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Renerve G
Renerve G

... Epilepsy typically requires long-term therapy. Dosage is determined by the treating physician according to individual tolerance and efficacy. Adults and adolescents: In clinical trials, the effective dosing range was 900 to 3600 mg/day. Therapy may be initiated by titrating the dose as described in ...
Direct Oral Anticoagulants (DOACs) for DVT and PE in adults
Direct Oral Anticoagulants (DOACs) for DVT and PE in adults

... weight heparin (LMWH) (e.g. dalteparin) for rapid anticoagulation whilst awaiting diagnostic workup. Once diagnosis is confirmed, a DOAC such as rivaroxaban or a vitamin K antagonist such as warfarin is initiated to treat the DVT or PE •Many CCG areas in England have started to use DOACs such as riv ...
MS Contin - Purdue Pharma
MS Contin - Purdue Pharma

... Patients should be instructed not to give MS Contin to anyone other than for whom it was prescribed, as such, inappropriate use may have severe medical consequences, including death. Patients should be cautioned not to consume alcohol while taking MS Contin, as it may increase the chance of experien ...
Nitro-Dur - Merck.com
Nitro-Dur - Merck.com

... The suggested starting dose is between 0.2 mg/hr* and 0.4 mg/hr*. Doses between 0.4 mg/hr* and 0.8 mg/hr* have shown continued effectiveness for 10 to 12 hours daily for at least 1 month (the longest period studied) of intermittent administration. Although the minimum nitrate-free interval has not b ...
PRODUKTRESUMÉ
PRODUKTRESUMÉ

... Cabergoline has been associated with somnolence . Dopamine agonists can be associated with sudden sleep onset episodes, in patients with Parkinson’s disease. Patients must be informed of this and advised to exercise caution while driving or operating machines during treatment with cabergoline. Patie ...
How I treat with anticoagulants in 2012: new and old
How I treat with anticoagulants in 2012: new and old

... low bioavailability, which results in high concentrations of active drug in the feces.20 Treatment with rivaroxaban was also associated with a significant increase of the risk for gastrointestinal bleeding16; hence, patients with intestinal angiodysplasia, inflammatory bowel disease, or diverticulos ...
Proposed Package Insert for LYRICA
Proposed Package Insert for LYRICA

... Effects on ability to drive and use machines: LYRICA frequently causes dizziness and somnolence. Therefore, patients are advised not to drive, operate complex machinery or engage in other potentially hazardous activities until it is known whether this medication affects their ability to perform thes ...
EFFECT OF SEPTILIN - A HERBAL PREPARATION ON
EFFECT OF SEPTILIN - A HERBAL PREPARATION ON

... hours was supported by the fact that CBZ steady state Tmax was prolonged, Cmax was decreased by about 62% and AUCO•24 was decreased approximately 65% by Septrlin!". In multiple dose sub-group, when CBZ only was continued for 14 days without Sept ilin'P, the plasma CBZ levels remain unaltered when co ...
Effects on upper gastrointestinal motility
Effects on upper gastrointestinal motility

... Metoclopramide influences various aspects of the motility of the upper digestive tract. The pressure in the lower esophageal sphincter is increased after intravenous or oral administration of the drug (3,4), the magnitude of the effect being dose-dependent, directly proportional to the basal pressur ...
Coma after levetiracetam overdose
Coma after levetiracetam overdose

... signs remained within normal limits, as did her urine output. Subsequent metabolic panels showed no signs of acute kidney injury. Approximately 32 hours after ingestion she was awake and could be extubated. She told the treating physicians and her husband she only ingested levetiracetam and expresse ...
(Dosing, switching, and other practical information).
(Dosing, switching, and other practical information).

... Use with caution in patients with renal insufficiency. Amisulpride is renally eliminated, and in patients with renal insufficiency, systemic clearance is reduced by a factor of 2.5 to 3. The AUC in mild renal failure is increased two-fold and almost tenfold in moderate renal failure. Although there ...
PRODUCT MONOGRAPH CYPROTERONE Cyproterone Acetate
PRODUCT MONOGRAPH CYPROTERONE Cyproterone Acetate

... changes were found in increased coagulation capability. There is an inherent risk for those patients with a history of thrombophlebitis or thromboembolism for recurrence of the disease. Cyproterone acetate should be discontinued at the first sign of thrombophlebitis or thromboembolism and the patien ...
A Comparison of Once-Daily Extended-Release
A Comparison of Once-Daily Extended-Release

... some high scores for behavior in the lab classroom, but both the low- and high-scoring sites showed similar PD patterns across the day. The interaction of dose ⴛ treatment was not significant, indicating that the pattern of treatment effects was consistent across each dose level. There were no stati ...
DEMEROL (meperidine hydrochloride
DEMEROL (meperidine hydrochloride

... DEMEROL should not be consumed with alcohol as it may increase the chance of experiencing dangerous side effects, including death (see CONTRAINDICATIONS and ADVERSE REACTIONS, Sedation, and DRUG INTERACTIONS). Severe pain antagonizes the subjective and respiratory depressant actions of opioid analge ...
Gout
Gout

... started 2 to 4 weeks after flare resolution, with a low initial dose that is increased as needed over a period of weeks to months, and with close monitoring of urate levels, renal function, and adverse effects. The dose should be adjusted as necessary to maintain a serum urate level below 6 mg per d ...
The use of injectable nonsteroidal anti
The use of injectable nonsteroidal anti

... Concern over the high incidence of reported adverse effects with ketorolac trometamol has led to its withdrawal from the market in some countries while in others its permitted dosage and maximum duration of treatment has been reduced. 23 Ketorolac has a narrow therapeutic margin and its risk becomes ...
Keppra® (levetiracetam)
Keppra® (levetiracetam)

... Such serious skin reactions may be life-threatening, and some patients have required hospitalization with very rare reports of fatal outcome. There is no way to tell if a mild rash will become a severe skin reaction. If any of these hypersensitivity reactions are suspected, and an alternative cause ...
RAZENE Presentation Indications Dosage and Administration
RAZENE Presentation Indications Dosage and Administration

... Cetirizine, a human metabolite of hydroxyzine, is a potent and selective antagonist of peripheral H 1-receptors. In vitro receptor binding studies have shown no measurable affinity for receptors other than H1-receptors. Ex vivo experiments in mice have shown that systemically administered cetirizine ...
Appendix 4.14 Psychotropic Medication Reference Chart 2010
Appendix 4.14 Psychotropic Medication Reference Chart 2010

... Maximum daily dosage 54 mg. Adolescents ages 13-17: Dosage titrated to achieve optimum response. Maximum daily dosage 72 mg. Children ages 6 and older: Dosage titrated to achieve optimum response. maximum daily dosage 60 mg. Children 6 and older: Dosage titrated to achieve optimum response. Maximum ...
Chapter 04: Reproductive System Concerns MULTIPLE CHOICE 1
Chapter 04: Reproductive System Concerns MULTIPLE CHOICE 1

... profuse; thin; and white, gray, or milky in color. Some women also may have mild irritation or pruritus. The discharge associated with candidiasis is thick, white, and lumpy and resembles cottage cheese. Trichomoniasis may be asymptomatic, but women commonly have a characteristic yellowish-to-greeni ...
IV-phenytoin-in-SE-version 3.1 final
IV-phenytoin-in-SE-version 3.1 final

... controlling seizures and its serious acute toxic effects (cardiac and CNS toxicity leading to arrhythmias, hypotension, and cardiovascular collapse) are directly related to its concentration in the plasma. ...
Ocuflox - Allergan
Ocuflox - Allergan

... rabbits, respectively. Nonteratogenic Effects Additional studies in rats with doses up to 360 mg/kg/day during late gestation showed no adverse effect on late fetal development, labor, delivery, lactation, neonatal viability, or growth of the newborn. There are, however, no adequate and well-control ...
here - Specialist Pharmacy Service
here - Specialist Pharmacy Service

... controlling seizures and its serious acute toxic effects (cardiac and CNS toxicity leading to arrhythmias, hypotension, and cardiovascular collapse) are directly related to its concentration in the plasma. ...
Warcillin LPD Version 2.0
Warcillin LPD Version 2.0

... Amoxicillin is stable in the presence of gastric acid and hence may be given with food. It is rapidly absorbed after oral administration. The absorption is better than that of ampicillin in fasting or non-fasting state. Amoxicillin diffuses readily into most body tissues and fluids, with the excepti ...
PRODUCT INFORMATION ZINNAT
PRODUCT INFORMATION ZINNAT

... Drugs which delay peristalsis eg opiates and diphenoxylate with atropine (LOMOTIL) may prolong and/or worsen the condition and should not be used. The sucrose content of ZINNAT suspension and granules (see PRESENTATION) should be taken into account when treating diabetic patients and appropriate adv ...
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Dydrogesterone



Dydrogesterone (INN, USAN, BAN), is also chemically known as 9β,10α-pregna-4,6-diene-3,20-dione. Dydrogesterone (6-dehydro-retroprogesterone) is a hormonally active, non-androgenic steroid that was developed in the 1950s.Dydrogesterone has selective progestational activity and does not inhibit ovulation. The greater rigidity of dydrogesterone also positively affects its selectivity, while natural progesterone is less selective, existing in different conformations that more easily bind to different receptors. As a consequence of its better bioavailability and the progestational activity of its main metabolites (20-, 21- and 16-hydroxy derivatives), the equivalent dose of dydrogesterone is 10–20 times lower than that of oral micronized progesterone.Dydrogesterone is used as an effective, orally active progestogen for gynaecological conditions related to a wide variety of progesterone deficiencies in pregnant women. The molecular structure and pharmacological effects are somewhat similar to endogenous progesterone, although in smaller amounts it is found to be orally active. Its freedom from hormonal effects like those related to corticoid, androgenic, estrogenic, anabolic, and other effects gives dydrogesterone an advantage over other synthesized progestogens.Dydrogesterone when used therapeutically is closely related to its physiological action on the neuro-endocrine control of ovarian function, as well as on the endometrium. This is an indication in all cases of endogeneous progesterone deficiency - relative or absolute. The molecule was licensed for use in several indications, including threatened or recurrent miscarriage, dysfunctional bleeding, infertility due to luteal insufficiency, dysmenorrhea, endometriosis, secondary amenorrhoea, irregular cycles, pre-menstrual syndrome and also as a hormone replacement therapy.Dydrogesterone has proven effective in the following conditions associated with progesterone deficiency: Infertility due to luteal insufficiency Threatened miscarriage Habitual or recurrent miscarriage. Menstrual disorders Premenstrual syndrome Endometriosis Dydrogesterone has also been registered as hormone replacement therapy (HRT) to counter-check the negative effects of unopposed estrogen on the endometrium in women with an intact uterus. Dydrogesterone is relatively safe and well tolerated, and does not exhibit the androgenic side effects that are common with some other progestins, like medroxyprogesterone acetate.
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