Transformations of phosphatidylinositol phosphates in the outer and
... metabolism is to decipher their global functional organization and coordination of the compartmentalized signaling processes. In this report we present evidence linking nuclear phosphoinositides cycle with endoplasmic reticulum synthesis and function. The rapid transformation of [3H]inositol-labeled ...
... metabolism is to decipher their global functional organization and coordination of the compartmentalized signaling processes. In this report we present evidence linking nuclear phosphoinositides cycle with endoplasmic reticulum synthesis and function. The rapid transformation of [3H]inositol-labeled ...
Address for Correspondence : VASaks
... responsible for the intracellular localization of organelles in many types of the cells, but their connection to mitochondria and role in regulation of mitochondrial function in muscle cells is still unknown. Microtubules are dynamic structures which depend on many factors, such as temperature and i ...
... responsible for the intracellular localization of organelles in many types of the cells, but their connection to mitochondria and role in regulation of mitochondrial function in muscle cells is still unknown. Microtubules are dynamic structures which depend on many factors, such as temperature and i ...
Stat3 and MMP7 Contribute to Pancreatic Ductal Adenocarcinoma
... It has been shown that pancreatitis is a risk factor for pancreatic ductal adenocarcinoma (PDA) development because pancreatitis has been shown to promote the development of pancreatic intraepithelial neoplasia (PanIN) and PDA in Kras-driven mouse models of PDA. However, the molecular mechanisms inv ...
... It has been shown that pancreatitis is a risk factor for pancreatic ductal adenocarcinoma (PDA) development because pancreatitis has been shown to promote the development of pancreatic intraepithelial neoplasia (PanIN) and PDA in Kras-driven mouse models of PDA. However, the molecular mechanisms inv ...
PDF - Bezanilla Lab
... because these cells no longer undergo tip growth, resulting in the inability to reach the appropriate size for cell division. Simultaneous knock down of all formin genes results in lethality, as evidenced by regions in the plants that exhibit a loss of chlorophyll fluorescence (Fig. S1 D), an indica ...
... because these cells no longer undergo tip growth, resulting in the inability to reach the appropriate size for cell division. Simultaneous knock down of all formin genes results in lethality, as evidenced by regions in the plants that exhibit a loss of chlorophyll fluorescence (Fig. S1 D), an indica ...
Dynamics of protein noise can distinguish between alternate
... importance of developing methods that pinpoint the source of noise in a given gene circuit. Gene-expression noise is often decomposed into intrinsic and extrinsic noise (Elowitz et al, 2002). While extrinsic noise arises from intercellular differences in the amounts of cellular components (e.g., RNA ...
... importance of developing methods that pinpoint the source of noise in a given gene circuit. Gene-expression noise is often decomposed into intrinsic and extrinsic noise (Elowitz et al, 2002). While extrinsic noise arises from intercellular differences in the amounts of cellular components (e.g., RNA ...
Protein S deficiency
... impaired interaction with APC, as found with an EGF1lacking abnormal protein S or with mutations affecting the TSR.32 Interestingly, a microdeletion reshaping the highest affinity Ca2+-binding site in the EGF4 (protein S Basiglio)33 results in an abnormal conformation of the Gla-domain, impairing ph ...
... impaired interaction with APC, as found with an EGF1lacking abnormal protein S or with mutations affecting the TSR.32 Interestingly, a microdeletion reshaping the highest affinity Ca2+-binding site in the EGF4 (protein S Basiglio)33 results in an abnormal conformation of the Gla-domain, impairing ph ...
Drosophila unpaired encodes a secreted protein that activates the
... brings their associated JAK molecules into close proximity, presumably facilitating trans-phosphorylation of the JAKs. Signals are then transmitted directly to the nucleus through the activation of appropriate STATs. Inactive STATs are found in the cytoplasm and, upon JAK activation, are recruited t ...
... brings their associated JAK molecules into close proximity, presumably facilitating trans-phosphorylation of the JAKs. Signals are then transmitted directly to the nucleus through the activation of appropriate STATs. Inactive STATs are found in the cytoplasm and, upon JAK activation, are recruited t ...
Insulin-Like Growth Factor and Potassium Depolarization Maintain
... these receptors possess distinct motifs capable of specifically interacting with a repertoire of effector proteins containing src homology 2 (SH2) and src homology 3 (SH3) domains (for review, see Chao, 1992; Schlessinger and Ullrich, 1992; Schlessinger et al., 1992; Kapeller and Cantley, 1994). Dif ...
... these receptors possess distinct motifs capable of specifically interacting with a repertoire of effector proteins containing src homology 2 (SH2) and src homology 3 (SH3) domains (for review, see Chao, 1992; Schlessinger and Ullrich, 1992; Schlessinger et al., 1992; Kapeller and Cantley, 1994). Dif ...
The structure and function of the Golgi apparatus
... budding of COPI coated vesicles (60–65% of the GA membranes), as well as by a COPI-independent mechanism (Misteli and Waren, 1995; Rabouille and Warren, 1997). Then, by the late telophase, the Golgi vesicles fuse to reform cisternae. A subset of cytosolic factors (NSF, SNAPs, p115, and p97) that lea ...
... budding of COPI coated vesicles (60–65% of the GA membranes), as well as by a COPI-independent mechanism (Misteli and Waren, 1995; Rabouille and Warren, 1997). Then, by the late telophase, the Golgi vesicles fuse to reform cisternae. A subset of cytosolic factors (NSF, SNAPs, p115, and p97) that lea ...
Proteomics insights: proteins related to larval attachment and
... The transition in an animal from a pelagic larval stage to a sessile benthic juvenile typically requires major morphological and behavioral changes. Larval competency, attachment and initiation of metamorphosis are thought to be regulated by intrinsic chemical signals and specific sets of proteins. ...
... The transition in an animal from a pelagic larval stage to a sessile benthic juvenile typically requires major morphological and behavioral changes. Larval competency, attachment and initiation of metamorphosis are thought to be regulated by intrinsic chemical signals and specific sets of proteins. ...
Identification of four small molecular mass proteins in the silk of
... in hot alkaline water during silk reeling. The structure and expression patterns of major silk genes have also been elucidated in the waxmoth, Galleria mellonella (suprafamily Pyraloidea), a lepidopteran distantly related to B. mori. It was found that the overall silk composition and the silk gene s ...
... in hot alkaline water during silk reeling. The structure and expression patterns of major silk genes have also been elucidated in the waxmoth, Galleria mellonella (suprafamily Pyraloidea), a lepidopteran distantly related to B. mori. It was found that the overall silk composition and the silk gene s ...
Arginine-induced stimulation of protein synthesis and survival in
... pathways, such as protein synthesis, proliferation, and migration (6, 25, 26, 32). Arginine supplementation stimulated protein synthesis and reduced protein degradation in LPStreated IPEC-1 cells (32). Studies in preconfluent Caco-2 cells suggest that arginine deprivation decreases cell proliferatio ...
... pathways, such as protein synthesis, proliferation, and migration (6, 25, 26, 32). Arginine supplementation stimulated protein synthesis and reduced protein degradation in LPStreated IPEC-1 cells (32). Studies in preconfluent Caco-2 cells suggest that arginine deprivation decreases cell proliferatio ...
A novel EVI1 gene family, MEL1, lacking a PR domain (MEL1S) is
... with 7 and 3 tandem zinc finger repeats, CtBP-binding motifs, and other possible transcriptional regulatory domains. In this study, we here identify 3 transcription start sites of MEL1 mRNA and 2 kinds of MEL1 gene products; one is the full-length MEL1 protein with a PR domain, and the other is a sh ...
... with 7 and 3 tandem zinc finger repeats, CtBP-binding motifs, and other possible transcriptional regulatory domains. In this study, we here identify 3 transcription start sites of MEL1 mRNA and 2 kinds of MEL1 gene products; one is the full-length MEL1 protein with a PR domain, and the other is a sh ...
actin filament-membrane attachment: are membrane particles
... the attachment of the actin filaments to membranes is by integral membrane proteins or proteins situated at least in part within the lipid bilayer. We selected for examination the only systems known in which the possible involvement of membrane particles in the attachment of actin filaments to membr ...
... the attachment of the actin filaments to membranes is by integral membrane proteins or proteins situated at least in part within the lipid bilayer. We selected for examination the only systems known in which the possible involvement of membrane particles in the attachment of actin filaments to membr ...
Dorsal Column Nuclei Neurons Recorded in a Brain Stem–Spinal
... nuclei (DCN) neurons may use glutamate as the main neurotransmitter since ionophoretic applications of glutamate in the vicinity of these neurons caused excitation (Galindo et al. 1967), while 1-hydroxy-3-aminopyrrolid-2-one (HA-966, an excitatory amino acid receptor antagonist) blocked excitatory s ...
... nuclei (DCN) neurons may use glutamate as the main neurotransmitter since ionophoretic applications of glutamate in the vicinity of these neurons caused excitation (Galindo et al. 1967), while 1-hydroxy-3-aminopyrrolid-2-one (HA-966, an excitatory amino acid receptor antagonist) blocked excitatory s ...
Branching morphogenesis of the Drosophila tracheal system. Annual Review of Cell Developmental Biology 19, 623-647. pdf
... that some tracheal genes (vvl, kni, knrl, tkv) are still expressed in trachealess mutants, suggests that additional, spatially restricted factors are required for tracheal cell fate specification. One such factor is ventral veins lacking (vvl), also called ventral veinless and drifter; jing may be a ...
... that some tracheal genes (vvl, kni, knrl, tkv) are still expressed in trachealess mutants, suggests that additional, spatially restricted factors are required for tracheal cell fate specification. One such factor is ventral veins lacking (vvl), also called ventral veinless and drifter; jing may be a ...
In Silico Prediction of the Peroxisomal Proteome in Fungi, Plants
... method to scan the Saccharomyces cerevisiae ORFs for potential peroxisomal proteins. Including both PTS1 and PTS2 motifs in their search, they found 18 new potential peroxisomal proteins. GFP fusions allowed them to confirm that about half of these proteins were truly located in the peroxisome. Anot ...
... method to scan the Saccharomyces cerevisiae ORFs for potential peroxisomal proteins. Including both PTS1 and PTS2 motifs in their search, they found 18 new potential peroxisomal proteins. GFP fusions allowed them to confirm that about half of these proteins were truly located in the peroxisome. Anot ...
The Saccharomyces cerevisiae SEC14 Gene Encodes a Cytosolic
... Golgi-related structures (Berkeley bodies) under nonpermissive conditions, and that the intracellular invertase pool that accumulates under such restrictive conditions consists of enzyme that exhibits fully matured outer glycosyl chains (8, 23). Previous analyses of the secretion competence of secl4 ...
... Golgi-related structures (Berkeley bodies) under nonpermissive conditions, and that the intracellular invertase pool that accumulates under such restrictive conditions consists of enzyme that exhibits fully matured outer glycosyl chains (8, 23). Previous analyses of the secretion competence of secl4 ...
Characterization of the Distal Polyadenylation Site of the ß
... Most genes have multiple polyadenylation sites (PAS), which are often selected in a tissue-specific manner, altering protein products and affecting mRNA stability, subcellular localization and/or translability. Here we studied the polyadenylation mechanisms associated to the beta-adducin gene (Add2) ...
... Most genes have multiple polyadenylation sites (PAS), which are often selected in a tissue-specific manner, altering protein products and affecting mRNA stability, subcellular localization and/or translability. Here we studied the polyadenylation mechanisms associated to the beta-adducin gene (Add2) ...
Analysis of Small Molecule Ligands Targeting the HIV
... Background: The HIV-1 matrix protein (MA) binds both RNA and phospholipids. Results: Ligands that compete with RNA for binding to MA were identified and characterized. Conclusion: Thiadiazolanes bind to residues in the HIV-1 MA β-II-V cleft that mediates RNA and phospholipid binding to MA. Significa ...
... Background: The HIV-1 matrix protein (MA) binds both RNA and phospholipids. Results: Ligands that compete with RNA for binding to MA were identified and characterized. Conclusion: Thiadiazolanes bind to residues in the HIV-1 MA β-II-V cleft that mediates RNA and phospholipid binding to MA. Significa ...
402 Blaylock 89-92.fm
... relatively high concentrations.6 For example, Mullenix demonstrated that fluoride accumulated in the hippocampus of rats exposed to sodium fluoride in drinking water.7 Similarly, fluoride has been shown to accumulate selectively in the pineal gland of adult humans, primarily in hydroxyapatite calcif ...
... relatively high concentrations.6 For example, Mullenix demonstrated that fluoride accumulated in the hippocampus of rats exposed to sodium fluoride in drinking water.7 Similarly, fluoride has been shown to accumulate selectively in the pineal gland of adult humans, primarily in hydroxyapatite calcif ...
Regulation of the heat stress response in Arabidopsis by
... phosphorylation (Knauf et al., 1996; Kline & Morimoto, 1997; Holmberg et al., 2001). So far, 5 phosphorylation sites have been characterized for mammalian Hsf1: S230, S303, S307, S326 and S363 (Chu et al., 1996). During non-stress conditions Hsf1 is a monomer and phosphorylated at S303, S307, S326 a ...
... phosphorylation (Knauf et al., 1996; Kline & Morimoto, 1997; Holmberg et al., 2001). So far, 5 phosphorylation sites have been characterized for mammalian Hsf1: S230, S303, S307, S326 and S363 (Chu et al., 1996). During non-stress conditions Hsf1 is a monomer and phosphorylated at S303, S307, S326 a ...
Chromatin plasticity in pluripotent cells
... transcriptional activity. Bearing in mind that pluripotency is no more (and no less) than the potential to become any cell type, gene expression in pluripotent cells can be viewed as a ‘catalogue’ and transcriptional activity as an open ‘index’ awaiting a choice of ‘product/service’ to be made in or ...
... transcriptional activity. Bearing in mind that pluripotency is no more (and no less) than the potential to become any cell type, gene expression in pluripotent cells can be viewed as a ‘catalogue’ and transcriptional activity as an open ‘index’ awaiting a choice of ‘product/service’ to be made in or ...
The Living World - Chapter 4 - McGraw Hill Higher Education
... The process is highly specific and very fast Fig. 4.31 ...
... The process is highly specific and very fast Fig. 4.31 ...
Report of attending the international CILIA 2016 in Amsterdam
... that Drosophila sensory cilia lacking MKS proteins exhibit striking defects during development but only subtle defects in adults. Interestingly, their results converge to our work in the conclusion that MKS proteins may play a role during tissue development, independantly of ciliogenesis. ...
... that Drosophila sensory cilia lacking MKS proteins exhibit striking defects during development but only subtle defects in adults. Interestingly, their results converge to our work in the conclusion that MKS proteins may play a role during tissue development, independantly of ciliogenesis. ...
Signal transduction
Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.