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Remodeling of endosomes during lysosome biogenesis involves
Remodeling of endosomes during lysosome biogenesis involves

... doi:10.1242/jcs.00259 ...
6.3. La supervivencia de las motoneuronas espinales de pollo mantenidas
6.3. La supervivencia de las motoneuronas espinales de pollo mantenidas

... seems to be involved in differentiation processes (Qiu and Green, 1992; Cowley et al., 1994; Fukuda et al., 1995; Pang et al., 1995). To understand the mechanisms implicated in the GDN F family- ...
Constrained transcription factor spacing is prevalent and important
Constrained transcription factor spacing is prevalent and important

... Transcription factors (TFs) are primary mediators of gene regulation, and they have long been known as essential regulators of cell fate decisions in the haematopoietic system. TF proteins form complexes, bind regulatory DNA sequences on enhancers and promoter regions and help to recruit the basic t ...
Non-Targeted and Targeted Protein Movement
Non-Targeted and Targeted Protein Movement

... Rather than compare sink with source leaves, which have limited symplastic trafficking, we chose to compare two types of leaves with different degrees of active symplastic connectivity; hence we used transition leaves. As large numbers of cells (50–200) were transfected and assessed for movement for ...
Functions of the Arabidopsis kinesin superfamily of microtubule
Functions of the Arabidopsis kinesin superfamily of microtubule

... 7 members that work to capture spindle microtubules at kinetochore sites. Therefore, shared membership within a particular kinesin clade does not necessarily mean that the plant and animal kinesins perform similar functions. Genome analysis indicates that the microtubule-based motor protein dynein ...
How to define flow cytometry ? Méthodes d’étude de la cellule
How to define flow cytometry ? Méthodes d’étude de la cellule

... nm via CY5, compensations could be elevated or difficult to realize so try to replace PE-CY5 by PECY5.5 or PE-CY7 in a combination with APC ...
The Grapevine fleshless berry Mutation. A Unique
The Grapevine fleshless berry Mutation. A Unique

... Glen Osmond, South Australia 5064, Australia (M.R.T.) ...
Anopheles  gambiae Drosophila melanogaster Bo Lindberg
Anopheles gambiae Drosophila melanogaster Bo Lindberg

... locally as well as into the hemocoel, the insect body cavity. The latter is referred to as the systemic immune response and is mainly regulated by the insect fat body, an organ comparable to the vertebrate liver and adipose tissues and the major production site of antimicrobials. Systemic responses ...
Publication : Exercise: Putting Action into Our Epigenome
Publication : Exercise: Putting Action into Our Epigenome

... Engaging in regular physical exercise prevents many chronic diseases, decreases mortality risk and increases longevity. However, the mechanisms involved are poorly understood. The modulating effect of physical (aerobic and resistance) exercise on gene expression has been known for some time now and ...
The basic helix–loop–helix protein BETA2 interacts with p300 to
The basic helix–loop–helix protein BETA2 interacts with p300 to

... Members of the basic helix–loop–helix (bHLH) family of transcription factors activate expression of tissue-specific genes in several developmental systems including the myogenic cascade and B-cell differentiation. The bHLH transcription factor BETA2 plays an important role in the development and dif ...
Endomembrane proton pumps: connecting membrane and vesicle
Endomembrane proton pumps: connecting membrane and vesicle

... secretory pathways is critical for protein sorting and vesicle trafficking, and is achieved by the activity of the vacuolar H+-ATPase (V-ATPase). Plants have an additional endomembrane pump, the vacuolar H+-pyrophosphatase (V-PPase), and previous research was largely focused on the respective functi ...
SNARE Complex Proteins in Rat Mast Cells Phosphorylation of
SNARE Complex Proteins in Rat Mast Cells Phosphorylation of

... and basophils, indicating the involvement of these proteins in leukocyte degranulation. It has been well-established that leukocyte degranulation requires a higher chemoattractant concentration than chemotaxis, which may reflect the need for activation of multiple signaling pathways for degranulatio ...
BAFF, APRIL and their receptors: Structure, function - Serval
BAFF, APRIL and their receptors: Structure, function - Serval

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Corticotropin-releasing hormone induces vascular endothelial
Corticotropin-releasing hormone induces vascular endothelial

... spectrophotometer (LS-5B, Shelton Chuck, CT). Cells were stimulated with CRH, antiIgE (Chemicon), or Br-A23187 (Sigma). For anti-IgE stimulation, hCBMC were resuspended (106 cells/ml) and passively sensitized by incubation with human myeloma IgE (2 µg/ml/106 cells; Chemicon) for 48 h before stimulat ...
Cadherins constitute a superfamily of transmembrane - HAL
Cadherins constitute a superfamily of transmembrane - HAL

... Homophilic interactions mediated by the extracellular domain of cadherins A variety of experiments demonstrate that the adhesive binding site of cadherin is primarily localized within the EC1 domain. From crystallographic studies, pairs of molecules are formed through the exchange of a N terminal  ...
The Relation Between Scale and the Completeness of Pattern in
The Relation Between Scale and the Completeness of Pattern in

... 1) How precise is the maintenance of the experimentally by creating two different proportions between pattern parts, in sets of abnormal conditions. terms of the relative space or cell numbers In the first test, so many presumptively devoted to them, under development at ventral cells (—those furthe ...
Glucose induces de novo lipogenesis in rat muscle satellite cells
Glucose induces de novo lipogenesis in rat muscle satellite cells

... Sterol-regulatory-element-binding proteins (SREBPs) regulate the transcription of genes involved in cholesterol and fatty acid metabolism (Brown and Goldstein, 1997). Three members of the SREBP family have been described in mammalian species. SREBP-1a and SREBP-1c are encoded by a single gene and pr ...
PDF
PDF

... fully compacted. Higher concentrations had irreversible effects within the first 6 h of culture (Table 3). Ultrastructural damage to the SER was detectable within 4 h of treatment (Fig. 6) but could be overcome if cholesterol or serum cholesterol (as FCS) was added to the culture within this period. ...
Purine nucleosides: endogenous neuroprotectants in hypoxic brain
Purine nucleosides: endogenous neuroprotectants in hypoxic brain

... of its effects, are apparently due to its metabolites as was reported, for example, for inosine (Haun et al. 1996). Inosine is formed by deamination of adenosine, mainly at high intracellular concentrations, which are associated with hypoxia, ischemia and other forms of cellular stress (Hasko et al. ...
Phosphorylation-Dependent Regulation of Septin
Phosphorylation-Dependent Regulation of Septin

... ring assembles between them (Bi et al., 1998; Lippincott et al., 2001). Subsequently, the actomyosin ring contracts and septation ensues. Activation of the mitotic exit network (MEN pathway) upon segregation of the sister chromatids triggers both septin ring splitting and actomyosin ring contraction ...
Here - Events
Here - Events

... experiments that investigate the remodeling of the rapid maternally controlled cell cycle into the extended cell cycle characteristic of later stages, the role of the DNA replication checkpoint in this process, and the relationship between this cell cycle transition and the restructuring of chromati ...
Expression and Inhibition of the Carboxylating
Expression and Inhibition of the Carboxylating

... vironment (Tortell et al., 1997). Indeed, in terms of primary inorganic acquisition, recent work has shown that diatoms acclimate to low pCO2 by increasing their affinity for both CO2 and HCO32 and that HCO32 transport contributes greater than one-half the carbon required for photosynthesis and grow ...
A Cellular Adventure Reader`s Theater Characters: 1. Teacher 2
A Cellular Adventure Reader`s Theater Characters: 1. Teacher 2

... Ryan: My name is Ryan. I just want to get out of here. Nucleus: You don’t leave here until I say so. Come here. Come a bit closer. I want to take a good look at you. Are you a lost lipid? Ryan? I am NOT a lipid! Nucleus: I know who you are. You’re the one who has been wandering around in the cell ge ...
Spindle pole body-anchored Kar3 drives the nucleus
Spindle pole body-anchored Kar3 drives the nucleus

... application of the core principle that drives nuclear migration in higher cells is used in yeast to drive nuclei toward each other before nuclear fusion. [Keywords: nuclear migration; microtubule; kinesin; karyogamy; spindle pole body; Kar3] Supplemental material is available for this article. Recei ...
Sample pages 1 PDF
Sample pages 1 PDF

... 1. Rate of Penetration The size of the sample should be appropriate for the selected fixative, the embedding method, and the objective of the experiment. For example, FAA is a common fixative for botanical specimens at the LM level. Penetration of fixing agents is fast and will not overly harden th ...
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Cellular differentiation



In developmental biology, cellular differentiation isa cell changes from one cell type to another. Most commonly this is a less specialized type becoming a more specialized type, such as during cell growth. Differentiation occurs numerous times during the development of a multicellular organism as it changes from a simple zygote to a complex system of tissues and cell types. Differentiation continues in adulthood as adult stem cells divide and create fully differentiated daughter cells during tissue repair and during normal cell turnover. Some differentiation occurs in response to antigen exposure. Differentiation dramatically changes a cell's size, shape, membrane potential, metabolic activity, and responsiveness to signals. These changes are largely due to highly controlled modifications in gene expression and are the study of epigenetics. With a few exceptions, cellular differentiation almost never involves a change in the DNA sequence itself. Thus, different cells can have very different physical characteristics despite having the same genome.A cell that can differentiate into all cell types of the adult organism is known as pluripotent. Such cells are called embryonic stem cells in animals and meristematic cells in higher plants. A cell that can differentiate into all cell types, including the placental tissue, is known as totipotent. In mammals, only the zygote and subsequent blastomeres are totipotent, while in plants many differentiated cells can become totipotent with simple laboratory techniques. In cytopathology, the level of cellular differentiation is used as a measure of cancer progression. ""Grade"" is a marker of how differentiated a cell in a tumor is.
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