PFIZER
... women who want to become pregnant after completing daunorubicin treatment, genetic counseling is also recommended. Pregnancy Studies in animals have shown reproductive toxicity (See section 5.3 Preclinical safety data). Like most other anticancer drugs, daunorubicin has shown embryotoxic, teratogeni ...
... women who want to become pregnant after completing daunorubicin treatment, genetic counseling is also recommended. Pregnancy Studies in animals have shown reproductive toxicity (See section 5.3 Preclinical safety data). Like most other anticancer drugs, daunorubicin has shown embryotoxic, teratogeni ...
Product Monograph Template - Standard
... or symptoms of acute hepatitis, in particular if drug-related hypersensitivity is suspected or with increased liver transaminases combined with rash or other systemic symptoms of potential hypersensitivity (e.g. pruritic rash, eosinophila or elevated IgE). Caution should also be used when administer ...
... or symptoms of acute hepatitis, in particular if drug-related hypersensitivity is suspected or with increased liver transaminases combined with rash or other systemic symptoms of potential hypersensitivity (e.g. pruritic rash, eosinophila or elevated IgE). Caution should also be used when administer ...
MEDICATION GUIDE ZEGERID® (ze ger id) (omeprazole / sodium
... Avoid concomitant use of ZEGERID with clopidogrel. Clopidogrel is a prodrug. Inhibition of platelet aggregation by clopidogrel is entirely due to an active metabolite. The metabolism of clopidogrel to its active metabolite can be impaired by use with concomitant medications, such as omeprazole, that ...
... Avoid concomitant use of ZEGERID with clopidogrel. Clopidogrel is a prodrug. Inhibition of platelet aggregation by clopidogrel is entirely due to an active metabolite. The metabolism of clopidogrel to its active metabolite can be impaired by use with concomitant medications, such as omeprazole, that ...
SPORANOX® Oral Solution
... It is a white to slightly yellowish powder, insoluble in water at pH 1-12, very slightly soluble in alcohols and freely soluble in dichloromethane. SPORANOX oral solution contains itraconazole 10 mg/mL, hydroxypropyl-beta-cyclodextrin, ...
... It is a white to slightly yellowish powder, insoluble in water at pH 1-12, very slightly soluble in alcohols and freely soluble in dichloromethane. SPORANOX oral solution contains itraconazole 10 mg/mL, hydroxypropyl-beta-cyclodextrin, ...
- Boehringer Ingelheim (Canada)
... of human response, ATROVENT HFA should be used during pregnancy only if the potential benefit justifies the potential risk to the unborn child. Nursing Women No specific studies have been conducted on the excretion of ipratropium bromide in breast milk. It is considered unlikely that ipratropium bro ...
... of human response, ATROVENT HFA should be used during pregnancy only if the potential benefit justifies the potential risk to the unborn child. Nursing Women No specific studies have been conducted on the excretion of ipratropium bromide in breast milk. It is considered unlikely that ipratropium bro ...
HYDROCODONE BITARTRATE AND ACETAMINOPHEN ORAL
... distributed throughout most body tissues. The plasma half-life is 1.25 to 3 hours, but may be increased by liver damage and following overdosage. Elimination of acetaminophen is principally by liver metabolism (conjugation) and subsequent renal excretion of metabolites. Approximately 85% of an oral ...
... distributed throughout most body tissues. The plasma half-life is 1.25 to 3 hours, but may be increased by liver damage and following overdosage. Elimination of acetaminophen is principally by liver metabolism (conjugation) and subsequent renal excretion of metabolites. Approximately 85% of an oral ...
% 4 L Memorandum
... assume that the mean weight was 70 kg when the dose is gilren as mg/kg without body weights. In the intravenous ...
... assume that the mean weight was 70 kg when the dose is gilren as mg/kg without body weights. In the intravenous ...
What are the differences between different brands of mesalazine
... Octasa MR 400mg was previously branded as Mesren MR. Octasa MR has not been compared to other mesalazine MR preparations in patient studies because to obtain a licence as a generic medicine, the product only needs to demonstrate bioequivalence to the brand leader (17, 21). Choice of preparation The ...
... Octasa MR 400mg was previously branded as Mesren MR. Octasa MR has not been compared to other mesalazine MR preparations in patient studies because to obtain a licence as a generic medicine, the product only needs to demonstrate bioequivalence to the brand leader (17, 21). Choice of preparation The ...
Pharmacokinetic interaction studies of atosiban with labetalol
... single intramuscular injection of 12 mg betamethasone or the two drugs in combination. Main outcome measure For Study 1, the outcome parameter for atosiban was area under the plasma concentration – time curve (AUC); the study parameters for labetalol were AUC, maximum plasma concentration (Cmax) and ...
... single intramuscular injection of 12 mg betamethasone or the two drugs in combination. Main outcome measure For Study 1, the outcome parameter for atosiban was area under the plasma concentration – time curve (AUC); the study parameters for labetalol were AUC, maximum plasma concentration (Cmax) and ...
depo-provera - Pfizer Canada
... only partial recovery of mean BMD at total hip, femoral neck and lumbar spine towards baseline by 24 months post-treatment. DEPO-PROVERA should be used as indicated only if other treatments have been considered to be unsuitable or unacceptable and should be used for the shortest period of time possi ...
... only partial recovery of mean BMD at total hip, femoral neck and lumbar spine towards baseline by 24 months post-treatment. DEPO-PROVERA should be used as indicated only if other treatments have been considered to be unsuitable or unacceptable and should be used for the shortest period of time possi ...
FIG 7: gingival index
... The serious toxic effects are uncommon; however, neurotoxic effects, such as vertigo, ataxy and leucopenia are reported. In general, short–duration therapies with metronidazole are well tolerated; however, some side effects which are completely reversible to the drug suspension might occur. The assu ...
... The serious toxic effects are uncommon; however, neurotoxic effects, such as vertigo, ataxy and leucopenia are reported. In general, short–duration therapies with metronidazole are well tolerated; however, some side effects which are completely reversible to the drug suspension might occur. The assu ...
Package Insert - Phenobarbital Oral Solution, USP
... doses, respiratory depression produced by barbiturates is similar to that which occurs during physiologic sleep and is accompanied by a slight decrease in blood pressure and heart rate. Studies in laboratory animals have shown that barbiturates cause reductions in the one and contractility of the ut ...
... doses, respiratory depression produced by barbiturates is similar to that which occurs during physiologic sleep and is accompanied by a slight decrease in blood pressure and heart rate. Studies in laboratory animals have shown that barbiturates cause reductions in the one and contractility of the ut ...
1 Name: Thyroglobulin (Proloid) Class: Thyroid Hormone Mech.: T3
... Mech.: Increases intestinal absorption of calcium and phosphate. Stimulates bone resorption by facilitating effects of PTH. Stimulates renal reabsorption of calcium and phosphate. Net result = ↑↑ calcium, ↑↑ phosphate. Absorpt.: Oral usu → adequate absorption. Bile essential for absorpt. Parenteral. ...
... Mech.: Increases intestinal absorption of calcium and phosphate. Stimulates bone resorption by facilitating effects of PTH. Stimulates renal reabsorption of calcium and phosphate. Net result = ↑↑ calcium, ↑↑ phosphate. Absorpt.: Oral usu → adequate absorption. Bile essential for absorpt. Parenteral. ...
PrKETOTIFEN OPHTHALMIC SOLUTION
... The acute toxicity of ketotifen fumarate has been investigated in mice, rats and rabbits. Oral LD 50 values were 165 mg/kg, 360 mg/kg and 790 mg/kg in mice, rats and rabbits, respectively. Subchronic and chronic oral toxicity studies in rats and dogs demonstrated that the liver was a target organ fo ...
... The acute toxicity of ketotifen fumarate has been investigated in mice, rats and rabbits. Oral LD 50 values were 165 mg/kg, 360 mg/kg and 790 mg/kg in mice, rats and rabbits, respectively. Subchronic and chronic oral toxicity studies in rats and dogs demonstrated that the liver was a target organ fo ...
balsalazide disodium capsules balsalazide disodium capsules
... Reproduction studies were performed in rats and rabbits at oral doses up to 2 g/kg/day, 2.4 and 4.7 times the recommended human dose based on body surface area for the rat and rabbit, respectively, and revealed no evidence of impaired fertility or harm to the fetus due to balsalazide disodium. There ...
... Reproduction studies were performed in rats and rabbits at oral doses up to 2 g/kg/day, 2.4 and 4.7 times the recommended human dose based on body surface area for the rat and rabbit, respectively, and revealed no evidence of impaired fertility or harm to the fetus due to balsalazide disodium. There ...
DRUG NAME: Cytarabine
... Neurotoxicity (8-10%) typically occurs 3-8 days after initiating therapy.2,4,12,22 Cerebellar dysfunction is characterized by difficulty with speech, trouble standing or walking, and tremors. Cerebral dysfunction may be seen concomitantly and is characterized by somnolence, confusion, personality ch ...
... Neurotoxicity (8-10%) typically occurs 3-8 days after initiating therapy.2,4,12,22 Cerebellar dysfunction is characterized by difficulty with speech, trouble standing or walking, and tremors. Cerebral dysfunction may be seen concomitantly and is characterized by somnolence, confusion, personality ch ...
procainamide hcl
... hydrochloride is usually absorbed from the intestine, but a few patients may absorb less than 50% of an oral dose. Oral absorption of procainamide is slowed by delayed gastric emptying, decreased intestinal motility, presence of food in the GI tract, decreases in intestinal pH, or decreased sphlanch ...
... hydrochloride is usually absorbed from the intestine, but a few patients may absorb less than 50% of an oral dose. Oral absorption of procainamide is slowed by delayed gastric emptying, decreased intestinal motility, presence of food in the GI tract, decreases in intestinal pH, or decreased sphlanch ...
Proventil
... beta-agonists, such as PROVENTIL Inhalation Solution, but may produce severe bronchospasm in asthmatic patients. Therefore, patients with asthma should not normally be treated with beta blockers. However, under certain circumstances, e.g., as prophylaxis after myocardial infarction, there may be no ...
... beta-agonists, such as PROVENTIL Inhalation Solution, but may produce severe bronchospasm in asthmatic patients. Therefore, patients with asthma should not normally be treated with beta blockers. However, under certain circumstances, e.g., as prophylaxis after myocardial infarction, there may be no ...
Spectinomycin - American Academy of Veterinary Pharmacology
... per kg of body weight every twelve to twenty-four hours,{R-11} has been used in clinical practice to treat respiratory infections and systemic infections caused by organisms sensitive to spectinomycin.{R-5} Extra-label withdrawal recommendation: U.S. and Canada— Pigs: Because injectable spectinomyci ...
... per kg of body weight every twelve to twenty-four hours,{R-11} has been used in clinical practice to treat respiratory infections and systemic infections caused by organisms sensitive to spectinomycin.{R-5} Extra-label withdrawal recommendation: U.S. and Canada— Pigs: Because injectable spectinomyci ...
Screening of Methanol Extract and Ethyl Acetate Fraction of Abies
... drug was not achieved at lower doses. Higher doses, i.e., 400 and 50 mg/kg of the methanol extract and EF, respectively, significantly increased mean number of entries in open arms of EPM in animals not only with respect to control but also equivalent to the standard drug. It is clearly evident from ...
... drug was not achieved at lower doses. Higher doses, i.e., 400 and 50 mg/kg of the methanol extract and EF, respectively, significantly increased mean number of entries in open arms of EPM in animals not only with respect to control but also equivalent to the standard drug. It is clearly evident from ...
Methylergonovine Heathcare Professional Letter
... A number of case reports have documented inadvertent administration of Methylergonovine Maleate Injection, USP to newborn infants when in fact this medication was intended for use in the mother. Toxic doses of ergot compounds may cause serious adverse effects in newborn infants such as respiratory d ...
... A number of case reports have documented inadvertent administration of Methylergonovine Maleate Injection, USP to newborn infants when in fact this medication was intended for use in the mother. Toxic doses of ergot compounds may cause serious adverse effects in newborn infants such as respiratory d ...
Oral and perioral herpes simplex virus type 1 (HSV
... is also recommended for severe HSV or VZV infections refractory to ACV (related to TK deficiency) (Cohen et al, 1999). Due to its nephrotoxic potential, foscarnet administration requires slow infusion, extensive prehydration and dose adjustment based upon creatinine clearance. No oral formulation of ...
... is also recommended for severe HSV or VZV infections refractory to ACV (related to TK deficiency) (Cohen et al, 1999). Due to its nephrotoxic potential, foscarnet administration requires slow infusion, extensive prehydration and dose adjustment based upon creatinine clearance. No oral formulation of ...
Introduction to Anabolic Steroids
... tested by examining the dose/response curve. If an effect is dependent only upon the activity of a receptor, then the log response should follow a sigmoidal function (an S shaped curve). The graph would be nearly flat both at low and high doses, and approximately linear at moderate doses. At moderat ...
... tested by examining the dose/response curve. If an effect is dependent only upon the activity of a receptor, then the log response should follow a sigmoidal function (an S shaped curve). The graph would be nearly flat both at low and high doses, and approximately linear at moderate doses. At moderat ...
hydralazine hydrochloride USP
... increased secretion of renin by the renal juxtaglomerular cells in response to reflex sympathetic discharge. This increase in renin activity leads to the production of angiotensin II, which then causes stimulation of aldosterone and consequent sodium reabsorption and fluid retention. Sodium retentio ...
... increased secretion of renin by the renal juxtaglomerular cells in response to reflex sympathetic discharge. This increase in renin activity leads to the production of angiotensin II, which then causes stimulation of aldosterone and consequent sodium reabsorption and fluid retention. Sodium retentio ...
QA408_3_Pregabalin_gabapentin_March2015
... titration of dose is required, whereas pregabalin possesses linear pharmacokinetics, which mean dosing regimes are more straightforward5. Pregabalin is recommended as one of the first-line treatment options for neuropathic pain (alongside amitriptyline, duloxetine and gabapentin), by the National In ...
... titration of dose is required, whereas pregabalin possesses linear pharmacokinetics, which mean dosing regimes are more straightforward5. Pregabalin is recommended as one of the first-line treatment options for neuropathic pain (alongside amitriptyline, duloxetine and gabapentin), by the National In ...
Dydrogesterone
Dydrogesterone (INN, USAN, BAN), is also chemically known as 9β,10α-pregna-4,6-diene-3,20-dione. Dydrogesterone (6-dehydro-retroprogesterone) is a hormonally active, non-androgenic steroid that was developed in the 1950s.Dydrogesterone has selective progestational activity and does not inhibit ovulation. The greater rigidity of dydrogesterone also positively affects its selectivity, while natural progesterone is less selective, existing in different conformations that more easily bind to different receptors. As a consequence of its better bioavailability and the progestational activity of its main metabolites (20-, 21- and 16-hydroxy derivatives), the equivalent dose of dydrogesterone is 10–20 times lower than that of oral micronized progesterone.Dydrogesterone is used as an effective, orally active progestogen for gynaecological conditions related to a wide variety of progesterone deficiencies in pregnant women. The molecular structure and pharmacological effects are somewhat similar to endogenous progesterone, although in smaller amounts it is found to be orally active. Its freedom from hormonal effects like those related to corticoid, androgenic, estrogenic, anabolic, and other effects gives dydrogesterone an advantage over other synthesized progestogens.Dydrogesterone when used therapeutically is closely related to its physiological action on the neuro-endocrine control of ovarian function, as well as on the endometrium. This is an indication in all cases of endogeneous progesterone deficiency - relative or absolute. The molecule was licensed for use in several indications, including threatened or recurrent miscarriage, dysfunctional bleeding, infertility due to luteal insufficiency, dysmenorrhea, endometriosis, secondary amenorrhoea, irregular cycles, pre-menstrual syndrome and also as a hormone replacement therapy.Dydrogesterone has proven effective in the following conditions associated with progesterone deficiency: Infertility due to luteal insufficiency Threatened miscarriage Habitual or recurrent miscarriage. Menstrual disorders Premenstrual syndrome Endometriosis Dydrogesterone has also been registered as hormone replacement therapy (HRT) to counter-check the negative effects of unopposed estrogen on the endometrium in women with an intact uterus. Dydrogesterone is relatively safe and well tolerated, and does not exhibit the androgenic side effects that are common with some other progestins, like medroxyprogesterone acetate.