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... proprioceptive sensations. Visceral- provide information about conditions within internal organs. Special senses- smell, taste, vision, hearing and equilibrium or balance. ...
... proprioceptive sensations. Visceral- provide information about conditions within internal organs. Special senses- smell, taste, vision, hearing and equilibrium or balance. ...
1 - Utrecht University Repository
... Integrins on leukocytes and platelets adhere, in addition to immobilized ECM proteins, to cellular receptors including ICAM (Inter-Cellular Adhesion Molecule), VCAM-1 (Vascular Cell Adhesion Molecule-1) and E-Cadherin, or to soluble ligands like fibrinogen and von Willebrand Factor (vWF). In contras ...
... Integrins on leukocytes and platelets adhere, in addition to immobilized ECM proteins, to cellular receptors including ICAM (Inter-Cellular Adhesion Molecule), VCAM-1 (Vascular Cell Adhesion Molecule-1) and E-Cadherin, or to soluble ligands like fibrinogen and von Willebrand Factor (vWF). In contras ...
Self-Interaction of the Herpes Simplex Virus Type 1
... were not found to be trans-dominant (Smith et al., 1991), which supports the notion that the zinc-finger-like region may be required for multimerization. RESULTS An ICP27 NLS mutant protein can be efficiently localized to the nucleus by heterodimer formation with wild-type ICP27 We showed previously ...
... were not found to be trans-dominant (Smith et al., 1991), which supports the notion that the zinc-finger-like region may be required for multimerization. RESULTS An ICP27 NLS mutant protein can be efficiently localized to the nucleus by heterodimer formation with wild-type ICP27 We showed previously ...
Phospholipase D Activation Correlates with Microtubule
... Hartog et al., 2001; Laxalt et al., 2001; Laxalt and Munnik, 2002). In some cases, evidence for PA stimulating the downstream responses also was provided (Munnik, 2001). In general, PA is thought to work by binding target proteins downstream in the signaling cascade. Binding may activate these compo ...
... Hartog et al., 2001; Laxalt et al., 2001; Laxalt and Munnik, 2002). In some cases, evidence for PA stimulating the downstream responses also was provided (Munnik, 2001). In general, PA is thought to work by binding target proteins downstream in the signaling cascade. Binding may activate these compo ...
Formation Costimulation in Immunological Synapse Live
... of costimulation involves B7 molecules (CD80 and CD86) on APC and their receptor on T cells, CD28. Numerous studies have shown that B7/CD28 ligation enhances proliferation and IL-2 secretion by CD4⫹ T cells (13, 14). CD28 engagement is linked to cytoskeletal rearrangements upon TCR ligation (5, 15), ...
... of costimulation involves B7 molecules (CD80 and CD86) on APC and their receptor on T cells, CD28. Numerous studies have shown that B7/CD28 ligation enhances proliferation and IL-2 secretion by CD4⫹ T cells (13, 14). CD28 engagement is linked to cytoskeletal rearrangements upon TCR ligation (5, 15), ...
Identification of Myosin XI Receptors in Arabidopsis Defines a
... its effector Rab11-family interacting protein-2 (Wang et al., 2008; Hammer and Sellers, 2012). Furthermore, a network of interactions involving Rab11A, myosin Vb, and exocyst subunit Sec15 is implicated in epithelial polarization (Bryant et al., 2010; Roland et al., 2011). Thus, the comparison of th ...
... its effector Rab11-family interacting protein-2 (Wang et al., 2008; Hammer and Sellers, 2012). Furthermore, a network of interactions involving Rab11A, myosin Vb, and exocyst subunit Sec15 is implicated in epithelial polarization (Bryant et al., 2010; Roland et al., 2011). Thus, the comparison of th ...
GFP-labelled Rubisco and aspartate aminotransferase are present
... Plastid stromules are membrane-bound protrusions of the plastid envelope that contain soluble stroma. Stromules are often found connecting plastids within a cell and ¯uorescence recovery after photobleaching (FRAP) experiments have demonstrated that green ¯uorescent protein (GFP) can move between pl ...
... Plastid stromules are membrane-bound protrusions of the plastid envelope that contain soluble stroma. Stromules are often found connecting plastids within a cell and ¯uorescence recovery after photobleaching (FRAP) experiments have demonstrated that green ¯uorescent protein (GFP) can move between pl ...
Chloride Channels Regulate HIT Cell Volume but Cannot
... unclear. The Clⴚ channel blockers 4,4ⴕ-diisothiocyanostilbene-2,2ⴕ-disulfonic acid (DIDS) and niflumic acid were evaluated for their ability to inhibit ICl,islet in clonal -cells (HIT cells). Both drugs blocked the channel, but the blockade due to niflumic acid was less voltage-dependent than the b ...
... unclear. The Clⴚ channel blockers 4,4ⴕ-diisothiocyanostilbene-2,2ⴕ-disulfonic acid (DIDS) and niflumic acid were evaluated for their ability to inhibit ICl,islet in clonal -cells (HIT cells). Both drugs blocked the channel, but the blockade due to niflumic acid was less voltage-dependent than the b ...
The impact of abiotic factors on cellulose synthesis
... Peaucelle et al., 2015), implying that cellulose may be directly or indirectly regulated by water availability. Under extreme osmotic stress, plasmolysis (the separation of the plasma membrane from the cell wall) will necessarily disrupt cellulose synthesis. Mild osmotic or ionic stress caused rapid ...
... Peaucelle et al., 2015), implying that cellulose may be directly or indirectly regulated by water availability. Under extreme osmotic stress, plasmolysis (the separation of the plasma membrane from the cell wall) will necessarily disrupt cellulose synthesis. Mild osmotic or ionic stress caused rapid ...
Peer-reviewed Article PDF
... polyamine biosynthetic pathway enzymes of T. brucei [17]. ZINC database is a free chemical database, consisting of nearly 13 million small commercially available molecules [18]. With the help of advanced computational biology, an arduous task of in-vitro testing of ODC inhibitors has been reduced dr ...
... polyamine biosynthetic pathway enzymes of T. brucei [17]. ZINC database is a free chemical database, consisting of nearly 13 million small commercially available molecules [18]. With the help of advanced computational biology, an arduous task of in-vitro testing of ODC inhibitors has been reduced dr ...
The lin-41 RBCC Gene Acts in the C. elegans Heterochronic
... a Tc1 transposon inserted at amino acid 713. Five other lin-41 mutations cause substitutions in the C-terminal conserved region of the protein (Figure 3 legend, Figure 4). lin-41(mg187) results in an alteration on a Southern blot probed with C12C8 (data not shown), suggesting that this mutation is a ...
... a Tc1 transposon inserted at amino acid 713. Five other lin-41 mutations cause substitutions in the C-terminal conserved region of the protein (Figure 3 legend, Figure 4). lin-41(mg187) results in an alteration on a Southern blot probed with C12C8 (data not shown), suggesting that this mutation is a ...
A cross-laboratory database of brain cell-type expression
... challenging their identification outside of the original study and understanding their role in normal and pathological brain function. Regardless of the methodology used, technical biases and artefacts introduced during different stages of cellular purification (e.g. stress) and analysis (e.g. norma ...
... challenging their identification outside of the original study and understanding their role in normal and pathological brain function. Regardless of the methodology used, technical biases and artefacts introduced during different stages of cellular purification (e.g. stress) and analysis (e.g. norma ...
Post-pubertal Emergence of Prefrontal Cortical Up
... activation of D1 and NMDA receptors in PFC pyramidal neurons may reflect the activity of a local neuronal network. D1--NMDA-mediated Plateau Depolarizations Involve Intracellular Ca2+, L-type Ca2+ Channels, Protein Kinase A and Voltage-gated Na+ Channels Several cellular mechanisms may also contribut ...
... activation of D1 and NMDA receptors in PFC pyramidal neurons may reflect the activity of a local neuronal network. D1--NMDA-mediated Plateau Depolarizations Involve Intracellular Ca2+, L-type Ca2+ Channels, Protein Kinase A and Voltage-gated Na+ Channels Several cellular mechanisms may also contribut ...
From signal to form: aspects of the cytoskeleton
... streaming, but how vesicles move within the vesicle-rich region is unclear. When root hairs of Equisetum hyemale and Limnobium stoloniferum were rapidly frozen by plunging in liquid propane and freeze-substituted for electron microscopy, microfilaments were not detected in the vesicle-rich region be ...
... streaming, but how vesicles move within the vesicle-rich region is unclear. When root hairs of Equisetum hyemale and Limnobium stoloniferum were rapidly frozen by plunging in liquid propane and freeze-substituted for electron microscopy, microfilaments were not detected in the vesicle-rich region be ...
I. Molecular mechanism for polyunsaturated fatty acid regulation of
... The reduction in hepatic malonyl-CoA is paralleled by a PUFA-dependent induction of genes encoding proteins involved in fatty acid oxidation and ketogenesis (3, 7, 11). These changes in gene transcription occur too quickly to be explained simply by altered hormone signaling resulting from modificati ...
... The reduction in hepatic malonyl-CoA is paralleled by a PUFA-dependent induction of genes encoding proteins involved in fatty acid oxidation and ketogenesis (3, 7, 11). These changes in gene transcription occur too quickly to be explained simply by altered hormone signaling resulting from modificati ...
machen2006
... Pier and colleagues have proposed that P. aeruginosa binds to CFTR at the first extracellular loop through interaction with the outer core oligosaccharide portion of bacterial LPS, and this binding leads to bacterial entry into the epithelial cell. Recent experiments (51, 86) have shown that CFTR ma ...
... Pier and colleagues have proposed that P. aeruginosa binds to CFTR at the first extracellular loop through interaction with the outer core oligosaccharide portion of bacterial LPS, and this binding leads to bacterial entry into the epithelial cell. Recent experiments (51, 86) have shown that CFTR ma ...
POP-1 and Anterior–Posterior Fate Decisions in
... for MS is killed (Mello et al., 1992). Thus, in some lineages, cell fates do not appear to be determined by external, environmental cues within the embryo. Despite the different molecular mechanisms that establish blastomere identities and the very different lineages that blastomeres execute, there ...
... for MS is killed (Mello et al., 1992). Thus, in some lineages, cell fates do not appear to be determined by external, environmental cues within the embryo. Despite the different molecular mechanisms that establish blastomere identities and the very different lineages that blastomeres execute, there ...
Protein kinase Ca activation by RET: evidence for a negative
... Y1062 is essential for mitogenic, transforming and survival RET signaling (Manie et al., 2001). Eventually, most recently, serine phosphorylation of RET kinase induced by cAMP has been shown to be important for lamellipodia formation, resulting from Rac1 activation (Fukuda et al., 2002). Protein kin ...
... Y1062 is essential for mitogenic, transforming and survival RET signaling (Manie et al., 2001). Eventually, most recently, serine phosphorylation of RET kinase induced by cAMP has been shown to be important for lamellipodia formation, resulting from Rac1 activation (Fukuda et al., 2002). Protein kin ...
feven tigistu-sahle – metabolism of polyunsaturated fatty
... The application of human bone marrow derived mesenchymal stromal cells (hBMSCs) for regenerative or immunomodulatory therapies, e.g. treatment of the graft-versus-host disease, requires in vitro expansion of the cells. The hBMSCs undergo subtle changes during expansion which may compromise their fun ...
... The application of human bone marrow derived mesenchymal stromal cells (hBMSCs) for regenerative or immunomodulatory therapies, e.g. treatment of the graft-versus-host disease, requires in vitro expansion of the cells. The hBMSCs undergo subtle changes during expansion which may compromise their fun ...
Actin Microfilaments Regulate Vacuolar Structures and Dynamics
... across the vacuolar surface and cell cortex showed that the MFs localized on the vacuolar surface more intensively (Fig. 2G, large arrow) than close to the cell cortex (Fig. 2G, small arrow). In the cytoplasmic strands, MFs seemed to localize at the periphery of the strands rather than at the center ...
... across the vacuolar surface and cell cortex showed that the MFs localized on the vacuolar surface more intensively (Fig. 2G, large arrow) than close to the cell cortex (Fig. 2G, small arrow). In the cytoplasmic strands, MFs seemed to localize at the periphery of the strands rather than at the center ...
pdf file - John Innes Centre
... Downloaded from www.jbc.org at JOHN INNES CENTRE LIBRARY, on October 22, 2010 ...
... Downloaded from www.jbc.org at JOHN INNES CENTRE LIBRARY, on October 22, 2010 ...
A Strong Loss-of-Function Mutation in RAN1 Results in Constitutive
... histidine kinases (Chang et al., 1993). Two-component systems are the major route by which bacteria sense and respond to external stimuli, such as phosphate availability and osmolarity (Stock et al., 1990). The C terminus of ETR1 is similar to both the histidine kinase domain of the sensor component ...
... histidine kinases (Chang et al., 1993). Two-component systems are the major route by which bacteria sense and respond to external stimuli, such as phosphate availability and osmolarity (Stock et al., 1990). The C terminus of ETR1 is similar to both the histidine kinase domain of the sensor component ...
At the Intersection of the Pathways for Exocytosis and
... These different pathways are in dynamic balance with the endocytic pathway, which, apart from facilitating uptake into the cell, allows the recovery of membrane from the plasma membrane following exocytosis, enabling the cell to control its surface area (Khandelwal et al., 2010). The molecular machi ...
... These different pathways are in dynamic balance with the endocytic pathway, which, apart from facilitating uptake into the cell, allows the recovery of membrane from the plasma membrane following exocytosis, enabling the cell to control its surface area (Khandelwal et al., 2010). The molecular machi ...
Crystal Structure of the Vesicular Transport Protein Sec17
... SNAP and NSF/Sec18 bind sequentially to SNARE complexes, forming 20S particles. In vitro reconstitution of the fusion between yeast vacuole-derived vesicles has shown that the requirement for the activity of Sec18 (NSF) and Sec17 (SNAP) can be fulfilled prior to vesicle docking (Mayer et al., 1996). ...
... SNAP and NSF/Sec18 bind sequentially to SNARE complexes, forming 20S particles. In vitro reconstitution of the fusion between yeast vacuole-derived vesicles has shown that the requirement for the activity of Sec18 (NSF) and Sec17 (SNAP) can be fulfilled prior to vesicle docking (Mayer et al., 1996). ...
Fig. 1 - The Journal of Cell Biology
... Tim23 pore. A surprising and still unresolved observation is that a loss of Tim50 leads to robust import defects for matrix proteins, but has a much lesser effect on precursors sorted into the inner membrane (Geissler et al., 2002). To assess the function of Tim50 in protein transport, we isolated m ...
... Tim23 pore. A surprising and still unresolved observation is that a loss of Tim50 leads to robust import defects for matrix proteins, but has a much lesser effect on precursors sorted into the inner membrane (Geissler et al., 2002). To assess the function of Tim50 in protein transport, we isolated m ...
Signal transduction
Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.