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Cell-to-cell communication and virulence in Vibrio anguillarum
Cell-to-cell communication and virulence in Vibrio anguillarum

... In Vibrio anguillarum, three parallel quorum-sensing phosphorelay systems channels information via three hybrid sensor kinases VanN, VanQ, and CqsS that function as receptors for signal molecules produced by the synthases VanM, VanS, and CqsA, respectively. The phosphorelay systems converge onto a s ...
Cell shrinkage and apoptosis: a role for potassium and sodium ion
Cell shrinkage and apoptosis: a role for potassium and sodium ion

... of embryonic development and tissue homeostasis. The most common and best described form of this type of cell death (programmed cell death) is apoptosis (Kerr et al, 1972), which can occur either from developmentally controlled activation of an endogenous suicide programme (Ellis et al, 1991; Kerr e ...
Primary cilia of human endothelial cells disassemble under laminar
Primary cilia of human endothelial cells disassemble under laminar

... est concentration of acetyl--tubulin (Fig. 3, A and B). HUVEC primary cilia occasionally were detectable by phase contrast (Fig. 4 B”). HUVEC expressed the highest percentage of primary cilia at passages 2–6. In contrast, they lacked cilia at passages higher than 12. To identify the intracellular l ...
Identification of the tRNA-binding Protein Arc1p as a Novel Target of
Identification of the tRNA-binding Protein Arc1p as a Novel Target of

Gene Regulation
Gene Regulation

... The first operon to be discovered The lac operon is regulated by several factors including the availability of glucose and lactose. It consists of a promoter, an operator, followed by a group of ...
starry night regulates tissue polarity - Development
starry night regulates tissue polarity - Development

... intercellular signaling/signal transduction pathway that regulates specific downstream effector genes and proteins in the cells that give rise to the different cuticular structures (Adler, 1992). ...
A Darwinian view of metabolism: molecular
A Darwinian view of metabolism: molecular

... enzymes making them, it is necessary to consider the types of physicochemical properties that substances possess that could act as a focus for selection. Like human characters, chemical characters have many facets to their personality and more than one facet may play a part in selection. However, th ...
Centronuclear myopathy in mice lacking a novel muscle
Centronuclear myopathy in mice lacking a novel muscle

... genes directly, or it may act indirectly by controlling the expression of subordinate transcription factors or signaling molecules that act as intermediaries to connect MEF2 to downstream targets that themselves are not dependent on MEF2-binding sites in their cis-regulatory regions. Indeed, vast ar ...
Cloning and characterization of the
Cloning and characterization of the

... phenotype of the S.cerevisiae los1∆ pus1∆ strain as well its sequence homology to scPus1p indicate that spPus1p may have pseudouridine synthase activity. To show this experimentally, we tested whether recombinant spPus1p exhibits a similar enzymatic activity to recombinant scPus1p. The spPUS1 ORF wa ...
CDK11p58 kinase activity is required to protect sister chromatid
CDK11p58 kinase activity is required to protect sister chromatid

... cohesion in these cells occurs beyond the G2/M transition. Vertebrates have evolved a mechanism, known as the "prophase pathway", by which cohesin is actively taken off chromosome arms during early mitosis stages, cohesion being protected at centromeres . The benefits of such a mechanism are not cle ...
PDF
PDF

... consisting of 147 bp of DNA wrapped around a histone octamer made up of two molecules of each histone: H2A, H2B, H3 and H4. Histones are classified as either canonical or variant, depending on their primary sequence and mode of deposition during the cell cycle. They are subjected to various post-tra ...
Power tools for gene expression and clonal analysis in
Power tools for gene expression and clonal analysis in

... 18 °C but does not repress GAL4 at 29 °C or higher temperatures. Alternatively, one can use recombinases to temporally control the expression of GAL80, as we will discuss below. This threecomponent system (GAL4-UAS, transgene and GAL80) is the basis of two powerful technologies: MARCM (discussed bel ...
Olanzapine Activates Hepatic Mammalian Target of Rapamycin
Olanzapine Activates Hepatic Mammalian Target of Rapamycin

... (LDL), very-low-density lipoprotein (VLDL), triglycerides (TG), and glucose were determined by the Piccolo Lipid Panel Plus Reagent Disc, used with the Piccolo Xpress Chemistry Analyzer (Abaxis, Inc., Union City, CA), according to the manufacturer’s instructions. Paraffin-embedded sections of liver ...
Cloning, Purification, and Partial Characterization of the
Cloning, Purification, and Partial Characterization of the

... and the intein is located between the highly conserved Lys and Ser residues. The alignment also revealed that the C-terminal part of the MCM protein is more conserved than the N-terminal portion. The C-terminal part of the molecule contains the AAA+ catalytic domains, known to be highly conserved am ...
Activity Regulates the Synaptic Localization of the NMDA Receptor
Activity Regulates the Synaptic Localization of the NMDA Receptor

Biochemical and Molecular Characterization of the Chicken
Biochemical and Molecular Characterization of the Chicken

... In addition to the LIM-homeodomain proteins, a number of small (10-30 kD) proteins that are comprised primarily of LIM domains have been identified. These include rhombotin (or Ttg-1) (McGuire et al., 1989; Boehm et al., 1990, 1991), the cysteine-rich intestinal protein (CRIP) t (Birkenmeier and Gor ...
An Introduction to the Nervous System
An Introduction to the Nervous System

... • The Structure of Neurons • The synapse • Presynaptic cell • Neuron that sends message • Postsynaptic cell • Cell that receives message • The synaptic cleft • The small gap that separates the presynaptic membrane and the postsynaptic membrane ...
A Triad of Costimulatory Molecules Synergize to
A Triad of Costimulatory Molecules Synergize to

... In Vitro Costimulation Analysis. Female C57BL/6 mice (6 – 8 weeks of age) were obtained from Taconic Farms (Germantown, NY). Naive T cells were isolated as described previously (22). For certain experiments, T cells were further fractionated into CD41 and CD81 populations by negative selection using ...
protein research
protein research

... Takara’s pCold TF DNA Vector is a fusion cold shock expression vector that expresses Trigger Factor (TF) chaperone as a soluble tag. Trigger Factor is a prokaryotic ribosome-associated chaperone protein (48 kDa) which facilitates co-translational folding of newly expressed polypeptides. Because of i ...
vollllllkkks_1
vollllllkkks_1

... may be synthesized and released as a neurotransmitter by the NANC neurons after their excitation by either electrical or chemical stimulation. In this regard we have suggested that NO is highly labile; therefore, it cannot be stored as a preformed neurotransmitter. There are at least three distinct ...
Fractal and Mathematical Morphology in Intricate
Fractal and Mathematical Morphology in Intricate

... naturally or as a tertiary structure into which a particular protein folds [2]. The two highly similar amino acid sequences (primary structures) would not necessarily mean protein functional similarity [2] [3]. Therefore it is evident that comparison of protein functionality requires the intricate ...
A Simple 1-D Physical Model for the Crawling Nematode Sperm Cell
A Simple 1-D Physical Model for the Crawling Nematode Sperm Cell

... Biochemical Regulation. The precise role played by pH in MSP turnover, bundling and adhesion is yet to be established. In the model, we use pH distribution as a marker for these processes. We assume that protons constantly appear at the cell body, and that protons leak out from the lamellipod, maint ...
DRUGS for DYSLIPIDEMIAS MED PHARM
DRUGS for DYSLIPIDEMIAS MED PHARM

... Heistad D. N Engl J Med 2003;349:2285-2287 ...
Fan et al.P65
Fan et al.P65

... mice bearing null or truncation mutations have been generated [29-31]. These mutant mice exhibit neurological phenotypes mimicking the RTT phenotype [29-31]. MeCP2 null male mice and female mice do not exhibit phenotypes until 6–8 weeks postnatally. After this presymptom period, mutant male mice sho ...


... strongly adhere to underwater surfaces (Waite, 1990). The hardening of insect carapaces is also facilitated by tyrosinase (Sugumaran, 1988). Plant and fungal forms of the tyrosinase enzyme are also responsible for the oxidation of produce, i.e. the browning of fruits, vegetables, and mushrooms (Zawi ...
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Signal transduction



Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.
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