Effect of Surface Chemistry on the Immune Responses and Cellular
... effective protection of the therapeutic cargos from undesirable degradation, facile surface functionalization, biodegradability and biocompatibility [4]. Since the change in the surface chemistry of the PSi NPs can render new properties to these NPs by affecting on their hydrophilicity, charge and a ...
... effective protection of the therapeutic cargos from undesirable degradation, facile surface functionalization, biodegradability and biocompatibility [4]. Since the change in the surface chemistry of the PSi NPs can render new properties to these NPs by affecting on their hydrophilicity, charge and a ...
Arabinogalactan proteins are involved in root hair development in
... 1246 | Marzec et al. species (Tsumuraya et al., 1988; Pennell et al., 1991; Seifert and Roberts, 2007). The form of post-translational modification of the AGPs may influence their function more strongly than does their peptide sequence (Nguema-Ona et al., 2012). An important tool for AGP investi ...
... 1246 | Marzec et al. species (Tsumuraya et al., 1988; Pennell et al., 1991; Seifert and Roberts, 2007). The form of post-translational modification of the AGPs may influence their function more strongly than does their peptide sequence (Nguema-Ona et al., 2012). An important tool for AGP investi ...
Arabidopsis Phragmoplast-Associated Kinesins Play
... In plant cells, cytokinesis is brought about by the phragmoplast. The phragmoplast has a dynamic microtubule array of two mirrored sets of microtubules, which are aligned perpendicularly to the division plane with their plus ends located at the division site. It is not well understood how the phragm ...
... In plant cells, cytokinesis is brought about by the phragmoplast. The phragmoplast has a dynamic microtubule array of two mirrored sets of microtubules, which are aligned perpendicularly to the division plane with their plus ends located at the division site. It is not well understood how the phragm ...
Lecture 06, case study - Taxol - Cal State LA
... A drug like Taxol probably could not have been developed through rational drug design (2) Microtubules are so unstable, they cannot be crystalized for structural studies - except by treating them with Taxol! - the binding site of Taxol was thus defined by electron crystallographic studies of tubulin ...
... A drug like Taxol probably could not have been developed through rational drug design (2) Microtubules are so unstable, they cannot be crystalized for structural studies - except by treating them with Taxol! - the binding site of Taxol was thus defined by electron crystallographic studies of tubulin ...
Rb is required for progression through myogenic differentiation but
... both stimulate cell cycle progression. In contrast, myotubes express high levels of p21 and hypophosphorylated pRb. Despite the abundance of hypophosphorylated pRb, p130– E2F4 complexes are the predominant E2F complexes in the myotube (Corbeil et al., 1995). Terminal differentiation and protection a ...
... both stimulate cell cycle progression. In contrast, myotubes express high levels of p21 and hypophosphorylated pRb. Despite the abundance of hypophosphorylated pRb, p130– E2F4 complexes are the predominant E2F complexes in the myotube (Corbeil et al., 1995). Terminal differentiation and protection a ...
A Comparison of the Oxidation of Clozapine and Olanzapine to
... data on the oxidation of olanzapine and clozapine by HOCl. Concentrations of drug and NaOCl were 500 and 50 mM, respectively. Reactions were performed in PBS (137 mM sodium chloride, 8 mM disodium hydrogen phosphate, 1.5 mM potassium dihydrogen phosphate, and 2.7 mM potassium chloride, pH 6.0) or in ...
... data on the oxidation of olanzapine and clozapine by HOCl. Concentrations of drug and NaOCl were 500 and 50 mM, respectively. Reactions were performed in PBS (137 mM sodium chloride, 8 mM disodium hydrogen phosphate, 1.5 mM potassium dihydrogen phosphate, and 2.7 mM potassium chloride, pH 6.0) or in ...
Foxp3-positive macrophages display immunosuppressive properties
... As shown in Fig. 5 A, single- or doublesorted F4/80+Foxp3+ cells inhibited proliferation of the CD4+ T cells to the same degree as CD4+Foxp3+ T reg cells. In contrast, no inhibition was observed with F4/80+ Foxp3 cells. We confirmed that at a lower F4/80+Foxp3+ to CD4+ T cell ratio, the Foxp3+ MØs ...
... As shown in Fig. 5 A, single- or doublesorted F4/80+Foxp3+ cells inhibited proliferation of the CD4+ T cells to the same degree as CD4+Foxp3+ T reg cells. In contrast, no inhibition was observed with F4/80+ Foxp3 cells. We confirmed that at a lower F4/80+Foxp3+ to CD4+ T cell ratio, the Foxp3+ MØs ...
RNDr. Jakub Tomala Immunocomplexes of IL-2 and anti-IL
... immune system, mostly as the prototypic autocrine growth factor produced by T cells after activation. This has led to exploiting IL-2 as a potential therapeutic agent. In 1984, recombinant IL-2 was used in cancer therapy for the first time, with novel roles in immune system slowly emerging after its ...
... immune system, mostly as the prototypic autocrine growth factor produced by T cells after activation. This has led to exploiting IL-2 as a potential therapeutic agent. In 1984, recombinant IL-2 was used in cancer therapy for the first time, with novel roles in immune system slowly emerging after its ...
The neutrophil in vascular inflammation
... Here we focus on how neutrophils have a key regulatory role in vascular inflammation. Recent studies using advanced imaging techniques have yielded new insights into the mechanisms by which neutrophils contribute to defense against bacterial infections and also against sterile injury. In these setti ...
... Here we focus on how neutrophils have a key regulatory role in vascular inflammation. Recent studies using advanced imaging techniques have yielded new insights into the mechanisms by which neutrophils contribute to defense against bacterial infections and also against sterile injury. In these setti ...
Gonadotropin-Releasing Hormone Containing Neurons and
... differing interpretations of what constitutes the ‘‘terminal nerve’’ vs. what might constitute an ‘‘extrabulbar olfactory projection’’ [49] vs. what might simply constitute a component of the vomeronasal system [72]. Several antibodies and lectins that recognize cell surface carbohydrates have been ...
... differing interpretations of what constitutes the ‘‘terminal nerve’’ vs. what might constitute an ‘‘extrabulbar olfactory projection’’ [49] vs. what might simply constitute a component of the vomeronasal system [72]. Several antibodies and lectins that recognize cell surface carbohydrates have been ...
A New Laboratory Cultivation of Paramecium bursaria Using Non
... conditions of conducted experiments. Therefore, I decided to examine the usefulness of selected non-pathogenic bacteria strains in laboratory cultivation of Paramecium bursaria. The aim of this research was to check the possibility of using unequivocally identified and also safe microbiological mater ...
... conditions of conducted experiments. Therefore, I decided to examine the usefulness of selected non-pathogenic bacteria strains in laboratory cultivation of Paramecium bursaria. The aim of this research was to check the possibility of using unequivocally identified and also safe microbiological mater ...
vascular tissue differentiation and pattern formation in plants
... evolved to have a variety of organizations (28). In a given cross section of primary stems and roots, the most prominent variation of anatomical structures among different species is the organization of vascular tissues. In the stems of woody plants, the vascular tissue, secondary xylem or wood, pro ...
... evolved to have a variety of organizations (28). In a given cross section of primary stems and roots, the most prominent variation of anatomical structures among different species is the organization of vascular tissues. In the stems of woody plants, the vascular tissue, secondary xylem or wood, pro ...
Drugs of abuse modulate dopaminergic neurotransmission : effects
... The term “drugs of abuse” refers to substances that are not taken for medical reasons, but usually for mind-altering effects including feelings of emotional warmth, empathy toward others, enhanced sensory perception, a general sense of well being and decreased anxiety. Many of these drugs are only t ...
... The term “drugs of abuse” refers to substances that are not taken for medical reasons, but usually for mind-altering effects including feelings of emotional warmth, empathy toward others, enhanced sensory perception, a general sense of well being and decreased anxiety. Many of these drugs are only t ...
Xyloglucan, galactomannan, glucuronoxylan, and
... the xyloglucan, galactomannan, glucuronoxylan, and rhamnogalacturonan I isolated from soybean (Glycine max) roots and root hair cell walls. The root hair is a plant cell that extends only at its tip. All other root cells have the ability to grow in different directions (diffuse growth). Although bot ...
... the xyloglucan, galactomannan, glucuronoxylan, and rhamnogalacturonan I isolated from soybean (Glycine max) roots and root hair cell walls. The root hair is a plant cell that extends only at its tip. All other root cells have the ability to grow in different directions (diffuse growth). Although bot ...
J., Schornack, S., Spallek, T., Geldner, N., Chory
... ER/Golgi-type vesicles accumulate at the penetration site of the growing haustorium (Takemoto et al., 2003; Micali et al., 2011). This is further substantiated by the localization pattern of the Arabidopsis powdery mildew resistance protein RPW8.2, which localizes to ER/Golgi-type vesicles and is pr ...
... ER/Golgi-type vesicles accumulate at the penetration site of the growing haustorium (Takemoto et al., 2003; Micali et al., 2011). This is further substantiated by the localization pattern of the Arabidopsis powdery mildew resistance protein RPW8.2, which localizes to ER/Golgi-type vesicles and is pr ...
Metronidazole
... Luminal parasites No resistance. They are diploid, a single mutation does not render them resistant. They lack alternative metabolic pathways to PFOR. P-glycoprotein pumps hydrophobic drugs from their cells, but metronidazole is hydrophilic. Pharmacokinetics Metronidazole enters cells by passive dif ...
... Luminal parasites No resistance. They are diploid, a single mutation does not render them resistant. They lack alternative metabolic pathways to PFOR. P-glycoprotein pumps hydrophobic drugs from their cells, but metronidazole is hydrophilic. Pharmacokinetics Metronidazole enters cells by passive dif ...
ppt
... efficiently to higher capacities and smaller feature sizes Understanding the retention time of modern DRAM devices can enable old or new methods to reduce the impact of refresh ...
... efficiently to higher capacities and smaller feature sizes Understanding the retention time of modern DRAM devices can enable old or new methods to reduce the impact of refresh ...
casanova and endoderm formation - Development
... activity, endodermal progenitors are respecified to mesoderm (Dickmeis et al., 2001a). Several genes instrumental to the formation of endoderm have been identified but it is now essential to understand how these genes, particularly cas, act within the Nodal signalling pathway to ensure proper endode ...
... activity, endodermal progenitors are respecified to mesoderm (Dickmeis et al., 2001a). Several genes instrumental to the formation of endoderm have been identified but it is now essential to understand how these genes, particularly cas, act within the Nodal signalling pathway to ensure proper endode ...
Effects of Ammonia and Lactate on Hybridoma Growth, Metabolism
... by the conversion of glutamate to a-ketoglutarate. Concentration of ammonia in cell culture is influenced by the mode of reactor operation, cell and glutamine concentrations, and cellular activities. Although ammonia concentrations of 2-5 mM are typical in batch cultures,” they can be higher in glut ...
... by the conversion of glutamate to a-ketoglutarate. Concentration of ammonia in cell culture is influenced by the mode of reactor operation, cell and glutamine concentrations, and cellular activities. Although ammonia concentrations of 2-5 mM are typical in batch cultures,” they can be higher in glut ...
HYDROGELS AS A DRUG DELIVERY SYSTEM AND APPLICATIONS: A REVIEW
... The microbial enzymes that are predominantly present in the colon can be used as signals for site-specific delivery of drugs to the colon. Hovgaard et al. [14] focused on the fact that microbial enzymes in the colon, such as dextranases, can degrade the polysaccharide dextran. They prepared dextran ...
... The microbial enzymes that are predominantly present in the colon can be used as signals for site-specific delivery of drugs to the colon. Hovgaard et al. [14] focused on the fact that microbial enzymes in the colon, such as dextranases, can degrade the polysaccharide dextran. They prepared dextran ...
The Vps13p–Cdc31p complex is directly required for TGN late
... Yeast VPS13 is the founding member of a eukaryotic gene family of growing interest in cell biology and medicine. Mutations in three of four human VPS13 genes cause autosomal recessive neurodegenerative or neurodevelopmental disease, making yeast Vps13p an important structural and functional model. U ...
... Yeast VPS13 is the founding member of a eukaryotic gene family of growing interest in cell biology and medicine. Mutations in three of four human VPS13 genes cause autosomal recessive neurodegenerative or neurodevelopmental disease, making yeast Vps13p an important structural and functional model. U ...
Cell encapsulation
Cell microencapsulation technology involves immobilization of the cells within a polymeric semi-permeable membrane that permits the bidirectional diffusion of molecules such as the influx of oxygen, nutrients, growth factors etc. essential for cell metabolism and the outward diffusion of waste products and therapeutic proteins. At the same time, the semi-permeable nature of the membrane prevents immune cells and antibodies from destroying the encapsulated cells regarding them as foreign invaders.The main motive of cell encapsulation technology is to overcome the existing problem of graft rejection in tissue engineering applications and thus reduce the need for long-term use of immunosuppressive drugs after an organ transplant to control side effects.