The importance of Wnt signalling for neurodegeneration in
... relieved, leading to the accumulation and nuclear translocation of β-catenin. Within the nucleus, β-catenin binds to TCF/LEF family transcription factors, thereby regulating gene expression. Note that canonical Wnt signalling can also affect the phosphorylation of other GSK3β targets, whereas β-cate ...
... relieved, leading to the accumulation and nuclear translocation of β-catenin. Within the nucleus, β-catenin binds to TCF/LEF family transcription factors, thereby regulating gene expression. Note that canonical Wnt signalling can also affect the phosphorylation of other GSK3β targets, whereas β-cate ...
Early Embryonic Expression of Ion Channels and Pumps in Chick
... embryogenesis. Clones with specific expression patterns are shown here at representative stages. A: Sense probe controls show no signal. B: A probe for the maternal gene Xombi shows that whole-mount in situ hybridization can detect vegetal mRNA localization when it is present (arrow). C: Sectioning p ...
... embryogenesis. Clones with specific expression patterns are shown here at representative stages. A: Sense probe controls show no signal. B: A probe for the maternal gene Xombi shows that whole-mount in situ hybridization can detect vegetal mRNA localization when it is present (arrow). C: Sectioning p ...
review cell division from a genetic perspective
... synthesis of specific gene products. It is of considerable interest to inquire therefore whether the gene-controlled steps that are identified by the thermolabile cell cycle mutations are organized into causal sequences. Two strategies exist for determining these sequences. The less precise method ( ...
... synthesis of specific gene products. It is of considerable interest to inquire therefore whether the gene-controlled steps that are identified by the thermolabile cell cycle mutations are organized into causal sequences. Two strategies exist for determining these sequences. The less precise method ( ...
Dicot and monocot plants differ in retinoblastoma
... OsRBR2 gene displayed only 52% identity to OsRBR1. The full-length OsRBR2 cDNA clone was 3383 bp long and encoded a polypeptide of 978 amino acids with a calculated molecular weight of 107.9 kDa and a pI of 8.10. The OsRBR1 and OsRBR2 proteins share 52% identity in amino acid sequence, which indicat ...
... OsRBR2 gene displayed only 52% identity to OsRBR1. The full-length OsRBR2 cDNA clone was 3383 bp long and encoded a polypeptide of 978 amino acids with a calculated molecular weight of 107.9 kDa and a pI of 8.10. The OsRBR1 and OsRBR2 proteins share 52% identity in amino acid sequence, which indicat ...
REVIEW CELL DIVISION FROM A GENETIC PERSPECTIVE
... synthesis of specific gene products. It is of considerable interest to inquire therefore whether the gene-controlled steps that are identified by the thermolabile cell cycle mutations are organized into causal sequences. Two strategies exist for determining these sequences. The less precise method ( ...
... synthesis of specific gene products. It is of considerable interest to inquire therefore whether the gene-controlled steps that are identified by the thermolabile cell cycle mutations are organized into causal sequences. Two strategies exist for determining these sequences. The less precise method ( ...
review cell division from a genetic perspective
... synthesis of specific gene products. It is of considerable interest to inquire therefore whether the gene-controlled steps that are identified by the thermolabile cell cycle mutations are organized into causal sequences. Two strategies exist for determining these sequences. The less precise method ( ...
... synthesis of specific gene products. It is of considerable interest to inquire therefore whether the gene-controlled steps that are identified by the thermolabile cell cycle mutations are organized into causal sequences. Two strategies exist for determining these sequences. The less precise method ( ...
NEK1 Facilitates Cohesin Removal during Mammalian
... include the SC protein SYCP3 [6] and FKBP6 [7]. During zygonema, the central element begins to form between the homologs, consisting of proteins such as SYCP1, SYCE1 and SYCE2 [8–12], thus tethering them together and ensuring they are paired along their entire lengths at pachynema. Mutations in the ...
... include the SC protein SYCP3 [6] and FKBP6 [7]. During zygonema, the central element begins to form between the homologs, consisting of proteins such as SYCP1, SYCE1 and SYCE2 [8–12], thus tethering them together and ensuring they are paired along their entire lengths at pachynema. Mutations in the ...
Thesis - KI Open Archive
... and reduced relapse-free survival specifically in those treated with two years of tamoxifen. Moreover, VEGF was highly correlated to RARA expression. We conclude that RARA may be of potential prognostic or predictive value for patients eligible for tamoxifen therapy. We used a similar MS-based prote ...
... and reduced relapse-free survival specifically in those treated with two years of tamoxifen. Moreover, VEGF was highly correlated to RARA expression. We conclude that RARA may be of potential prognostic or predictive value for patients eligible for tamoxifen therapy. We used a similar MS-based prote ...
The Cell Adhesion Molecule Neuroplastin
... Na2HPO4, pH 7.3). Cells were then detached from the culture dishes by incubating with 2.5 ml of 5 mM EDTA in PBS for 5 min at room temperature. The resulting cell suspension was diluted in 6 ml of cold Dulbecco’s modified Eagle’s medium and centrifuged for 5 min at 1,500 rpm. The cell pellet from fo ...
... Na2HPO4, pH 7.3). Cells were then detached from the culture dishes by incubating with 2.5 ml of 5 mM EDTA in PBS for 5 min at room temperature. The resulting cell suspension was diluted in 6 ml of cold Dulbecco’s modified Eagle’s medium and centrifuged for 5 min at 1,500 rpm. The cell pellet from fo ...
Lysophospholipids and fat digestibility
... fatty acid chains (Fig. 3). In the case of lysophospholipids only a single fatty acid chain is observed. The polar heads can be a choline, an ethanolamine, a serine or an inositol (Fig. 3). For a greater diversity fatty acids chains present variable lengths and degrees of saturation, so there are se ...
... fatty acid chains (Fig. 3). In the case of lysophospholipids only a single fatty acid chain is observed. The polar heads can be a choline, an ethanolamine, a serine or an inositol (Fig. 3). For a greater diversity fatty acids chains present variable lengths and degrees of saturation, so there are se ...
Systemic Organ Wasting Induced by Localized Expression of the
... of the downregulated muscle transcriptome revealed a striking enrichment of multiple metabolic processes impinging on carbohydrate metabolism (p = 0.0018), amino acid metabolism (p = 1.32 3 107), metabolism of vitamins and cofactors (p = 1.32 3 107), and metabolism of xenobiotics by cytochrome P45 ...
... of the downregulated muscle transcriptome revealed a striking enrichment of multiple metabolic processes impinging on carbohydrate metabolism (p = 0.0018), amino acid metabolism (p = 1.32 3 107), metabolism of vitamins and cofactors (p = 1.32 3 107), and metabolism of xenobiotics by cytochrome P45 ...
Fibronectin and a5b1 integrin mediate binding of Pseudomonas
... ABSTRACT: Initial infection of the airway by Pseudomonas aeruginosa may occur through a variety of bacterial strategies including binding to epithelial receptors present at the surface of the respiratory epithelium. In order to characterize the adherence sites for P. aeruginosa in damaged and repair ...
... ABSTRACT: Initial infection of the airway by Pseudomonas aeruginosa may occur through a variety of bacterial strategies including binding to epithelial receptors present at the surface of the respiratory epithelium. In order to characterize the adherence sites for P. aeruginosa in damaged and repair ...
Silk-inspired polymers and proteins - Pure
... Natural silk proteins can be stored at high concentrations without the onset of undesirable aggregation inside the silkworm or spider. When necessary the silkworm or spider exposes the proteins to chemical and mechanical stimuli triggering protein assembly into fibres in a precisely controlled manne ...
... Natural silk proteins can be stored at high concentrations without the onset of undesirable aggregation inside the silkworm or spider. When necessary the silkworm or spider exposes the proteins to chemical and mechanical stimuli triggering protein assembly into fibres in a precisely controlled manne ...
Minus End-Directed Kinesin-Like Motor Protein
... undergo a profound transformation during mitosis. In Haemanthus endosperm, the metaphase spindle is predominantly barrel-shaped, but usually becomes convergent in anaphase [Smirnova and Bajer, 1994]. The change of spindle shape in anaphase is an important feature of mitosis, preventing formation of ...
... undergo a profound transformation during mitosis. In Haemanthus endosperm, the metaphase spindle is predominantly barrel-shaped, but usually becomes convergent in anaphase [Smirnova and Bajer, 1994]. The change of spindle shape in anaphase is an important feature of mitosis, preventing formation of ...
Electrostatic Interactions in Wild
... charge at residue 68 is stabilized by a favorable Coulombic interaction with the heme iron. In the absence of this interaction, as in the metcyano and ferrous deoxy derivatives, the relatively nonpolar protein interior cannot stabilize an isolated buried negative charge, and the carboxylate is eithe ...
... charge at residue 68 is stabilized by a favorable Coulombic interaction with the heme iron. In the absence of this interaction, as in the metcyano and ferrous deoxy derivatives, the relatively nonpolar protein interior cannot stabilize an isolated buried negative charge, and the carboxylate is eithe ...
Tolerance to mutations in the foot-and
... the glycosaminoglycan heparan sulfate (HS) as receptor, acquired by multiple passage on BHK21 cells, has been abolished. The capsid sequence context determined infectivity in cultured cells and directed the selection of additional replacements in structural proteins. Interestingly, a viral populatio ...
... the glycosaminoglycan heparan sulfate (HS) as receptor, acquired by multiple passage on BHK21 cells, has been abolished. The capsid sequence context determined infectivity in cultured cells and directed the selection of additional replacements in structural proteins. Interestingly, a viral populatio ...
Evaluation of flow cytometry as replacement for plating in in vitro
... bacteriolytic). They are also usually classified as either broad or narrow spectrum. Most antibiotics target processes involved in bacterial growth, such as DNA replication, DNA packing, and RNA or protein or cell wall synthesis.3 Other antibiotics target metabolic pathways, or the structure of the ...
... bacteriolytic). They are also usually classified as either broad or narrow spectrum. Most antibiotics target processes involved in bacterial growth, such as DNA replication, DNA packing, and RNA or protein or cell wall synthesis.3 Other antibiotics target metabolic pathways, or the structure of the ...
Neuron Physiology and Synapses
... The action potential does not occur all along the length of the myelinated axon only at the neurofibril nodes where there is only bare cell membrane of the axon between the intracellular and extracellular fluids. As a result an action potential in a myelinated axon jumps along the axon from node to ...
... The action potential does not occur all along the length of the myelinated axon only at the neurofibril nodes where there is only bare cell membrane of the axon between the intracellular and extracellular fluids. As a result an action potential in a myelinated axon jumps along the axon from node to ...
European Journal of Biochemistry
... 100 pl of the suspension in each well and drying the plate at 37°C. The wells were subsequently filled with Pi/NaCl containing 5% newborn calf serum and incubated for two hours at 37°C in order to block the remaining binding sites. The blocking solution was removed and 100 p1 aliquots of Isolation o ...
... 100 pl of the suspension in each well and drying the plate at 37°C. The wells were subsequently filled with Pi/NaCl containing 5% newborn calf serum and incubated for two hours at 37°C in order to block the remaining binding sites. The blocking solution was removed and 100 p1 aliquots of Isolation o ...
Iboga – mit in resničnost
... against asthenia 1939-1970: neuromuscular stimulant 8mg per pill against fatigue, depression and at reconvalescence after infectious diseases 1969: 4-5mg/kg as fantasy enhancer at psychotherapy ...
... against asthenia 1939-1970: neuromuscular stimulant 8mg per pill against fatigue, depression and at reconvalescence after infectious diseases 1969: 4-5mg/kg as fantasy enhancer at psychotherapy ...
What Are Enzymes?
... called an ACTIVE SITE. • One or more molecules called SUBSTRATES chemically bond to the enzyme’s active site. • When joined they are called an ENZYME-SUBSTRATE COMPLEX • Changes in how the atoms are bonded occur resulting in new ...
... called an ACTIVE SITE. • One or more molecules called SUBSTRATES chemically bond to the enzyme’s active site. • When joined they are called an ENZYME-SUBSTRATE COMPLEX • Changes in how the atoms are bonded occur resulting in new ...
C7orf30 is necessary for biogenesis of the large
... nuclear genes and imported to mitochondria from the cytosol. Human mitoribosomes consist of a large (mt-LSU) and small subunit (mt-SSU) of 39S and 28S, respectively, and the entire ribosome has a sedimentation coefficient of 55S (2). Many genetic defects can lead to perturbations of the OXPHOS system ...
... nuclear genes and imported to mitochondria from the cytosol. Human mitoribosomes consist of a large (mt-LSU) and small subunit (mt-SSU) of 39S and 28S, respectively, and the entire ribosome has a sedimentation coefficient of 55S (2). Many genetic defects can lead to perturbations of the OXPHOS system ...
Engineering of metabolic pathways by artificial enzyme channels
... Living cells are highly dynamic and complex metabolic systems in which most enzymes do not function in isolation but form supramolecular complexes (Jørgensen et al., 2005). By providing spatial and temporal organization of molecules within the cell, these complexes allow optimized substrate channel ...
... Living cells are highly dynamic and complex metabolic systems in which most enzymes do not function in isolation but form supramolecular complexes (Jørgensen et al., 2005). By providing spatial and temporal organization of molecules within the cell, these complexes allow optimized substrate channel ...
Signal transduction
Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.