GP/Locum Drug List – 5 May 2013
... Immune modulator, can be used as adjunct for viral illnesses, apthous stomatitis, HPV infection, SSPE, alopecia, HIV and immunodeficiency Course of 10 tabs Treatment of herpes simplex virus infection, either oral or genital. Min 1 week course, kiv 2+ weeks Ideally initiated within 24hrs of rash, but ...
... Immune modulator, can be used as adjunct for viral illnesses, apthous stomatitis, HPV infection, SSPE, alopecia, HIV and immunodeficiency Course of 10 tabs Treatment of herpes simplex virus infection, either oral or genital. Min 1 week course, kiv 2+ weeks Ideally initiated within 24hrs of rash, but ...
Product Monograph
... treatment with a MAOI, (including linezolid, an antibiotic which is a reversible non-selective MAO inhibitor and methylene blue, which is a MAOI). Similarly, at least 14 days should elapse after discontinuing citalopram treatment before starting a MAOI. PIMOZIDE Citalopram should not be used in comb ...
... treatment with a MAOI, (including linezolid, an antibiotic which is a reversible non-selective MAO inhibitor and methylene blue, which is a MAOI). Similarly, at least 14 days should elapse after discontinuing citalopram treatment before starting a MAOI. PIMOZIDE Citalopram should not be used in comb ...
Atrovent® HFA - Boehringer Ingelheim
... Oral reproduction studies were performed in mice, rats and rabbits at doses approximately 200, 40,000, and 10,000 times, respectively, the maximum recommended human daily inhalation dose (MRHDID) in adults (on a mg/m2 basis at maternal doses in each species of 10, 1,000, and 125 mg/kg/day, respectiv ...
... Oral reproduction studies were performed in mice, rats and rabbits at doses approximately 200, 40,000, and 10,000 times, respectively, the maximum recommended human daily inhalation dose (MRHDID) in adults (on a mg/m2 basis at maternal doses in each species of 10, 1,000, and 125 mg/kg/day, respectiv ...
PRODUCT MONOGRAPH Pr INDERAL®-LA (Propranolol
... There may be increased difficulty in treating an allergic type reaction in patients on betablockers. In these patients, the reaction may be more severe due to the pharmacological effects of beta-blockers and problems with fluid changes. Epinephrine should be administered with caution, since it may ...
... There may be increased difficulty in treating an allergic type reaction in patients on betablockers. In these patients, the reaction may be more severe due to the pharmacological effects of beta-blockers and problems with fluid changes. Epinephrine should be administered with caution, since it may ...
Public Assessment Report Decentralised Procedure Trazodone hydrochloride 50 mg/5 ml Oral
... Stopping Trazodone Oral Solution suddenly can lead to withdrawal symptoms such as feeling sick, headaches and feeling generally unwell. How does Trazodone hydrochloride 50 mg/5 ml Oral Solution work? Trazodone hydrochloride is a triazolopyridine derivative which differs chemically from other current ...
... Stopping Trazodone Oral Solution suddenly can lead to withdrawal symptoms such as feeling sick, headaches and feeling generally unwell. How does Trazodone hydrochloride 50 mg/5 ml Oral Solution work? Trazodone hydrochloride is a triazolopyridine derivative which differs chemically from other current ...
Use of Codeine in Children
... dose-related opioid adverse effects1 o It is difficult to predict who is an ultra-rapid codeine metabolizer. Genetic tests are available on the market but are not widely accessible outside of the research setting. o Individuals carrying the ultra-rapid metabolizer genotype are found in about 3% of t ...
... dose-related opioid adverse effects1 o It is difficult to predict who is an ultra-rapid codeine metabolizer. Genetic tests are available on the market but are not widely accessible outside of the research setting. o Individuals carrying the ultra-rapid metabolizer genotype are found in about 3% of t ...
Product Information: Lisdexamfetamine dimesilate
... approximately 3.5 hours following single-dose oral administration of lisdexamfetamine dimesilate either 30 mg, 50 mg, or 70 mg after an 8-hour overnight fast. The Tmax of lisdexamfetamine dimesilate was approximately 1 hour. Linear pharmacokinetics of dexamphetamine after singledose oral administrat ...
... approximately 3.5 hours following single-dose oral administration of lisdexamfetamine dimesilate either 30 mg, 50 mg, or 70 mg after an 8-hour overnight fast. The Tmax of lisdexamfetamine dimesilate was approximately 1 hour. Linear pharmacokinetics of dexamphetamine after singledose oral administrat ...
Product Monograph Template - Standard
... treatment with a MAOI, (including linezolid, an antibiotic which is a reversible non-selective MAO inhibitor and methylene blue, which is a MAOI). Similarly, at least 14 days should elapse after discontinuing citalopram treatment before starting a MAOI. PIMOZIDE Citalopram should not be used in comb ...
... treatment with a MAOI, (including linezolid, an antibiotic which is a reversible non-selective MAO inhibitor and methylene blue, which is a MAOI). Similarly, at least 14 days should elapse after discontinuing citalopram treatment before starting a MAOI. PIMOZIDE Citalopram should not be used in comb ...
prescribing information xylocaine® ointment 5%
... doses commensurate with their age, weight and physical condition because they may be more sensitive to systemic effects due to increased blood levels of lidocaine following repeated doses. Pregnant Women: There are no adequate and well-controlled studies in pregnant women on the effect of lidocaine ...
... doses commensurate with their age, weight and physical condition because they may be more sensitive to systemic effects due to increased blood levels of lidocaine following repeated doses. Pregnant Women: There are no adequate and well-controlled studies in pregnant women on the effect of lidocaine ...
CELEXA PM MKT Control 149419 10Jan2012 En
... treatment with a MAOI, (including linezolid, an antibiotic which is a reversible non-selective MAO inhibitor and methylene blue, which is a MAOI). Similarly, at least 14 days should elapse after discontinuing citalopram treatment before starting a MAOI. PIMOZIDE Citalopram should not be used in comb ...
... treatment with a MAOI, (including linezolid, an antibiotic which is a reversible non-selective MAO inhibitor and methylene blue, which is a MAOI). Similarly, at least 14 days should elapse after discontinuing citalopram treatment before starting a MAOI. PIMOZIDE Citalopram should not be used in comb ...
Physician`s Labeling Rule_Content
... A variety of abnormal thinking and behavior changes have been reported to occur in association with the use of sedative/hypnotics. Some of these changes may be characterized by decreased inhibition (e.g., aggressiveness and extroversion that seem out of character), similar to effects produced by alc ...
... A variety of abnormal thinking and behavior changes have been reported to occur in association with the use of sedative/hypnotics. Some of these changes may be characterized by decreased inhibition (e.g., aggressiveness and extroversion that seem out of character), similar to effects produced by alc ...
Methadone—metabolism, pharmacokinetics and interactions
... usually not associated with clinically evident withdrawal symptoms [25]. During maintenance treatment, the plasma half-life of the -phase of elimination varies little in the same patient, even if the dose of methadone is increased or decreased, from 22 to 25 h, even though maintaining significant d ...
... usually not associated with clinically evident withdrawal symptoms [25]. During maintenance treatment, the plasma half-life of the -phase of elimination varies little in the same patient, even if the dose of methadone is increased or decreased, from 22 to 25 h, even though maintaining significant d ...
HYPOTHESES 59
... contained 8.33 mg DMT, 14.13 mg harmine, 0.96 mg harmaline, and 11.36 mg THH. Thus, the alkaloid concentrations in the original tea were as follows: DMT 0.53 mg/ml, harmine 0.90 mg/ml, harmaline 0.06 mg/ml, and THH 0.72 mg/ml. The DMT concentration found in the tea was similar to that reported previ ...
... contained 8.33 mg DMT, 14.13 mg harmine, 0.96 mg harmaline, and 11.36 mg THH. Thus, the alkaloid concentrations in the original tea were as follows: DMT 0.53 mg/ml, harmine 0.90 mg/ml, harmaline 0.06 mg/ml, and THH 0.72 mg/ml. The DMT concentration found in the tea was similar to that reported previ ...
Simvastatin
... drug blocked cholesterol synthesis after a single oral dose with ID50 values of less than 0.2 mg.kg-1. Studies have been carried out in the dog to assess the effects of Simvastatin on serum total lipoprotein cholesterol. The drug effectively lowers circulating cholesterol in this species, both in th ...
... drug blocked cholesterol synthesis after a single oral dose with ID50 values of less than 0.2 mg.kg-1. Studies have been carried out in the dog to assess the effects of Simvastatin on serum total lipoprotein cholesterol. The drug effectively lowers circulating cholesterol in this species, both in th ...
Anticancer Potential of Turmeric
... Turmeric given to 16 chronic smokers in doses of 1.5 g/d for 30 days reduced the urinary excretion of mutagens in a controlled trial. (16) There was no change in mutagen excretion in the urine of controls. Although suggestive, measuring surrogate outcomes, such as urinary mutagens, does not necessar ...
... Turmeric given to 16 chronic smokers in doses of 1.5 g/d for 30 days reduced the urinary excretion of mutagens in a controlled trial. (16) There was no change in mutagen excretion in the urine of controls. Although suggestive, measuring surrogate outcomes, such as urinary mutagens, does not necessar ...
Product Monograph Template - Standard
... Inhibition of CYP2D6 can lead to reduced plasma concentrations of a primary active metabolite (endoxifen). Chronic use of CYP2D6 inhibitors, including certain SSRIs, together with tamoxifen can lead to persistent reduction in levels of endoxifen (see also DRUG INTERACTIONS, Tamoxifen). Some studies ...
... Inhibition of CYP2D6 can lead to reduced plasma concentrations of a primary active metabolite (endoxifen). Chronic use of CYP2D6 inhibitors, including certain SSRIs, together with tamoxifen can lead to persistent reduction in levels of endoxifen (see also DRUG INTERACTIONS, Tamoxifen). Some studies ...
PrVIBRAMYCIN* CAPSULES
... toxic megacolon, or perforation of colon subsequent to the administration of any antibacterial agent. CDAD has been reported to occur over 2 months after the administration of antibacterial agents. Treatment with antibacterial agents may alter the normal flora of the colon and may permit overgrowth ...
... toxic megacolon, or perforation of colon subsequent to the administration of any antibacterial agent. CDAD has been reported to occur over 2 months after the administration of antibacterial agents. Treatment with antibacterial agents may alter the normal flora of the colon and may permit overgrowth ...
Artemisia annua (Asteraceae) Description of the plant Plant parts
... consisted in reduced activity with convulsions in single dogs before death. Minimal effects occurred at 20 mg/kg in 5 from 8 dogs. Neuronal damages occurred in all animals at 40 and 80 mg/kg following intramuscular treatment. No comparable lesions were observed after oral administration. Both i.m. a ...
... consisted in reduced activity with convulsions in single dogs before death. Minimal effects occurred at 20 mg/kg in 5 from 8 dogs. Neuronal damages occurred in all animals at 40 and 80 mg/kg following intramuscular treatment. No comparable lesions were observed after oral administration. Both i.m. a ...
PAXIL PRODUCT MONOGRAPH
... Inhibition of CYP2D6 can lead to reduced plasma concentrations of a primary active metabolite (endoxifen). Chronic use of CYP2D6 inhibitors, including certain SSRIs, together with tamoxifen can lead to persistent reduction in levels of endoxifen (see also DRUG INTERACTIONS, Tamoxifen). Some studies ...
... Inhibition of CYP2D6 can lead to reduced plasma concentrations of a primary active metabolite (endoxifen). Chronic use of CYP2D6 inhibitors, including certain SSRIs, together with tamoxifen can lead to persistent reduction in levels of endoxifen (see also DRUG INTERACTIONS, Tamoxifen). Some studies ...
APO–KETOCONAZOLE
... levels of astemizole and its active metabolite desmethylastemizole which may prolong QT intervals. Concomitant administration of oral ketoconazole and cisapride is contraindicated because it has resulted in markedly elevated cisapride plasma concentrations and prolonged QT intervals. This interactio ...
... levels of astemizole and its active metabolite desmethylastemizole which may prolong QT intervals. Concomitant administration of oral ketoconazole and cisapride is contraindicated because it has resulted in markedly elevated cisapride plasma concentrations and prolonged QT intervals. This interactio ...
Paxil - GlaxoSmithKline
... Inhibition of CYP2D6 can lead to reduced plasma concentrations of a primary active metabolite (endoxifen). Chronic use of CYP2D6 inhibitors, including certain SSRIs, together with tamoxifen can lead to persistent reduction in levels of endoxifen (see also DRUG INTERACTIONS, Tamoxifen). Some studies ...
... Inhibition of CYP2D6 can lead to reduced plasma concentrations of a primary active metabolite (endoxifen). Chronic use of CYP2D6 inhibitors, including certain SSRIs, together with tamoxifen can lead to persistent reduction in levels of endoxifen (see also DRUG INTERACTIONS, Tamoxifen). Some studies ...
Serevent - GlaxoSmithKline
... response should be monitored clinically and by lung function tests. Sudden or progressive deterioration in asthma control is potentially life-threatening; treatment plan must be re-evaluated, and consideration be given to increasing corticosteroid therapy. In patients at risk, daily peak flow monito ...
... response should be monitored clinically and by lung function tests. Sudden or progressive deterioration in asthma control is potentially life-threatening; treatment plan must be re-evaluated, and consideration be given to increasing corticosteroid therapy. In patients at risk, daily peak flow monito ...
Comparing Inhaled Corticosteroids
... related to a decrease in airway inflammation.13 The longterm use of inhaled corticosteroids has been shown to reduce both airway inflammation and secondary airway remodeling.14 The fundamentally important role of inhaled corticosteroids in treating asthma has been demonstrated by several studies, wh ...
... related to a decrease in airway inflammation.13 The longterm use of inhaled corticosteroids has been shown to reduce both airway inflammation and secondary airway remodeling.14 The fundamentally important role of inhaled corticosteroids in treating asthma has been demonstrated by several studies, wh ...
Quinolones: a class of antimicrobial agents G. S Review Article
... The 6-fluoroquinolones (also known as 4-quinolones or quinolones; Figure 1) are a series of synthetic antibacterial agents derived from, or related to, nalidixic acid and oxolinic acid. Position 1 is nitrogen in the bicyclical aromatic ring structure, with an alkyl group (ethyl or perhaps cyclopropy ...
... The 6-fluoroquinolones (also known as 4-quinolones or quinolones; Figure 1) are a series of synthetic antibacterial agents derived from, or related to, nalidixic acid and oxolinic acid. Position 1 is nitrogen in the bicyclical aromatic ring structure, with an alkyl group (ethyl or perhaps cyclopropy ...
FDA Approved Labeling 12.19.08 3pm NovaDel Pharma Inc.
... Use in patients with concomitant illness: Clinical experience with zolpidem tartrate in patients with concomitant systemic illness is limited. Caution is advisable in using Zolpimist in patients with diseases or conditions that could affect metabolism or hemodynamic responses. Although studies did n ...
... Use in patients with concomitant illness: Clinical experience with zolpidem tartrate in patients with concomitant systemic illness is limited. Caution is advisable in using Zolpimist in patients with diseases or conditions that could affect metabolism or hemodynamic responses. Although studies did n ...
Dydrogesterone
Dydrogesterone (INN, USAN, BAN), is also chemically known as 9β,10α-pregna-4,6-diene-3,20-dione. Dydrogesterone (6-dehydro-retroprogesterone) is a hormonally active, non-androgenic steroid that was developed in the 1950s.Dydrogesterone has selective progestational activity and does not inhibit ovulation. The greater rigidity of dydrogesterone also positively affects its selectivity, while natural progesterone is less selective, existing in different conformations that more easily bind to different receptors. As a consequence of its better bioavailability and the progestational activity of its main metabolites (20-, 21- and 16-hydroxy derivatives), the equivalent dose of dydrogesterone is 10–20 times lower than that of oral micronized progesterone.Dydrogesterone is used as an effective, orally active progestogen for gynaecological conditions related to a wide variety of progesterone deficiencies in pregnant women. The molecular structure and pharmacological effects are somewhat similar to endogenous progesterone, although in smaller amounts it is found to be orally active. Its freedom from hormonal effects like those related to corticoid, androgenic, estrogenic, anabolic, and other effects gives dydrogesterone an advantage over other synthesized progestogens.Dydrogesterone when used therapeutically is closely related to its physiological action on the neuro-endocrine control of ovarian function, as well as on the endometrium. This is an indication in all cases of endogeneous progesterone deficiency - relative or absolute. The molecule was licensed for use in several indications, including threatened or recurrent miscarriage, dysfunctional bleeding, infertility due to luteal insufficiency, dysmenorrhea, endometriosis, secondary amenorrhoea, irregular cycles, pre-menstrual syndrome and also as a hormone replacement therapy.Dydrogesterone has proven effective in the following conditions associated with progesterone deficiency: Infertility due to luteal insufficiency Threatened miscarriage Habitual or recurrent miscarriage. Menstrual disorders Premenstrual syndrome Endometriosis Dydrogesterone has also been registered as hormone replacement therapy (HRT) to counter-check the negative effects of unopposed estrogen on the endometrium in women with an intact uterus. Dydrogesterone is relatively safe and well tolerated, and does not exhibit the androgenic side effects that are common with some other progestins, like medroxyprogesterone acetate.