A proteomic chronology of gene expression through the cell cycle in
... have also been performed in mammalian cells, particularly in HeLa cells, to compare mRNA expression levels across the cell cycle (Cho et al., 2001; Whitfield et al., 2002). More recently, several groups have also examined cell cycle variation in the mammalian proteome and phosphoproteome in cell lin ...
... have also been performed in mammalian cells, particularly in HeLa cells, to compare mRNA expression levels across the cell cycle (Cho et al., 2001; Whitfield et al., 2002). More recently, several groups have also examined cell cycle variation in the mammalian proteome and phosphoproteome in cell lin ...
Monomeric alpha-catenin links cadherin to the actin cytoskeleton
... complex to the interaction between actin and the adherens junction remains an intensely investigated subject that centres on the function of α-catenin, which binds to cadherin through β-catenin and can bind F-actin directly or indirectly. Here, we delineate regions within Drosophila α-Catenin (α-Cat ...
... complex to the interaction between actin and the adherens junction remains an intensely investigated subject that centres on the function of α-catenin, which binds to cadherin through β-catenin and can bind F-actin directly or indirectly. Here, we delineate regions within Drosophila α-Catenin (α-Cat ...
Roles of hepatic stellate cells in liver inflammation: a new perspective
... nonalcoholic fatty liver in that NASH is characterized by the presence of intrahepatic inflammation accompanied by hepatocyte damage with or without fibrosis [26]. Upon liver injury, various liver resident cells such as Kupffer cells and HSCs are activated and, at the same time, inflammatory cells a ...
... nonalcoholic fatty liver in that NASH is characterized by the presence of intrahepatic inflammation accompanied by hepatocyte damage with or without fibrosis [26]. Upon liver injury, various liver resident cells such as Kupffer cells and HSCs are activated and, at the same time, inflammatory cells a ...
Inter-specific scaling of phytoplankton production and cell size in the
... size on resource acquisition (Chisholm, 1992; Raven, 1998). Elongated or prolate cell shapes, the presence of the vacuole, the ability to store nutrients intracellularly and the capacity to migrate vertically in the water column, among other characteristics, may allow large species to sustain compar ...
... size on resource acquisition (Chisholm, 1992; Raven, 1998). Elongated or prolate cell shapes, the presence of the vacuole, the ability to store nutrients intracellularly and the capacity to migrate vertically in the water column, among other characteristics, may allow large species to sustain compar ...
epithelial cell - David Geffen School of Medicine at UCLA
... 3.3 Epithelia – Cell Surfaces – Recap; Next Topics Topics covered so far: • The 6 most common types of epithelia and their very general locations and functions. • The different types of junctions between epithelial cells. Topics to be covered next: - The basement membrane – a connective tissue laye ...
... 3.3 Epithelia – Cell Surfaces – Recap; Next Topics Topics covered so far: • The 6 most common types of epithelia and their very general locations and functions. • The different types of junctions between epithelial cells. Topics to be covered next: - The basement membrane – a connective tissue laye ...
Molecular Regulation of Vascular Cambium Identity and Activity
... development thanks to the activity of meristems, which harbor and protect the stem cell populations located in the different parts of the plant body (Evert, 2006a). Plant stem cells, or the “meristematic cells” or the “initials”, similar to their animal counterparts are reservoirs of cells that can ...
... development thanks to the activity of meristems, which harbor and protect the stem cell populations located in the different parts of the plant body (Evert, 2006a). Plant stem cells, or the “meristematic cells” or the “initials”, similar to their animal counterparts are reservoirs of cells that can ...
IL-5 Receptor-mediated Tyrosine Phosphorylation of SH2
... Interleukin 5 (I1`5) induces proliferation and differentiation of B cells and eosinophils by interacting with its receptor (I1`5R) which consists of two distinct polypeptide chains, c~and j8 (~/c). Although both I1`5Ro~ and /3c lack a kinase catalytic domain, I1`5 is capable of inducing tyrosine pho ...
... Interleukin 5 (I1`5) induces proliferation and differentiation of B cells and eosinophils by interacting with its receptor (I1`5R) which consists of two distinct polypeptide chains, c~and j8 (~/c). Although both I1`5Ro~ and /3c lack a kinase catalytic domain, I1`5 is capable of inducing tyrosine pho ...
Mastoparan Alters Subcellular Distribution of
... birch pollen profilin co-localizes with dynamic AFs when expressed in animal cells (Mayboroda et al. 1997). This suggests that plant and animal profilins obey the same principles responsible for their subcellular localizations (for animal cells see, e.g., Hartwig et al. 1989, Buß et al. 1992, Bubb e ...
... birch pollen profilin co-localizes with dynamic AFs when expressed in animal cells (Mayboroda et al. 1997). This suggests that plant and animal profilins obey the same principles responsible for their subcellular localizations (for animal cells see, e.g., Hartwig et al. 1989, Buß et al. 1992, Bubb e ...
The L5 epitope: an early marker for neural induction in the chick
... Neural induction is the process during which the axial mesoderm interacts with the overlying ectoderm to instruct it to become nervous system. In the absence of such an inductive interaction, uninduced epiblast only gives rise to epidermis (reviewed by Nieuwkoop et al. 1985). It was first discovered ...
... Neural induction is the process during which the axial mesoderm interacts with the overlying ectoderm to instruct it to become nervous system. In the absence of such an inductive interaction, uninduced epiblast only gives rise to epidermis (reviewed by Nieuwkoop et al. 1985). It was first discovered ...
Quaternary ammonium surfactant structure determines selective
... Results: QAS toxicity normalized relative to surfactant critical micelle concentration showed n-dodecylpyridinium bromide (C12PB) to be the most effective, with a therapeutic index of ∼10 for an MDR strain of Escherichia coli and .20 for Neisseria gonorrhoeae after 1 h of exposure. Three modes of QA ...
... Results: QAS toxicity normalized relative to surfactant critical micelle concentration showed n-dodecylpyridinium bromide (C12PB) to be the most effective, with a therapeutic index of ∼10 for an MDR strain of Escherichia coli and .20 for Neisseria gonorrhoeae after 1 h of exposure. Three modes of QA ...
Early Cell Cycle Entry and Cell Division Murine Neonatal
... showed more rapid division in vivo, upon transfer to lymphopenic RAG2⫺/⫺ hosts (Fig. 2, right column). Together, these results indicate that faster kinetics of proliferation is a universal phenomenon among neonatal T cell populations—it occurs both in vivo and in vitro, it occurs in several strains ...
... showed more rapid division in vivo, upon transfer to lymphopenic RAG2⫺/⫺ hosts (Fig. 2, right column). Together, these results indicate that faster kinetics of proliferation is a universal phenomenon among neonatal T cell populations—it occurs both in vivo and in vitro, it occurs in several strains ...
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... – Serves as a scaffold providing structural support and maintaining cell shape. – Serves as an internal framework to organize organelles within the cell. – Directs cellular locomotion and the movement of materials within the cell. ...
... – Serves as a scaffold providing structural support and maintaining cell shape. – Serves as an internal framework to organize organelles within the cell. – Directs cellular locomotion and the movement of materials within the cell. ...
Overexpression of yeast karyopherin Pse1p/Kap121p stimulates the
... A. Mitochondrial proteins used in this study are distributed according to their mesohydrophobicity values (which is an average regional hydrophobicity value determined over a 60±80 residue window) and to the hydrophobicity of the most hydrophobic 17 residue segment (< H17 >) using the MITOPROT II so ...
... A. Mitochondrial proteins used in this study are distributed according to their mesohydrophobicity values (which is an average regional hydrophobicity value determined over a 60±80 residue window) and to the hydrophobicity of the most hydrophobic 17 residue segment (< H17 >) using the MITOPROT II so ...
Proteomic Strategies to Analyze Cell
... The use of Proteomic strategies in the discovery process is imperative since post-transcriptional modification can produce dramatic changes in protein levels and activity that are invisible to DNA arrays. The introduction of new and improved proteomics solutions with increased sensitivity, specifici ...
... The use of Proteomic strategies in the discovery process is imperative since post-transcriptional modification can produce dramatic changes in protein levels and activity that are invisible to DNA arrays. The introduction of new and improved proteomics solutions with increased sensitivity, specifici ...
Cytoplasmic Actin in Neuronal Processes as a Possible Mediator of
... or neurons. Whether this reflects their rarity, their destruction during permeation and fixation, or their true absence in the cell remains uncertain (15). This, and the excess of actin over myosin leads to the speculation that most of the actin in nonmuscle cells is involved in support-providing fu ...
... or neurons. Whether this reflects their rarity, their destruction during permeation and fixation, or their true absence in the cell remains uncertain (15). This, and the excess of actin over myosin leads to the speculation that most of the actin in nonmuscle cells is involved in support-providing fu ...
Text - Enlighten: Publications
... the inclusion of a detergent (0.85 mM Triton-X100) in the labeling protocol and noted no discernable difference in labeling results. Control experiments also showed that the labeling was specific. Table 1 provides a summary of antibodies used and labeling results that were obtained for the following ...
... the inclusion of a detergent (0.85 mM Triton-X100) in the labeling protocol and noted no discernable difference in labeling results. Control experiments also showed that the labeling was specific. Table 1 provides a summary of antibodies used and labeling results that were obtained for the following ...
PDQ Histology - McMaster University`s Faculty of Health Sciences
... or lymph. A profusion of functional cell products passes into these body fluids from the tissues, ranging from secreted matrix constituents and plasma proteins to hormones and various other signaling molecules. Histology is essentially the study of the body tissues. Although there are only four basi ...
... or lymph. A profusion of functional cell products passes into these body fluids from the tissues, ranging from secreted matrix constituents and plasma proteins to hormones and various other signaling molecules. Histology is essentially the study of the body tissues. Although there are only four basi ...
Abstract Panax ginseng Meyer, belonging to the genus Panax of the
... carbohydrate-binding specificities [43]. Animal lectins were discovered before plant lectins, although many were not recognized as carbohydrate binding proteins for many years after first being reported [44]. Although plant and animal lectins do not have homologous primary structures, they have sim ...
... carbohydrate-binding specificities [43]. Animal lectins were discovered before plant lectins, although many were not recognized as carbohydrate binding proteins for many years after first being reported [44]. Although plant and animal lectins do not have homologous primary structures, they have sim ...
Topical aldose reductase inhibitor for correcting
... 13 diabetic patients were found to have no diabetic retinopathy or simple (background) retinopathy at the pretreatment examination. During the observation period, however, neovascularisations of the retinal vessels elsewhere (proliferative diabetic retinopathy) appeared in two of the CT-1 12 treated ...
... 13 diabetic patients were found to have no diabetic retinopathy or simple (background) retinopathy at the pretreatment examination. During the observation period, however, neovascularisations of the retinal vessels elsewhere (proliferative diabetic retinopathy) appeared in two of the CT-1 12 treated ...
Actin-based motility of endosomes is linked to the polar tip growth of
... In both yeast and mammals, the phosphoinositide PI(3)P accumulates preferentially in endosomal membranes (Gillooly et al., 2000), and binding of FYVEdomain proteins to PI(3)P is sufficient to target endosomal proteins to these subcellular compartments. For A. thaliana it is known that the classical F ...
... In both yeast and mammals, the phosphoinositide PI(3)P accumulates preferentially in endosomal membranes (Gillooly et al., 2000), and binding of FYVEdomain proteins to PI(3)P is sufficient to target endosomal proteins to these subcellular compartments. For A. thaliana it is known that the classical F ...
2015 – PKc-theta is a novel sc35 splicing factor regulator in
... of immune responses, alternative splicing of pre-mRNA is an emerging theme in the regulation of T cell function (5, 6). Several T cell genes, such as CD44 and CD45, undergo alternative splicing to produce distinct protein isoforms (7, 8). Furthermore, antigenic stimulation alters the pattern of alte ...
... of immune responses, alternative splicing of pre-mRNA is an emerging theme in the regulation of T cell function (5, 6). Several T cell genes, such as CD44 and CD45, undergo alternative splicing to produce distinct protein isoforms (7, 8). Furthermore, antigenic stimulation alters the pattern of alte ...
Role of cholesterol in SNARE-mediated trafficking on intracellular
... The cell surface delivery of extracellular matrix (ECM) and integrins is fundamental for cell migration in wound healing and during cancer cell metastasis. This process is not only driven by several soluble NSF attachment protein (SNAP) receptor (SNARE) proteins, which are key players in vesicle tra ...
... The cell surface delivery of extracellular matrix (ECM) and integrins is fundamental for cell migration in wound healing and during cancer cell metastasis. This process is not only driven by several soluble NSF attachment protein (SNAP) receptor (SNARE) proteins, which are key players in vesicle tra ...
Extracellular matrix
In biology, the extracellular matrix (ECM) is a collection of extracellular molecules secreted by cells that provides structural and biochemical support to the surrounding cells. Because multicellularity evolved independently in different multicellular lineages, the composition of ECM varies between multicellular structures; however, cell adhesion, cell-to-cell communication and differentiation are common functions of the ECM.The animal extracellular matrix includes the interstitial matrix and the basement membrane. Interstitial matrix is present between various animal cells (i.e., in the intercellular spaces). Gels of polysaccharides and fibrous proteins fill the interstitial space and act as a compression buffer against the stress placed on the ECM. Basement membranes are sheet-like depositions of ECM on which various epithelial cells rest.The plant ECM includes cell wall components, like cellulose, in addition to more complex signaling molecules. Some single-celled organisms adopt multicelluar biofilms in which the cells are embedded in an ECM composed primarily of extracellular polymeric substances (EPS).