TCA Cycle Defects and Cancer: When Metabolism Tunes Redox State
... of PHD targets may contribute to tumorigenesis regardless of HIF-1α activity and the acquisition of a hypoxic signature. For instance, it has been proposed that SDH deficiency could impair PHD-dependent programmed cell death of neurons, therefore setting the stage for neoplastic transformation of ne ...
... of PHD targets may contribute to tumorigenesis regardless of HIF-1α activity and the acquisition of a hypoxic signature. For instance, it has been proposed that SDH deficiency could impair PHD-dependent programmed cell death of neurons, therefore setting the stage for neoplastic transformation of ne ...
Part B
... (b) In an unmyelinated axon, voltage-gated Na+ and K+ channels regenerate the action potential at each point along the axon, so voltage does not decay. Conduction is slow because movements of ions and of the gates of channel proteins take time and must occur before voltage regeneration occurs. Stimu ...
... (b) In an unmyelinated axon, voltage-gated Na+ and K+ channels regenerate the action potential at each point along the axon, so voltage does not decay. Conduction is slow because movements of ions and of the gates of channel proteins take time and must occur before voltage regeneration occurs. Stimu ...
Human red blood cells-1 - Science Publishing Group
... Aging of the red blood cell revealed a decrease of cholesterol-to-phospholipids moral ratio , followed by a marked decrease in the activities of the membrane-bound enzymes, Na+,K+-ATPase [E.C.3.6.1.7] which is the marker of erythroid differentiation [30], is inactive in the intact membrane and is ac ...
... Aging of the red blood cell revealed a decrease of cholesterol-to-phospholipids moral ratio , followed by a marked decrease in the activities of the membrane-bound enzymes, Na+,K+-ATPase [E.C.3.6.1.7] which is the marker of erythroid differentiation [30], is inactive in the intact membrane and is ac ...
moth`s nervous system - Wageningen UR E
... associated with the MGC: the male-specific local and projection neurons. Stimulus quality. By means of intracellular recording and staining methods, we have examined the activity of AL neurons in response to stimulation of the ipsilateral antenna with each of the sex-pheromone components aswell as p ...
... associated with the MGC: the male-specific local and projection neurons. Stimulus quality. By means of intracellular recording and staining methods, we have examined the activity of AL neurons in response to stimulation of the ipsilateral antenna with each of the sex-pheromone components aswell as p ...
Adipocyte metabolic pathways regulated by diet control
... GSC maintenance, whereas lipid and iron transport from adipocytes controls vitellogenesis and GSC ...
... GSC maintenance, whereas lipid and iron transport from adipocytes controls vitellogenesis and GSC ...
Bacterial tail anchors can target to the mitochondrial outer
... mitochondrial OM that would allow full integration of mitochondria within the ancestral ...
... mitochondrial OM that would allow full integration of mitochondria within the ancestral ...
DNA Specificity of the Bicoid Activator Protein Is Determined by
... al., 1989; this paper). It seemed possible that Bicoid and other homeodomain proteins distinguish between these sites using residues in the recognition helix which differ, and are in positions corresponding to those important for repressor-DNA recognition. In this study, we employed fusion proteins ...
... al., 1989; this paper). It seemed possible that Bicoid and other homeodomain proteins distinguish between these sites using residues in the recognition helix which differ, and are in positions corresponding to those important for repressor-DNA recognition. In this study, we employed fusion proteins ...
Document
... • The summed effect of EPSPs and IPSPs determines whether an axon hillock will reach threshold and generate an action potential ...
... • The summed effect of EPSPs and IPSPs determines whether an axon hillock will reach threshold and generate an action potential ...
Microbial Adaptations to the Psychrosphere/Piezosphere
... with pH and osmolarity changes). Thus, pressure is both a unique and a fundamental thermodynamic parameter. Identification of Pressure Sensitive Processes in Mesophilic Microorganisms Although the basis of pressure effects on many simple chemical processes have been described, pinpointing the physic ...
... with pH and osmolarity changes). Thus, pressure is both a unique and a fundamental thermodynamic parameter. Identification of Pressure Sensitive Processes in Mesophilic Microorganisms Although the basis of pressure effects on many simple chemical processes have been described, pinpointing the physic ...
The Amino-terminal Domain of the Golgi Protein Giantin Interacts
... matrix protein 130; PAGE, polyacrylamide gel electrophoresis; kb, kilobase(s); PCR, polymerase chain reaction; MALDI, matrix-assisted laser desorption and ionization. This paper is available on line at http://www.jbc.org ...
... matrix protein 130; PAGE, polyacrylamide gel electrophoresis; kb, kilobase(s); PCR, polymerase chain reaction; MALDI, matrix-assisted laser desorption and ionization. This paper is available on line at http://www.jbc.org ...
Studying Cell–Surface Interactions In Vitro: A Survey of
... functionalities. A set of experimental approaches has been used in the past to evaluate the cyto-compatibility of a given surface. These established techniques cover a significant range of technical sophistication comprising low and high tech. On the low-tech side, for instance, the number of cells ...
... functionalities. A set of experimental approaches has been used in the past to evaluate the cyto-compatibility of a given surface. These established techniques cover a significant range of technical sophistication comprising low and high tech. On the low-tech side, for instance, the number of cells ...
Insights into Rapid Modulation of Neuroplasticity by Brain Estrogens
... (e.g., cortex and hippocampus); 2) describe the mechanisms that control the bioavailability of active estrogens within discrete regions of the brain, in particular focusing on the ability to synthesize estradiol in nervous tissue; 3) examine the cellular consequence of rapid estrogenicsignaling on p ...
... (e.g., cortex and hippocampus); 2) describe the mechanisms that control the bioavailability of active estrogens within discrete regions of the brain, in particular focusing on the ability to synthesize estradiol in nervous tissue; 3) examine the cellular consequence of rapid estrogenicsignaling on p ...
Multiscale View of Cytoskeletal Mechanoregulation of Cell and
... such as migrating directionally as individuals or collectively (Vicente-Manzanares et al. 2009; Devreotes and Horwitz 2015). It is also essential for cell ability to maintain properly its architecture and function by regulating cytoskeletal organization, trafficking, and signaling events (Guyer and ...
... such as migrating directionally as individuals or collectively (Vicente-Manzanares et al. 2009; Devreotes and Horwitz 2015). It is also essential for cell ability to maintain properly its architecture and function by regulating cytoskeletal organization, trafficking, and signaling events (Guyer and ...
Proliferation-Independent Control of Tumor Glycolysis by PDGFR
... rarely expressed glucose receptor has been identified in prostate cancer cells and phosphorylation of pyruvate kinase M2 by the fibroblast growth factor receptor (FGFR) has been reported (11, 12), it is not known whether any RTKs directly regulate aerobic glycolysis in tumors. The typically synchronou ...
... rarely expressed glucose receptor has been identified in prostate cancer cells and phosphorylation of pyruvate kinase M2 by the fibroblast growth factor receptor (FGFR) has been reported (11, 12), it is not known whether any RTKs directly regulate aerobic glycolysis in tumors. The typically synchronou ...
PDF
... xyloglucan and a glucuronan. Ulvan is the family of sulfated polysaccharides that consist of large quantities of glucuronic acid and rhamnose with the main repeating disaccharide being →4)-β-dGlcAp-(1→4)-α-l-Rhap-(1→. α-l-Iduronic acid or β-xylose can replace glucuronic acid to a certain extent with ...
... xyloglucan and a glucuronan. Ulvan is the family of sulfated polysaccharides that consist of large quantities of glucuronic acid and rhamnose with the main repeating disaccharide being →4)-β-dGlcAp-(1→4)-α-l-Rhap-(1→. α-l-Iduronic acid or β-xylose can replace glucuronic acid to a certain extent with ...
Biology: Cellular Respiration Practice Problems
... 13. What would happen to the cellular respiration process if the enzyme (aka catalyst) for one step of the process was missing or defective? 14. On average, how many ATP can be made from each NADH during the electron transport process? 15. On average, how many ATP can be made from each FADH2 during ...
... 13. What would happen to the cellular respiration process if the enzyme (aka catalyst) for one step of the process was missing or defective? 14. On average, how many ATP can be made from each NADH during the electron transport process? 15. On average, how many ATP can be made from each FADH2 during ...
Biological ontologies for human functional annotation and
... Annotation of Biological Entities We have shown that interleukin-1 (IL-1)
and IL-2
...
... Annotation of Biological Entities We have shown that
Weight Regulation Activity
... receptors that are sensitive to the presence of leptin. In the brain, some of these receptors help to transport leptin across the blood-brain barrier. Once in the hypothalamus, the leptin binds to specialized forms of receptors on the surface of neurons in a region known as the arcuate nucleus. Once ...
... receptors that are sensitive to the presence of leptin. In the brain, some of these receptors help to transport leptin across the blood-brain barrier. Once in the hypothalamus, the leptin binds to specialized forms of receptors on the surface of neurons in a region known as the arcuate nucleus. Once ...
PDF
... Obesity is characterized by an expansion of white adipose tissue mass that results from an increase in the size and the number of adipocytes. However, the mechanisms responsible for the formation of adipocytes during development and the molecular mechanisms regulating their increase and maintenance ...
... Obesity is characterized by an expansion of white adipose tissue mass that results from an increase in the size and the number of adipocytes. However, the mechanisms responsible for the formation of adipocytes during development and the molecular mechanisms regulating their increase and maintenance ...
How proteins produce cellular membrane curvature
... elasticity is characterized by the elastic moduli, such as the bending moduli of the membrane monolayer, κm, and bilayer, κB, the moduli of the Gaussian curvature of the monolayer and bilayer, κ m and κ B , respectively, the membrane stretching modulus, Г (see Supplementary information S1 (box) and ...
... elasticity is characterized by the elastic moduli, such as the bending moduli of the membrane monolayer, κm, and bilayer, κB, the moduli of the Gaussian curvature of the monolayer and bilayer, κ m and κ B , respectively, the membrane stretching modulus, Г (see Supplementary information S1 (box) and ...
Self-Interaction of the Herpes Simplex Virus Type 1
... were not found to be trans-dominant (Smith et al., 1991), which supports the notion that the zinc-finger-like region may be required for multimerization. RESULTS An ICP27 NLS mutant protein can be efficiently localized to the nucleus by heterodimer formation with wild-type ICP27 We showed previously ...
... were not found to be trans-dominant (Smith et al., 1991), which supports the notion that the zinc-finger-like region may be required for multimerization. RESULTS An ICP27 NLS mutant protein can be efficiently localized to the nucleus by heterodimer formation with wild-type ICP27 We showed previously ...
Signal transduction
Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.