A cap `n` collar protein isoform contains a selective Hox repressor
... The third class of cDNAs from the locus corresponded to cncC transcripts. These cDNAs have identical sequence to the cncB cDNAs, except that exon B1 is absent, and five additional exons (C1-C5) are spliced onto the 5′ end of exon B2. A probe containing the C1-C4 exons detects the 6.6 kb cncC transcr ...
... The third class of cDNAs from the locus corresponded to cncC transcripts. These cDNAs have identical sequence to the cncB cDNAs, except that exon B1 is absent, and five additional exons (C1-C5) are spliced onto the 5′ end of exon B2. A probe containing the C1-C4 exons detects the 6.6 kb cncC transcr ...
Amyloid-b Acts as a Regulator of Neurotransmitter Release
... Alzheimer’s disease (AD) are associated with synaptic damage caused by oligomers of the toxic amyloid-b peptide (Ab42). However, the underlying molecular and cellular mechanisms behind these deficits are not fully understood. Here we provide evidence of a mechanism by which Ab42 affects synaptic tra ...
... Alzheimer’s disease (AD) are associated with synaptic damage caused by oligomers of the toxic amyloid-b peptide (Ab42). However, the underlying molecular and cellular mechanisms behind these deficits are not fully understood. Here we provide evidence of a mechanism by which Ab42 affects synaptic tra ...
PROTEIN METABOLISM
... circumstantial evidence that there was a life form before us on this planet, from which we emerged—boy, it’s very strong! —Gerald Joyce, quoted in commentary in Science, 1992 ...
... circumstantial evidence that there was a life form before us on this planet, from which we emerged—boy, it’s very strong! —Gerald Joyce, quoted in commentary in Science, 1992 ...
Enhanced intracellular Ca concentrations in and after addition
... Enhancement of penicillin G in elicited cultures may be related to the morphological changes caused by the elicitation (Radman et al. 2004). Elicitors also effect the transcription of genes for antibiotic biosynthesis (Murphy et al. 2007 b; Nair et al. 2009). However, a possible mechanism by which e ...
... Enhancement of penicillin G in elicited cultures may be related to the morphological changes caused by the elicitation (Radman et al. 2004). Elicitors also effect the transcription of genes for antibiotic biosynthesis (Murphy et al. 2007 b; Nair et al. 2009). However, a possible mechanism by which e ...
Origin and evolution of endoderm and mesoderm
... this reflects the ancestral type of gastrulation for protostomes (reviewed in Nielsen, 2001; Arendt et al., 2001). Interestingly, the comparison of molecular markers of the oral field and the blastopore in basal protostomes and basal deuterostomes suggests that the common ancestor, the Urbilateria, ...
... this reflects the ancestral type of gastrulation for protostomes (reviewed in Nielsen, 2001; Arendt et al., 2001). Interestingly, the comparison of molecular markers of the oral field and the blastopore in basal protostomes and basal deuterostomes suggests that the common ancestor, the Urbilateria, ...
Olfaction and the Chemical Senses
... the odor source (Chee-Ruiter and Laurent, 1995). We will discuss some of the cues that insects may use in locating an odor source in §1.10.3. The grasshopper, Melanoplus sanguinipes, is attracted to the odors of its host plants, wheat, ryegrass, sorghum and alfalfa (Hopkins and Young, 1990; see Hart ...
... the odor source (Chee-Ruiter and Laurent, 1995). We will discuss some of the cues that insects may use in locating an odor source in §1.10.3. The grasshopper, Melanoplus sanguinipes, is attracted to the odors of its host plants, wheat, ryegrass, sorghum and alfalfa (Hopkins and Young, 1990; see Hart ...
Focus Issue on Plastid Biology Update Novel
... FTR accepts electrons from photosynthetic electron transport and donates them to the various thioredoxins as redox transmitters. In addition to this conventional pathway, NTRC was identified in a genome wide screen for thioredoxin reductase (NTR)-like proteins which are enzymes found in the cytosol ...
... FTR accepts electrons from photosynthetic electron transport and donates them to the various thioredoxins as redox transmitters. In addition to this conventional pathway, NTRC was identified in a genome wide screen for thioredoxin reductase (NTR)-like proteins which are enzymes found in the cytosol ...
Mixed Lineage Kinase Domain-like Protein Mediates Necrosis
... The importance of necrotic cell death has been illustrated by several recent findings. Breeding onto a RIP3 knockout background rescues the developmental defects of caspase-8 knockout mice. This indicates that the cardiac, vascular, and hematopoietic defects that occur during the development of casp ...
... The importance of necrotic cell death has been illustrated by several recent findings. Breeding onto a RIP3 knockout background rescues the developmental defects of caspase-8 knockout mice. This indicates that the cardiac, vascular, and hematopoietic defects that occur during the development of casp ...
Apoptotic cell clearance: basic biology and therapeutic potential
... with the release of extracellular traps (termed neutrophil extracellular traps (NETs)) in response to pathogens and sterile inflammatory mediators150,151 with potential antimicrobial but pro-inflammatory consequences. A key feature of membrane lysis is the display and/or release of intracellular mol ...
... with the release of extracellular traps (termed neutrophil extracellular traps (NETs)) in response to pathogens and sterile inflammatory mediators150,151 with potential antimicrobial but pro-inflammatory consequences. A key feature of membrane lysis is the display and/or release of intracellular mol ...
FGF signalling: diverse roles during early vertebrate embryogenesis
... 1995). Whether the role for FGF during axial and paraxial mesoderm formation is in the initial induction or in the maintenance of these mesodermal subtypes has remained a contentious issue for some time. Recently, Fletcher and Harland addressed this question by performing a careful analysis of the i ...
... 1995). Whether the role for FGF during axial and paraxial mesoderm formation is in the initial induction or in the maintenance of these mesodermal subtypes has remained a contentious issue for some time. Recently, Fletcher and Harland addressed this question by performing a careful analysis of the i ...
Are viruses a source of new protein folds for organisms? Virosphere
... time of the Cambrian explosion until today, could have been sampled by a viral gene during the written history of humankind. It is well known that protein structure is much more conserved than sequence ([41], quantified in ref. [42]). Thus, the interference between cellular and viral protein domains ...
... time of the Cambrian explosion until today, could have been sampled by a viral gene during the written history of humankind. It is well known that protein structure is much more conserved than sequence ([41], quantified in ref. [42]). Thus, the interference between cellular and viral protein domains ...
the influence of dissolved copper on the production of domoic acid
... Bruland 2001, Maldonado et al. 2002). This physiological function is immediately suggested by a consideration ofDA's molecular structure. Domoic acid features two distinct structural domains: a prolyl ring with two carbonyl moieties at the '1 and '2 position and an isoprenoid side chain attached to ...
... Bruland 2001, Maldonado et al. 2002). This physiological function is immediately suggested by a consideration ofDA's molecular structure. Domoic acid features two distinct structural domains: a prolyl ring with two carbonyl moieties at the '1 and '2 position and an isoprenoid side chain attached to ...
FREE Sample Here
... 66. What causes potassium ions to leave the axon just after the peak of the action potential? A. a continuing concentration gradient and the opening of the potassium gates B. an increase in the concentration gradient across the membrane C. increased tendency of the sodium-potassium pump to pump pota ...
... 66. What causes potassium ions to leave the axon just after the peak of the action potential? A. a continuing concentration gradient and the opening of the potassium gates B. an increase in the concentration gradient across the membrane C. increased tendency of the sodium-potassium pump to pump pota ...
proteins: three-dimensional structure
... (Section 3-2B)—protein chemists were chagrined by the complexity and apparent lack of regularity in the structure of myoglobin. In retrospect, such irregularity seems essential for proteins to fulfill their diverse biological roles. However, comparisons of the ,7000 protein structures now known have ...
... (Section 3-2B)—protein chemists were chagrined by the complexity and apparent lack of regularity in the structure of myoglobin. In retrospect, such irregularity seems essential for proteins to fulfill their diverse biological roles. However, comparisons of the ,7000 protein structures now known have ...
PDF - Walter Lab
... its translocation across the membrane are strictly coupled (Blobel and Dobberstein, 1975). Two components, signal recognition particle (SRP) and SRP receptor, of the cellular machinery promoting this process have been purified (Walter and Blobel, 1980; Gilmore et al., 1982). These components functio ...
... its translocation across the membrane are strictly coupled (Blobel and Dobberstein, 1975). Two components, signal recognition particle (SRP) and SRP receptor, of the cellular machinery promoting this process have been purified (Walter and Blobel, 1980; Gilmore et al., 1982). These components functio ...
Sensory receptors
... Overview: Sensing and Acting • Bats use sonar to detect their prey • Moths, a common prey for bats, can detect the bat’s sonar and attempt to flee • Both organisms have complex sensory systems that facilitate survival • These systems include diverse mechanisms that sense stimuli and generate ap ...
... Overview: Sensing and Acting • Bats use sonar to detect their prey • Moths, a common prey for bats, can detect the bat’s sonar and attempt to flee • Both organisms have complex sensory systems that facilitate survival • These systems include diverse mechanisms that sense stimuli and generate ap ...
Systematic Structure-Function Analysis of the Small GTPase Arf1 in Yeast.
... 2001). Deletion of ARF2 results in no observable phenotype, likely due to low expression of this gene relative to ARF1 (Stearns et al., 1990b). ARF3 does not compensate for the loss of ARF1 and ARF2 and based on sequence comparison with human Arfs, which are subdivided into three classes, represents ...
... 2001). Deletion of ARF2 results in no observable phenotype, likely due to low expression of this gene relative to ARF1 (Stearns et al., 1990b). ARF3 does not compensate for the loss of ARF1 and ARF2 and based on sequence comparison with human Arfs, which are subdivided into three classes, represents ...
File
... support and maintaining cell shape. – Serves as an internal framework to organize organelles within the cell. – Directs cellular locomotion and the movement of materials within the cell. ...
... support and maintaining cell shape. – Serves as an internal framework to organize organelles within the cell. – Directs cellular locomotion and the movement of materials within the cell. ...
isolation and characterization of membranes from the cells of maize
... Mg2+-ATPase at pH 6-5. The enzymic activity was investigated with endogenous sterols as well as with added /?-sitosterol. The addition of /?-sitosterol enhanced the activity by 2-4-fold in the various membrane fractions. The high recovery (135 %) could be due to dilution of an inhibitor or activatio ...
... Mg2+-ATPase at pH 6-5. The enzymic activity was investigated with endogenous sterols as well as with added /?-sitosterol. The addition of /?-sitosterol enhanced the activity by 2-4-fold in the various membrane fractions. The high recovery (135 %) could be due to dilution of an inhibitor or activatio ...
Spindle pole body-anchored Kar3 drives the nucleus
... the two SPBs toward each other and thus of the entire nuclei. This process depends on the activity of the Kar3 motor protein. To explain the mechanism of force generation for nuclear congression, two different models were proposed. Both models involve direct interactions between MTs from the opposit ...
... the two SPBs toward each other and thus of the entire nuclei. This process depends on the activity of the Kar3 motor protein. To explain the mechanism of force generation for nuclear congression, two different models were proposed. Both models involve direct interactions between MTs from the opposit ...
Gustatory Responses of Eel Palatine Receptors to Amino Acids and
... Thus the chemical senses of the fish are a most suitable system to use to explore the receptor mechanisms for amino acids. The eel is nocturnal and its chemical senses are considered to be highly developed. In this study, we find that the gustatory receptors on the palate of the eel are highly sensi ...
... Thus the chemical senses of the fish are a most suitable system to use to explore the receptor mechanisms for amino acids. The eel is nocturnal and its chemical senses are considered to be highly developed. In this study, we find that the gustatory receptors on the palate of the eel are highly sensi ...
2013_BJ_SCFBio_Website
... Calculate resultant unit vector for each of the ORFs Classify the ORFs as genes or nongenes depending on their orientation w.r.t. universal plane (DNA space) Genes and false positives Screening of potential genes based on stereochemical properties of proteins (Protein space) Second stage screening b ...
... Calculate resultant unit vector for each of the ORFs Classify the ORFs as genes or nongenes depending on their orientation w.r.t. universal plane (DNA space) Genes and false positives Screening of potential genes based on stereochemical properties of proteins (Protein space) Second stage screening b ...
Signal transduction
Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.