NYMALIZE PRODUCT FACT SHEET
... throughout organogenesis but not at 3 mg/kg/day. In the second study, an increased incidence of stunted fetuses was seen at 1 mg/kg/day but not at higher doses (3 mg/kg/day and 10 mg/kg/day). Nimodipine was embryotoxic, causing resorption and stunted growth of fetuses in rats at 100 mg/kg/day admini ...
... throughout organogenesis but not at 3 mg/kg/day. In the second study, an increased incidence of stunted fetuses was seen at 1 mg/kg/day but not at higher doses (3 mg/kg/day and 10 mg/kg/day). Nimodipine was embryotoxic, causing resorption and stunted growth of fetuses in rats at 100 mg/kg/day admini ...
Subsys Prescribing Information
... Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals (2.1) Individualize dosing based on the severity of pain, patient response, prior analgesic experience, and risk factors for addiction, abuse, and misuse. ...
... Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals (2.1) Individualize dosing based on the severity of pain, patient response, prior analgesic experience, and risk factors for addiction, abuse, and misuse. ...
Optimizing orthodontic treatment in patients taking
... rate than skeletal bones because of the constant masticatory forces.18 After BP is incorporated into the bone, drug elimination occurs slowly and is regulated by the physiologic rate of bone turnover.9,17,19 Since high bone turnover occurs during orthodontic treatment, more BP might be bound and inc ...
... rate than skeletal bones because of the constant masticatory forces.18 After BP is incorporated into the bone, drug elimination occurs slowly and is regulated by the physiologic rate of bone turnover.9,17,19 Since high bone turnover occurs during orthodontic treatment, more BP might be bound and inc ...
DILAUDID - Purdue Pharma
... DOSAGE FORMS, COMPOSITION AND PACKAGING section of the Prescribing Information. ...
... DOSAGE FORMS, COMPOSITION AND PACKAGING section of the Prescribing Information. ...
Rational Selection of Antimicrobials for Use in Horses
... host of the disease ● The identity of the infecting organism is known or at least reasonably suspected a. Cytologic examination and culture of appropriate samples ● The organism(s) is (are) susceptible to the drug(s) selected as determined by a. MIC—quantitative susceptibility test (preferred becaus ...
... host of the disease ● The identity of the infecting organism is known or at least reasonably suspected a. Cytologic examination and culture of appropriate samples ● The organism(s) is (are) susceptible to the drug(s) selected as determined by a. MIC—quantitative susceptibility test (preferred becaus ...
Martindale: The Complete Drug Reference
... Oxandrolone is rapidly absorbed from the gastrointestinal tract, and extensively bound to plasma proteins. It is excreted mainly in the urine as unchanged oxandrolone and some metabolites, with an elimination half-life of about 9 to 10 hours. A small amount is excreted in the faeces. (last reviewed ...
... Oxandrolone is rapidly absorbed from the gastrointestinal tract, and extensively bound to plasma proteins. It is excreted mainly in the urine as unchanged oxandrolone and some metabolites, with an elimination half-life of about 9 to 10 hours. A small amount is excreted in the faeces. (last reviewed ...
Subjects
... The unimodal distribution is in accordance with some studies (13,38), whereas in others a bimodal (10,14) or even a trimodal distribution appears (12). The distribution of CMRs in the Faroes would argue against the occurrence of genetic heterogeneities alone being responsible for the higher CYP1A2 a ...
... The unimodal distribution is in accordance with some studies (13,38), whereas in others a bimodal (10,14) or even a trimodal distribution appears (12). The distribution of CMRs in the Faroes would argue against the occurrence of genetic heterogeneities alone being responsible for the higher CYP1A2 a ...
Opioid Metabolism
... opioid metabolism; however, the processes described occur with many medications. Altered metabolism in a patient or population can result in an opioid or metabolite leaving the body too rapidly, not reaching its therapeutic target, or staying in the body too long and producing toxic effects. Opioid ...
... opioid metabolism; however, the processes described occur with many medications. Altered metabolism in a patient or population can result in an opioid or metabolite leaving the body too rapidly, not reaching its therapeutic target, or staying in the body too long and producing toxic effects. Opioid ...
Diuretics - JUdoctors
... H2O and HCO3- (weak CA inhibitory effect) They are effective orally (OOA 30-60 min ; DOA ≈ 6 hrs) and parenterally (OOA 5 min; DOA ≈ 2 hrs) more rapid effect in IV preparation They are albumin bound, eliminated in urine by filtration and tubular secretion and 1/3 rd of oral dose is excreted in bile ...
... H2O and HCO3- (weak CA inhibitory effect) They are effective orally (OOA 30-60 min ; DOA ≈ 6 hrs) and parenterally (OOA 5 min; DOA ≈ 2 hrs) more rapid effect in IV preparation They are albumin bound, eliminated in urine by filtration and tubular secretion and 1/3 rd of oral dose is excreted in bile ...
Relative potency of proton-pump inhibitors-comparison of
... uals, with higher mean pH values and better efficacy of PPIs in Hp-positive individuals [12–14]. There also might be differences in gastric pH values among patients with GERD since gastric acid production is significantly higher in GERD patients than in non-GERD patients due to differences in noctur ...
... uals, with higher mean pH values and better efficacy of PPIs in Hp-positive individuals [12–14]. There also might be differences in gastric pH values among patients with GERD since gastric acid production is significantly higher in GERD patients than in non-GERD patients due to differences in noctur ...
PRODUCT MONOGRAPH Frisium® (clobazam) Tablets, 10 MG
... Most studies of the potential interactions of clobazam with other antiepileptic agents have failed to demonstrate significant interactions with phenytoin, phenobarbital, or carbamazepine. However, one study noted that the addition of clobazam caused a 25% increase in serum drug levels in 29% of pati ...
... Most studies of the potential interactions of clobazam with other antiepileptic agents have failed to demonstrate significant interactions with phenytoin, phenobarbital, or carbamazepine. However, one study noted that the addition of clobazam caused a 25% increase in serum drug levels in 29% of pati ...
Australian public assessment report for Axitinib
... applications. The subcommittee was not assured that the proposed Product Information (PI) statements regarding effects on QT interval2 had been appropriately checked or reliably derived from the population PK analysis. The PSC noted the high incidence of diarrhoea associated with the administration ...
... applications. The subcommittee was not assured that the proposed Product Information (PI) statements regarding effects on QT interval2 had been appropriately checked or reliably derived from the population PK analysis. The PSC noted the high incidence of diarrhoea associated with the administration ...
Product Monograph
... Because of reports of thrombocytopenia, inhibition of the second phase of platelet aggregation, and abnormal coagulation parameters (e.g., low fibrinogen), platelet counts and coagulation tests are recommended before initiating therapy and at periodic intervals. It is recommended that patients recei ...
... Because of reports of thrombocytopenia, inhibition of the second phase of platelet aggregation, and abnormal coagulation parameters (e.g., low fibrinogen), platelet counts and coagulation tests are recommended before initiating therapy and at periodic intervals. It is recommended that patients recei ...
Safety and Side Effects of Cannabidiol, a Cannabis sativa Constituent
... of treatment and induced fewer side effects, such as extrapyramidal symptoms, increased prolactin levels, and weight gain, compared to amilsupride [83]. The efficacy and safety of CBD on Parkinson’s disease patients with psychotic symptoms were study in a 4-week open trial. A flexible oral dose of C ...
... of treatment and induced fewer side effects, such as extrapyramidal symptoms, increased prolactin levels, and weight gain, compared to amilsupride [83]. The efficacy and safety of CBD on Parkinson’s disease patients with psychotic symptoms were study in a 4-week open trial. A flexible oral dose of C ...
FLUOROPLEX (fluorouracil) 1% Topical Cream DESCRIPTION
... teratogenic in mice, rats and hamsters, and embryolethal in monkeys. Fluorouracil is contraindicated in women who are or may become pregnant. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to ...
... teratogenic in mice, rats and hamsters, and embryolethal in monkeys. Fluorouracil is contraindicated in women who are or may become pregnant. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to ...
CIPROXIN Tablets PI
... pathogen is not likely to be inhibited if the antimicrobial compound in the blood reaches the concentrations usually achievable; other therapy should be selected. Note: The prevalence of resistance may vary geographically for selected species and local information on resistance is desirable, particu ...
... pathogen is not likely to be inhibited if the antimicrobial compound in the blood reaches the concentrations usually achievable; other therapy should be selected. Note: The prevalence of resistance may vary geographically for selected species and local information on resistance is desirable, particu ...
Oxycodone Vitabalans film
... St Johns Wort, a CYP3A4 inducer, administered as 300 mg three times a day for fifteen days, reduced the AUC of oral oxycodone. On average, the AUC was approximately 50% lower (range 37-57%). Rifampicin, a CYP3A4 inducer, administered as 600 mg once-daily for seven days, reduced the AUC of oral ...
... St Johns Wort, a CYP3A4 inducer, administered as 300 mg three times a day for fifteen days, reduced the AUC of oral oxycodone. On average, the AUC was approximately 50% lower (range 37-57%). Rifampicin, a CYP3A4 inducer, administered as 600 mg once-daily for seven days, reduced the AUC of oral ...
Passionflower: A review of research and clinical
... mice model, showing a synergistic anti-depressive effect of P. incarnata with Hypericum.36 Oral administration of extracts of P. incarnata given for 15 days have also shown hypoglycemic and hypolipidemic effects in streptozotocin-induced diabetic mice, suggesting the possibility of additive or syner ...
... mice model, showing a synergistic anti-depressive effect of P. incarnata with Hypericum.36 Oral administration of extracts of P. incarnata given for 15 days have also shown hypoglycemic and hypolipidemic effects in streptozotocin-induced diabetic mice, suggesting the possibility of additive or syner ...
Anticoagulation-Warfarin - National Medical Research Council
... Warfarin (irrespective of INR) is not fully effective in the first several days of therapy because of a delayed decrease in several circulating clotting factors. Loading doses can increase a patient’s risk of supra-therapeutic INR and make it more difficult to determine a steady-state dose. 5.1.2 Th ...
... Warfarin (irrespective of INR) is not fully effective in the first several days of therapy because of a delayed decrease in several circulating clotting factors. Loading doses can increase a patient’s risk of supra-therapeutic INR and make it more difficult to determine a steady-state dose. 5.1.2 Th ...
Extract from the Clinical Evaluation Report for Fentanyl citrate
... The ability to achieve a rapid analgesic effect is important in the management of pain for patients with cancer who, despite continuous background analgesia, often experience recurrent episodes of acute transitory pain otherwise known as breakthrough pain (BTP). Opioid analgesics are standard treatm ...
... The ability to achieve a rapid analgesic effect is important in the management of pain for patients with cancer who, despite continuous background analgesia, often experience recurrent episodes of acute transitory pain otherwise known as breakthrough pain (BTP). Opioid analgesics are standard treatm ...
FLUNIXIN - American Academy of Veterinary Pharmacology and
... (because nonsteroidal anti-inflammatory drugs [NSAIDs] have been associated with inhibition of platelet aggregation, their administration to animals with bleeding problems, including coagulation or platelet function disorders, could increase the risk of adverse effects) Gastrointestinal bleeding or ...
... (because nonsteroidal anti-inflammatory drugs [NSAIDs] have been associated with inhibition of platelet aggregation, their administration to animals with bleeding problems, including coagulation or platelet function disorders, could increase the risk of adverse effects) Gastrointestinal bleeding or ...
Clavulin - GlaxoSmithKline
... colitis and haemorrhagic colitis) have been reported rarely. Mucocutaneous candidiasis has been reported commonly. If gastrointestinal reactions are evident, they may be reduced by taking CLAVULIN® at the start of the meal. A U.S./Canadian clinical trial compared a 10-day CLAVULIN® b.i.d. regimen (4 ...
... colitis and haemorrhagic colitis) have been reported rarely. Mucocutaneous candidiasis has been reported commonly. If gastrointestinal reactions are evident, they may be reduced by taking CLAVULIN® at the start of the meal. A U.S./Canadian clinical trial compared a 10-day CLAVULIN® b.i.d. regimen (4 ...
EMEND (fosaprepitant dimeglumine) for injection
... Infusion-site reactions were reported in 2.2% of patients treated with the EMEND regimen compared to 0.6% of patients treated with standard therapy. The infusion-site reactions included: infusion-site pain (1.2%, 0.4%), injection-site irritation (0.2%, 0.0%), vessel puncture-site pain (0.2%, 0.0%), ...
... Infusion-site reactions were reported in 2.2% of patients treated with the EMEND regimen compared to 0.6% of patients treated with standard therapy. The infusion-site reactions included: infusion-site pain (1.2%, 0.4%), injection-site irritation (0.2%, 0.0%), vessel puncture-site pain (0.2%, 0.0%), ...
TETRACYCLINE AND DOXYCYCLINE APPLICATIONS
... drugs may cause alterations of human protein synthesis. If treatment of a patient with renal insufficiency is necessary, dosing should be increased to every 18-24 hours for doxycycline and every 8-12 hours for tetracycline. Outdated tetracycline also has been associated with ...
... drugs may cause alterations of human protein synthesis. If treatment of a patient with renal insufficiency is necessary, dosing should be increased to every 18-24 hours for doxycycline and every 8-12 hours for tetracycline. Outdated tetracycline also has been associated with ...
Prescribing Information
... Infusion-site reactions were reported in 2.2% of patients treated with the EMEND regimen compared to 0.6% of patients treated with standard therapy. The infusion-site reactions included: infusionsite pain (1.2%, 0.4%), injection-site irritation (0.2%, 0.0%), vessel puncture-site pain (0.2%, 0.0%), a ...
... Infusion-site reactions were reported in 2.2% of patients treated with the EMEND regimen compared to 0.6% of patients treated with standard therapy. The infusion-site reactions included: infusionsite pain (1.2%, 0.4%), injection-site irritation (0.2%, 0.0%), vessel puncture-site pain (0.2%, 0.0%), a ...
Dydrogesterone
Dydrogesterone (INN, USAN, BAN), is also chemically known as 9β,10α-pregna-4,6-diene-3,20-dione. Dydrogesterone (6-dehydro-retroprogesterone) is a hormonally active, non-androgenic steroid that was developed in the 1950s.Dydrogesterone has selective progestational activity and does not inhibit ovulation. The greater rigidity of dydrogesterone also positively affects its selectivity, while natural progesterone is less selective, existing in different conformations that more easily bind to different receptors. As a consequence of its better bioavailability and the progestational activity of its main metabolites (20-, 21- and 16-hydroxy derivatives), the equivalent dose of dydrogesterone is 10–20 times lower than that of oral micronized progesterone.Dydrogesterone is used as an effective, orally active progestogen for gynaecological conditions related to a wide variety of progesterone deficiencies in pregnant women. The molecular structure and pharmacological effects are somewhat similar to endogenous progesterone, although in smaller amounts it is found to be orally active. Its freedom from hormonal effects like those related to corticoid, androgenic, estrogenic, anabolic, and other effects gives dydrogesterone an advantage over other synthesized progestogens.Dydrogesterone when used therapeutically is closely related to its physiological action on the neuro-endocrine control of ovarian function, as well as on the endometrium. This is an indication in all cases of endogeneous progesterone deficiency - relative or absolute. The molecule was licensed for use in several indications, including threatened or recurrent miscarriage, dysfunctional bleeding, infertility due to luteal insufficiency, dysmenorrhea, endometriosis, secondary amenorrhoea, irregular cycles, pre-menstrual syndrome and also as a hormone replacement therapy.Dydrogesterone has proven effective in the following conditions associated with progesterone deficiency: Infertility due to luteal insufficiency Threatened miscarriage Habitual or recurrent miscarriage. Menstrual disorders Premenstrual syndrome Endometriosis Dydrogesterone has also been registered as hormone replacement therapy (HRT) to counter-check the negative effects of unopposed estrogen on the endometrium in women with an intact uterus. Dydrogesterone is relatively safe and well tolerated, and does not exhibit the androgenic side effects that are common with some other progestins, like medroxyprogesterone acetate.