The basic helix–loop–helix protein BETA2 interacts with p300 to
... very low levels alone or with coexpressed E47, a ubiquitous bHLH protein (Fig. 2A, columns 1,3). Cotransfecting increasing amounts of a p300 expression plasmid further potentiated BETA2-dependent transcription to >100-fold greater than the reporter alone. The failure of p300 to transactivate the rep ...
... very low levels alone or with coexpressed E47, a ubiquitous bHLH protein (Fig. 2A, columns 1,3). Cotransfecting increasing amounts of a p300 expression plasmid further potentiated BETA2-dependent transcription to >100-fold greater than the reporter alone. The failure of p300 to transactivate the rep ...
Uncoupling effect of polyunsaturated fatty acid deficiency in isolated
... results with isolated mitochondria did not support this conclusion [6,7]. Moreover, some studies have suggested that changes in oxidative phosphorylation in mitochondria from PUFA-deficient rats might be an artifact, resulting from damage sustained by the deficient mitochondria during their isolatio ...
... results with isolated mitochondria did not support this conclusion [6,7]. Moreover, some studies have suggested that changes in oxidative phosphorylation in mitochondria from PUFA-deficient rats might be an artifact, resulting from damage sustained by the deficient mitochondria during their isolatio ...
Enhanced intracellular Ca concentrations in and after addition
... specific proteins, gene expression and stress signals (Norris et al. 1996; Jones et al. 2002; Dominguez, 2004). Cytosolic Ca2+ concentration in E. coli is similar to that in eukaryotic systems suggesting that bacteria regulate Ca2+ homeostasis and that the Ca2+ gradient could be used for transmittin ...
... specific proteins, gene expression and stress signals (Norris et al. 1996; Jones et al. 2002; Dominguez, 2004). Cytosolic Ca2+ concentration in E. coli is similar to that in eukaryotic systems suggesting that bacteria regulate Ca2+ homeostasis and that the Ca2+ gradient could be used for transmittin ...
Full Text - Molecular Cancer Research
... Abstract The early development of vertebrate embryos is characterized by rapid cell proliferation necessary to support the embryo's growth. During this period, the embryo must maintain a balance between ongoing cell proliferation and mechanisms that arrest or delay the cell cycle to repair oxidative ...
... Abstract The early development of vertebrate embryos is characterized by rapid cell proliferation necessary to support the embryo's growth. During this period, the embryo must maintain a balance between ongoing cell proliferation and mechanisms that arrest or delay the cell cycle to repair oxidative ...
Cytokinin Lecture
... Cytokinin suppresses the size and cell division activity of roots. (A) Wild type (B) Plants over-expressing cytokinin oxidase to reduce the level of cytokinin. Root meristem is indicated in bright blue (nuclear DNA staining). ...
... Cytokinin suppresses the size and cell division activity of roots. (A) Wild type (B) Plants over-expressing cytokinin oxidase to reduce the level of cytokinin. Root meristem is indicated in bright blue (nuclear DNA staining). ...
Morphologic and functional characterization of granulocytes and
... From www.bloodjournal.org by guest on June 11, 2017. For personal use only. ...
... From www.bloodjournal.org by guest on June 11, 2017. For personal use only. ...
The Anatomy of the Limbus
... eter averages 10.6 mm vertically, but 11.7 mm horizontally (Fig. 2). This difference becomes important in planning surgery in the limbal region as discussed in the section on the surgi cal limbus. Just beneath the conjunctiva, the anterior extent of the capsule of Tenon, a dense, collagenous, conne ...
... eter averages 10.6 mm vertically, but 11.7 mm horizontally (Fig. 2). This difference becomes important in planning surgery in the limbal region as discussed in the section on the surgi cal limbus. Just beneath the conjunctiva, the anterior extent of the capsule of Tenon, a dense, collagenous, conne ...
The cell biology of lignification in higher plants
... cell types. Lignification is part of the normal differentiation programme and functioning of specific cell types, but can also be triggered as a response to various biotic and abiotic stresses in cells that would not otherwise be lignifying. Scope Cell wall lignification exhibits specific characte ...
... cell types. Lignification is part of the normal differentiation programme and functioning of specific cell types, but can also be triggered as a response to various biotic and abiotic stresses in cells that would not otherwise be lignifying. Scope Cell wall lignification exhibits specific characte ...
Parathyroid hormone and bone
... found to dissolve over a few days in culture in the presence of high concentrations of PTE [26-321. The degrees of histological and biochemical changes seen in the bone and culture fluid were in some cases proportional to the concentration of added parathyroid activity, leading to the development of ...
... found to dissolve over a few days in culture in the presence of high concentrations of PTE [26-321. The degrees of histological and biochemical changes seen in the bone and culture fluid were in some cases proportional to the concentration of added parathyroid activity, leading to the development of ...
Calcium-induced calcium release supports recruitment of synaptic
... four cells there was an initial overshoot in EPSC frequency (data not shown), indicative of an increased permeability to calcium, perhaps due to the activation of store-operated calcium channels (Lukyanenko et al. 2001). Together these data support the conclusion that there is a presynaptic role for ...
... four cells there was an initial overshoot in EPSC frequency (data not shown), indicative of an increased permeability to calcium, perhaps due to the activation of store-operated calcium channels (Lukyanenko et al. 2001). Together these data support the conclusion that there is a presynaptic role for ...
Anatomical Characterization and Cellular Physiology of Rat Aortic
... found in association with a group of local neurons (>30). In vagus nerve-RLN wholemounts, AB chemoreceptor (type I) cells were immunoreactive against the vesicular acetylcholine (ACh) transporter, and were surrounded by nerve terminals immunopositive for purinergic P2X2 and P2X3 receptor subunits, s ...
... found in association with a group of local neurons (>30). In vagus nerve-RLN wholemounts, AB chemoreceptor (type I) cells were immunoreactive against the vesicular acetylcholine (ACh) transporter, and were surrounded by nerve terminals immunopositive for purinergic P2X2 and P2X3 receptor subunits, s ...
Mechanism of isoniazid uptake in Mycobacterium
... proposed that [“C]INH enters cells by passive diffusion through the bacterial envelope, and that its oxidation by KatG then leads to the accumulation of radioactive derivatives inside the cells. A consequence of this model is that the initial transport velocity of INH is independent of KatG, but lab ...
... proposed that [“C]INH enters cells by passive diffusion through the bacterial envelope, and that its oxidation by KatG then leads to the accumulation of radioactive derivatives inside the cells. A consequence of this model is that the initial transport velocity of INH is independent of KatG, but lab ...
Liposome- A Versatile Drug Delivery System
... of relatively biocompatible and biodegradable material, and they consist of an aqueous volume entrapped by oneor more bilayers of natural and/or synthetic lipids. Drugs with widely varying lipophilicities can be encapsulated in liposomes, either in the phospholipid bilayer, in the entrapped aqueous ...
... of relatively biocompatible and biodegradable material, and they consist of an aqueous volume entrapped by oneor more bilayers of natural and/or synthetic lipids. Drugs with widely varying lipophilicities can be encapsulated in liposomes, either in the phospholipid bilayer, in the entrapped aqueous ...
Emtriva - Gilead Sciences, Inc.
... -----------------------DOSAGE FORMS AND STRENGTHS------------------- Capsules: 200 mg (3) Oral solution: 10 mg per mL (3) --------------------------------CONTRAINDICATIONS----------------------------EMTRIVA is contraindicated in patients with previously demonstrated hypersensitivity to any of the ...
... -----------------------DOSAGE FORMS AND STRENGTHS------------------- Capsules: 200 mg (3) Oral solution: 10 mg per mL (3) --------------------------------CONTRAINDICATIONS----------------------------EMTRIVA is contraindicated in patients with previously demonstrated hypersensitivity to any of the ...
ANTAGONISM OF Bacillus spp. TOWARDS Microcystis aeruginosa Philosophiae Doctor
... (HABs) all over the world. The HABs are sometimes a direct result of anthropogenic pollution entering water bodies, such as partially treated nutrient-rich effluents and the leaching of fertilisers and animal wastes. Microcystis species are the dominant cyanobacteria (algae) that proliferate in thes ...
... (HABs) all over the world. The HABs are sometimes a direct result of anthropogenic pollution entering water bodies, such as partially treated nutrient-rich effluents and the leaching of fertilisers and animal wastes. Microcystis species are the dominant cyanobacteria (algae) that proliferate in thes ...
Mitochondrial behaviour throughout the lytic cycle of Toxoplasma
... is expressed from a heterologous promoter9. We generated a fluorescent marker for the mitochondrial periphery via fusion of the TGME49_215430 encoded protein11 to the yellow fluorescent protein (YFP) by endogenous tagging. This protein was found in a search for T. gondii proteins that contain each a ...
... is expressed from a heterologous promoter9. We generated a fluorescent marker for the mitochondrial periphery via fusion of the TGME49_215430 encoded protein11 to the yellow fluorescent protein (YFP) by endogenous tagging. This protein was found in a search for T. gondii proteins that contain each a ...
A Big Future for Small Delivery: The State of the Art of
... Authors show success of four different LNPsiRNAs to reduce therapeutic endpoints in four different critical disease models: atherosclerosis, myocardial infarct, type I diabetes, and tumor size in lymphoma (24). Intriguingly, these publications illustrate that siRNA therapy is limited by the need for ...
... Authors show success of four different LNPsiRNAs to reduce therapeutic endpoints in four different critical disease models: atherosclerosis, myocardial infarct, type I diabetes, and tumor size in lymphoma (24). Intriguingly, these publications illustrate that siRNA therapy is limited by the need for ...
Cell Functions Phospholipid-Binding Motif that Regulates T Subunit
... of the plasma membrane, thereby shielding them from phosphorylation (12). This notion is consistent with in vitro studies demonstrating that phospholipid binding by the CD3 chains can limit the magnitude of their ITAM phosphorylation (12, 13). Based on these findings, a new mechanism for regulating ...
... of the plasma membrane, thereby shielding them from phosphorylation (12). This notion is consistent with in vitro studies demonstrating that phospholipid binding by the CD3 chains can limit the magnitude of their ITAM phosphorylation (12, 13). Based on these findings, a new mechanism for regulating ...
Light and Electron Microscopy of the Sheath of a Blue
... cells the striae became looser and more open, they split lengthwise, expanded and became less densely stained. In the outermost regions the sheath structure comprised a fine micro-fibrillar network in which the meshes were elongated along the filament. The finest fibrils were estimated to have a dia ...
... cells the striae became looser and more open, they split lengthwise, expanded and became less densely stained. In the outermost regions the sheath structure comprised a fine micro-fibrillar network in which the meshes were elongated along the filament. The finest fibrils were estimated to have a dia ...
Cellular control of cholesterol
... The uptake of LDL into cells is classic example of receptor-mediated endocytosis. Cells express LDL receptor on their plasma membrane. The receptor binds to sites on Apoprotein in LDL. Bound receptors cluster in coated pits and are then endocytosed by clathrin. The endocytic vesicles acidify to beco ...
... The uptake of LDL into cells is classic example of receptor-mediated endocytosis. Cells express LDL receptor on their plasma membrane. The receptor binds to sites on Apoprotein in LDL. Bound receptors cluster in coated pits and are then endocytosed by clathrin. The endocytic vesicles acidify to beco ...
isolation and characterization of the membrane
... The membrane envelope enclosing the bacteroids in soybean root nodules is shown by ultrastructural and biochemical studies to be derived from, and to retain the characteristics of, the host cell plasma membrane. During the early stages of the infection process, which occurs through an invagination, ...
... The membrane envelope enclosing the bacteroids in soybean root nodules is shown by ultrastructural and biochemical studies to be derived from, and to retain the characteristics of, the host cell plasma membrane. During the early stages of the infection process, which occurs through an invagination, ...
Identification and Characterization of the Acid Phosphatase HppA in
... controls ammonium flux across the bacterial membrane, perhaps in conjunction with metal cation transport, which is thought to be essential for the survival of acidophiles and their adaptation to an acidic environment [1, 4, 16]. Interestingly, ATPases have been suggested to be involved in the regula ...
... controls ammonium flux across the bacterial membrane, perhaps in conjunction with metal cation transport, which is thought to be essential for the survival of acidophiles and their adaptation to an acidic environment [1, 4, 16]. Interestingly, ATPases have been suggested to be involved in the regula ...
Cell encapsulation
Cell microencapsulation technology involves immobilization of the cells within a polymeric semi-permeable membrane that permits the bidirectional diffusion of molecules such as the influx of oxygen, nutrients, growth factors etc. essential for cell metabolism and the outward diffusion of waste products and therapeutic proteins. At the same time, the semi-permeable nature of the membrane prevents immune cells and antibodies from destroying the encapsulated cells regarding them as foreign invaders.The main motive of cell encapsulation technology is to overcome the existing problem of graft rejection in tissue engineering applications and thus reduce the need for long-term use of immunosuppressive drugs after an organ transplant to control side effects.