Developmental roles of Rhomboid proteases
... triggered by a combination of transcription factors that collectively define the correct time and place. For example, activation by the midline transcription factor Single minded triggers rhomboid1 expression in the midline [27]. This type of expression is spatially “static” and temporally transient, ...
... triggered by a combination of transcription factors that collectively define the correct time and place. For example, activation by the midline transcription factor Single minded triggers rhomboid1 expression in the midline [27]. This type of expression is spatially “static” and temporally transient, ...
Advances in Environmental Biology
... is considered as one of the most important tropical disease by World Health Organization [WHO] [1]. VL causes significant mortality worldwide, constituting an important public health problem [1,2]. Leishmanicidal drugs are costly, high toxic, frequently have unpleasant side effects. In addition, dru ...
... is considered as one of the most important tropical disease by World Health Organization [WHO] [1]. VL causes significant mortality worldwide, constituting an important public health problem [1,2]. Leishmanicidal drugs are costly, high toxic, frequently have unpleasant side effects. In addition, dru ...
Muramatsu M
... rounds of glutathione-agarose chromatography. The purified GST fusion protein was confirmed by Western blot analyses as described previously (26) using anti-AID antisera, which were prepared by immunizing rabbits with a multiple-antigen peptide (27) containing residues 185–198 (EVDDLRDAFRMLGF). Cyti ...
... rounds of glutathione-agarose chromatography. The purified GST fusion protein was confirmed by Western blot analyses as described previously (26) using anti-AID antisera, which were prepared by immunizing rabbits with a multiple-antigen peptide (27) containing residues 185–198 (EVDDLRDAFRMLGF). Cyti ...
Developmental control of blood cell migration by the Drosophila VEGF pathway. Cell 108, 865-876. pdf
... period in midembryogenesis they migrate along specific pathways to disperse throughout the body, where they function as immune and interstitial cells. Like vertebrate monocytes and macrophages, insect hemocytes phagocytose or encapsulate foreign material and apoptotic cells (Hoffmann et al., 1999). ...
... period in midembryogenesis they migrate along specific pathways to disperse throughout the body, where they function as immune and interstitial cells. Like vertebrate monocytes and macrophages, insect hemocytes phagocytose or encapsulate foreign material and apoptotic cells (Hoffmann et al., 1999). ...
Understanding High-Dose Therapy with Stem Cell Rescue
... two decades. Transplant doctors attempt to kill as many myeloma cells – or “reduce the tumor burden”– as much as possible before collecting stem cells and administering HDT. Patients therefore receive induction or “frontline” therapy with various drugs before they begin the process of HDT with stem ...
... two decades. Transplant doctors attempt to kill as many myeloma cells – or “reduce the tumor burden”– as much as possible before collecting stem cells and administering HDT. Patients therefore receive induction or “frontline” therapy with various drugs before they begin the process of HDT with stem ...
Wnt Signaling Translocates Lys48-Linked
... Protein degradation takes place in two different cellular compartments, proteasomes and lysosomes, but whether a physiologically regulated crosstalk between these protein degradation pathways exists is unknown (Ciechanover, 2005; Park and Cuervo, 2013). Lysosomal catabolism includes membrane protein ...
... Protein degradation takes place in two different cellular compartments, proteasomes and lysosomes, but whether a physiologically regulated crosstalk between these protein degradation pathways exists is unknown (Ciechanover, 2005; Park and Cuervo, 2013). Lysosomal catabolism includes membrane protein ...
PDGF signalling controls the migration of mesoderm cells during
... towards factors produced by the forming headprocess and notochord, notably FGF4 (Yang et al., 2002). It is, however, to be expected that a wider array of guidance molecules is required to guide the different mesodermal cell populations to their correct targets. Indeed, experiments in other organisms ...
... towards factors produced by the forming headprocess and notochord, notably FGF4 (Yang et al., 2002). It is, however, to be expected that a wider array of guidance molecules is required to guide the different mesodermal cell populations to their correct targets. Indeed, experiments in other organisms ...
Delamination of neural crest cells requires transient
... long been recognised as crucial for the generation of tissues and organs in both vertebrates and invertebrates. However, because EMT converts epithelial cells into migratory and invasive mesenchymal cells, it has also been established as an important step in the metastatic cascade of tumours (Nieto, ...
... long been recognised as crucial for the generation of tissues and organs in both vertebrates and invertebrates. However, because EMT converts epithelial cells into migratory and invasive mesenchymal cells, it has also been established as an important step in the metastatic cascade of tumours (Nieto, ...
Cannabidiol Enhances the Inhibitory Effects of Δ9
... We then tested the ratios for each treatment within a compartment to determine if they significantly differed from 1.0, indicating a treatment effect for that particular treatment. Finally, we tested for a significant interaction of cannabidiol and Δ9-THC, each at its lowest dose by ANOVA with an in ...
... We then tested the ratios for each treatment within a compartment to determine if they significantly differed from 1.0, indicating a treatment effect for that particular treatment. Finally, we tested for a significant interaction of cannabidiol and Δ9-THC, each at its lowest dose by ANOVA with an in ...
Expression and Endocytosis of Lysosomal
... Incubation was continued further for different time periods to allow the expressed polypeptides to be transported to their final destination. Neuron-specific expression of AGA was detected by double labeling with mouse antibody against 160 kDa neurofilament polypeptide and rabbit antiserum raised ag ...
... Incubation was continued further for different time periods to allow the expressed polypeptides to be transported to their final destination. Neuron-specific expression of AGA was detected by double labeling with mouse antibody against 160 kDa neurofilament polypeptide and rabbit antiserum raised ag ...
The perichromatin region of the plant cell nucleus is the area with
... The second group of splicing factors consists of snRNAs. To compare the pattern of the localisation of snRNAs and antigens forming the speckles, in situ hybridisation of U2 snRNA was conducted. In situ hybridisation of U2 snRNA showed signals in large clusters representing Cajal bodies (CBs) and in ...
... The second group of splicing factors consists of snRNAs. To compare the pattern of the localisation of snRNAs and antigens forming the speckles, in situ hybridisation of U2 snRNA was conducted. In situ hybridisation of U2 snRNA showed signals in large clusters representing Cajal bodies (CBs) and in ...
The Pore Size of Non-Graminaceous Plant Cell
... The AIR prepared from B-deficient, 10B-treated, and 11Bgrown cells, containing ,0.1, 1.0, and 1.6 mm g21 B, respectively, had similar glycosyl residue compositions and contained similar amounts of RG-II (Table I). 10B accounts for approximately 80% of the B found in the 10B-treated cells. Somewhat u ...
... The AIR prepared from B-deficient, 10B-treated, and 11Bgrown cells, containing ,0.1, 1.0, and 1.6 mm g21 B, respectively, had similar glycosyl residue compositions and contained similar amounts of RG-II (Table I). 10B accounts for approximately 80% of the B found in the 10B-treated cells. Somewhat u ...
Assessment of antimicrobial compounds by microscopy techniques
... state, which is strongly dependent on temperature. For example, DMPC 1 bilayers are in a gel (ordered) phase at low temperatures but undergo a gel to liquid (disordered) phase transition as temperature increases, modifying extensively the mechanical properties of the bilayer [29, 31]. Thus, the phys ...
... state, which is strongly dependent on temperature. For example, DMPC 1 bilayers are in a gel (ordered) phase at low temperatures but undergo a gel to liquid (disordered) phase transition as temperature increases, modifying extensively the mechanical properties of the bilayer [29, 31]. Thus, the phys ...
Molecular Targets and Cancer Therapeutics
... receptor, is expressed in a variety of cancers and has been revealed as the most highly expressed gene in preclinical models with acquired resistance, and second most common alteration in EGFR (epidermal growth factor receptor) inhibitor-resistant tumors, behind the T790M mutation. Up-regulation and ...
... receptor, is expressed in a variety of cancers and has been revealed as the most highly expressed gene in preclinical models with acquired resistance, and second most common alteration in EGFR (epidermal growth factor receptor) inhibitor-resistant tumors, behind the T790M mutation. Up-regulation and ...
How to build a grid cell
... are unlikely to oscillate independently at different frequencies over sufficiently long periods of time [18], making it more likely that the VCOs are driven by synaptic inputs from direction-sensitive neurons [15,19]. At any rate, action potential firing in this type of model is produced when the VC ...
... are unlikely to oscillate independently at different frequencies over sufficiently long periods of time [18], making it more likely that the VCOs are driven by synaptic inputs from direction-sensitive neurons [15,19]. At any rate, action potential firing in this type of model is produced when the VC ...
Dynamic Localization of Rop GTPases to the
... chambers remain connected to neighboring chambers. The fluorescence is not evenly distributed throughout the endomembrane system. Certain regions are much brighter than others. In most cases, small spheres or tubules have strong fluorescence, whereas larger chambers contain weaker fluorescence. Fluo ...
... chambers remain connected to neighboring chambers. The fluorescence is not evenly distributed throughout the endomembrane system. Certain regions are much brighter than others. In most cases, small spheres or tubules have strong fluorescence, whereas larger chambers contain weaker fluorescence. Fluo ...
Bell Work: What is the fundamental unit of life?
... Centrosomes and Centrioles In animal cells, microtubules grow out from a centrosome near the nucleus In animal cells, the centrosome has a pair of centrioles, each with nine triplets of microtubules arranged in a ring ...
... Centrosomes and Centrioles In animal cells, microtubules grow out from a centrosome near the nucleus In animal cells, the centrosome has a pair of centrioles, each with nine triplets of microtubules arranged in a ring ...
DNA asymmetry in stem cells – immortal or mortal?
... the various techniques used to address this question, and discuss their strengths and limitations. In the majority of studies, nucleotide analogs such as 5-bromo29-deoxyuridine (BrdU) have been used to label and distinguish two sister chromatids. In a pulse–chase experiment (Fig. 1A), nucleotide ana ...
... the various techniques used to address this question, and discuss their strengths and limitations. In the majority of studies, nucleotide analogs such as 5-bromo29-deoxyuridine (BrdU) have been used to label and distinguish two sister chromatids. In a pulse–chase experiment (Fig. 1A), nucleotide ana ...
Abstract
... novel essential functions for the products of genes with already characterized non- ...
... novel essential functions for the products of genes with already characterized non- ...
Cell encapsulation
Cell microencapsulation technology involves immobilization of the cells within a polymeric semi-permeable membrane that permits the bidirectional diffusion of molecules such as the influx of oxygen, nutrients, growth factors etc. essential for cell metabolism and the outward diffusion of waste products and therapeutic proteins. At the same time, the semi-permeable nature of the membrane prevents immune cells and antibodies from destroying the encapsulated cells regarding them as foreign invaders.The main motive of cell encapsulation technology is to overcome the existing problem of graft rejection in tissue engineering applications and thus reduce the need for long-term use of immunosuppressive drugs after an organ transplant to control side effects.