LSEHWP40
... (through PubMed resource) and Scopus from January 2000 to June 2013. The studies were selected and included based on the PICOS approach. Studies were included if they contained primary data on the influence of RA medications on the disease activity of pregnant women with RA, as well as any foetal co ...
... (through PubMed resource) and Scopus from January 2000 to June 2013. The studies were selected and included based on the PICOS approach. Studies were included if they contained primary data on the influence of RA medications on the disease activity of pregnant women with RA, as well as any foetal co ...
Commentary: Reproductive Risks of Leflunomide (ArravaR
... in vivo. Leflunomide has demonstrated prophylactic and therapeutic effects in animal models of autoimmune disease. In preclinical models of chronic graft versus host disease (GvHD) and solid organ graft rejection, it has prolonged the time to rejection and/or reversed ongoing rejection. In addition ...
... in vivo. Leflunomide has demonstrated prophylactic and therapeutic effects in animal models of autoimmune disease. In preclinical models of chronic graft versus host disease (GvHD) and solid organ graft rejection, it has prolonged the time to rejection and/or reversed ongoing rejection. In addition ...
Trental (pentoxifylline)
... Antihypertensive agents: Trental (pentoxifylline) may potentiate the action of antihypertensive agents. Patients receiving these agents require blood pressure monitoring and possibly a dose reduction of the antihypertensive agents. Anticoagulants: There have been reports of bleeding and/or prolonged ...
... Antihypertensive agents: Trental (pentoxifylline) may potentiate the action of antihypertensive agents. Patients receiving these agents require blood pressure monitoring and possibly a dose reduction of the antihypertensive agents. Anticoagulants: There have been reports of bleeding and/or prolonged ...
T Th he eo
... of selectivity of theophylline for any of the PDE isoenzyme families, although it remains a possibility that unique PDE isoenzymes may be discovered that are more sensitive to theophylline. It is also possible that certain PDE isoenzymes are induced in asthmatic airways, and this may increase the se ...
... of selectivity of theophylline for any of the PDE isoenzyme families, although it remains a possibility that unique PDE isoenzymes may be discovered that are more sensitive to theophylline. It is also possible that certain PDE isoenzymes are induced in asthmatic airways, and this may increase the se ...
consumer medicine information
... No evidence of teratogenicity or embryotoxicity was observed when erythromycin base was given by oral gavage to pregnant rats and mice at 700 mg/kg/day (approximately 9 times the maximum human dose), and to pregnant rabbits at 125 mg/kg/day (approximately 1.5 times the maximum human dose). A slight ...
... No evidence of teratogenicity or embryotoxicity was observed when erythromycin base was given by oral gavage to pregnant rats and mice at 700 mg/kg/day (approximately 9 times the maximum human dose), and to pregnant rabbits at 125 mg/kg/day (approximately 1.5 times the maximum human dose). A slight ...
Chemotherapy-Induced Nausea and Vomiting
... class, these agents have few adverse effects of their own and no limiting toxicity at typical doses. The most common adverse events include mild headache, transient elevation of hepatic aminotransferase levels, and constipation. Single-dose daily schedules are similar in efficacy to multipledose dai ...
... class, these agents have few adverse effects of their own and no limiting toxicity at typical doses. The most common adverse events include mild headache, transient elevation of hepatic aminotransferase levels, and constipation. Single-dose daily schedules are similar in efficacy to multipledose dai ...
Effects of Nonsteroidal Antiinflammatory Drugs on Platelet Function
... By virtue of its ability to inhibit platelet aggregation, aspirin prolongs the bleeding time in many normal individuals, and the effect is dose-dependent. Although it is not a consistent finding, a paradoxically greater bleeding time prolongation has occurred with lower doses. 61 -63 This may be bec ...
... By virtue of its ability to inhibit platelet aggregation, aspirin prolongs the bleeding time in many normal individuals, and the effect is dose-dependent. Although it is not a consistent finding, a paradoxically greater bleeding time prolongation has occurred with lower doses. 61 -63 This may be bec ...
1. NAME OF THE MEDICINAL PRODUCT Ciprinol 250 mg film
... Ciprofloxacin must not be used in patients concomitantly receiving tizanidine (see 4.5). 4.4 Special warning and precautions for the use Use in patients with epilepsy and other central nervous system (CNS) disorders: In patients with epilepsy or other lesions of the central nervous system (e.g. redu ...
... Ciprofloxacin must not be used in patients concomitantly receiving tizanidine (see 4.5). 4.4 Special warning and precautions for the use Use in patients with epilepsy and other central nervous system (CNS) disorders: In patients with epilepsy or other lesions of the central nervous system (e.g. redu ...
Document
... class, these agents have few adverse effects of their own and no limiting toxicity at typical doses. The most common adverse events include mild headache, transient elevation of hepatic aminotransferase levels, and constipation. Single-dose daily schedules are similar in efficacy to multipledose dai ...
... class, these agents have few adverse effects of their own and no limiting toxicity at typical doses. The most common adverse events include mild headache, transient elevation of hepatic aminotransferase levels, and constipation. Single-dose daily schedules are similar in efficacy to multipledose dai ...
Flagystatin (metronidazole, nystatin)
... Metronidazole is bactericidal against anaerobic bacteria; it exerts trichomonacidal activity and is also active against Giardia lamblia and Entamoeba histolytica. Its exact mechanism of action has not been entirely determined as yet. It has been proposed that an intermediate in the reduction of metr ...
... Metronidazole is bactericidal against anaerobic bacteria; it exerts trichomonacidal activity and is also active against Giardia lamblia and Entamoeba histolytica. Its exact mechanism of action has not been entirely determined as yet. It has been proposed that an intermediate in the reduction of metr ...
Determining the subjective and physiological effects
... harm (FDA 2008). Although controversial, TFMPP was later removed from the schedule due to a lack of evidence demonstrating the potential for harm. In contrast, both BZP and TFMPP are still legally available in the UK. However, the World Health Organisation has recently called for submissions regardi ...
... harm (FDA 2008). Although controversial, TFMPP was later removed from the schedule due to a lack of evidence demonstrating the potential for harm. In contrast, both BZP and TFMPP are still legally available in the UK. However, the World Health Organisation has recently called for submissions regardi ...
![phenytoin [see Drug Interactions (7)].](http://s1.studyres.com/store/data/000752461_1-e2f2c2eeaa79c174a4cc28c1e1447438-300x300.png)
phenytoin [see Drug Interactions (7)].
... KALETRA tablets and oral solution should not be administered once-daily in pediatric patients < 18 years of age. The recommended dosage of KALETRA in patients 6 months to 12 years of age should be calculated based on body weight (kg) and should not exceed the recommended adult dose. Healthcare profe ...
... KALETRA tablets and oral solution should not be administered once-daily in pediatric patients < 18 years of age. The recommended dosage of KALETRA in patients 6 months to 12 years of age should be calculated based on body weight (kg) and should not exceed the recommended adult dose. Healthcare profe ...
fosrenol - Shire Canada
... studied. Patients requiring chelation treatment who are taking FOSRENOL should be monitored closely. Long-term Effects There were no differences in the rates of fracture in patients treated with FOSRENOL compared to Standard Therapy∗ for up to 3 years. The duration of treatment exposure and time of ...
... studied. Patients requiring chelation treatment who are taking FOSRENOL should be monitored closely. Long-term Effects There were no differences in the rates of fracture in patients treated with FOSRENOL compared to Standard Therapy∗ for up to 3 years. The duration of treatment exposure and time of ...
Product Monograph
... studied. Patients requiring chelation treatment who are taking FOSRENOL should be monitored closely. Long-term Effects There were no differences in the rates of fracture in patients treated with FOSRENOL compared to Standard Therapy∗ for up to 3 years. The duration of treatment exposure and time of ...
... studied. Patients requiring chelation treatment who are taking FOSRENOL should be monitored closely. Long-term Effects There were no differences in the rates of fracture in patients treated with FOSRENOL compared to Standard Therapy∗ for up to 3 years. The duration of treatment exposure and time of ...
Terbutaline Sulfate Tablets
... after administration of terbutaline sulfate to pregnant women. In the mother, these adverse reactions include increased heart rate, transient hyperglycemia, hypokalemia, cardiac arrhythmias, pulmonary edema and myocardial ischemia. Increased fetal heart rate and neonatal hypoglycemia may occur as a ...
... after administration of terbutaline sulfate to pregnant women. In the mother, these adverse reactions include increased heart rate, transient hyperglycemia, hypokalemia, cardiac arrhythmias, pulmonary edema and myocardial ischemia. Increased fetal heart rate and neonatal hypoglycemia may occur as a ...
Panadol® Osteo - GSK Australia
... therapeutically equivalent to standard immediate release paracetamol (2 tablets) based on patient global assessment 4 hours after treatment. There was no significant difference between PANADOL Osteo and standard immediate release paracetamol in either development of analgesia or peak analgesic effec ...
... therapeutically equivalent to standard immediate release paracetamol (2 tablets) based on patient global assessment 4 hours after treatment. There was no significant difference between PANADOL Osteo and standard immediate release paracetamol in either development of analgesia or peak analgesic effec ...
Atarax™
... is reached approximately two hours after oral intake. After single oral doses of 25 mg and 50 mg in adults, Cmax concentrations are typically 30 and 70 ng/ml, respectively. The rate and extent of exposure to hydroxyzine is very similar when given as tablet or as a syrup. Following repeat administrat ...
... is reached approximately two hours after oral intake. After single oral doses of 25 mg and 50 mg in adults, Cmax concentrations are typically 30 and 70 ng/ml, respectively. The rate and extent of exposure to hydroxyzine is very similar when given as tablet or as a syrup. Following repeat administrat ...
71: Cyclic Antidepressants
... prolongation) rather than altered repolarization.90 Although QT prolongation predisposes to the development of torsade de pointes, this dysrhythmia is uncommon in patients with CA poisoning due to the prominent tachycardia. Hypotension is caused by direct myocardial depression secondary to altered s ...
... prolongation) rather than altered repolarization.90 Although QT prolongation predisposes to the development of torsade de pointes, this dysrhythmia is uncommon in patients with CA poisoning due to the prominent tachycardia. Hypotension is caused by direct myocardial depression secondary to altered s ...
GHB - EHC Medical Office
... weight and health; whether the person is used to taking it; and whether other drugs are taken around the same time. The following effects may begin within 15 to 20 minutes of taking GHB and may last for around 3 to 4 hours: Feelings of euphoria Memory lapses Diarrhea Urinary incontinence Nausea Dizz ...
... weight and health; whether the person is used to taking it; and whether other drugs are taken around the same time. The following effects may begin within 15 to 20 minutes of taking GHB and may last for around 3 to 4 hours: Feelings of euphoria Memory lapses Diarrhea Urinary incontinence Nausea Dizz ...
AusPAR: Lixisenatide - Therapeutic Goods Administration
... patients with T2DM, mean apparent half-life generally ranged from 1.5 to 4.5 h and the mean apparent clearance ranged from 20 to 67 L/h at steady state. The same test method, a ligand binding assay designated DOH0498, was used for the determination of lixisenatide in Studies BDR6864 and BEQ11094. Ho ...
... patients with T2DM, mean apparent half-life generally ranged from 1.5 to 4.5 h and the mean apparent clearance ranged from 20 to 67 L/h at steady state. The same test method, a ligand binding assay designated DOH0498, was used for the determination of lixisenatide in Studies BDR6864 and BEQ11094. Ho ...
LACTULOSE 3.3G/5ML ORAL SOLUTION PL 10321/0002 UKPAR
... deficiency or glucose-galactose malabsorption should not take this medicine. Because of the physiological mode of action of Lactulose Liquid Ph. Eur it may take up to 48 hours before effects are obtained. In addition there is a carry-over effect which may enable the patient to reduce the effective d ...
... deficiency or glucose-galactose malabsorption should not take this medicine. Because of the physiological mode of action of Lactulose Liquid Ph. Eur it may take up to 48 hours before effects are obtained. In addition there is a carry-over effect which may enable the patient to reduce the effective d ...
norspan® transdermal patch - Research Review Australia
... vs 14% NORSPAN® patch]. The most common adverse events reported were those commonly associated with the use of opioids [nausea, vomiting, dizziness, somnolence, headache and constipation]. BP98-1201 was a randomised, double-blind trial comparing the efficacy and safety of NORSPAN® patches 5, 10 and ...
... vs 14% NORSPAN® patch]. The most common adverse events reported were those commonly associated with the use of opioids [nausea, vomiting, dizziness, somnolence, headache and constipation]. BP98-1201 was a randomised, double-blind trial comparing the efficacy and safety of NORSPAN® patches 5, 10 and ...
Product Monograph - Ask Novartis Pharma
... Occasionally, symptomatic hypotension has occurred after administration of valsartan, in some cases after the first dose. It is more likely to occur in patients who are volume-depleted by diuretic therapy, dietary salt restriction, dialysis, diarrhea, or vomiting. In these patients, because of the p ...
... Occasionally, symptomatic hypotension has occurred after administration of valsartan, in some cases after the first dose. It is more likely to occur in patients who are volume-depleted by diuretic therapy, dietary salt restriction, dialysis, diarrhea, or vomiting. In these patients, because of the p ...
Etopophos and associated names - Art. 30 referral
... more than 5 days or is associated with fever or infection, if platelet count less than 25,000 cells/mm occurs, if any grade 3 or 4 toxicity develops or if renal clearance is less than 50 ml/min. Severe myelosuppression with resulting infection or haemorrhage may occur. Bacterial infections should be ...
... more than 5 days or is associated with fever or infection, if platelet count less than 25,000 cells/mm occurs, if any grade 3 or 4 toxicity develops or if renal clearance is less than 50 ml/min. Severe myelosuppression with resulting infection or haemorrhage may occur. Bacterial infections should be ...
... Since loratadine is excreted in breast milk and because of the increased risk of antihistamines for infants, particularly newborns and premature infants, a decision should be made whether to discontinue nursing or discontinue the drug. OVERDOSAGE INFORMATION: Somnolence, tachycardia and headache hav ...
Dydrogesterone
Dydrogesterone (INN, USAN, BAN), is also chemically known as 9β,10α-pregna-4,6-diene-3,20-dione. Dydrogesterone (6-dehydro-retroprogesterone) is a hormonally active, non-androgenic steroid that was developed in the 1950s.Dydrogesterone has selective progestational activity and does not inhibit ovulation. The greater rigidity of dydrogesterone also positively affects its selectivity, while natural progesterone is less selective, existing in different conformations that more easily bind to different receptors. As a consequence of its better bioavailability and the progestational activity of its main metabolites (20-, 21- and 16-hydroxy derivatives), the equivalent dose of dydrogesterone is 10–20 times lower than that of oral micronized progesterone.Dydrogesterone is used as an effective, orally active progestogen for gynaecological conditions related to a wide variety of progesterone deficiencies in pregnant women. The molecular structure and pharmacological effects are somewhat similar to endogenous progesterone, although in smaller amounts it is found to be orally active. Its freedom from hormonal effects like those related to corticoid, androgenic, estrogenic, anabolic, and other effects gives dydrogesterone an advantage over other synthesized progestogens.Dydrogesterone when used therapeutically is closely related to its physiological action on the neuro-endocrine control of ovarian function, as well as on the endometrium. This is an indication in all cases of endogeneous progesterone deficiency - relative or absolute. The molecule was licensed for use in several indications, including threatened or recurrent miscarriage, dysfunctional bleeding, infertility due to luteal insufficiency, dysmenorrhea, endometriosis, secondary amenorrhoea, irregular cycles, pre-menstrual syndrome and also as a hormone replacement therapy.Dydrogesterone has proven effective in the following conditions associated with progesterone deficiency: Infertility due to luteal insufficiency Threatened miscarriage Habitual or recurrent miscarriage. Menstrual disorders Premenstrual syndrome Endometriosis Dydrogesterone has also been registered as hormone replacement therapy (HRT) to counter-check the negative effects of unopposed estrogen on the endometrium in women with an intact uterus. Dydrogesterone is relatively safe and well tolerated, and does not exhibit the androgenic side effects that are common with some other progestins, like medroxyprogesterone acetate.