Core Data Sheet
... Budesonide has not been observed to interact with any drug used for the treatment of rhinitis. The metabolism of budesonide is primarily mediated by CYP3A4. Inhibitors of this enzyme, eg, ketoconazole and itraconazole, can therefore increase systemic exposure to budesonide several times. Since there ...
... Budesonide has not been observed to interact with any drug used for the treatment of rhinitis. The metabolism of budesonide is primarily mediated by CYP3A4. Inhibitors of this enzyme, eg, ketoconazole and itraconazole, can therefore increase systemic exposure to budesonide several times. Since there ...
Product Information
... study conducted in rats, caffeine (administered as base) did not increase tumour incidence at oral doses up to 102 mg/kg/day in males and 170 mg/kg/day in females. Systemic exposure in animals at these doses is estimated to be 2-6 times higher than that in neonates at the recommended maintenance dos ...
... study conducted in rats, caffeine (administered as base) did not increase tumour incidence at oral doses up to 102 mg/kg/day in males and 170 mg/kg/day in females. Systemic exposure in animals at these doses is estimated to be 2-6 times higher than that in neonates at the recommended maintenance dos ...
PRODUCT MONOGRAPH Pr LAMISIL® Terbinafine tablets 250 mg
... Women of child-bearing potential: Some cases of menstrual irregularities have been reported in patients taking LAMISIL tablets concomitantly with oral contraceptives, although the incidence of these disorders remains within the background incidence of patients taking oral contraceptives alone. There ...
... Women of child-bearing potential: Some cases of menstrual irregularities have been reported in patients taking LAMISIL tablets concomitantly with oral contraceptives, although the incidence of these disorders remains within the background incidence of patients taking oral contraceptives alone. There ...
20110503_Manuscript - international journal of advances in
... are still high[1]. So there is a need for therapy which may be more effective in this condition. Thrombin plays an important role in the generation of a thrombus. Because thrombin is the last serine protease in the blood coagulation cascade that causes conversion of fibrinogen to fibrin clot. One ap ...
... are still high[1]. So there is a need for therapy which may be more effective in this condition. Thrombin plays an important role in the generation of a thrombus. Because thrombin is the last serine protease in the blood coagulation cascade that causes conversion of fibrinogen to fibrin clot. One ap ...
O A
... first-pass effect after oral administration results in an active metabolite that can contribute to the pharmacological effects. Oral KT has been used sporadically as premedication for anesthesia in children [18,1]. Also In fractious cats, is administered by squirting the drug into the mouth with a s ...
... first-pass effect after oral administration results in an active metabolite that can contribute to the pharmacological effects. Oral KT has been used sporadically as premedication for anesthesia in children [18,1]. Also In fractious cats, is administered by squirting the drug into the mouth with a s ...
Pharmacokinetics and pharmacodynamics of the - e
... pharmacokinetic parameters. Interesting is in one study which reported the data where the serum half-life was increased after multiple doses.50 The reason for this is not known but may be related to saturation of excretory pathways. ...
... pharmacokinetic parameters. Interesting is in one study which reported the data where the serum half-life was increased after multiple doses.50 The reason for this is not known but may be related to saturation of excretory pathways. ...
LIDOCAINE VISCOUS 2%
... gargled and may be swallowed. This dose should not be administered at intervals of less than three hours, and not more than eight doses should be given in a 24-hour period. The dosage should be adjusted commensurate with the patient’s age, weight and physical condition (see PRECAUTIONS). Pediatric C ...
... gargled and may be swallowed. This dose should not be administered at intervals of less than three hours, and not more than eight doses should be given in a 24-hour period. The dosage should be adjusted commensurate with the patient’s age, weight and physical condition (see PRECAUTIONS). Pediatric C ...
Telfast 180mg
... Fexofenadine hydrochloride is rapidly absorbed into the body following oral administration, with Tmax occurring at approximately 1-3 hours post dose. The mean Cmax value was approximately 494 ng/ml following the administration of a 180 mg dose once daily. Fexofenadine is 60-70% plasma protein bound. ...
... Fexofenadine hydrochloride is rapidly absorbed into the body following oral administration, with Tmax occurring at approximately 1-3 hours post dose. The mean Cmax value was approximately 494 ng/ml following the administration of a 180 mg dose once daily. Fexofenadine is 60-70% plasma protein bound. ...
Product Monograph
... systemic exposure to amphetamine (Cmax and AUC) than adults for a given dose of ADDERALL XR, which was attributed to the higher dose administered to children on a mg/kg body weight basis compared to adults. Upon dose normalization on a mg/kg basis, children showed 30% less systemic exposure compared ...
... systemic exposure to amphetamine (Cmax and AUC) than adults for a given dose of ADDERALL XR, which was attributed to the higher dose administered to children on a mg/kg body weight basis compared to adults. Upon dose normalization on a mg/kg basis, children showed 30% less systemic exposure compared ...
Ciproxin Tablets 250mg - electronic Medicines Compendium (eMC
... with limited human data. Treating physicians should refer to national and/or international consensus documents regarding the treatment of anthrax. Children and adolescents The use of ciprofloxacin in children and adolescents should follow available official guidance. Ciprofloxacin treatment should b ...
... with limited human data. Treating physicians should refer to national and/or international consensus documents regarding the treatment of anthrax. Children and adolescents The use of ciprofloxacin in children and adolescents should follow available official guidance. Ciprofloxacin treatment should b ...
product information
... t1/2α, t1/2β and t1/2γ were determined by compartmental analysis (Cycles 1-3 combined). ...
... t1/2α, t1/2β and t1/2γ were determined by compartmental analysis (Cycles 1-3 combined). ...
adderall xr - Shire Canada
... systemic exposure to amphetamine (Cmax and AUC) than adults for a given dose of ADDERALL XR, which was attributed to the higher dose administered to children on a mg/kg body weight basis compared to adults. Upon dose normalization on a mg/kg basis, children showed 30% less systemic exposure compared ...
... systemic exposure to amphetamine (Cmax and AUC) than adults for a given dose of ADDERALL XR, which was attributed to the higher dose administered to children on a mg/kg body weight basis compared to adults. Upon dose normalization on a mg/kg basis, children showed 30% less systemic exposure compared ...
6 Topiramate for the Management of Seizures in Children
... half-life in adults is between 18 and 25 hours.1,13 The pharmacokinetic profile of topiramate has also been evaluated in infants and children. In 1999, Rosenfeld and coworkers published their evaluation of topiramate pharmacokinetics in 18 children.14 Dosing was initiated at 1 mg/kg/day. and titrate ...
... half-life in adults is between 18 and 25 hours.1,13 The pharmacokinetic profile of topiramate has also been evaluated in infants and children. In 1999, Rosenfeld and coworkers published their evaluation of topiramate pharmacokinetics in 18 children.14 Dosing was initiated at 1 mg/kg/day. and titrate ...
PDR - Seroquel Tablets
... within the proposed clinical dose range, and quetiapine accumulation is predictable upon multiple dosing. Elimination of quetiapine is mainly via hepatic metabolism with a mean terminal half-life of about 6 hours within the proposed clinical dose range. Steady-state concentrations are expected to be ...
... within the proposed clinical dose range, and quetiapine accumulation is predictable upon multiple dosing. Elimination of quetiapine is mainly via hepatic metabolism with a mean terminal half-life of about 6 hours within the proposed clinical dose range. Steady-state concentrations are expected to be ...
Paresthesia (including formication) (postmarketing AE), reformating
... systemic exposure to amphetamine (Cmax and AUC) than adults for a given dose of ADDERALL XR, which was attributed to the higher dose administered to children on a mg/kg body weight basis compared to adults. Upon dose normalization on a mg/kg basis, children showed 30% less systemic exposure compared ...
... systemic exposure to amphetamine (Cmax and AUC) than adults for a given dose of ADDERALL XR, which was attributed to the higher dose administered to children on a mg/kg body weight basis compared to adults. Upon dose normalization on a mg/kg basis, children showed 30% less systemic exposure compared ...
Nasacort (triamcinolone acetonide)
... NASACORT Allergy 24HR / NASACORT AQ in nursing mothers requires that the possible benefits of the drug be weighed against the potential hazards to the infant. Pediatrics NASACORT Allergy 24HR / NASACORT AQ is not presently recommended for children younger than 4 years of age due to limited clinical ...
... NASACORT Allergy 24HR / NASACORT AQ in nursing mothers requires that the possible benefits of the drug be weighed against the potential hazards to the infant. Pediatrics NASACORT Allergy 24HR / NASACORT AQ is not presently recommended for children younger than 4 years of age due to limited clinical ...
Aust Dent J 2014. Protocol in Managing Oral Surgical Patients
... creatinine clearance of <50 ml/min, and the drug is contraindicated in patients with creatinine clearance of <30 ml/min.14 Dabigatran is not metabolized by cytochrome p450, and it displays low protein binding (approximately 35%), and so the risk of drug interaction is low.15 The major advantages of ...
... creatinine clearance of <50 ml/min, and the drug is contraindicated in patients with creatinine clearance of <30 ml/min.14 Dabigatran is not metabolized by cytochrome p450, and it displays low protein binding (approximately 35%), and so the risk of drug interaction is low.15 The major advantages of ...
Scabies
... communities or mass population displacements and in the management of epidemics in closed communities such as nursing homes or jails. -All persons in the communities should be treated irrespective of whether they are symptomatic or not. -Oral ivermectin is easier to administer than traditional topic ...
... communities or mass population displacements and in the management of epidemics in closed communities such as nursing homes or jails. -All persons in the communities should be treated irrespective of whether they are symptomatic or not. -Oral ivermectin is easier to administer than traditional topic ...
GABAPENTIN: A PHARMACOTHERAPEUTIC PANACEA Review Article MUDDASIR BANDAY
... bioavailability varies inversely with dose. After a single dose of 300 or 600mg bioavailability was found to be approximately 60% and 40% respectively [7,8] and this decreases to further 35% at a steady state with doses of 1600mg thrice daily. After ingestion of single dose of 300mg, peak plasma con ...
... bioavailability varies inversely with dose. After a single dose of 300 or 600mg bioavailability was found to be approximately 60% and 40% respectively [7,8] and this decreases to further 35% at a steady state with doses of 1600mg thrice daily. After ingestion of single dose of 300mg, peak plasma con ...
DATA SHEET Tramal Capsules Solution for Injection
... was observed in a mouse carcinogenicity study, particularly in aged mice dosed orally up to 30 mg/kg for approximately two years. Although the study was not conducted using the Maximum Tolerated Dose, or at exposure levels expected in clinical use, this finding is not believed to suggest risk in hum ...
... was observed in a mouse carcinogenicity study, particularly in aged mice dosed orally up to 30 mg/kg for approximately two years. Although the study was not conducted using the Maximum Tolerated Dose, or at exposure levels expected in clinical use, this finding is not believed to suggest risk in hum ...
ASMANEX™ TWISTHALER™ PRODUCT MONOGRAPH
... respiratory function (see DOSAGE AND ADMINISTRATION). For transfer of patients being treated with oral corticosteroids, ASMANEX® Twisthaler® should first be added to the existing oral steroid therapy, which is then gradually withdrawn. Particular care is needed for patients who are transferred from ...
... respiratory function (see DOSAGE AND ADMINISTRATION). For transfer of patients being treated with oral corticosteroids, ASMANEX® Twisthaler® should first be added to the existing oral steroid therapy, which is then gradually withdrawn. Particular care is needed for patients who are transferred from ...
EryTab PI 03-A919-R2 Rev. July 2013 Final2
... this occurs, patients should contact their physician as soon as possible. Drug Interactions Theophylline Erythromycin use in patients who are receiving high doses of theophylline may be associated with an increase in serum theophylline levels and potential theophylline toxicity. In case of theophyll ...
... this occurs, patients should contact their physician as soon as possible. Drug Interactions Theophylline Erythromycin use in patients who are receiving high doses of theophylline may be associated with an increase in serum theophylline levels and potential theophylline toxicity. In case of theophyll ...
PACLitaxel - Cancer Care Ontario
... National Cancer Institute by the U.S. Forest Service. An extract, paclitaxel, was randomly chosen for testing for cytotoxic activity as part of a large-scale screening program and demonstrated activity against murine tumour lines. Paclitaxel's structure was determined in 1971 and its mechanism of ac ...
... National Cancer Institute by the U.S. Forest Service. An extract, paclitaxel, was randomly chosen for testing for cytotoxic activity as part of a large-scale screening program and demonstrated activity against murine tumour lines. Paclitaxel's structure was determined in 1971 and its mechanism of ac ...
(500 mg metronidazole and 100,000 IU nystatin) Vaginal Ovules Vaginal Cream
... Metronidazole is bactericidal against anaerobic bacteria; it exerts trichomonacidal activity and is also active against Giardia lamblia and Entamoeba histolytica. Its exact mechanism of action has not been entirely determined as yet. It has been proposed that an intermediate in the reduction of metr ...
... Metronidazole is bactericidal against anaerobic bacteria; it exerts trichomonacidal activity and is also active against Giardia lamblia and Entamoeba histolytica. Its exact mechanism of action has not been entirely determined as yet. It has been proposed that an intermediate in the reduction of metr ...
Levonorgestrel - Therapeutic Goods Administration
... new product incorporates a silver ring/profile (to facilitate detection in ultrasound examination) and the inserter device uses a new coloured flange (pink). The biocompatibility of the silver ring/profile was assessed in vitro in assays for cytotoxicity, haemolysis and genotoxicity and in vivo in s ...
... new product incorporates a silver ring/profile (to facilitate detection in ultrasound examination) and the inserter device uses a new coloured flange (pink). The biocompatibility of the silver ring/profile was assessed in vitro in assays for cytotoxicity, haemolysis and genotoxicity and in vivo in s ...
Dydrogesterone
Dydrogesterone (INN, USAN, BAN), is also chemically known as 9β,10α-pregna-4,6-diene-3,20-dione. Dydrogesterone (6-dehydro-retroprogesterone) is a hormonally active, non-androgenic steroid that was developed in the 1950s.Dydrogesterone has selective progestational activity and does not inhibit ovulation. The greater rigidity of dydrogesterone also positively affects its selectivity, while natural progesterone is less selective, existing in different conformations that more easily bind to different receptors. As a consequence of its better bioavailability and the progestational activity of its main metabolites (20-, 21- and 16-hydroxy derivatives), the equivalent dose of dydrogesterone is 10–20 times lower than that of oral micronized progesterone.Dydrogesterone is used as an effective, orally active progestogen for gynaecological conditions related to a wide variety of progesterone deficiencies in pregnant women. The molecular structure and pharmacological effects are somewhat similar to endogenous progesterone, although in smaller amounts it is found to be orally active. Its freedom from hormonal effects like those related to corticoid, androgenic, estrogenic, anabolic, and other effects gives dydrogesterone an advantage over other synthesized progestogens.Dydrogesterone when used therapeutically is closely related to its physiological action on the neuro-endocrine control of ovarian function, as well as on the endometrium. This is an indication in all cases of endogeneous progesterone deficiency - relative or absolute. The molecule was licensed for use in several indications, including threatened or recurrent miscarriage, dysfunctional bleeding, infertility due to luteal insufficiency, dysmenorrhea, endometriosis, secondary amenorrhoea, irregular cycles, pre-menstrual syndrome and also as a hormone replacement therapy.Dydrogesterone has proven effective in the following conditions associated with progesterone deficiency: Infertility due to luteal insufficiency Threatened miscarriage Habitual or recurrent miscarriage. Menstrual disorders Premenstrual syndrome Endometriosis Dydrogesterone has also been registered as hormone replacement therapy (HRT) to counter-check the negative effects of unopposed estrogen on the endometrium in women with an intact uterus. Dydrogesterone is relatively safe and well tolerated, and does not exhibit the androgenic side effects that are common with some other progestins, like medroxyprogesterone acetate.