lipids and thyroid hormones - Deep Blue
... the diversity of thyroid hormone effects. ~°5 Another is in testis. 29a These binders await certification as receptors. Are the criteria for defining a receptor molecule by its binding properties to thyroid hormones sufficiently rigorous to exclude other lipophilic proteins found in membranes? A sim ...
... the diversity of thyroid hormone effects. ~°5 Another is in testis. 29a These binders await certification as receptors. Are the criteria for defining a receptor molecule by its binding properties to thyroid hormones sufficiently rigorous to exclude other lipophilic proteins found in membranes? A sim ...
Relationship of Net Chloride Flow across the Human Erythrocyte
... agreement with this prediction (Knauf et al ., 1977 ; Hunter, 1977 ; Gunn, 1978) . Furthermore, it would be predicted that those anions that bind more strongly to the substrate site should have lower net permeabilities, since net flow depends on the amount of unloaded carrier, and this decreases if ...
... agreement with this prediction (Knauf et al ., 1977 ; Hunter, 1977 ; Gunn, 1978) . Furthermore, it would be predicted that those anions that bind more strongly to the substrate site should have lower net permeabilities, since net flow depends on the amount of unloaded carrier, and this decreases if ...
Glycine Binding Sites of Presynaptic NMDA Receptors May
... CA) with a resistance of 4 – 6 M⍀ were pulled using a horizontal puller (model P-97, Sutter Instruments, Novato, CA). The pipette solution contained (in mM) 130 cesium methanesulfonate, 5 NaCl, 5 QX-314, 2 MgCl2, 0.1 CaCl2, 1 EGTA, 10 HEPES, 2 Na2ATP, and 0.25 Na3GTP (pH 7.3–7.4, adjusted with CsOH, ...
... CA) with a resistance of 4 – 6 M⍀ were pulled using a horizontal puller (model P-97, Sutter Instruments, Novato, CA). The pipette solution contained (in mM) 130 cesium methanesulfonate, 5 NaCl, 5 QX-314, 2 MgCl2, 0.1 CaCl2, 1 EGTA, 10 HEPES, 2 Na2ATP, and 0.25 Na3GTP (pH 7.3–7.4, adjusted with CsOH, ...
GENE EXPRESSION SIGNATURES IN TREE SHREW RETINA
... models treated with optical manipulations - minus lens (ML) or form deprivation (FD) the emmetropization mechanism is stimulated to increase the axial elongation to compensate for the visual stimulus (Schaeffel, Glasser, & Howland, 1988; Siegwart & Norton, 1993; Troilo & Wallman, 1991; Wiesel & Ravi ...
... models treated with optical manipulations - minus lens (ML) or form deprivation (FD) the emmetropization mechanism is stimulated to increase the axial elongation to compensate for the visual stimulus (Schaeffel, Glasser, & Howland, 1988; Siegwart & Norton, 1993; Troilo & Wallman, 1991; Wiesel & Ravi ...
Co-activation of VTA DA and GABA neurons mediates nicotine
... morbidity and mortality. According to the World Health Organization, more than five million smokers die every year from the consequences.1 Dissecting the underlying neurobiological mechanisms of this disorder has recently made important progress with the use of genetically modified mice,2 but they rem ...
... morbidity and mortality. According to the World Health Organization, more than five million smokers die every year from the consequences.1 Dissecting the underlying neurobiological mechanisms of this disorder has recently made important progress with the use of genetically modified mice,2 but they rem ...
Preview Sample 2
... 53) Lipophobic molecules that are to be released by cells are stored in membrane-bound structures called ________. A) secretory vesicles B) inclusions C) the Golgi apparatus D) excretory vesicles E) the endoplasmic reticulum Answer: A Diff: 4 Page Ref: 32 54) Continuous with the outer portion of th ...
... 53) Lipophobic molecules that are to be released by cells are stored in membrane-bound structures called ________. A) secretory vesicles B) inclusions C) the Golgi apparatus D) excretory vesicles E) the endoplasmic reticulum Answer: A Diff: 4 Page Ref: 32 54) Continuous with the outer portion of th ...
Regulation of Skeletal Muscle Physiology and Metabolism by
... compounds (Xu et al., 1999; Gervois et al., 2007). Endogenous substances that can activate PPAR include eicosanoids, leukotrienes, and prostaglandins, but the vitamin A metabolite retinoic acid has also been shown to be a ligand for PPAR␦ (Yu et al., 1995; Schug et al., 2007). Other endogenous subst ...
... compounds (Xu et al., 1999; Gervois et al., 2007). Endogenous substances that can activate PPAR include eicosanoids, leukotrienes, and prostaglandins, but the vitamin A metabolite retinoic acid has also been shown to be a ligand for PPAR␦ (Yu et al., 1995; Schug et al., 2007). Other endogenous subst ...
... welcoming and for making me feel part of the family. Good luck to all the path residents! Joe, la señorita finally did it!! Bob, figurin!! It was great to meet you! Listening to you was always amazing! I will never forget your comments, which were always very uplifting, and the views from the plane. ...
Jelena Raspopovic Molecular basis for digit patterning in the vertebrate limb
... also present my two publications with the respective supplementary material. My first publication with the title “A GDF5 Point Mutation Strikes Twice - Causing BDA1 and SYNS2”, is a collaboration with the laboratory of Petra Seemann at the BerlinBrandenburg Center for Regenerative Therapies (BCRT). ...
... also present my two publications with the respective supplementary material. My first publication with the title “A GDF5 Point Mutation Strikes Twice - Causing BDA1 and SYNS2”, is a collaboration with the laboratory of Petra Seemann at the BerlinBrandenburg Center for Regenerative Therapies (BCRT). ...
thèse - Université Evry Val d`Essonne
... proteins. mtDNA generally encodes catalytic subunits of the complexes of the respiratory chain with tRNA and rRNA components of the mitochondrial translation system, but it can also contain additional proteins; in S. cerevisiae, besides seven subunits of complexes involved in oxidative phosphorylati ...
... proteins. mtDNA generally encodes catalytic subunits of the complexes of the respiratory chain with tRNA and rRNA components of the mitochondrial translation system, but it can also contain additional proteins; in S. cerevisiae, besides seven subunits of complexes involved in oxidative phosphorylati ...
Classes of programmed cell death in plants
... gene SAG12 (McClellan et al., 2009). Cathepsins have also been implicated in some types of animal PCD (Kroemer and Jäättelä, 2005). Animal cathepsins are localized in the lysosome (an organelle equivalent to plant vacuoles) and include, according to their active site amino acid, at least two seri ...
... gene SAG12 (McClellan et al., 2009). Cathepsins have also been implicated in some types of animal PCD (Kroemer and Jäättelä, 2005). Animal cathepsins are localized in the lysosome (an organelle equivalent to plant vacuoles) and include, according to their active site amino acid, at least two seri ...
The role of auxin and gibberellin in tomato fruit set
... might be involved in tomato fruit set is DIAGEOTROPICA (DGT). In tomato, dgt mutants, fruit set, fruit weight, number of seeds and locules per fruit were strongly affected (Balbi and Lomax, 2003). These mutants exhibit reduced auxin sensitivity (Kelly and Bradford, 1986; Mito and Bennett, 1995). The ...
... might be involved in tomato fruit set is DIAGEOTROPICA (DGT). In tomato, dgt mutants, fruit set, fruit weight, number of seeds and locules per fruit were strongly affected (Balbi and Lomax, 2003). These mutants exhibit reduced auxin sensitivity (Kelly and Bradford, 1986; Mito and Bennett, 1995). The ...
Cathepsin D released by lactating rat mammary epithelial cells is
... extracts from rat mammary tissue (Baldocchi et al., 1992) and by microsomal pellets from MCF-7 cells (Khurana et al., 1999), and it was suggested that the 16 kDa PRL was generated by CD within the lysosomes. Huge quantities of pituitary PRL is released in the circulation at each milking during lacta ...
... extracts from rat mammary tissue (Baldocchi et al., 1992) and by microsomal pellets from MCF-7 cells (Khurana et al., 1999), and it was suggested that the 16 kDa PRL was generated by CD within the lysosomes. Huge quantities of pituitary PRL is released in the circulation at each milking during lacta ...
Placental Transporters Relevant to Drug Distribution across the
... fetus is also of serious health concern. One of the pivotal functions of the placenta is to provide essential nutrients to the developing fetus from the mother, but it is generally assumed that the placental barrier protects the fetus by restricting the passage of harmful chemicals. Unfortunately, t ...
... fetus is also of serious health concern. One of the pivotal functions of the placenta is to provide essential nutrients to the developing fetus from the mother, but it is generally assumed that the placental barrier protects the fetus by restricting the passage of harmful chemicals. Unfortunately, t ...
Ser/Thr
... • Sequential action of b4GalT and b3GlcNAcT gives rise to polylactosamine chains (Type II repeats) • Type I repeats (Galb3GlcNAcb4) also occur • GlcNAcb6Gal branches (Iantigen) can occur • The ends of the chains are capped in a-linked sugars, e.g. a3/4Fuc and a3/6sialic acids • Terminal structures m ...
... • Sequential action of b4GalT and b3GlcNAcT gives rise to polylactosamine chains (Type II repeats) • Type I repeats (Galb3GlcNAcb4) also occur • GlcNAcb6Gal branches (Iantigen) can occur • The ends of the chains are capped in a-linked sugars, e.g. a3/4Fuc and a3/6sialic acids • Terminal structures m ...
- Department of Biosystems Science and
... important proteins and helps in the assembly of multimeric complexes [1–3]. With the aid of several co-chaperones and driven by its own ATPase activity, Hsp90 dynamically associates with target proteins (termed clients), keeping them in a stable or a stimulus-responsive conformation (Box 1). The cli ...
... important proteins and helps in the assembly of multimeric complexes [1–3]. With the aid of several co-chaperones and driven by its own ATPase activity, Hsp90 dynamically associates with target proteins (termed clients), keeping them in a stable or a stimulus-responsive conformation (Box 1). The cli ...
The Platform Protein Is Essential for Type IV Pilus
... The resulting mechanical energy is thought to be transferred via an inner membrane protein(s) to drive pilin subunits into the base of the growing fiber during polymerization (23). Pilus depolymerization may result from reversal of this process using a second, retraction ATPase (PilT in P. aeruginos ...
... The resulting mechanical energy is thought to be transferred via an inner membrane protein(s) to drive pilin subunits into the base of the growing fiber during polymerization (23). Pilus depolymerization may result from reversal of this process using a second, retraction ATPase (PilT in P. aeruginos ...
Bile-Acid Sequestrants: Glucose-Lowering Mechanisms - HAL
... The nuclear receptor FXR is highly expressed in liver and intestine, the main sites of bile acid metabolism, but also in adipose tissue, pancreas and adrenals [2]. CDCA is most effective in activating FXR, while LCA, DCA and CA bind with lower affinity and specificity. Upon ligandbinding, FXR acts e ...
... The nuclear receptor FXR is highly expressed in liver and intestine, the main sites of bile acid metabolism, but also in adipose tissue, pancreas and adrenals [2]. CDCA is most effective in activating FXR, while LCA, DCA and CA bind with lower affinity and specificity. Upon ligandbinding, FXR acts e ...
Cells Phenotype of Human Tolerogenic Dendritic Glycolytic
... and pathogen-derived triggers. To characterize the rapid changes that occur during this process, we analyzed the underlying metabolic activity across a spectrum of functional DC activation states, from immunogenic to tolerogenic. We found that in contrast to the pronounced proinflammatory program of ...
... and pathogen-derived triggers. To characterize the rapid changes that occur during this process, we analyzed the underlying metabolic activity across a spectrum of functional DC activation states, from immunogenic to tolerogenic. We found that in contrast to the pronounced proinflammatory program of ...
Huntingtin Aggregation Kinetics and Their Pathological
... on expression of the poly(Q)-containing first exon of Htt alone, the 588-aa fragment is truncated near a number of well-characterized caspase cleavage sites important in the generation of aggregate-forming Htt fragments (Kim et al. 2001; Wellington et al. 2002; Graham et al. 2006). Additionally, many ...
... on expression of the poly(Q)-containing first exon of Htt alone, the 588-aa fragment is truncated near a number of well-characterized caspase cleavage sites important in the generation of aggregate-forming Htt fragments (Kim et al. 2001; Wellington et al. 2002; Graham et al. 2006). Additionally, many ...
metabolism - Garland Science
... of nutrition, from inorganic compounds, is known as autotrophy (“self-feeding”). Organisms that obtain their carbon and nitrogen only from organic compounds—that is, ultimately, from plants—have a form of nutrition known as heterotrophy (“otherfeeding”). Photosynthesis is not only a basic process of ...
... of nutrition, from inorganic compounds, is known as autotrophy (“self-feeding”). Organisms that obtain their carbon and nitrogen only from organic compounds—that is, ultimately, from plants—have a form of nutrition known as heterotrophy (“otherfeeding”). Photosynthesis is not only a basic process of ...
Endoplasmic Reticulum-Associated Degradation of Ricin A Chain
... Ricin is a heterodimeric ribosome-inactivating protein that accumulates in castor bean (Ricinus communis) endosperm cells during seed development. The mature toxin comprises a catalytic A chain (RTA) and a Galbinding B chain (RTB) linked by a single disulfide bond. However, when it is synthesized in ...
... Ricin is a heterodimeric ribosome-inactivating protein that accumulates in castor bean (Ricinus communis) endosperm cells during seed development. The mature toxin comprises a catalytic A chain (RTA) and a Galbinding B chain (RTB) linked by a single disulfide bond. However, when it is synthesized in ...
Duration Tuning across Vertebrates
... (medial) superior olivary complex (Guinan et al., 1972; Grothe et al., 1997, 2001), where dense excitatory projections lead into the ICc (Oliver et al., 1995). GABAergic offset responding neurons in the superior paraolivary complex are not candidates for providing offset-evoked excitatory input to t ...
... (medial) superior olivary complex (Guinan et al., 1972; Grothe et al., 1997, 2001), where dense excitatory projections lead into the ICc (Oliver et al., 1995). GABAergic offset responding neurons in the superior paraolivary complex are not candidates for providing offset-evoked excitatory input to t ...
Signal transduction
Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.