reproduction (Smetacek, 2012). The major limiting nutrients of primary production in the oceans are nitrogen, phosph ...