Theme 1 Molecules, Cells and the Basis for Disease
... K33.1 Investigations of novel redox-dependent cellular stress response mechanisms ............................. 35 K34.1 Generation of stem cell derived 3-D mini liver through understanding of the transcriptional regulation during human hepatic progenitor maturation ............................. ...
... K33.1 Investigations of novel redox-dependent cellular stress response mechanisms ............................. 35 K34.1 Generation of stem cell derived 3-D mini liver through understanding of the transcriptional regulation during human hepatic progenitor maturation ............................. ...
THE USE OF STABLE ISOTOPES IN BIOLOGICAL
... zation of lead by plants, revealed some of the pos- the use of isotope techniques in the investigation sibilities of the use of tracer technique for bio- of related problems in one field: the biosynthesis chemical research. The exploitation of these pos- and metabolism of porphyrins. sibilities mark ...
... zation of lead by plants, revealed some of the pos- the use of isotope techniques in the investigation sibilities of the use of tracer technique for bio- of related problems in one field: the biosynthesis chemical research. The exploitation of these pos- and metabolism of porphyrins. sibilities mark ...
In Vitro and In Vivo Delivery of Drugs and siRNA Mediated by Water
... Nanomaterials have gained much attention as their potential applications in the fields of material and biological sciences. Especially in the field of biomedical applications, development of drug delivery systems is a challenging work since improving drug efficacy and reducing side effects of drugs. ...
... Nanomaterials have gained much attention as their potential applications in the fields of material and biological sciences. Especially in the field of biomedical applications, development of drug delivery systems is a challenging work since improving drug efficacy and reducing side effects of drugs. ...
FABRICATING AND CHARACTERIZATION OF Cu2O/TiO2
... Use of oxide semiconductors such as Cu2O and TiO2 as alternatives to silicon for solar cells attract much attention among the researchers. Cu2O is a p-type semiconductor with a direct band gap of 2.1 eV and is regarded as a suitable material for high-efficiency solar cells [1-4]. TiO2 is an n-type s ...
... Use of oxide semiconductors such as Cu2O and TiO2 as alternatives to silicon for solar cells attract much attention among the researchers. Cu2O is a p-type semiconductor with a direct band gap of 2.1 eV and is regarded as a suitable material for high-efficiency solar cells [1-4]. TiO2 is an n-type s ...
Conditional lethality of a yeast strain expressing human RHOA in place of RHO1 .
... (RHOIN46s) that encodes a functional protein that cannot be ADP ribosylated to serve as a negative control; indeed, in such a strain (YOC724), the Rholp band was not observed (Fig. 4, lane 1). In cells expressing both the yeast RHOIN46s and human RHOA (YOC726), we found that levels of the RHOA prote ...
... (RHOIN46s) that encodes a functional protein that cannot be ADP ribosylated to serve as a negative control; indeed, in such a strain (YOC724), the Rholp band was not observed (Fig. 4, lane 1). In cells expressing both the yeast RHOIN46s and human RHOA (YOC726), we found that levels of the RHOA prote ...
Changes in the Nuclear Envelope Environment Affect
... composition affects spindle pole body function. The synthetic lethality between spo7D and mps3 mutants was suppressed by deletion of specific nucleoporin genes. In fact, these gene deletions bypassed the requirement for Mps3p entirely, suggesting that under certain conditions spindle pole body dupli ...
... composition affects spindle pole body function. The synthetic lethality between spo7D and mps3 mutants was suppressed by deletion of specific nucleoporin genes. In fact, these gene deletions bypassed the requirement for Mps3p entirely, suggesting that under certain conditions spindle pole body dupli ...
Regulatory Mechanisms for Specification and Patterning of Plant
... Plant vascular tissues, the conduits of water, nutrients, and small molecules, play important roles in plant growth and development. Vascular tissues have allowed plants to successfully adapt to various environmental conditions since they evolved 450 Mya. The majority of plant biomass, an important ...
... Plant vascular tissues, the conduits of water, nutrients, and small molecules, play important roles in plant growth and development. Vascular tissues have allowed plants to successfully adapt to various environmental conditions since they evolved 450 Mya. The majority of plant biomass, an important ...
Connecting muscles to tendons - Development
... The precise connectivity between muscles, tendons and bones is crucial for optimal locomotion of the organism, yet the pathways involved in this process are poorly understood. Several mechanisms could underlie the accurate connectivity between these three tissues. First, parallel independent develop ...
... The precise connectivity between muscles, tendons and bones is crucial for optimal locomotion of the organism, yet the pathways involved in this process are poorly understood. Several mechanisms could underlie the accurate connectivity between these three tissues. First, parallel independent develop ...
Mycobacterial hypersensitivity pneumonitis + requires TLR9–MyD88 in lung CD11b + cells
... present in hot water aerosols from hot tubs, whirlpools and spas [6, 7]. Mycobacteria have pathogenic potential not only as immunogenic agents for HP, but also as infectious agents for chronic pulmonary infections even in immunocompetent subjects [8–12]. Such epidemiological features of mycobacteria ...
... present in hot water aerosols from hot tubs, whirlpools and spas [6, 7]. Mycobacteria have pathogenic potential not only as immunogenic agents for HP, but also as infectious agents for chronic pulmonary infections even in immunocompetent subjects [8–12]. Such epidemiological features of mycobacteria ...
Calcium Activation of ERK Mediated by Calmodulin Kinase I
... 185) and p38 (phospho-p38, threonine 180/tyrosine 182) were also purchased from Cell Signaling. Monoclonal antibodies specific to phosphorylated and activated CaMKI (pCaMKI, threonine 178) were generated from immunized mice. Antibodies to ERK2 were purchased from Santa Cruz Biotechnology Inc. Antibo ...
... 185) and p38 (phospho-p38, threonine 180/tyrosine 182) were also purchased from Cell Signaling. Monoclonal antibodies specific to phosphorylated and activated CaMKI (pCaMKI, threonine 178) were generated from immunized mice. Antibodies to ERK2 were purchased from Santa Cruz Biotechnology Inc. Antibo ...
Actin-based motility of endosomes is linked to the polar tip growth of
... A tandem FYVE construct recognizes plant endosomes In both yeast and mammals, the phosphoinositide PI(3)P accumulates preferentially in endosomal membranes (Gillooly et al., 2000), and binding of FYVEdomain proteins to PI(3)P is sufficient to target endosomal proteins to these subcellular compartment ...
... A tandem FYVE construct recognizes plant endosomes In both yeast and mammals, the phosphoinositide PI(3)P accumulates preferentially in endosomal membranes (Gillooly et al., 2000), and binding of FYVEdomain proteins to PI(3)P is sufficient to target endosomal proteins to these subcellular compartment ...
Endometriosis - Gina Nelson MD, Obstetrics and Gynecology
... UÊ 7 >ÌÊÃÊi`iÌÀÃö UÊ ÜÊVÊÃÊi`iÌÀÃö UÊ 7 iÀiÊ`iÃÊi`iÌÀÃÃÊVVÕÀ¶ UÊ ÜÊ`iÃÊi`iÌÀÃÃÊV>ÕÃiÊ«ÀLiö UÊ 7 >ÌÊÃÊÌ iÊÊLiÌÜiiÊviÀÌÌÞÊ>`Êi`iÌÀÃö UÊ 7 >ÌÊ>ÀiÊÌ iÊÃÞ«ÌÃÊvÊi`iÌÀÃö UÊ ÜÊÃÊi`iÌÀÃÃÊ`>}Ãi`¶ UÊ ÜÊÃÊi`iÌÀÃÃÊÌÀi> ...
... UÊ 7 >ÌÊÃÊi`iÌÀÃö UÊ ÜÊVÊÃÊi`iÌÀÃö UÊ 7 iÀiÊ`iÃÊi`iÌÀÃÃÊVVÕÀ¶ UÊ ÜÊ`iÃÊi`iÌÀÃÃÊV>ÕÃiÊ«ÀLiö UÊ 7 >ÌÊÃÊÌ iÊÊLiÌÜiiÊviÀÌÌÞÊ>`Êi`iÌÀÃö UÊ 7 >ÌÊ>ÀiÊÌ iÊÃÞ«ÌÃÊvÊi`iÌÀÃö UÊ ÜÊÃÊi`iÌÀÃÃÊ`>}Ãi`¶ UÊ ÜÊÃÊi`iÌÀÃÃÊÌÀi> ...
Axonal Regeneration in the Peripheral and Central Nervous
... ABSTRACT: Injured nerves regenerate their axons in the peripheral (PNS) but not the central nervous system (CNS). The contrasting capacities have been attributed to the growth permissive Schwann cells in the PNS and the growth inhibitory environment of the oligodendrocytes in the CNS. In the current ...
... ABSTRACT: Injured nerves regenerate their axons in the peripheral (PNS) but not the central nervous system (CNS). The contrasting capacities have been attributed to the growth permissive Schwann cells in the PNS and the growth inhibitory environment of the oligodendrocytes in the CNS. In the current ...
Slam and germ cell migration - Development
... to gain insights into these processes, as germ cell migration shares with them key features such as invasion through an epithelium, cell-cell adhesion and directed migration to a target tissue. Germ cell migration is a well-conserved process in species such as human, mouse, fish and fly. Drosophila ...
... to gain insights into these processes, as germ cell migration shares with them key features such as invasion through an epithelium, cell-cell adhesion and directed migration to a target tissue. Germ cell migration is a well-conserved process in species such as human, mouse, fish and fly. Drosophila ...
B. fragilis ΔPSA
... Our intestinal tract is a nutrient-rich environment packed with up to 100 trillion (1014) microbes. The vast majority reside in our colon where densities approach 1011–1012 cells/ml, the highest recorded for any microbial habitat Today, there are 6.5 billion humans living on Earth. Together, we ...
... Our intestinal tract is a nutrient-rich environment packed with up to 100 trillion (1014) microbes. The vast majority reside in our colon where densities approach 1011–1012 cells/ml, the highest recorded for any microbial habitat Today, there are 6.5 billion humans living on Earth. Together, we ...
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
... opportunity for the efficient delivery of therapeutic agents to these cells with the aid of colloidal drug delivery systems (usually in the form of liposomes, polymeric nanospheres, micelles, and oil-in-water emulsions), following parenteral administration (Poznansky and Juliano, 1984). For example, ...
... opportunity for the efficient delivery of therapeutic agents to these cells with the aid of colloidal drug delivery systems (usually in the form of liposomes, polymeric nanospheres, micelles, and oil-in-water emulsions), following parenteral administration (Poznansky and Juliano, 1984). For example, ...
Actin Dynamics in Papilla Cells of Brassica rapa
... cascade leading to the rejection of self pollen. However, the mechanism controlling hydration and germination arrest during self-pollination is unclear. In this study, we examined the role of actin, a key cytoskeletal component regulating the transport system for hydration and germination in the pap ...
... cascade leading to the rejection of self pollen. However, the mechanism controlling hydration and germination arrest during self-pollination is unclear. In this study, we examined the role of actin, a key cytoskeletal component regulating the transport system for hydration and germination in the pap ...
+Tec - Blood Journal
... cells. This peptide could not be detected in the lysate of 3T3 cells that do not express the tec message endogenously (data not shown). Therefore, we conclude that Tec type IV is a peptide of 70 kD in vivo. A peptide of approximately 80 kD observed in Fig 3, lane 32D, is of the nonspecific binding o ...
... cells. This peptide could not be detected in the lysate of 3T3 cells that do not express the tec message endogenously (data not shown). Therefore, we conclude that Tec type IV is a peptide of 70 kD in vivo. A peptide of approximately 80 kD observed in Fig 3, lane 32D, is of the nonspecific binding o ...
Adaptative Response of Vitis Root to Anoxia
... Fig. 5 (A) Changes in membrane potential after changes in K+ concentration of the bathing solution in a cell located in the transition zone (around 800–1,000 µm from the root apex) of V. rupestris. In this representative recording, from an initial membrane potential of –188 mV, the membrane depolari ...
... Fig. 5 (A) Changes in membrane potential after changes in K+ concentration of the bathing solution in a cell located in the transition zone (around 800–1,000 µm from the root apex) of V. rupestris. In this representative recording, from an initial membrane potential of –188 mV, the membrane depolari ...
14-3-3 associates with cell surface aminopeptidase N in the
... direct tissue development and repair. Increasing evidence suggests that bidirectional signaling between stromal and epithelial cells plays a crucial role in maintaining the integrity of the extracellular matrix (ECM) and that a disruption in this communication can lead to fibrogenesis (Deitch et al. ...
... direct tissue development and repair. Increasing evidence suggests that bidirectional signaling between stromal and epithelial cells plays a crucial role in maintaining the integrity of the extracellular matrix (ECM) and that a disruption in this communication can lead to fibrogenesis (Deitch et al. ...
Plant Growth Regulators II: Cytokinins, their Analogues and
... DNA yielded a compound with the same adsorption peak and chemical behaviour as the one discovered from the yeast extract. It was also isolated in a crystalline form from samples of DNA autoclaved under acidic conditions. The new growth factor was named `kinetin' because it stimulated cell division i ...
... DNA yielded a compound with the same adsorption peak and chemical behaviour as the one discovered from the yeast extract. It was also isolated in a crystalline form from samples of DNA autoclaved under acidic conditions. The new growth factor was named `kinetin' because it stimulated cell division i ...
Reversible translocation of cytidylyltransferase between cytosol and
... Addition of oleic acid to Krebs II cells induced a rapid incorporation of [3H]choline into phosphatidylcholine, since 500 /M of the fatty acid stimulated choline incorporation by 5-fold over the control after 5 min of incubation. In fact, a noticeable increase in phosphatidylcholine labelling could ...
... Addition of oleic acid to Krebs II cells induced a rapid incorporation of [3H]choline into phosphatidylcholine, since 500 /M of the fatty acid stimulated choline incorporation by 5-fold over the control after 5 min of incubation. In fact, a noticeable increase in phosphatidylcholine labelling could ...
Instrumentation in Neurosurgery
... control of harmonic Scalpels coagulation rate & cutting speed depends on time & force applied to the tissue by the end effector. The Harmonic Scalpel uses ultrasonic technology, & energy that allows both cutting & coagulation at the point of impact. As compared to electro surgery 1) fewer instrument ...
... control of harmonic Scalpels coagulation rate & cutting speed depends on time & force applied to the tissue by the end effector. The Harmonic Scalpel uses ultrasonic technology, & energy that allows both cutting & coagulation at the point of impact. As compared to electro surgery 1) fewer instrument ...
the influence of dissolved copper on the production of domoic acid
... strategy may include the production of novel metabolites to buffer abiotic and biotic challenges. Phycotoxins, which comprise a broad group of metabolites, are produced by only a Hmited number of species withln the diverse taxonomy of algae whlch occur throughout the world's oceans (Turner and Test ...
... strategy may include the production of novel metabolites to buffer abiotic and biotic challenges. Phycotoxins, which comprise a broad group of metabolites, are produced by only a Hmited number of species withln the diverse taxonomy of algae whlch occur throughout the world's oceans (Turner and Test ...
Fibroblast growth factor during mesoderm induction
... from one of the clones, was used as probe in this study. The entire coding region of the putative chicken bFGF second exon contained in pGF4.2 and flanking regions at both ends are shown in Fig. IB. The homology between the chicken exon sequence and the corresponding bFGF exon sequence in other spec ...
... from one of the clones, was used as probe in this study. The entire coding region of the putative chicken bFGF second exon contained in pGF4.2 and flanking regions at both ends are shown in Fig. IB. The homology between the chicken exon sequence and the corresponding bFGF exon sequence in other spec ...
Tissue engineering
Tissue engineering is the use of a combination of cells, engineering and materials methods, and suitable biochemical and physicochemical factors to improve or replace biological functions. While it was once categorized as a sub-field of biomaterials, having grown in scope and importance it can be considered as a field in its own right.While most definitions of tissue engineering cover a broad range of applications, in practice the term is closely associated with applications that repair or replace portions of or whole tissues (i.e., bone, cartilage, blood vessels, bladder, skin, muscle etc.). Often, the tissues involved require certain mechanical and structural properties for proper functioning. The term has also been applied to efforts to perform specific biochemical functions using cells within an artificially-created support system (e.g. an artificial pancreas, or a bio artificial liver). The term regenerative medicine is often used synonymously with tissue engineering, although those involved in regenerative medicine place more emphasis on the use of stem cells or progenitor cells to produce tissues.