With-the-great-explosion-of-use-of
... structure rather than the tertiary structure. The conformational space accessible to a peptide is defined by those regions of the 3N-dimensional configurational space � N being the number of atoms � that have a significant probability of being populated. The size and characteristics of this subspace ...
... structure rather than the tertiary structure. The conformational space accessible to a peptide is defined by those regions of the 3N-dimensional configurational space � N being the number of atoms � that have a significant probability of being populated. The size and characteristics of this subspace ...
Mechanism of Induction: Induced Pluripotent Stem Cells (iPSCs)
... expression of transcriptional factor genes critical for maintaining the properties of ESCs. This reversion of adult cells to a state resembling ESCs offers unprecedented potential to generate patient and disease specific tissues for targeted disease research, as well as drug screening methods for th ...
... expression of transcriptional factor genes critical for maintaining the properties of ESCs. This reversion of adult cells to a state resembling ESCs offers unprecedented potential to generate patient and disease specific tissues for targeted disease research, as well as drug screening methods for th ...
In vivo assays to study histone ubiquitylation
... methylation of adjacent lysine residues in the H3 N tail by several SET domain proteins [40–43]. These results are not consistent with a model in which histone ubiquitylation merely serves a structural role to open chromatin. Ubiquitylation of proteins destined for degradation occurs through a conce ...
... methylation of adjacent lysine residues in the H3 N tail by several SET domain proteins [40–43]. These results are not consistent with a model in which histone ubiquitylation merely serves a structural role to open chromatin. Ubiquitylation of proteins destined for degradation occurs through a conce ...
Dirty Business - American Chemical Society
... and nails, has a molecular mass in the 50,000-70,000 Dalton range. On the other hand, titin, the largest known protein, consists of 34,350 amino acids, with a molecular mass of approximately 3.8 million Daltons. Protein molecules are so large they are often referred to as macromolecules. In addition ...
... and nails, has a molecular mass in the 50,000-70,000 Dalton range. On the other hand, titin, the largest known protein, consists of 34,350 amino acids, with a molecular mass of approximately 3.8 million Daltons. Protein molecules are so large they are often referred to as macromolecules. In addition ...
Barbiturates Directly Inhibit the Calmodulin/Calcineurin Complex: a
... and cell biological evidence support the notion that the serine/threonine phosphatase calcineurin is a rate-limiting intracellular signaling enzyme involved in TCR-mediated signal transduction (Batiuk et al., 1997). Calcineurin activity is regulated by the intracellular concentration of calcium and ...
... and cell biological evidence support the notion that the serine/threonine phosphatase calcineurin is a rate-limiting intracellular signaling enzyme involved in TCR-mediated signal transduction (Batiuk et al., 1997). Calcineurin activity is regulated by the intracellular concentration of calcium and ...
New metal complexes as potential therapeutics
... their ability to bind DNA. As an exception, the antimetastatic activities of NAMI and its analog (ImH)trans[Ru(Im)(Me2SO)Cl4] (NAMI-A) (Figure 4a) do not appear to involve DNA binding. Instead, they interfere with type IV collagenolytic activity and reduce the metastatic potential of the tumors [48] ...
... their ability to bind DNA. As an exception, the antimetastatic activities of NAMI and its analog (ImH)trans[Ru(Im)(Me2SO)Cl4] (NAMI-A) (Figure 4a) do not appear to involve DNA binding. Instead, they interfere with type IV collagenolytic activity and reduce the metastatic potential of the tumors [48] ...
NuMA assembles into an extensive filamentous structure when
... however, are much less certain due to the lack of defined functional assays for specific nuclear function. It has been proposed that NuMA is a structural component of the core fibers of the ...
... however, are much less certain due to the lack of defined functional assays for specific nuclear function. It has been proposed that NuMA is a structural component of the core fibers of the ...
Ecological and molecular investigations of cyanotoxin production
... Cyanobacteria have special adaptations such as; nitrogen ¢xation, ability to regulate buoyancy, light harvesting pigments, and di¡erentiated cell types for reproduction or resting, allowing them an advantage over many competitors. Anthropogenic factors such as increased nutrient loading in freshwate ...
... Cyanobacteria have special adaptations such as; nitrogen ¢xation, ability to regulate buoyancy, light harvesting pigments, and di¡erentiated cell types for reproduction or resting, allowing them an advantage over many competitors. Anthropogenic factors such as increased nutrient loading in freshwate ...
SPI-1 encoded genes ofSalmonellaTyphimurium influence
... phagosome membrane and is essential for Salmonella survival and replication inside professional phagocytic cells [3]. Macrophages represent the key cells of host defense against Salmonella as well as other infections. Within the last decade, macrophages have been shown to have a plastic phenotype, w ...
... phagosome membrane and is essential for Salmonella survival and replication inside professional phagocytic cells [3]. Macrophages represent the key cells of host defense against Salmonella as well as other infections. Within the last decade, macrophages have been shown to have a plastic phenotype, w ...
Characterisation and functional properties of watermelon (Citrullus
... BACKGROUND: People in developing countries depend largely on non-conventional protein sources to augment the availability of proteins in their diets. Watermelon seed meal is reported to contain an adequate amount of nutritional proteins that could be extracted for use as nutritional ingredients in f ...
... BACKGROUND: People in developing countries depend largely on non-conventional protein sources to augment the availability of proteins in their diets. Watermelon seed meal is reported to contain an adequate amount of nutritional proteins that could be extracted for use as nutritional ingredients in f ...
Substrate specificity of protein kinase A in reaction with
... a key role in multiple signaling and regulatory phenomena in cell. It has been estimated that as much as 20-50% of all the cellular proteins undergo phosphorylation in vivo (Pinna and Ruzzene, 1996) .On the other hand, there is great diversity of protein kinase forms involved in eukaryote signaling ...
... a key role in multiple signaling and regulatory phenomena in cell. It has been estimated that as much as 20-50% of all the cellular proteins undergo phosphorylation in vivo (Pinna and Ruzzene, 1996) .On the other hand, there is great diversity of protein kinase forms involved in eukaryote signaling ...
Vanadium(V) complexes in enzyme systems: aqueous chemistry
... S. Bhattacharyya, A.S. Tracey / Journal of Inorganic Biochemistry 85 (2001) 9 – 13 [5] M.J. Gresser, A.S. Tracey, N.D. Chasteen, in: Vanadates as Phosphate Analogs in Biochemistry. Vanadium in Biological Systems, ...
... S. Bhattacharyya, A.S. Tracey / Journal of Inorganic Biochemistry 85 (2001) 9 – 13 [5] M.J. Gresser, A.S. Tracey, N.D. Chasteen, in: Vanadates as Phosphate Analogs in Biochemistry. Vanadium in Biological Systems, ...
New approaches for live cell imaging
... human Golgi-resident enzyme N-acetylgalactosaminyltransferase-2 ...
... human Golgi-resident enzyme N-acetylgalactosaminyltransferase-2 ...
A CBS domain-containing pyrophosphatase of Moorella
... Consequently, disruption of PPi metabolism can lead to a variety of pathological conditions [2]. PPi is mainly hydrolysed to Pi (orthophosphate) by PPase (inorganic pyrophosphatase) (EC 3.6.1.1), an enzyme that is essential for life [3–6]. There are two known types of PPase: soluble and integral mem ...
... Consequently, disruption of PPi metabolism can lead to a variety of pathological conditions [2]. PPi is mainly hydrolysed to Pi (orthophosphate) by PPase (inorganic pyrophosphatase) (EC 3.6.1.1), an enzyme that is essential for life [3–6]. There are two known types of PPase: soluble and integral mem ...
Calcium binding chaperones of the endoplasmic reticulum
... Ca2+ store refilling is controlled by the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) (Lipskaia et al. 2009) while the Na+/Ca2+ exchanger and the plasma membrane Ca2+ ATPase actively remove Ca2+ from the cells (Rhodes and Sanderson 2009). Taken together, both the ER Ca2+ buffering proteins and t ...
... Ca2+ store refilling is controlled by the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) (Lipskaia et al. 2009) while the Na+/Ca2+ exchanger and the plasma membrane Ca2+ ATPase actively remove Ca2+ from the cells (Rhodes and Sanderson 2009). Taken together, both the ER Ca2+ buffering proteins and t ...
Autophagosome expansion due to amino acid deprivation
... Autophagy is one of the major pathways for degradation of intracellular macromolecules in animal cells (Klionsky and Emr, 2000). It is a physiological intracellular process that plays a key role in the turnover of long-lived proteins, RNA and other cytoplasmic macromolecules (Seglen et al., 1991; Mo ...
... Autophagy is one of the major pathways for degradation of intracellular macromolecules in animal cells (Klionsky and Emr, 2000). It is a physiological intracellular process that plays a key role in the turnover of long-lived proteins, RNA and other cytoplasmic macromolecules (Seglen et al., 1991; Mo ...
The Escherichia coli trmE (mnmE) gene, involved in tRNA
... processes tRNA. o548 codes for a 60 kDa inner membrane protein (Hansen et al., 1985; Sääf et al., 1998) whose precise function has not been identified so far. This protein is homologous to that encoded by OXA1, a S.cerevisiae nuclear gene involved in a novel and general protein export machinery of ...
... processes tRNA. o548 codes for a 60 kDa inner membrane protein (Hansen et al., 1985; Sääf et al., 1998) whose precise function has not been identified so far. This protein is homologous to that encoded by OXA1, a S.cerevisiae nuclear gene involved in a novel and general protein export machinery of ...
Leading to a Mild Immunodeficiency Activator trans
... http://www.jimmunol.org/content/167/3/1787.full#ref-list-1 Information about subscribing to The Journal of Immunology is online at: http://jimmunol.org/subscription Submit copyright permission requests at: http://www.aai.org/About/Publications/JI/copyright.html Receive free email-alerts when new art ...
... http://www.jimmunol.org/content/167/3/1787.full#ref-list-1 Information about subscribing to The Journal of Immunology is online at: http://jimmunol.org/subscription Submit copyright permission requests at: http://www.aai.org/About/Publications/JI/copyright.html Receive free email-alerts when new art ...
Role of Polo-like kinase in the degradation of early mitotic inhibitor 1
... It has been shown previously that Emi1 is targeted for degradation by the SCF-TrCP ubiquitin ligase complex and that its phosphorylation on a DSGxxS consensus site is required for this process (15, 16). However, the protein kinase(s) involved in this phosphorylation has not been identified. In the ...
... It has been shown previously that Emi1 is targeted for degradation by the SCF-TrCP ubiquitin ligase complex and that its phosphorylation on a DSGxxS consensus site is required for this process (15, 16). However, the protein kinase(s) involved in this phosphorylation has not been identified. In the ...
Tubular secretion
... Nervous and endocrine mechanisms that maintain blood pressure and affect kidneys ...
... Nervous and endocrine mechanisms that maintain blood pressure and affect kidneys ...
Mycobacterium tuberculosis adhesins: potential
... the most common form of bacterial adhesins. They are elongated, multi-subunit protein structures that are able to interact with glycoprotein and glycolipid receptors found on host cells (Esko & Sharon, 2009). To be functional, adhesins must be anchored onto or displayed on the bacterial cell surface ...
... the most common form of bacterial adhesins. They are elongated, multi-subunit protein structures that are able to interact with glycoprotein and glycolipid receptors found on host cells (Esko & Sharon, 2009). To be functional, adhesins must be anchored onto or displayed on the bacterial cell surface ...
Systems-Level Comparison of Host-Responses Elicited by Avian
... from each macrophage donor separately to define the donor-todonor variation after influenza infection. We used a 62-fold change in gene expression as the cut-off value and genes were classified into those that, relative to mock-infected cells, were $2fold up-regulated (+) or down-regulated (2) and t ...
... from each macrophage donor separately to define the donor-todonor variation after influenza infection. We used a 62-fold change in gene expression as the cut-off value and genes were classified into those that, relative to mock-infected cells, were $2fold up-regulated (+) or down-regulated (2) and t ...
Peeping in on the cytoskeleton: light microscopy
... determines the extent of the useful range of these modalities43. For samples with low H (< 20), WHD is most appropriate, while SDCM is best for the intermediate range of H (20 < H < 200). For 200 < H < 1000, the LSCM performs the best and for H > 1000 none of these modalities is useful. Total intern ...
... determines the extent of the useful range of these modalities43. For samples with low H (< 20), WHD is most appropriate, while SDCM is best for the intermediate range of H (20 < H < 200). For 200 < H < 1000, the LSCM performs the best and for H > 1000 none of these modalities is useful. Total intern ...
Regulation of Arabidopsis 14-3
... Abscisic acid (ABA) and ethylene signalling are important in responses to stress and in the regulation of primary metabolism in Arabidopsis seedlings (Gazzarrini & McCourt 2001). Since GABA might be involved in responses to stress and/or nutrients, we were interested to test whether these signalling ...
... Abscisic acid (ABA) and ethylene signalling are important in responses to stress and in the regulation of primary metabolism in Arabidopsis seedlings (Gazzarrini & McCourt 2001). Since GABA might be involved in responses to stress and/or nutrients, we were interested to test whether these signalling ...
The bit used for relationship between smell and taste
... glomeruli such that each glomerulus receives input primarily from olfactory receptor neurons that express the same olfactory receptor. Glomeruli are also permeated by ...
... glomeruli such that each glomerulus receives input primarily from olfactory receptor neurons that express the same olfactory receptor. Glomeruli are also permeated by ...
Signal transduction
Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.