FLONASE (fluticasone propionate) Nasal Spray, 50 mcg
... receptor system involving binding and gene expression afforded 50% responses at 1.25 and 0.17 nM concentrations, respectively. Fluticasone propionate was 3-fold to 5-fold more potent than dexamethasone in these assays. Data from the McKenzie vasoconstrictor assay in man also support its potent gluco ...
... receptor system involving binding and gene expression afforded 50% responses at 1.25 and 0.17 nM concentrations, respectively. Fluticasone propionate was 3-fold to 5-fold more potent than dexamethasone in these assays. Data from the McKenzie vasoconstrictor assay in man also support its potent gluco ...
What’s special about methadone?
... body to a toxic level if it is taken too often, if the amount taken is too high, or if it is taken with certain other medicines or supplements. Methadone has specific toxic effects on the heart (QT prolongation and Torsades de Pointes). Physicians prescribing methadone should be familiar with methad ...
... body to a toxic level if it is taken too often, if the amount taken is too high, or if it is taken with certain other medicines or supplements. Methadone has specific toxic effects on the heart (QT prolongation and Torsades de Pointes). Physicians prescribing methadone should be familiar with methad ...
prescribing information xylocaine viscous 2%
... Labour and Delivery: Should XYLOCAINE Viscous 2% be used concomitantly with other products containing lidocaine during labour and delivery, the total dose contributed by all formulations must be kept in mind. Nursing Women: Lidocaine and its metabolites are excreted in the breast milk. At therapeuti ...
... Labour and Delivery: Should XYLOCAINE Viscous 2% be used concomitantly with other products containing lidocaine during labour and delivery, the total dose contributed by all formulations must be kept in mind. Nursing Women: Lidocaine and its metabolites are excreted in the breast milk. At therapeuti ...
... occur owing to inefficient valve control or leakage around the facemask. Clinical studies Three spacers have been introduced for the treatment of young children: Babyhaler, AeroChamber and NebuChamber. The efficiency of dose delivery from Babyhaler has been illustrated in clinical studies of the eff ...
PRODUCT INFORMATION EES 400 mg tablets (erythromycin 400
... No evidence of teratogenicity or embryotoxicity was observed when erythromycin base was given by oral gavage to pregnant rats and mice at 700 mg/kg/day (approximately 9 times the maximum human dose), and to pregnant rabbits at 125 mg/kg/day (approximately 1.5 times the maximum human dose). A slight ...
... No evidence of teratogenicity or embryotoxicity was observed when erythromycin base was given by oral gavage to pregnant rats and mice at 700 mg/kg/day (approximately 9 times the maximum human dose), and to pregnant rabbits at 125 mg/kg/day (approximately 1.5 times the maximum human dose). A slight ...
Pediatric Codeine Formularly Restriction
... Fasting or acutely malnourished and/or dehydrated due to vomiting, diarrhea or fever (reduced hepatic glutathione stores) ...
... Fasting or acutely malnourished and/or dehydrated due to vomiting, diarrhea or fever (reduced hepatic glutathione stores) ...
antimicrobial use
... Issues: Although Pseudomonas aeruginosa is an important cause of 30-35% of nosocomial pneumonias, empiric antipseudomonal regimens are often continued too long when the antimicrobial spectrum can be narrowed. Antimicrobial therapy in general for nosocomial pneumonia is generally “too long.” MRSA ser ...
... Issues: Although Pseudomonas aeruginosa is an important cause of 30-35% of nosocomial pneumonias, empiric antipseudomonal regimens are often continued too long when the antimicrobial spectrum can be narrowed. Antimicrobial therapy in general for nosocomial pneumonia is generally “too long.” MRSA ser ...
Clinical application of extended-release hydromorphone for pain
... countries. For example, there is a 12-h formulation available in Canada (Hydromorph Contin) and the UK and Germany (Palladone SR) [1] . Additionally, Palladone XL, a 24-h preparation, was approved for use in Canada [1] . Like OROS hydromorphone, the advantages of the Palladone formulations are a sim ...
... countries. For example, there is a 12-h formulation available in Canada (Hydromorph Contin) and the UK and Germany (Palladone SR) [1] . Additionally, Palladone XL, a 24-h preparation, was approved for use in Canada [1] . Like OROS hydromorphone, the advantages of the Palladone formulations are a sim ...
Chapter-3 Drug and Excipients profile
... a full understanding of the risks of Isotretinoin therapy and monitoring requirements. The capsules should be taken with food once or twice daily. Adults including adolescents and the elderly Isotretinoin therapy should be started at a dose of 0.5 mg/kg daily. The therapeutic response to Isotretinoi ...
... a full understanding of the risks of Isotretinoin therapy and monitoring requirements. The capsules should be taken with food once or twice daily. Adults including adolescents and the elderly Isotretinoin therapy should be started at a dose of 0.5 mg/kg daily. The therapeutic response to Isotretinoi ...
Diovan HCT Prescribing Information
... myocardial infarctions. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes, including hydrochlorothiazide and the ARB class to which valsartan principally belongs. There are no controlled trials demonstrating risk reduction with ...
... myocardial infarctions. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes, including hydrochlorothiazide and the ARB class to which valsartan principally belongs. There are no controlled trials demonstrating risk reduction with ...
Gentamicin
... Untoward effects of gentamicin Ototoxicity (耳毒性) is the most serious effect.(The incidence of ototoxicity is in part genetically determined, having been linked to point mutations in mitochondrial DNA, and occurs in 1–5% for patients receiving gentamicin for more than 5 days. ) ...
... Untoward effects of gentamicin Ototoxicity (耳毒性) is the most serious effect.(The incidence of ototoxicity is in part genetically determined, having been linked to point mutations in mitochondrial DNA, and occurs in 1–5% for patients receiving gentamicin for more than 5 days. ) ...
Gentamicin
... Untoward effects of gentamicin Ototoxicity (耳毒性) is the most serious effect.(The incidence of ototoxicity is in part genetically determined, having been linked to point mutations in mitochondrial DNA, and occurs in 1–5% for patients receiving gentamicin for more than 5 days. ) ...
... Untoward effects of gentamicin Ototoxicity (耳毒性) is the most serious effect.(The incidence of ototoxicity is in part genetically determined, having been linked to point mutations in mitochondrial DNA, and occurs in 1–5% for patients receiving gentamicin for more than 5 days. ) ...
Loxamine - Medsafe
... moderate, however, in some patients they may be severe in intensity. They usually occur within the first few days of discontinuing treatment, but there have been very rare reports of such symptoms in patients who have inadvertently missed a dose. Generally these symptoms are self-limiting and usuall ...
... moderate, however, in some patients they may be severe in intensity. They usually occur within the first few days of discontinuing treatment, but there have been very rare reports of such symptoms in patients who have inadvertently missed a dose. Generally these symptoms are self-limiting and usuall ...
Coadministration of Oral Cyclosporin A Enables Oral Therapy with
... courses. The pharmacokinetics of paclitaxel and its major metabolites were determined during the first two courses. In addition, levels of CsA, Cremophor EL, and ethanol were measured. Bioavailability of oral paclitaxel in combination with CsA was 8-fold higher than after oral paclitaxel alone (P < ...
... courses. The pharmacokinetics of paclitaxel and its major metabolites were determined during the first two courses. In addition, levels of CsA, Cremophor EL, and ethanol were measured. Bioavailability of oral paclitaxel in combination with CsA was 8-fold higher than after oral paclitaxel alone (P < ...
Drug - University of Washington
... With advanced macrolide (azithromycin) for CAP treated on inpatient basis, non ICU (especially if aspiration pneumonia is a concern) ...
... With advanced macrolide (azithromycin) for CAP treated on inpatient basis, non ICU (especially if aspiration pneumonia is a concern) ...
Salmeson Inhalation powder pre
... therefore, that the patient is reviewed regularly and the dose of inhaled corticosteroid is reduced to the lowest dose at which effective control of asthma is maintained. Prolonged treatment of patients with high doses of inhaled corticosteroids may result in adrenal suppression and acute adrenal cr ...
... therefore, that the patient is reviewed regularly and the dose of inhaled corticosteroid is reduced to the lowest dose at which effective control of asthma is maintained. Prolonged treatment of patients with high doses of inhaled corticosteroids may result in adrenal suppression and acute adrenal cr ...
effects of cytochrome p450 enzyme inhibitors and inducers
... or grapefruit juice increased the exposure to oral S-ketamine by 2.6- and 3.0-fold. Unexpectedly, CYP3A4 inhibition by itraconazole caused no significant alterations in the plasma concentrations of oral S-ketamine. CYP3A4 induction by St. John´s wort or rifampicin decreased profoundly the concentrat ...
... or grapefruit juice increased the exposure to oral S-ketamine by 2.6- and 3.0-fold. Unexpectedly, CYP3A4 inhibition by itraconazole caused no significant alterations in the plasma concentrations of oral S-ketamine. CYP3A4 induction by St. John´s wort or rifampicin decreased profoundly the concentrat ...
Clinical Implications of Dihydropyrimidine
... chemotherapists to propose time-modified 5-FU infusions to optimize drug delivery during a 24-hour period. In Western Europe, some oncologists have reported potential benefit with such regimens in the treatment of certain human cancers.[7] DPD enzyme activity in normal tissues (peripheral blood mono ...
... chemotherapists to propose time-modified 5-FU infusions to optimize drug delivery during a 24-hour period. In Western Europe, some oncologists have reported potential benefit with such regimens in the treatment of certain human cancers.[7] DPD enzyme activity in normal tissues (peripheral blood mono ...
Prescribing Information
... Codeine is metabolized by the CYP2D6 and CYP3A4 isoenzymes [see Clinical Pharmacology (12.3)]. The concurrent use of drugs that preferentially induce codeine N-demethylation (via CYP3A4) may increase the plasma concentrations of codeine’s inactive metabolite norcodeine. Drugs that inhibit codeine O- ...
... Codeine is metabolized by the CYP2D6 and CYP3A4 isoenzymes [see Clinical Pharmacology (12.3)]. The concurrent use of drugs that preferentially induce codeine N-demethylation (via CYP3A4) may increase the plasma concentrations of codeine’s inactive metabolite norcodeine. Drugs that inhibit codeine O- ...
WARNING: DEATH RELATED TO ULTRA
... Codeine is metabolized by the CYP2D6 and CYP3A4 isoenzymes [see Clinical Pharmacology (12.3)]. The concurrent use of drugs that preferentially induce codeine N-demethylation (via CYP3A4) may increase the plasma concentrations of codeine’s inactive metabolite norcodeine. Drugs that inhibit codeine O- ...
... Codeine is metabolized by the CYP2D6 and CYP3A4 isoenzymes [see Clinical Pharmacology (12.3)]. The concurrent use of drugs that preferentially induce codeine N-demethylation (via CYP3A4) may increase the plasma concentrations of codeine’s inactive metabolite norcodeine. Drugs that inhibit codeine O- ...
Baclofen Intoxication
... of baclofen overdose are well defined in the literature, and include somnolence, coma, seizures, encephalopathy, respiratory depression, flaccidity, hyporeflexia, and cardiac conduction abnormalities.[2,6] Autonomic disturbances are also frequent but inconsistent; patients may have either bradycardi ...
... of baclofen overdose are well defined in the literature, and include somnolence, coma, seizures, encephalopathy, respiratory depression, flaccidity, hyporeflexia, and cardiac conduction abnormalities.[2,6] Autonomic disturbances are also frequent but inconsistent; patients may have either bradycardi ...
I2326E-IF2326E- Savage NITROBID
... Dosing regimens for most chronically used drugs are designed to provide plasma concentrations that are continuously greater than a minimally effective concentration. This strategy is inappropriate for organic nitrates. Several well-controlled clinical trials have used exercise testing to assess the ...
... Dosing regimens for most chronically used drugs are designed to provide plasma concentrations that are continuously greater than a minimally effective concentration. This strategy is inappropriate for organic nitrates. Several well-controlled clinical trials have used exercise testing to assess the ...
EFAVIRENZ RAT MODEL Research Article
... metabolism of other drugs metabolized by the same enzyme. The decreased metabolism can result in higher drug levels and increased potential for toxicity. When drugs that induce CYP450 enzymes are administered to a patient, the body responds by increasing the production of speci ...
... metabolism of other drugs metabolized by the same enzyme. The decreased metabolism can result in higher drug levels and increased potential for toxicity. When drugs that induce CYP450 enzymes are administered to a patient, the body responds by increasing the production of speci ...
R
... and extended release 20–40 mg per day) and minocycline (100–200 mg per day), are commonly used oral therapies. Second generation tetracyclines have an improved bioavailability, longer elimination half-life, once-daily dosing, and can be taken with food, which minimizes gastrointestinal side effects. ...
... and extended release 20–40 mg per day) and minocycline (100–200 mg per day), are commonly used oral therapies. Second generation tetracyclines have an improved bioavailability, longer elimination half-life, once-daily dosing, and can be taken with food, which minimizes gastrointestinal side effects. ...
Preclinical Absorption, Distribution, Metabolism, and Excretion of an
... DNA [14,16]. The clearance of gemcitabine is driven by rapid and extensive inactivation by cytidine deaminase, which is present ubiquitously and at high levels in both plasma and in the liver, to its primary metabolite, 2',2'-difluoro-deoxyuridine (dFdU) [14,17]. Clinical studies have shown that eff ...
... DNA [14,16]. The clearance of gemcitabine is driven by rapid and extensive inactivation by cytidine deaminase, which is present ubiquitously and at high levels in both plasma and in the liver, to its primary metabolite, 2',2'-difluoro-deoxyuridine (dFdU) [14,17]. Clinical studies have shown that eff ...
Dydrogesterone
Dydrogesterone (INN, USAN, BAN), is also chemically known as 9β,10α-pregna-4,6-diene-3,20-dione. Dydrogesterone (6-dehydro-retroprogesterone) is a hormonally active, non-androgenic steroid that was developed in the 1950s.Dydrogesterone has selective progestational activity and does not inhibit ovulation. The greater rigidity of dydrogesterone also positively affects its selectivity, while natural progesterone is less selective, existing in different conformations that more easily bind to different receptors. As a consequence of its better bioavailability and the progestational activity of its main metabolites (20-, 21- and 16-hydroxy derivatives), the equivalent dose of dydrogesterone is 10–20 times lower than that of oral micronized progesterone.Dydrogesterone is used as an effective, orally active progestogen for gynaecological conditions related to a wide variety of progesterone deficiencies in pregnant women. The molecular structure and pharmacological effects are somewhat similar to endogenous progesterone, although in smaller amounts it is found to be orally active. Its freedom from hormonal effects like those related to corticoid, androgenic, estrogenic, anabolic, and other effects gives dydrogesterone an advantage over other synthesized progestogens.Dydrogesterone when used therapeutically is closely related to its physiological action on the neuro-endocrine control of ovarian function, as well as on the endometrium. This is an indication in all cases of endogeneous progesterone deficiency - relative or absolute. The molecule was licensed for use in several indications, including threatened or recurrent miscarriage, dysfunctional bleeding, infertility due to luteal insufficiency, dysmenorrhea, endometriosis, secondary amenorrhoea, irregular cycles, pre-menstrual syndrome and also as a hormone replacement therapy.Dydrogesterone has proven effective in the following conditions associated with progesterone deficiency: Infertility due to luteal insufficiency Threatened miscarriage Habitual or recurrent miscarriage. Menstrual disorders Premenstrual syndrome Endometriosis Dydrogesterone has also been registered as hormone replacement therapy (HRT) to counter-check the negative effects of unopposed estrogen on the endometrium in women with an intact uterus. Dydrogesterone is relatively safe and well tolerated, and does not exhibit the androgenic side effects that are common with some other progestins, like medroxyprogesterone acetate.